Clinical trials: Neuromuscular Control, open to volunteers
Lumbar Spinal Stenosis, Lumbar Radiculopathy
Continuous Erector Spinae Block for Analgesia Following Lumbar Decompression
Lumbar spinal surgery is common, and the incidence of spinal fusion has increased dramatically over the past three decades. Patients requiring spinal surgery are typically prescribed several analgesics, (including opioids) while…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Radiculopathy, Persistent Postsurgical Pain
- Trial name
- Lumbar-ESP (NCT06987409)
- Testing
- Continuous erector spinae plane block
- Volunteers
- 100 people
- Sponsor
- Nova Scotia Health Authority
Myasthenia Gravis
A Study to Evaluate the Efficacy and Safety of Maintenance Ublituximab Following Induction With Efgartigimod Administration in Participants With Myasthenia Gravis (MG)
The primary purpose of this study is to evaluate the efficacy of ublituximab in adult participants with MG responding to treatment with efgartigimod.
- Trial name
- NCT07673744
- Testing
- Ublituximab
- Where
- 7 sites in United States
- Volunteers
- 120 people
- Sponsor
- TG Therapeutics, Inc.
Fibromyalgia
Melatonin and Immunonutrition for Pain Relief in Fibromyalgia
Fibromyalgia (FMS) is characterized by chronic musculoskeletal pain, sleep disturbances, and fatigue. It is not entirely clear how Bcomplex vitamins affect the human pain system, while at the same time there have been approaches…
- Trial name
- NCT07863232
- Testing
- Melatonin 1mg and intravenous B-complex vitamin drip
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- University of Thessaly
Athletic Performance, Neuromuscular Adaptations
Squat Jump Performance and Chiropractic Ankle Manipulation
The goal of this clinical trial is to learn if chiropractic ankle manipulation can improve squat jump performance. It will also learn about the relationship among chiropractic ankle manipulation, ankle range of motion, and squat…
- Conditions
- Athletic Performance, Neuromuscular Adaptations, Lower Limb, Chiropractic Manipulation
- Trial name
- NCT07641621
- Testing
- Manual Therapy Procedure: Chiropractic Ankle Manipulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northeast College of Health Sciences
Amyotrophic Lateral Sclerosis
Neural Stem Cell Treatment for Amyotrophic Lateral Sclerosis (STEMALS)
A Not for Profit Phase II Study to Evaluate Safety, Efficacy and Biomarkers secondary endpoints of Human Neural Stem cell intracerebroventricular transplantation in amyotrophic lateral sclerosis patients: a randomized, placebo…
- Trial name
- STEMALS (NCT06344260)
- Testing
- human Neural Stem Cells (hNSC)
- Where
- 4 sites in Italy
- Volunteers
- 30 people
- Sponsor
- Casa Sollievo della Sofferenza IRCCS
Diabetic Polyneuropathy
Effect of Feldenkrais Method in Enhancing Postural Control for Patients with Diabetic Polyneuropathy
Background: Postural Control is a major complication of polyneuropathy, affecting patients suffering from diabetes mellitus. Purpose: To examine the effect of the Feldenkrais Method on dynamic balance, limits of stability and…
- Trial name
- FeM (NCT06904417)
- Testing
- The Feldenkrais-based intervention, conventional balance training program
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Frailty at Older Adults, Sarcopenia
A Clinical Study on the Improvement of Frailty and Sarcopenia in Elderly Community Residents Through Pulsed Electromagnetic Field Therapy
The entire clinical study will be conducted strictly following the following procedure: 1) Informed Consent If you decide to participate in this trial, we will first ensure that you fully understand the research purpose…
- Trial name
- NCT07834697
- Testing
- Standard treatment with pulsed magnetic therapy apparatus, Fake stimulation therapy with pulse magnetic therapy device
- Volunteers
- 100 people
- Sponsor
- Xuanwu Hospital, Beijing
Fibromyalgia
Auricular Neuromodulation in Veterans With Fibromyalgia
PENFS (percutaneous electrical nerve field stimulation) is an FDA-cleared acupuncture-like therapy applied to the external ear targeting several cranial nerve branches including the auricular branch of the vagus nerve to improve…
- Trial name
- PENFS (NCT06415591)
- Testing
- Percutaneous electrical nerve field stimulation
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- VA Office of Research and Development
Duchenne Muscular Dystrophy (DMD), Muscular Dystrophy, Duchenne
Efficacy, Safety, and Tolerability of Zeleciment Rostudirsen (DYNE-251) Administered Intravenously Every 4 Weeks in Ambulatory Participants With Duchenne Muscular Dystrophy (FORZETTO)
The purpose of the study is to assess the efficacy, safety, and tolerability of zeleciment rostudirsen (DYNE-251) administered intravenously (IV) every 4 weeks to ambulatory Duchenne muscular dystrophy (DMD) participants, 4 to 18…
- Conditions
- Duchenne Muscular Dystrophy (DMD), Muscular Dystrophy, Duchenne, Muscular Dystrophy (DMD), DMD
- Trial name
- FORZETTO (NCT07608432)
- Testing
- Zeleciment Rostudirsen (DYNE-251)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Dyne Therapeutics
Complex Regional Pain Syndromes
Graded Motor Imagery Effects on Body Perception Disturbance in Complex Regional Pain Syndrome : a Randomised Controlled Trial
Complex Regional Pain Syndrome (CRPS) is a debilitating pain condition that usually develops following trauma. Patients with CRPS experience intense, continuing, disproportionate pain and multiple symptoms such as changes or…
- Trial name
- Bath-Min (NCT07818174)
- Testing
- Graded Motor Imagery + Therapeutic exercises
- Where
- 20 sites in France
- Volunteers
- 80 people
- Sponsor
- Nantes University Hospital
Fibromyalgia
Effectiveness of an IVR-based Therapeutic Exercise Program With Altered Visual Feedback in Fibromyalgia Patients
The primary aim of this randomized controlled trial is to determine the efficacy of a 6-week immersive virtual reality (IVR)-based therapeutic exercise intervention, which manipulates visual proprioceptive input during exercise…
- Trial name
- IVR-F (NCT06948500)
- Testing
- Immersive Virtual Reality, Physical Activity
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Cardenal Herrera University
Neuromuscular Performance, Reaction Time
Effects of Virtual Reality Exergaming on Reaction Time, Physical Performance, and Muscle Activity in Children
This randomized controlled trial will investigate the immediate effects of virtual reality (VR) exergaming on reaction time, physical performance, balance, and muscle activity in children aged 10-14 years with different athletic…
- Conditions
- Neuromuscular Performance, Reaction Time, Postural Balance
- Trial name
- PED-VR-EMG (NCT07916155)
- Testing
- Immersive Virtual Reality Exergaming
- Where
- Romania
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Babes-Bolyai University
Radiculopathy, Cervical, Myelopathy Cervical
Cervical Arthroplasty Cost Effectiveness Study (CACES)
To date, no consensus exists on which anterior surgical technique is more cost-effective to treat cervical degenerative disc disease (CDDD).
- Conditions
- Radiculopathy, Cervical, Myelopathy Cervical, Myelopathy, Compressive, Radiculopathy, Cervical Region
- Trial name
- CACES (NCT04623593)
- Testing
- ACDF, ACDA
- Where
- Netherlands
- Volunteers
- 198 people
- Sponsor
- Valérie Schuermans
Neuromuscular Blockade
Safety and Efficacy of HRS-9190 Compared to Rocuronium for Tracheal Intubation and Bolus Maintenance in Adults
The study will enroll adult patients scheduled for elective surgery requiring general anesthesia. Participants will be randomly assigned to receive either HRS-9190 for Injection or Rocuronium.
- Trial name
- NCT07746726
- Testing
- HRS-9190, Rocuronium
- Where
- 2 sites in China
- Volunteers
- 320 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Amyotrophic Lateral Sclerosis (ALS)
Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis
Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis
- Trial name
- UNITE-ALS (NCT07023835)
- Testing
- 50 mg Usnoflast, 75 mg Usnoflast
- Where
- 49 sites in United States, Australia and 10 more
- Volunteers
- 240 people
- Sponsor
- Zydus Therapeutics Inc.
Congenital Myasthenic Syndrome, CMS
A Study to Assess Efficacy and Safety of Adimanebart in Adult and Pediatric Participants With DOK7-,MUSK-, AGRN-, or LRP4- Congenital Myasthenic Syndromes (CMS)
The purpose of this study is to assess efficacy and safety of adimanebart in participants at least 12 years of age with DOK7-, MUSK-, AGRN-, or LRP4- Congenital Myasthenic Syndromes (CMS).
- Trial name
- CoMetS (NCT07746089)
- Testing
- Adimanebart IV
- Volunteers
- 105 people
- Sponsor
- argenx
Obesity, Sarcopenia
Effectiveness of Combined GLP-1/GIP Dual Agonist Therapy and Structured Exercise on Skeletal Muscle Morphology, Quality, and Physical Function in Overweight and Obese Individuals
This randomized controlled trial aims to investigate the effects of a 24-week home-based progressive resistance exercise program combined with tirzepatide treatment on skeletal muscle mass, muscle quality, and functional capacity…
- Conditions
- Obesity, Sarcopenia, Overweight (Without Type 2 Diabetes) With Weight-related Comorbidities
- Trial name
- NCT07609160
- Testing
- Resistance exercise, Lifestyle recommendations
- Volunteers
- 108 people
- Sponsor
- Acibadem University
Duchenne Muscular Dystrophy (DMD)
A Study in Participants With Duchenne Muscular Dystrophy Amenable to Exon 45 Skipping to Evaluate the Safety and Efficacy of ENTR-601-45
This is a study of the investigational medicine ENTR-601-45 in participants who have Duchenne muscular dystrophy (DMD), a rare genetic condition.
- Trial name
- ELEVATE-45 (NCT07038824)
- Testing
- ENTR-601-45
- Where
- 15 sites in Belgium, Italy and 3 more
- Volunteers
- 24 people
- Sponsor
- Entrada Therapeutics, Inc.
Postoperative Pain, Pain Management
Comparison of Two Postoperative Care Strategies After Breast Surgery
The goal of this clinical trial is to compare two postoperative analgesia strategies in adult women undergoing breast surgery and to evaluate their effects on postoperative pain and quality of recovery after hospital discharge.
- Conditions
- Postoperative Pain, Pain Management, Breast Surgery, Chronic Postoperative Pain
- Trial name
- NCT07880223
- Testing
- Patient Education, Paracetamol, Dexketoprofen
- Where
- Greece
- Volunteers
- 108 people
- Sponsor
- Moumtzidou Maria Aikaterini
Magnetotherapy, Carpal Tunnel Syndrome (CTS)
Magnetotherapy in Carpal Tunnel Syndrome: Randomized Controlled Study
This study is designed to investigate the effectiveness of low-frequency pulsed electromagnetic field therapy in individuals diagnosed with mild-to-moderate carpal tunnel syndrome (CTS).
- Conditions
- Magnetotherapy, Carpal Tunnel Syndrome (CTS), Median Nerve Compression
- Trial name
- NCT07435961
- Testing
- Arm 1: Active Magnetotherapy Group, Arm 3: Conservative Treatment (Wait-List Control) Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital