Clinical trials: Neuromuscular Blockade
Observation of Neuromuscular Block, Respiratory Paralysis
Comparison of AMG and EMG to Avoid Residual Paralysis After General Anesthesia
This study evaluates three different neuromuscular monitoring devices (acceleromyography, one- or three-dimensional, and electromyography) with regard to their precision to detect residual paralysis after injection of…
- Conditions
- Observation of Neuromuscular Block, Respiratory Paralysis, Anaesthesia
- Trial name
- CAMEM (NCT02126852)
- Testing
- Acceleromyography (AMG, one-dimensionally), Acceleromyography (AMG, three-dimensionally), Electromyography (EMG)
- Where
- 2 sites in Germany
- Volunteers
- 214 people
- Sponsor
- Technical University of Munich
Neuromuscular Blockade
Study to Determine if Administration of Sugammadex Impacts Hospital Efficiency
The purpose of this study is to evaluate the efficacy of Sugammadex in rapidly reversing deep neuromuscular blockaded (induced by rocuronium)
- Trial name
- NCT02860507
- Testing
- sugammadex, Neostigmine, Glycopyrrolate
- Volunteers
- 50 people
- Sponsor
- University of South Florida
Neuromuscular Blockade
Efficacy and Safety of Sugammadex Dosed According to Actual Body Weight (ABW) or Ideal Body Weight (IBW) in Reversal of Neuromuscular Blockade (NMB) in Morbidly Obese Participants (MK-8616-146)
The purpose of this trial is to evaluate the safety and efficacy of Sugammadex when administered according to actual body weight (ABW) as compared to ideal body weight (IBW) for the reversal of both moderate and deep…
- Trial name
- NCT03346070
- Testing
- Sugammadex 2 mg/kg ABW, Sugammadex 2 mg/kg IBW, Sugammadex 4 mg/kg ABW
- Where
- 24 sites in United States, Austria and 3 more
- Volunteers
- 207 people
- Sponsor
- Merck Sharp & Dohme LLC
Postherpetic Neuralgia
Erector Spinae Plane Block in Post-herpetic Neuralgia
This randomized clinical study will be carried out on 72 patients admitted to the pain clinic in Tanta University Hospitals with post-herpetic neuralgia.
- Trial name
- NCT04546334
- Testing
- Medical treatment, Real Erector Spinae block, Real Erector Spinae block with magnesium sulphate
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Hypersensitivity, Anaphylaxis
A Study to Evaluate the Incidence of Hypersensitivity After Administration of Sugammadex in Healthy Participants (MK-8616-101)
The purpose of this study is to assess the potential for hypersensitivity symptoms upon repeat exposure to sugammadex. Healthy participants will be randomized to one of three treatment arms: sugammadex 4 mg/kg, sugammadex 16…
- Trial name
- NCT02028065
- Testing
- Sugammadex
- Volunteers
- 382 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Hemodialysis Complication
PMR Versus MLD on RLS and Sleep Quality in Hemodialysis Patients
Progressive muscle relaxation versus manual lymphatic drainage on restless leg syndrome and sleep quality in hemodialysis patients
- Trial name
- NCT06481800
- Testing
- Progressive muscle relaxation (PMR), cnotrol group, Manual lymphatic drainage (MLD)
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- MTI University
Functional Gastrointestinal Disorders
Effects of Imagery Therapy vs Progressive Muscle Relaxation Therapy on Patients With Functional Abdominal Bloating
65% of the general population reported experiencing moderate to severe bloating symptoms. Bloating could be disturbing to patients and frustrating to the physicians as an effective treatment is still lacking.
- Trial name
- NCT04789967
- Testing
- Guided Imagery, Progressive Muscle Relaxation, Educational Audiobook
- Where
- Malaysia
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Anesthesia
Efficacy and Safety of Optimal Muscle Tension Management During Laparoscopic Cholecystectomy
Our study is intended to compare optimal muscle tension management or conventional anesthetic management in laparoscopic cholecystectomy about surgical condition during the surgery and other conditions after surgery at POR.
- Trial name
- NCT04165057
- Testing
- Optimal muscle tension management
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Neuromuscular Blockade
Reversal With Sugammadex From Deep Neuromuscular Blockade Induced by Rocuronium in Children: Randomised Clinical Trial
The purpose of this clinical trial is to prove that the administration of sugammadex at a dose of 4 mg/kg for counteracting deep blockage [without train-of-four (TOF) ratio response and post-tetanic count (PTC) < of 2 induced and…
- Trial name
- SUGAPED-01 (NCT01809886)
- Testing
- Sugammadex, Neostigmine
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Sedation Complication, Acute Respiratory Distress Syndrome Due to COVID-19
Assessment of Sedation Depth Using Processed EEG in ICU Patients With ARDS Receiving Neuromuscular Blockade: A Prospective Observational Study"
"In intensive care units, therapeutic paralysis has been a routine treatment method for many years in a select group of patients.
- Conditions
- Sedation Complication, Acute Respiratory Distress Syndrome Due to COVID-19, Anesthesia Awareness
- Trial name
- NCT06337877
- Testing
- Depth of sedation monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Tepecik Training and Research Hospital
Neuromuscular Blockade, Pain
Recovery After Laparoscopic Hysterectomy With Deep Neuromuscular Blockade and Low Intra-abdominal Pressure
The purpose of this study on laparoscopic hysterectomy is to investigate postoperative pain. Patients are allocated to either deep neuromuscular blockade and low intra-abdominal pressure (8 mmHg) or moderate neuromuscular…
- Conditions
- Neuromuscular Blockade, Pain, Laparoscopy
- Trial name
- NCT01722097
- Testing
- Rocuronium
- Where
- Denmark
- Volunteers
- 110 people
- Sponsor
- Herlev Hospital
Neuromuscular Blocking Agents, Reversal of Neuromuscular Blockade
Recovery Times of Half Dose Sugammadex and Neostigmine for Rocuronium-induced Neuromuscular Blockade
In operating procedure with general anesthesia muscle relaxant is usually used to increase success rate of the operation and to give better outcome.
- Conditions
- Neuromuscular Blocking Agents, Reversal of Neuromuscular Blockade, Recovery Time
- Trial name
- NCT06794450
- Testing
- Sugammadex 1 mg/kg, Neostigmine + Atropine
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Padjadjaran
Neuromuscular Blockade
Reversal of Neuromuscular Blockade During the General Anaesthesia
There are individual reports indicating that after the reversal of nondepolarizing neuromuscular blockade with neostigmine, some patients starts to relax spontaneously again after the tof ratio has already recovered to the safe…
- Trial name
- NCT04048655
- Testing
- Neostigmine, Combinations
- Where
- Finland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Neuromuscular Blockade
Comparing Reversal With Neostigmine and Sugammadex in Paediatric
A reversal agent is commonly given to improve neuromuscular function after intra-operative administration of non-depolarizing neuromuscular blocking agents.
- Trial name
- JS (NCT03137290)
- Testing
- Neostigmine, Sugammadex Sodium
- Where
- Malaysia
- Volunteers
- 80 people
- Sponsor
- Universiti Sains Malaysia
Neuromuscular Blockade
Postoperative Urinary Retention in Patients After Noncardiac Surgery and Reversal of Neuromuscular Block
The investigators propose a randomized trial comparing sugammadex and neostigmine for the reversal of neuromuscular blocks induced by rocuronium or vecuronium in adults having general anesthesia with muscular block for noncardiac…
- Trial name
- NCT05545280
- Testing
- Neostigmine with glycopyrrolate, Sugammadex
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The Cleveland Clinic
Muscle Relaxation
MgSO4 Combined With Rocuronium Priming
Priming with either rocuronium or MgSO4 is known to accelerate the effect of rocuronium on muscle relaxation. The purpose of this study is to define the effect of MgSO4 on the rocuronium-priming.
- Trial name
- NCT01389791
- Testing
- magnesium sulfate, priming, magnesium sulfate and priming
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Bundang Hospital
Sleep Disorders, Obese Pregnant Women
A Nurse-Led Sleep Hygiene and Progressive Muscle Relaxation Intervention on Sleep Quality Among Obese Pregnant Women
Sleep is essential for maternal and fetal health, with adequate sleep being crucial for energy, fetal development, and overall pregnancy well-being.
- Trial name
- NCT06890910
- Testing
- evidence based intervention
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Elective Surgery
Neuromuscular Blocking Agents in the Elderly
The number of elderly patients (>80 years) is increasing and a large proportion of these patients will require surgery and anaestheasia within the next decades.
- Trial name
- NCT03857750
- Testing
- Rocuronium
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acinar Cell Carcinoma, Adenoid Cystic Carcinoma
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors
This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may…
- Conditions
- Acinar Cell Carcinoma, Adenoid Cystic Carcinoma, Adrenal Cortical Carcinoma, Adrenal Gland Pheochromocytoma
- Trial name
- NCT02834013
- Testing
- Biospecimen Collection, Computed Tomography, Echocardiography Test
- Where
- 1,007 sites in United States, Guam
- Volunteers
- 798 people
- Sponsor
- National Cancer Institute (NCI)
Meniscus Tear
Addressing Kinesiophobia in Post-Meniscoplasty Patients Through Progressive Muscle Relaxation Training and Acupressure
The objective of this clinical trial is to determine whether progressive muscle relaxation training and acupressure can reduce kinesiophobia (fear of movement) in patients recovering from meniscoplasty surgery.
- Trial name
- NCT06409715
- Testing
- Enhanced Care with PMRT and Acupressure, standard care
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Gansu University of Chinese Medicine