Clinical trials: Neuromuscular Block
Muscle Relaxation
Deep vs Moderate Neuromuscular Blockade in Day Case Laparoscopic Cholecystectomy.
Laparoscopic cholecystectomy (LC) is commonly performed on ambulatory basis as a result of its ability to improve postoperative quality of recovery (QOR) and significantly reduce hospital stay .
- Trial name
- NCT03881423
- Testing
- Rocuronium Bromide
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wahba bakhet
Hallux Valgus and Bunion (Disorder), Morton Neuroma
Feasibility of Specific Anesthesia of the Forefoot Preserving the Sensitivity of the Heel for Foot Surgery
Foot surgery is a painful surgery that is usually scheduled in outpatients. A good management of analgesia is the crucial point.
- Conditions
- Hallux Valgus and Bunion (Disorder), Morton Neuroma, Metatarsal Fracture, Ingrown Nail
- Trial name
- DISTIB (NCT03504462)
- Testing
- Specific block of medial and lateral plantar nerves
- Where
- France
- Volunteers
- 27 people
- Sponsor
- CMC Ambroise Paré
Intubation
Succinylcholine Versus Rocuronium for Emergency Intubation in Intensive Care
Emergency intubation of patients in intensive care is a high-risk endeavour. For many decades, succinylcholine has been the neuromuscular blocking agent of choice.
- Trial name
- NCT00355368
- Testing
- Succinylcholine, Rocuronium
- Where
- Switzerland
- Volunteers
- 420 people
- Sponsor
- University Hospital, Basel, Switzerland
Residual Neuromuscular Blockade
Electromyographic Assessment of Onset and Recovery of Neuromuscular Blockade
Residual neuromuscular blockade (weakness) is a common occurrence in the postanesthesia care unit when muscle relaxant drugs have been used in the operating room.
- Trial name
- NCT01678625
- Testing
- Train-of-four ratio calculation (T4-EMG)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Endeavor Health
Neuromuscular Blockade, Residual
Incidence of Postoperative Residual Curarization
An incomplete postoperative recovery of neuromuscular function (postoperative residual curarization - PORC) represents a common problem in post-anesthesia care units (PACU), potentially exposing the patient to adverse respiratory…
- Trial name
- PORC (NCT06193213)
- Testing
- measurement of train of four ratio (TOFR) to assess residual neuromuscolar block
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Neuromuscular Blockade, Intubation Complication
A Comparison of Rocuronium 0.6 mg/kg and Remifentanil 2 µg/kg in Elderly Patients Over 80 Years
The number of elderly patients above 80 years is increasing and a large proportion of these patients will require surgery and anesthesia.
- Conditions
- Neuromuscular Blockade, Intubation Complication, Anesthesia
- Trial name
- NCT04287426
- Testing
- Rocuronium 0.6 mg/kg, Remifentanil 2 µg/kg
- Where
- 2 sites in Denmark
- Volunteers
- 78 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Healthy
Phase I Clinical Trial to Evaluate the Safety, Pharmacokinetics and Efficacy of CW002
The purpose of this study is to test the safety and efficacy of an investigational neuromuscular blocking agent called CW002 and to document its effects on healthy adult volunteers.
- Trial name
- CW002 (NCT01338935)
- Testing
- CW 002
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Neuromuscular Blocking Agents
Effect of Nitrous Oxide on Cisatracurium Infusion Demands
Background: Recent studies have questioned our previous understanding on the effect of nitrous oxide on muscle relaxants, since nitrous oxide has been shown to potentiate the action of bolus doses of mivacurium, rocuronium and…
- Trial name
- NCT01152905
- Where
- Finland
- Volunteers
- 70 people
- Sponsor
- Turku University Hospital
Postoperative Pain, Video-assisted Thoracoscopic Surgery
ESP Block, CNP and QoL After VATS
The Erector Spinae Plane Block (ESPB) is an adequate alternative for pain management after video-assisted thoracoscopy surgery (VATS).
- Trial name
- NCT04737902
- Testing
- Erector spinae plane block
- Where
- Colombia
- Volunteers
- 42 people
- Sponsor
- Hospital Universitario San Ignacio
Laparoscopic Herniotomy
Optimizing Surgical Conditions During Laparoscopic Herniotomy With Deep Neuromuscular Blockade
The purpose of this study is to investigate surgical work space and surgical conditions in patients scheduled for laparoscopic umbilical, -linea alba and incisional herniotomy.
- Trial name
- NCT02247466
- Testing
- Rocuronium and Sugammadex
- Where
- 2 sites in Denmark
- Volunteers
- 37 people
- Sponsor
- Herlev Hospital
Gallbladder Disease
A Study Comparing the Use of Deep or Standard Neuromuscular Blockade in Combination With Low or Standard Insufflation Pressures in Participants Undergoing Laparoscopic Cholecystectomy (P07982)
The purpose of this pilot study is to compare the use of deep or standard neuromuscular blockade (NMB) in combination with low or standard insufflation pressure in participants undergoing a surgical procedure, laparoscopic…
- Trial name
- NCT01728584
- Testing
- Rocuronium, Insufflation, Sugammadex
- Where
- 2 sites in Germany, Italy
- Volunteers
- 127 people
- Sponsor
- Merck Sharp & Dohme LLC
Amyotrophic Lateral Sclerosis
Multiple Doses of AT-1501-A201 in Adults With ALS
This is a Phase 2a, multi-center, open label, multiple dose study of AT-1501, a humanized monoclonal antibody antagonist to CD40 ligand (CD40L).
- Trial name
- NCT04322149
- Testing
- AT-1501
- Where
- 13 sites in United States, Canada
- Volunteers
- 54 people
- Sponsor
- Anelixis Therapeutics, LLC
Anesthesia, Neuromuscular Blockade
Comparing Train-of-Four Recovery in the Adductor Pollicis Versus the Adductor Digiti Minimi in Elective Surgery Patients
The train-of-four (TOF) ratio is a quantitative measure used in anesthesia to assess the degree of neuromuscular blockade induced by neuromuscular blocking agents during surgical procedures.
- Trial name
- NCT06467448
- Testing
- EMG Assessement of Recovery of Neuromuscular Function
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of North Carolina, Chapel Hill
Neuromuscular Blockade
Understanding the Cognition and Decision Making of Community Anesthesiologists
The investigators are interested in studying why experienced clinicians make specific decisions regarding the monitoring of patients' physiological states and why clinicians might make decisions that are contrary to current best…
- Trial name
- NCT04195178
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Vanderbilt University Medical Center
Neuromuscular Blockade
Effect of Magnesium Sulphate on Neostigmine
The purpose of this study is to evaluate the effect of magnesium sulphate on neostigmine-induced reversal of neuromuscular block by rocuronium
- Trial name
- NCT03020706
- Testing
- Magnesium Sulfate, Injectable
- Where
- South Korea
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Gachon University Gil Medical Center
Anesthesia
Clinical Evaluation of a Novel Neuromuscular Blockade Monitoring System
This study is designed to formally evaluate the performance of the QTOF, as compared with the newest commercially available NMB monitoring equipment, EMG (the TwitchView).
- Trial name
- NCT04406740
- Testing
- TwitchView EMG Unit, Novel QTOF Device
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Minnesota
Respiratory Failure, Respiratory Infection
Avoiding Neuromuscular Blockers to Reduce Complications
The goal of this study to evaluate whether eliminating the use of non-depolarizing neuromuscular blocking agents (NMBA) for maintenance of general anesthesia reduces postoperative pulmonary complications in higher risk patients.
- Conditions
- Respiratory Failure, Respiratory Infection, Aspiration Pneumonia, Pneumonitis
- Trial name
- NCT03962725
- Testing
- Neuromuscular Blocking Agents, Anesthetic Adjuncts
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Beth Israel Deaconess Medical Center
Inclusion Body Myositis, Sporadic
Ruxolitinib Treatment in Inclusion Body Myositis
Refer to the "Detailed Description" section.
- Trial name
- BIGTIM (NCT06536166)
- Testing
- Ruxolitinib
- Where
- 21 sites in France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anesthesia, Regional Anesthesia
Postoperative Follow-up Via Text Messages Automated Versus Telephone in Patients With Continuous Regional Anesthesia
Monitoring performed by a trained operator has proven to be useful and valued by patients after the use of continuous regional anesthesia. A health professional calls each patient to gather information about their recovery.
- Conditions
- Anesthesia, Regional Anesthesia, Nerve Pain
- Trial name
- txt-RA (NCT06313294)
- Testing
- Tracking application app, Telephone interview
- Where
- Chile
- Volunteers
- 100 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Colorectal Disorders, Observation of Neuromuscular Block
Effectiveness of Transverse Abdominus Plane Catheter Blocks to Patient-controlled Analgesia in Laparoscopic Colon Resections
The control of postoperative pain has become a major issue in surgery awareness and it is considered an important measurement of patient satisfaction. Improvements in pain relief, including stopping pain before it starts (i.e.
- Trial name
- NCT01592630
- Testing
- 0.2% ropivacaine, Saline
- Where
- 2 sites in United States
- Sponsor
- Stamford Hospital