Clinical trials: Neuromuscular Block
Residual Neuromuscular Block
Neostigmine Reversal And Neuromuscular Recovery
Patients undergoing surgery often receive paralytic agents (or neuromuscular blocking agents (NMBAs)) to facilitate the procedure. At the end of surgery, the effects NMBAs are reversed with a drug called neostigmine.
- Trial name
- NCT02433808
- Testing
- Neostigmine Group, No Neostigmine group
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Postoperative Residual Curarization
Comparison of Train of Four, Tetanus 50 and 100 Hz Recovery After Rocuronium Block Reversed by Sugammadex
Despite neuromuscular transmission monitoring and pharmacological reversal allowing a train of four ratio recovery higher than 0.9, patients receiving neuromuscular blocking agent during general anesthesia have a high risk of…
- Trial name
- NCT05003024
- Testing
- TOF SCAN, ITF
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Poitiers University Hospital
Postoperative Residual Curarization, Neuromuscular Blockade
Infantile - Postoperative Residual Curarization - Study
The primary object of this study is, to investigate the current procedure of neuromuscular monitoring at a tertiary academic university medical center.
- Conditions
- Postoperative Residual Curarization, Neuromuscular Blockade, Neuromuscular Monitoring
- Trial name
- I-PORC (NCT03804346)
- Testing
- Acceleromyography
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Regensburg
Neuromuscular Blockade, Cholecystectomy
Acceleromyography Versus Electromyography for Neuromuscular Recovery Assessment at the End of Surgery
This prospective observational study aims to evaluate the agreement between acceleromyography and electromyography for measuring train-of-four (TOF) ratio at the end of surgery before reversal of neuromuscular blockade.
- Trial name
- NCT07739862
- Testing
- Simultaneous Acceleromyography and Electromyography Monitoring
- Where
- Chile
- Volunteers
- 70 people
- Sponsor
- Clínica Dávila
Anesthesia, General, Neuromuscular Blockade
Pharmacokinetic-pharmacodynamic Analysis of Sugammadex in Children
This study administers sugammadex sodium to pediatric patients under general anesthesia with rocuronium. Pharmacokinetic and pharmacodynamic analysis are performed based on plasma concentration of sugammadex sodium and monitoring…
- Trial name
- NCT03943888
- Testing
- Sugammadex Injection 2mg/kg, Sugammadex Injection 4mg/kg, Sugammadex Injection 8mg/kg
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
COVID-19 Acute Respiratory Distress Syndrome, Sedation Complication
Comparison for the Effect of Neuromuscular Blocking Agents Versus Sedation Alone on Severe ARDS Patients Due to COVID-19
Many questions about management of COVID-19 are still not answered. So, we recruit this study aiming to evaluate improvement of oxygenation in COVID-19 patients with severe ARDS, to improve morbidity and mortality of ICU covid…
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, Sedation Complication, ICU Acquired Weakness
- Trial name
- NCT04922814
- Testing
- muscle relaxation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Observation of Neuromuscular Block, Flexor Hallucis
Evaluation of Monitoring Neuromuscular Blockade the Flexor Hallucis Compared to the Adductor Pollicis
Current guidelines recommend monitoring of neuromuscular blockade at the adductor pollicis by stimulation of the ulnar nerve at the wrist.
- Conditions
- Observation of Neuromuscular Block, Flexor Hallucis, Adductor Pollicis
- Trial name
- CurHaTOF (NCT02825121)
- Testing
- Monitoring Neuromuscular Blockade the Flexor Hallucis, Monitoring Neuromuscular Blockade adductor of the thumb.
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Poitiers University Hospital
Prostate Cancer, Renal Cancer
Effect of Neuromuscular Block and Arterial PCO2 on Surgical Rating Scale (SRS), Following Reversal With Sugammadex
The purpose of this study is to study the effect of variations in the arterial CO2 concentration during deep neuromuscular block on the surgical conditions as assessed by the surgical rating scale
- Trial name
- BLISSS2 (NCT01968447)
- Testing
- hypocapnia, normocapnia
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Leiden University Medical Center
Trigeminal Neuralgia, Facial Pain
Incidence of Intravascular (IV) Injection During Trigeminal Nerve Blocks
The purpose of this study is to investigate the incidence of intravascular injection during trigeminal nerve blocks.
- Conditions
- Trigeminal Neuralgia, Facial Pain, Postherpetic Neuralgia, Cluster Headache
- Trial name
- NCT04467398
- Testing
- trigeminal nerve block
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University
General Anesthesia, Breast Disease
Neuromuscular Block in Laryngeal Mask Airway(LMA) Insertion
The aim of this study is to evaluate the success rate, insertion time and complication depending on the use of neuromuscular blocking agent when inserting the laryngeal mask airway (LMA).
- Trial name
- NCT01035021
- Testing
- use of rocuronium when the LMA is inserted
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Seoul National University Bundang Hospital
Post Operative Pulmonary Complications, Neuromuscular Blockade
Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease
The purpose of the study is to determine which combination of neuromuscular blocking agent and reversal agent is safer to use during anesthesia for patients with chronic kidney disease.
- Conditions
- Post Operative Pulmonary Complications, Neuromuscular Blockade, General Anesthesia
- Trial name
- NCT07203287
- Testing
- Rocuronium, Cisatracurium, Sugammadex
- Where
- United States
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Residual Neuromuscular Block
Impact of Sugammadex Versus Neostigmine on Early Postoperative Pulmonary Function
Residual neuromuscular blockade (NMB) after general anesthesia increases the risk of postoperative respiratory complications (atelectasis, pneumonia, re-intubation) and delays pulmonary function recovery.
- Trial name
- NCT07309393
- Testing
- Sugammadex, Neostigmine
- Where
- 3 sites in China
- Volunteers
- 240 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Bulbar Palsy
A Nerve Block Therapy for Bulbar Palsy Pharyngeal Dysphagia
This was a multicenter randomized controlled study. 66 post-stroke patients with pharyngeal dysphagia were randomly allocated to the observation group or the control group.
- Trial name
- NCT06347250
- Testing
- Nerve Block, Lidocaine Hydrochloride, routine therapy
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Babujinaya Cela
Neuromuscular Blockade
Pharmacokinetics of Rocuronium for Deep Block (DeepRocu)
Rocuronium is a non-depolarising neuromuscular blocking agent. The compound has a rapid onset and an intermediate duration of action.
- Trial name
- DeepRocu (NCT03545308)
- Testing
- Rocuronium
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Muscle Relaxation
The Effect of Sugammadex Given Based on Ideal, Actual or Adjusted Body Weight on Reversal of Rocuronium.
The aim of this study is compare the reversal of rocuronium induced neuromuscular blockade in morbidly obese patients using three doses of sugammadex; based on ideal body weight, adjusted body weight, and actual body weight.
- Trial name
- NCT03381209
- Testing
- Sugammadex
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Neuromuscular Block
Sugammadex and Neostigmine at Shallow Neuromuscular Blockade
This study is designed to compare recovery times after reversal of a residual neuromuscular block (TOF-ratio 0.5) with different doses of either neostigmine or sugammadex.
- Trial name
- SUNDRO (NCT00895609)
- Testing
- Sugammadex, Neostigmine, Saline
- Where
- Germany
- Volunteers
- 99 people
- Sponsor
- Technical University of Munich
Postoperative Residual Neuromuscular Blockade
Electromyographic Monitoring and Postoperative Recovery
Residual neuromuscular blockade (weakness) is a common occurrence in the postanesthesia care unit when muscle relaxant drugs have been used in the operating room.
- Trial name
- NCT03891381
- Testing
- Tetragraph quantitative monitoring
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Diabetic Foot, Diabetic Neuropathies
Dose-finding Study: Popliteal Sciatic Nerve Block in Patients Undergoing Diabetic Foot Surgery
The purpose of this study was to determine the minimum effective dose of a local anesthetic for proper anesthesia for popliteal sciatic nerve block under ultrasound guidance in patients undergoing surgery for diabetic foot…
- Trial name
- NCT04981067
- Testing
- Maintain the concentration of ropivacaine as same as those used in the previous participant, Decrease the ropivacaine concentration by 0.05% from the concentration used in the previous participant, Increase the ropivacaine concentration by 0.05% from the concentration used in the previous participant
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Seoul National University Hospital
Critical Care, Mechanical Ventilation
Neuromuscular Blockade in the Intentive Care Unit, an Observational Study.
The study Short description of the protocol intended for the lay public. Include a brief statement of the study hypothesis. (Limit: 5000 characters) Neuromuscular blocking agents (NMBAs) are drug capable of inducing a complete…
- Conditions
- Critical Care, Mechanical Ventilation, Neuromuscular Blockade
- Trial name
- CURATIV (NCT04028362)
- Testing
- Neuromuscular Blocking Agents
- Where
- 11 sites in France
- Volunteers
- 282 people
- Sponsor
- French Society for Intensive Care
Neuromuscular Blockade
Comparison of Acceleromyography (AMG) and Mechanomyography (MMG) for Establishing Potency of Neuromuscular Blocking Agents
The purpose of this study was to compare two methods for neuromuscular monitoring, acceleromyography and mechanomyography for establishing the dose-response relationship and the potency of a neuromuscular blocking agent using…
- Trial name
- NCT00660413
- Testing
- TOF-Watch SX (Acceleromyography)
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet