Clinical trials: Neuromuscular Block
Neuromuscular Blockade
Efficacy, Safety, and Pharmacokinetics of Sugammadex for Reversal of Neuromuscular Blockade (NMB) in Pediatric Participants (MK-8616-089)
This trial will evaluate the efficacy, safety, and pharmacokinetics of sugammadex for the reversal of both moderate and deep neuromuscular blockade (NMB) induced by either rocuronium or vecuronium in pediatric participants.
- Trial name
- NCT03351608
- Testing
- Sugammadex 2 mg/kg, Sugammadex 4 mg/kg, Neostigmine + Glycopyrrolate
- Where
- 30 sites in United States, Austria and 6 more
- Volunteers
- 288 people
- Sponsor
- Merck Sharp & Dohme LLC
Neuromuscular Block, Residual, Pain Management
Methylprednisolone vs Dexamethasone Interaction With Sugammadex in Pediatric Patients
This randomized controlled trial aims to compare the interaction of methylprednisolone and dexamethasone with sugammadex in pediatric patients undergoing adenoidectomy and/or tonsillectomy.
- Conditions
- Neuromuscular Block, Residual, Pain Management, Postoperative Nausea
- Trial name
- NCT07175623
- Testing
- Methyl Prednisolone (MP), Dexamethasone (0.2 mg/kg), Saline (0.9% NaCl)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Konya City Hospital
Carpal Tunnel Syndrome, Anesthesia, Local
Ultrasound-guided Peripheral Nerve Block Versus Forearm Bier's Block in Patients Undergoing Carpal Tunnel Release
By means of an observer-blinded, randomized controlled trial, the analgesic efficacy of the forearm intravenous regional anesthesia and the ultrasound guided peripheral nerve block will be investigated in patients undergoing…
- Trial name
- NCT03411551
- Testing
- regional anesthesia
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jessa Hospital
Neuromuscular Blockade
The Clinical Effect of Sugammadex Sodium (Domestic) for Antagonizing Neuromuscular Blockade After Thoracic Surgery
This study aims to compare the use of sugammadex (domestic) and neostigmine for antagonism after thoracic surgery, and observe the effect of sugammadex (domestic) on neuromuscular blockade antagonism after thoracic surgery, in…
- Trial name
- NCT06334562
- Testing
- SUGAMMADEX SODIUM 100 Mg in 1 mL, Neostigmine
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Disorder of Maxillary and Mandibular Dental Arch Relationship
Impact of Complete Removable Prosthetic Rehabilitations Performed by an Innovative DDTENS Protocol, on the Quality of Masticatory Function and the Management of Completely Edentulous Patients
Total edentulism is a profound physical, psychic and social handicap, which affects 5 million people in France. The most frequent complaint of edentulous patients rehabilitated by conventional Complete Removable Prostheses (CRP)…
- Trial name
- DD-TENS (NCT05096624)
- Testing
- DD-TENS system, Gold Standard, Digital Denture system
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Neuromuscular Blockade
Reversal of Residual Neuromuscular Blockade at Train-of-four Ratio 0.3 With Sugammadex and Neostigmine
The aim of this study is to estimate the optimal dose of sugammadex and neostigmine reversal of a vecuronium-induced residual neuromuscular block at train-of-four ratio 0.3.
- Trial name
- NCT03656614
- Testing
- Sugammadex, Neostigmine, Saline 0.9%
- Where
- China
- Volunteers
- 121 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Postcardiac Arrest Therapeutic Hypothermia
When Cooling a Patient After Cardiac Arrest, Does Use of a Neuromuscular Blocking Agent Make Your Job Easier?
After successful resuscitation from cardiac arrest, cooling the whole body is a well established treatment that improves the chances of the brain recovering.
- Trial name
- NCT02033733
- Testing
- Cisatracurium infusion, Cisatracurium prn bolus
- Where
- 2 sites in Canada
- Volunteers
- 400 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Surgical Procedures, Elective
Study of Sugammadex Versus Usual Care on Incidence of Residual Blockade at Post Anesthesia Care Unit Admission (P07981)
This study will compare the incidence of residual neuromuscular blockade in participants who undergo reversal of neuromuscular blockade with sugammadex compared to those who undergo reversal of neuromuscular blockade with usual…
- Trial name
- NCT01479764
- Testing
- Sugammadex, Neostigmine, Glycopyrrolate
- Volunteers
- 154 people
- Sponsor
- Merck Sharp & Dohme LLC
Neuromuscular Blockade
Safety and Efficacy of HRS-9190 Compared to Rocuronium for Tracheal Intubation in Adults
The study will enroll adult patients scheduled for elective surgery requiring general anesthesia with tracheal intubation. Participants will be randomly assigned to receive either HRS-9190 for Injection or Rocuronium.
- Trial name
- NCT07252921
- Testing
- HRS-9190
- Where
- 2 sites in China
- Volunteers
- 70 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Cardiac Index
Effects of Neuromuscular Blockade Level and Intra-abdominal Pressure on Surgical Conditions and Cardiopulmonary Responses During Laparoscopic Colon Surgery With the Trendelenburg Position
The purpose of this study is to find out the effect of low abdominal pressure vs. standard abdominal pressure on the cardiac and respiratory function of the patients undergoing laparoscopic colon surgery in Trendelenberg…
- Trial name
- NCT02249585
- Testing
- Standard abdominal pressure, Low abdominal pressure, Conventional neuromuscular blockade
- Where
- South Korea
- Volunteers
- 131 people
- Sponsor
- Seoul National University Hospital
Acute Respiratory Distress Syndrome, Ventilator-Induced Lung Injury
Impact of the Depth of Neuromuscular Blockade on Respiratory Mechanics in Moderate to Severe ARDS Patients
Neuromuscular blockade (NMB) is proposed in patients with moderate to severe acute respiratory distress syndrome (ARDS). The supposed benefit of these muscle relaxants could be partly linked to their effects on respiratory…
- Trial name
- NCT05697666
- Testing
- Modulation of the depth of the neuromuscular blockade
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Centre Hospitalier de Saint-Brieuc
Postoperative Pulmonary Complications
Postoperative Pulmonary Complications After Use of Supraglottic Airway Devices and Neuromuscular Blockade
SupAIR is an international, multicenter, randomized controlled trial investigating whether airway management and neuromuscular blockade during general anesthesia influence postoperative pulmonary complications.
- Trial name
- SupAIR (NCT07829094)
- Testing
- Airway management strategy, Initiation of neuromuscular blockade (NMB), Deep versus moderate neuromuscular blockade (NMB)
- Volunteers
- 6,800 people
- Sponsor
- University Hospital Ulm
Inguinal Hernia, Abdominal Wall Muscles
Transversus Abdominis Plane Block and Inguinal Hernia Repair
This prospective, randomized, double blinded, placebo-controlled study is designed to evaluate the postoperative analgesic efficacy of the ultrasound-guided transversus abdominis plane block with ropivacaine 0,75 %, in patients…
- Conditions
- Inguinal Hernia, Abdominal Wall Muscles, Regional Anesthesia, Postoperative Pain
- Trial name
- NCT02030223
- Testing
- Transversus abdominis plane block
- Where
- Greece
- Volunteers
- 59 people
- Sponsor
- Papacharalampous Panagiota
Neuromuscular Block, Surgery
MRI Measurement of the Effects of Deep Neuromuscular Blockade on the Abdominal Working Space During Laparoscopy
During laparoscopy, a surgical working space is obtained by creation of a pneumoperitoneum. Optimal surgical conditions are essential to ensure the patient's safety.
- Trial name
- RELAX-2 (NCT03287388)
- Testing
- No Rocuronium, Rocuronium (moderate NMB), Rocuronium (deep NMB)
- Volunteers
- 8 people
- Sponsor
- Radboud University Medical Center
Anesthesia, Surgery
Time Prediction for Complete Recovery From Neuromuscular Blockade After Visual Recovery With Double Burst Stimulation
The purpose is to calculate the time for an optimal recovery (T4/T1 > 0.9) from the moment when 2 responses to double burst stimulation are visually identical and this for 95% of patients.
- Trial name
- DBS PREDICTION (NCT02893436)
- Testing
- Surgery with tracheal intubation curarisation
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Lumbar Spine Disease
Deep Neuromuscular Block on Postoperative Delirium in Lumbar Surgery
The effect of deep neuromuscular blockade (NMB) during spine surgery reduced postoperative pain and bleeding in recent studies. Therefore by reducing these two factors, which were the contributing factors for postoperative…
- Trial name
- NCT05453929
- Testing
- Rocuronium for deep NMB, Rocuronium for moderate NMB
- Where
- South Korea
- Volunteers
- 230 people
- Sponsor
- Korea University Guro Hospital
Underdosing of Other General Anesthetics
Influence of Mild Hypothermia on Reversal of Rocuronium With Sugammadex
The primary efficacy endpoint is the time from the start of administration of sugammadex to recovery of the TOF ratio to 0.9 in deep neuromuscular block (1-2 twitches post-tetanic count) induced by rocuronium during mild…
- Trial name
- NCT01965067
- Testing
- sugammadex
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- MSD Korea Ltd.
Neuromuscular Blockade, Neuromuscular Monitoring
A Comparison Between TOF Watch® SX and Tetragraph®
This observational study was designed to assess the agreement between the recently marketed electromyographic neuromuscular blockade monitor Tetragraph® (Senzime, Uppsala, Sweden) and the TOF Watch® SX (Organon Teknika B.V.…
- Trial name
- NCT04947306
- Testing
- Tetragraph® (Senzime, Uppsala, Sweden), TOF Watch® SX (Organon Teknika B.V., Boxtel, Holland)
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Neuromuscular Blockade, Statin-Associated Myopathy
Evaluation of Neuromuscular Blockade Responses in Statin-Using and Non-Using Patients
This study aims to compare the neuromuscular blockade responses in patients undergoing elective surgery under general anesthesia, with a focus on the use of statins.
- Conditions
- Neuromuscular Blockade, Statin-Associated Myopathy, Neuromuscular Monitoring
- Trial name
- NCT06834776
- Testing
- TOF (Train-of-Four) monitoring for depth of neuromuscular blockade.
- Volunteers
- 104 people
- Sponsor
- Ankara City Hospital Bilkent
Stomach Cancer
The Effect of Deep Neuromuscular Block on the Perioperative Stress Response Reduction and Postoperative Recovery Enhancement in Robot-assisted Stomach Cancer Surgery
Stress reactions caused by surgical stimuli can cause sympathetic nervous system activation and increased stress hormones, such as catecholamines, inflammatory cytokines, and pituitary hormones, and insulin resistance.
- Trial name
- NCT03937440
- Testing
- Deep neuromuscular block with 'rocunium®', Moderate neuromuscular block with 'rocunium®'
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Yonsei University