Clinical trials: Neuromuscular Block
Neostigmine, Neuromuscular Blocking Agents
Reversal of Moderate or Superficial Neuromuscular Blockade Induced by Cisatracurium
The administration of acetylcholinesterase inhibiting agents (such as neostigmine) has been used to reverse the muscle paralysis induced by non-depolarizing neuromuscular blocking agents.
- Conditions
- Neostigmine, Neuromuscular Blocking Agents, Muscle Weakness
- Trial name
- NCT04920682
- Testing
- Reversal of moderate neuromuscular blockade, Reversal of superficial neuromuscular blockade, Two-step reversal
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Catolica de Sao Paulo
Neuromuscular Blockade
Efficacy and Safety of Sugammadex Dosed According to Actual Body Weight (ABW) or Ideal Body Weight (IBW) in Reversal of Neuromuscular Blockade (NMB) in Morbidly Obese Participants (MK-8616-146)
The purpose of this trial is to evaluate the safety and efficacy of Sugammadex when administered according to actual body weight (ABW) as compared to ideal body weight (IBW) for the reversal of both moderate and deep…
- Trial name
- NCT03346070
- Testing
- Sugammadex 2 mg/kg ABW, Sugammadex 2 mg/kg IBW, Sugammadex 4 mg/kg ABW
- Where
- 24 sites in United States, Austria and 3 more
- Volunteers
- 207 people
- Sponsor
- Merck Sharp & Dohme LLC
Neuromuscular Blockade
Dialysis of Sugammadex in Participants With Severe Renal Impairment (Study 19.4.333) (P05773)
The clinical trial objectives were to evaluate the dialysability of the sugammadex-rocuronium complex; it's safety and efficacy in participants with severe renal impairment.
- Trial name
- NCT00656799
- Testing
- sugammadex, Rocuronium
- Volunteers
- 6 people
- Sponsor
- Merck Sharp & Dohme LLC
Cluneal Syndrome, Nerve Entrapment Syndrome
Study on the Efficacy of Infiltration of Upper Cluneal Nerves in Chronic Pain Related to Cluneal Syndrome
Lower back pain is a very common complaint in the Chronic Pain Clinic. Its etiology is nonspecific in 85% of the cases. In 1957, Strong and Davila reported that the superior cluneal nerves (SCNs) and middle cluneal nerves (MCNs)…
- Trial name
- NCT05423132
- Testing
- Ropivacaine injection, Physiological serum injection
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Airway Reflexes, Protective, Recovery After Neuromuscular Block
Impact of Anesthetic Choice (Sevoflurane Versus Desflurane) on Airway Reflex Recovery in the Context of Antagonized Neuromuscular Block
Protective airway reflexes may be impaired in the postoperative period, creating the potential for aspiration of gastric contents, even after a patient exhibits appropriate response to command.
- Conditions
- Airway Reflexes, Protective, Recovery After Neuromuscular Block, Anesthetic Recovery
- Trial name
- NCT01199237
- Testing
- Sevoflurane, Desflurane, Rocuronium
- Where
- 2 sites in United States
- Volunteers
- 107 people
- Sponsor
- University of California, San Francisco
Bowel Dysfunction, Postoperative Complications
Sugammadex To IMprove Bowel Function
Colon and rectal surgery is associated with high cost, long length of stay, high postoperative surgical site infection rate, high incidence of postoperative nausea and vomiting, and a high rate of hospital readmission.
- Conditions
- Bowel Dysfunction, Postoperative Complications, Neuromuscular Blockade
- Trial name
- STIM_Bowel (NCT04546672)
- Testing
- Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Oregon Health and Science University
Residual Paralysis
Residual Paralysis in the Post Anesthesia Care Unit: the Association Beetween Residual Neuromuscular Block Risk Prediction Score and the Train-of-Four Ratio. a Prospective Single-Center Open-Label Cohort Study
The reported incidence of rNMB varies between 16% to more than 70 depending on the used definition (train-of-four [TOF] ratio 0.7 or 0.9), type of NMBA, type of reversal agent, and timing of measurements The degree of residual…
- Trial name
- NCT06796777
- Volunteers
- 91 people
- Sponsor
- Assiut University
Anesthesiology Management
Recovery From Anesthesia After Robotic Assisted Radical Cystectomy
Robot-assisted radical cystectomy (RARC) requires specific surgical conditions: steep Trendelenburg position, prolonged pneumoperitoneum, effective neuromuscular block until the final stages of surgery.
- Trial name
- NCT03144453
- Testing
- Sugammadex Injectable Product, Neostigmine, Atropine
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Regina Elena Cancer Institute
Observation of Neuromuscular Block, Complication of Ventilation Therapy
Deep Neuromuscular Block During General Anaesthesia in Robotic Surgery
The aim of this project is to show, whether the use of the deep neuromuscular block in certain laparoscopic robot-assisted surgery can positively influence main physiological functions compared to the use of standard…
- Conditions
- Observation of Neuromuscular Block, Complication of Ventilation Therapy, Postoperative Recovery
- Trial name
- NCT03420937
- Testing
- Sugammadex, Neostigmine, Atropin Biotika
- Where
- Czechia
- Volunteers
- 138 people
- Sponsor
- University Hospital Olomouc
Shoulder Hand Syndrome, Complex Regional Pain Syndromes
Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome
Shoulder-hand syndrome (SHS) in stroke patients is painful and lowers quality of life. Unfortunately, the cause of SHS is not known, diagnosing SHS can be difficult, and treating it can be hard.
- Trial name
- NCT03291197
- Testing
- Suprascapular and median nerve blocks
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Ottawa Hospital Research Institute
Postherpetic Neuralgia
Ultrasound-Guided Thoracic Paravertebral Block With Steroid and Local Anesthetic for Acute Herpes Zoster: Effects on Pain Control and Prevention of Postherpetic Neuralgia
Background: Acute herpes zoster causes severe neuropathic pain and may progress to postherpetic neuralgia (PHN). This study aims to evaluate ultrasound-guided thoracic paravertebral block with local anesthetic and steroid in…
- Trial name
- NCT07349680
- Testing
- Valacyclovir + Paracetamol (Acetaminophen) + Gabapentin (standard medical therapy), Ultrasound-guided thoracic paravertebral block (TPVB) with bupivacaine 0.25% + methylprednisolone 40 mg
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Malignant Neoplasms of Digestive Organs, Malignant Neoplasms of Female Genital Organs
Neuromuscular Blockade on Shoulder Pain of Elderly
Insufflation pressure (IP) is the creation of a pressure barrier of air/gas within the abdomen to allow the surgeon more space to work during abdominal surgery.
- Conditions
- Malignant Neoplasms of Digestive Organs, Malignant Neoplasms of Female Genital Organs, Malignant Neoplasms of Male Genital Organs, Malignant Neoplasms of Urinary Tract
- Trial name
- NCT03210376
- Testing
- Deep Neuromuscular Blockade (NMB), Moderate Neuromuscular Blockade (NMB), Sugammadex
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
Anesthesia, Neuromuscular Blockade
Comparing 4.0 mg.Kg-1 Sugammadex With Placebo in the Reversal of Profound Neuromuscular Blockade (P05767)
The current trial was designed to demonstrate faster recovery in participants undergoing elective surgeries requiring profound neuromuscular blockade induced by rocuronium to a fourth twitch/first twitch (T4/T1) ratio of 0.9…
- Trial name
- NCT00758485
- Testing
- Sugammadex, 0.9% sodium chloride (NaCl)
- Volunteers
- 140 people
- Sponsor
- Merck Sharp & Dohme LLC
Nerve Block, Pain, Postoperative
Pudendal Nerve Block in Vaginal Surgery
The objective of this this randomized controlled study is to determine whether a pudendal nerve block at the time of vaginal surgery is associated with improved postoperative pain control and decrease opioid consumption compared…
- Conditions
- Nerve Block, Pain, Postoperative, Pelvic Floor Disorders, Pelvic Organ Prolapse
- Trial name
- NCT04198714
- Testing
- Pudendal block
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Neuromuscular Blockade
A Prospective, Randomized Controlled Trial Comparing Traditional Methods of Neuromuscular Block Reversal to Sugammadex for Extubation in the Operating Room in ASA 4 and 4E Patients
To demonstrate that the use of Sugammadex enables physicians to perform early extubation in the operating room in ASA 4 \& 4E patients Primary endpoint: Extubation in the operating room before transfer to the PACU or ICU versus…
- Trial name
- NCT01761552
- Testing
- Sugammadex Reversal, Atropine/Neostigmine
- Where
- Israel
- Volunteers
- 130 people
- Sponsor
- Hadassah Medical Organization
Rheumatoid Arthritis, Osteoarthritis
Low Dose Dexamethasone in Supraclavicular Blocks
Brachial plexus nerve blocks provide superior analgesia over opioids while avoiding unwanted side effects. Single shot blocks with local anesthetic alone usually do not last the duration of the acute post-surgical pain period.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Nerve Entrapment, Ligament Injury
- Trial name
- NCT02666443
- Testing
- Control intervention (no dexamethasone), Peri-neural Dexamethasone 1 mg, Intravenous Dexamethasone 1 mg
- Where
- Canada
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Renal Disease
Comparison of Low Versus Normal Pressure Pneumoperitoneum - With Profound Low Versus Normal Pressure Pneumoperitoneum -With Profound Muscle Relaxation- During Laparoscopic Donor Nephrectomy
As both patients with end-stage kidney disease and society benefit tremendously from live kidney donation, the safety and well-being of kidney donors are highly important objectives in live kidney donation.
- Trial name
- LEOPARD2 (NCT02146417)
- Testing
- Low pressure pneumoperitoneum, Normal pressure pneumoperitoneum (12 mmHg), Deep neuromuscular block
- Where
- Netherlands
- Volunteers
- 64 people
- Sponsor
- Radboud University Medical Center
Lumbar Spinal Stenosis, Lumbar Radiculopathy
Continuous Erector Spinae Block for Analgesia Following Lumbar Decompression
Lumbar spinal surgery is common, and the incidence of spinal fusion has increased dramatically over the past three decades. Patients requiring spinal surgery are typically prescribed several analgesics, (including opioids) while…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Radiculopathy, Persistent Postsurgical Pain
- Trial name
- Lumbar-ESP (NCT06987409)
- Testing
- Continuous erector spinae plane block
- Volunteers
- 100 people
- Sponsor
- Nova Scotia Health Authority
Neuromuscular Blockade
Abdominal Muscle Volume and a Neuromuscular Blocking Agent
With the recent development of image analysis and artificial intelligence, it has become possible to measure the muscle volume from preoperative computed tomography (CT) images.
- Trial name
- NCT06769932
- Testing
- preoperative computed tomography
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Seoul National University Bundang Hospital
Neuromuscular Blockade
Interaction of Volatile Anesthetics With Magnesium
Magnesium and volatiles anesthetics both have an effect on the neuromuscular transmission. The primary objective of the study is to quantify the effect of a perfusion of intravenous magnesium on neuromuscular transmission…
- Trial name
- Volmag (NCT05261516)
- Testing
- Magnesium Sulfate
- Where
- Switzerland
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Christoph Czarnetzki