Clinical trials: Neuromuscular Block
Anesthesia, Pregnancy Related
Upper vs Lower Extremity BP in Spinal Cesarean Using ClearSight
This is a single-center, prospective observational study in patients undergoing cesarean delivery under spinal or combined spinal-epidural anesthesia.
- Conditions
- Anesthesia, Pregnancy Related, Blockades Neuromuscular
- Trial name
- NCT07685730
- Testing
- ClearSight
- Where
- United States
- Volunteers
- 327 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Postoperative Residual Neuromuscular Blockade
Electromyographic Monitoring and Postoperative Recovery
Residual neuromuscular blockade (weakness) is a common occurrence in the postanesthesia care unit when muscle relaxant drugs have been used in the operating room.
- Trial name
- NCT03891381
- Testing
- Tetragraph quantitative monitoring
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Gastrointestinal Cancer, Sarcopenia
Sarcopenia and Neuromuscular Block in Gastrointestinal Cancer Surgery
This prospective observational study aims to evaluate the effects of sarcopenia on intraoperative neuromuscular block (NMB) in patients undergoing gastrointestinal cancer surgery.
- Conditions
- Gastrointestinal Cancer, Sarcopenia, Neuromuscular Blockade
- Trial name
- NCT07003061
- Testing
- Standard Anesthesia Management
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Anesthesia, Pain
A Comparison of US and Evoked Motor Response-guided Placement of Continuous Femoral Nerve Block Following TKA
The purpose of this study is to determine which technique for catheter placement in continuous femoral nerve block (FNB) is most successful - guidance with (1) ultrasound or (2) nerve stimulation and ultrasound.
- Conditions
- Anesthesia, Pain, Nerve Pain, Knee Arthroplasty
- Trial name
- NCT03121976
- Testing
- Ultrasound, Ultrasound + Nerve Stimulation
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- Sunnybrook Health Sciences Centre
Neuromuscular Block, Surgery
MRI Measurement of the Effects of Deep Neuromuscular Blockade on the Abdominal Working Space During Laparoscopy
During laparoscopy, a surgical working space is obtained by creation of a pneumoperitoneum. Optimal surgical conditions are essential to ensure the patient's safety.
- Trial name
- RELAX-2 (NCT03287388)
- Testing
- No Rocuronium, Rocuronium (moderate NMB), Rocuronium (deep NMB)
- Volunteers
- 8 people
- Sponsor
- Radboud University Medical Center
Anesthesia, General, Neuromuscular Blockade
Efficacy and Safety of 4.0 mg/kg Sugammadex at 1-2 PTC in Chinese and European Subjects (Study 19.4.335)(P05775AM1)(COMPLETED)
The present trial is set up to evaluate the efficacy and safety of 4.0 mg.kg-1 sugammadex in Chinese and Caucasian subjects for registration purposes in China.
- Trial name
- NCT00826176
- Testing
- Sugammadex
- Volunteers
- 164 people
- Sponsor
- Merck Sharp & Dohme LLC
Anesthesia, General, Neuromuscular Blockade
Pharmacokinetic-pharmacodynamic Analysis of Sugammadex for Conventional Reversal in Children
This study administers sugammadex sodium to pediatric patients under general anesthesia with rocuronium. Pharmacokinetic and pharmacodynamic analysis are performed based on plasma concentration of sugammadex sodium and monitoring…
- Trial name
- NCT04347486
- Testing
- Sugammadex Injection 2mg/kg, Sugammadex Injection 4mg/kg, Sugammadex Injection 8mg/kg
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Seoul National University Hospital
Muscle Relaxation
Deep NMB in Ambulatory Gynecological Laparoscopy
Gynecological laparoscopic surgery is commonly performed as an ambulatory basis for the aim of rapid discharge, reduce hospital stay with reduced costs and to improve postoperative QOR [1,2].
- Trial name
- NCT04105764
- Testing
- Rocuronium, Rocuronium bromide
- Where
- Kuwait
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wahba bakhet
Bulbar Palsy
The Effectiveness of Stellate Ganglion Block in Managing Dysphagia in Patients With Medullary Infarction
This is a randomized controlled study, including dysphagic patients with bulbar palsy after ischemic stroke who were received in the department of rehabilitation medicine.
- Trial name
- NCT06301698
- Testing
- Comprehensive rehabilitation, Injection, Lidocaine Hydrochloride
- Volunteers
- 80 people
- Sponsor
- Ahmadu Bello University Teaching Hospital
Carpal Tunnel Syndrome
Onset and Duration of Forearm Nerve Blockade
This pilot study will evaluate the latency of onset and duration of sensory-motor block in patients undergoing hand surgery. Patients will be randomized to receive nerve blocks of the distal forearm or of the distal and proximal…
- Trial name
- NCT03649763
- Testing
- Lidocaine, Bupivacaine
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- New York School of Regional Anesthesia
Postoperative Residual Curarisation, Postoperative Hypoxemia
Postoperative Residual Curarisation at Arrival in the Post-anesthesia Care Unit
Several studies have documented that neuromuscular block often persists in the postanesthesia care unit (PACU). Residual paralysis is associated with postoperative complications such as hypoxia, weakness, and respiratory failure.
- Conditions
- Postoperative Residual Curarisation, Postoperative Hypoxemia, Postoperative Airway Obstruction
- Trial name
- NCT01362647
- Testing
- neuromuscular transmission monitoring, Pulse oximetry measurement
- Where
- Belgium
- Volunteers
- 625 people
- Sponsor
- Onze Lieve Vrouw Hospital
Complex Regional Pain Syndromes
Sympatholytic Effects of High Thoracic Erector Spinae Plane Block: Changes in Optic Nerve Sheath Diameter
The thoracic erector spinae plane (ESP) block is suggested to potentially affect the stellate ganglion, a key component of the sympathetic nervous system, thereby influencing autonomic functions.
- Trial name
- NCT06468384
- Testing
- thoracic erector spinae plane (ESP) block
- Volunteers
- 15 people
- Sponsor
- Pamukkale University
Brain Tumors
Effect of Sugammadex for Reversal of Rocuronium-induced Neuromuscular Block on Perioperative Management of Awake Craniotomy
Effect of sugammadex for reversal of rocuronium-induced neuromuscular block on Perioperative Management of awake Craniotomy
- Trial name
- NCT05202899
- Testing
- sugammadex
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Neuromuscular Blockade
Abdominal Muscle Volume and a Neuromuscular Blocking Agent
With the recent development of image analysis and artificial intelligence, it has become possible to measure the muscle volume from preoperative computed tomography (CT) images.
- Trial name
- NCT06769932
- Testing
- preoperative computed tomography
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Seoul National University Bundang Hospital
Valve Stenoses, Aortic, Amyloidosis Cardiac
Impact of Amyloidosis on TAVI Patients
To analyze the prevalence and impact on the prognosis of amyloidosis due to transthyretin in patients with severe aortic stenosis who undergo percutaneous aortic valve implantation.
- Trial name
- AMY-TAVI (NCT03984877)
- Testing
- Diagnosis of amyloidosis
- Where
- Spain
- Volunteers
- 320 people
- Sponsor
- Javier López Pais
Peripheral Arterial Disease, Peripheral Artery Disease
Blood Flow Changes in Femoral-popliteal Bypass Grafts After Neuromuscular Electrical Stimulation (NMES).
The muscles of the leg require a regular supply of oxygen and nutrients. This is supplied by blood carried by a network of large blood vessels known as arteries.
- Conditions
- Peripheral Arterial Disease, Peripheral Artery Disease, Peripheral Vascular Disease, Femoral Popliteal Occlusion
- Trial name
- HAEMUS (NCT04109287)
- Testing
- REVITIVE® device
- Where
- United Kingdom
- Sponsor
- Imperial College Healthcare NHS Trust
Cardiac Index
Effects of Neuromuscular Blockade Level and Intra-abdominal Pressure on Surgical Conditions and Cardiopulmonary Responses During Laparoscopic Colon Surgery With the Trendelenburg Position
The purpose of this study is to find out the effect of low abdominal pressure vs. standard abdominal pressure on the cardiac and respiratory function of the patients undergoing laparoscopic colon surgery in Trendelenberg…
- Trial name
- NCT02249585
- Testing
- Standard abdominal pressure, Low abdominal pressure, Conventional neuromuscular blockade
- Where
- South Korea
- Volunteers
- 131 people
- Sponsor
- Seoul National University Hospital
Neuromuscular Blockade Reversal Agent
The Effect of Neostigmine and Sugammadex on the Optic Nerve Sheath Diameter
This study will compare how two drugs, sugammadex and neostigmine-used to reverse muscle relaxation after surgery-affect the size of the optic nerve sheath (the nerve behind the eye) as patients wake up and have their breathing…
- Trial name
- NCT07666984
- Testing
- Sugammadex 2 mg/kg, Neostigmine + Atropine
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Cukurova University
Neuromuscular Blockade
OS NMB Depth Measured by Central and Peripheral Monitor.
Comparing during anesthesia in the same patient 2 neuromuscular monitors on the same arm.
- Trial name
- NCT03660891
- Testing
- measuring neuromuscular block
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- AZ Sint-Jan AV
Laryngoscopic Surgical Procedures
Deep vs Moderate Neuromuscular Blockade With Rocuronium in Patients Undergoing Endolaryngeal Procedures
It is unknown the impact of deep neuromuscular paralysis and using a novel agent, sugammadex as an reversal in endolaryngeal surgery.
- Trial name
- NCT02451202
- Testing
- Deep Neuromuscular Blockade, Moderate Neuromuscular Blockade, Sugammadex
- Volunteers
- 102 people
- Sponsor
- Chulalongkorn University