Clinical trials: Neuromuscular Block
Bariatric Surgery Candidate
Rates and Severity of PONV for Neuromuscular Block Reversal in Patients Receiving Gastric Bypass Bariatric Surgery
Patients who require bariatric surgery frequently bring a panoply of pre-existing comorbidities to the operating theatre. With body mass indices routinely in the 50s and 60s, patients who have bariatric surgery frequently have…
- Trial name
- NCT03432845
- Testing
- compare reversal agents
- Sponsor
- WellSpan Health
Neuromuscular Blockade, Laparoscopy
Deep Neuromuscular Block Affect the Quality of Recovery After Laparoscopic Hysterectomy
BACKGROUND: Some studies have revealed that deep neuromuscular block (NMB) improve surgical conditions and alleviated postoperative pain compared with moderate NMB.
- Trial name
- NCT06469866
- Testing
- low-pressure pneumoperitoneum, standard-pressure pneumoperitoneum
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Anqing Municipal Hospital
Inclusion Body Myositis, Sporadic
Ruxolitinib Treatment in Inclusion Body Myositis
Refer to the "Detailed Description" section.
- Trial name
- BIGTIM (NCT06536166)
- Testing
- Ruxolitinib
- Where
- 21 sites in France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Amyotrophic Lateral Sclerosis, Respiratory Function
The Safety and Effectiveness of Cholinergic Receptor Block Therapy in the Treatment of ALS
Thirty cases of amyotrophic lateral sclerosis patients were recruited from the neurology department of Ruijin Hospital, the pain department and the encephalopathy center of Luwan Branch of Ruijin Hospital.
- Conditions
- Amyotrophic Lateral Sclerosis, Respiratory Function, Scopolamine
- Trial name
- NCT04391361
- Testing
- Scopolamine, atropine, edaravone and dexmedetomidine, Edaravone
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Ruijin Hospital
Surgical Conditions, Rating Scales
Validation of Subjective Rating Scales Used to Assess Surgical Conditions in Abdominal Surgery
Use of neuromuscular blockade (NMB) may improve the surgical work space in patients scheduled for laparoscopic surgical cases (e.g. hysterectomy, ovarian cystectomy, myomectomy).
- Conditions
- Surgical Conditions, Rating Scales, Laparoscopy, Neuromuscular Blockade
- Trial name
- NCT02079337
- Testing
- Rocuronium, sugammadex
- Where
- Denmark
- Volunteers
- 14 people
- Sponsor
- Herlev Hospital
Neuromuscular Blockade
Qualitative Analysis of Barriers to Consistent Use of Neuromuscular Monitoring in General Anaesthesia
Monitoring the degree of neuromuscular blockade in general anaesthesia reduces complications and patient discomfort. However, monitoring is not applied consistently by Danish anaesthesia personnel.
- Trial name
- NCT02239965
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Herlev Hospital
Laparoscopy, Anesthesia Recovery Period
Deep Neuromuscular Block for Laparoscopic Surgery
Trial summary: deep neuromuscular block is proposed as a technique to improve operative conditions for laparoscopy. Early clinical data would suggest that there may also be patient benefits beyond the operative period related to…
- Trial name
- DEEPBLOCK (NCT03034577)
- Testing
- Sugammadex, Neostigmine
- Where
- 4 sites in Australia
- Volunteers
- 350 people
- Sponsor
- University of Melbourne
Prostate Cancer
The Effect of Deep Versus Moderate Muscle Relaxants in Men During and After Robotic Surgery for Prostate Cancer
The purpose of this study is to determine if there is a difference in intra-abdominal pressure which surgeons use during surgery and post-surgery pain in men who undergo robotic prostate surgery with deep neuromuscular blockade…
- Trial name
- NCT03808077
- Testing
- Rocuronium 0.3mg/kg/hr, Rocuronium 1.5mg/kg/hr
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Peripheral Nerve Injury
Needle Nerve Contact in Ultrasound Guided Femoral Block
Ultrasound-guided femoral nerve block is a common regional anesthesia technique. The optimal method of needle guidance (in-plane versus out-of-plane) with regards to the block efficacy and avoidance of needle-nerve contact has…
- Trial name
- NCT01554722
- Testing
- Needle placement
- Where
- 2 sites in United States, Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Pain, Postoperative, Crohn Disease
Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel®)
Traditionally, opioids are heavily utilized in treating postoperative pain but they are associated with numerous side effects. The use of the transversus abdominis plane (TAP) blocks have become standard practice to extend the…
- Conditions
- Pain, Postoperative, Crohn Disease, Inflammatory Bowel Diseases, Colorectal Cancer
- Trial name
- TINGLE (NCT03723447)
- Testing
- Liposomal bupivacaine, Bupivacaine/epinephrine/dexamethasone
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Cedars-Sinai Medical Center
Anaesthesia
Electromyographic (EMG) on the Anaesthesia Monitor
Intubation may induce electromyographic (EMG) activity, causing depth of anaesthesia monitors to show misleadingly high values. The investigators want to investigate whether this EMG activity can be visually seen on the…
- Trial name
- NCT01142635
- Testing
- Rocuronium bromide
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Tampere University Hospital
Thyroid Neoplasms
The Effects of Deep Neuromuscular Blockade During Robot-assisted Transaxillary Thyroidectomy on Postoperative Pain and Sensory Change
As robotic surgery has been applied to various surgeries, the minimally invasive surgery is rapidly evolving. In particular, robot-assisted thyroidectomy is one of the leading techniques in minimally invasive surgery fields.
- Trial name
- NCT03871387
- Testing
- Deep Group, Control Group
- Where
- South Korea
- Volunteers
- 88 people
- Sponsor
- Yonsei University
Postoperative Pain, Lung Cancer
Pain After Lung Cancer Surgery - Comparing Traditional Versus Prolonged Release Nerve Blockades
To investigate the effect of liposomal bupivacaine compared with bupivacaine hydrochloride for intercostal blockades for patients undergoing Video-assisted thoracoscopic surgery.
- Conditions
- Postoperative Pain, Lung Cancer, Video Assisted Thoracoscopic Surgery, Blockades Neuromuscular
- Trial name
- NCT05038007
- Testing
- Liposomal bupivacaine, Bupivacaine Hydrochloride
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Jannie Bisgaard Stæhr
Neuromuscular Blockade
A Randomized Double Blind Controlled Trial Comparing Sugammadex and Neostigmine After Thoracic Anesthesia
At the end of anesthesia it's important to avoid residual neuromuscular block to ensure adequate respiratory function preventing postoperative pulmonary complications.
- Trial name
- DATA (NCT02256280)
- Testing
- Sugammadex, Neostigmine
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Organophosphate Poisoning
A Pilot Study Using Rocuronium to Prevent Intermediate Syndrome After Organophosphorus Insecticide Poisoning
Organophosphate pesticide poisoning causes close to 300 000 deaths per year worldwide. Many patients who ingest organophosphates require ventilation; of these patients approximately 50% die.
- Trial name
- NCT02147054
- Testing
- Rocuronium, Sugammadex
- Where
- Sri Lanka
- Volunteers
- 45 people
- Sponsor
- University of Edinburgh
Neuromuscular Blockade
Deep Versus Moderate Neuromuscular Blockade in Bariatric Surgery
The aim of this study is to investigate the effect of depth of neuromuscular blockade on the surgical field, patient postoperative pain, intestinal motility, the incidence of postoperative nausea and vomiting and the effect of…
- Trial name
- NCT06553066
- Testing
- Deep neuromascular blockage, Moderate neuromascular blockage
- Volunteers
- 50 people
- Sponsor
- University Hospital of Patras
CRPS (Complex Regional Pain Syndrome) Type I
Evaluation of the Relationship Between the Duration of the Evolution of the Complex Regional Pain Syndrome Type 1 (CRPS 1) and Effectiveness of the Continuous Peripheral Nerve Block (CPNB) Associated With an Intensive Rehabilitation Program
The study evaluates the relationship between the duration of evolution of SDRC1 and the efficacy of continuous peripheral nerve block (c-PNB) associated with an intensive rehabilitation program to improve the therapeutic strategy…
- Trial name
- BLOCALGO (NCT04767646)
- Testing
- Intensive rehabilitation program with CPNB
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Pôle Saint Hélier
Surgical Conditions
Effect of Deep Versus Moderate Neuromuscular Block During Sevoflurane Anesthesia on Intraoperative Surgical Conditions.
A deep neuromuscular block (NMB) is often associated with improved surgical conditions especially in laparoscopic surgery. We previously showed that deep NMB is superior to a moderate NMB under propofol anesthesia.
- Trial name
- BLISS4 (NCT03170661)
- Testing
- Deep neuromuscular block
- Where
- Netherlands
- Volunteers
- 98 people
- Sponsor
- Leiden University Medical Center
Healthy
The Efficacy and Safety of Gantacurium Chloride for Injection in Tracheal Intubation in Healthy Adult Patients Undergoing Surgery Under General Anesthesia
This is a multicenter, randomized, controlled, observer-blinded, dose-response study to evaluate the efficacy in tracheal intubation and safety of gantacurium chloride for injection in healthy adult patients undergoing surgery…
- Trial name
- NCT00235976
- Testing
- Gantacurium Chloride for Injection (AV430A)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Avera Pharmaceuticals
Laparoscopic Surgery
Dose for Deep Neuromuscular Blockade Deciding Factor of Neuromuscular Blocker Dose for Deep Neuromuscular Blockade
Find out the deciding factor(total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index, skeletal muscle mass, body fat) of neuromuscular blocker dose for deep neuromuscular blockade.
- Trial name
- NCT04688268
- Testing
- deep neuromuscular blockade
- Volunteers
- 90 people
- Sponsor
- Seoul National University Bundang Hospital