Clinical trials: Neuromuscular Disease
Myofascial Pain Dysfunction Syndrome
Lidocaine Versus Magnesium Sulphate in Management of Myofascial Pain Dysfunction Syndrome
The goal of this clinical trial is to investigate the effectiveness of Magnesium Sulphate in the management of myofascial pain dysfunction syndrome in comparison to Lidocaine and Saline.
- Trial name
- NCT06595017
- Testing
- Magnesium sulphate, Lidocaine (drug), Saline
- Volunteers
- 75 people
- Sponsor
- Misr University for Science and Technology
Multiple Sclerosis
Safety and Efficacy Study of Oral Fampridine-SR in Patients With Multiple Sclerosis
Multiple Sclerosis (MS) is a disorder of the body's immune system that affects the Central Nervous System (CNS). Normally, nerve fibers carry electrical impulses through the spinal cord, providing communication between the brain…
- Trial name
- NCT00053417
- Testing
- 10 milligram (mg) fampridine-SR (4-aminopyridine, 4-AP), 15 mg fampridine-SR (4-aminopyridine, 4-AP), 20 mg fampridine-SR (4-aminopyridine, 4-AP)
- Where
- 25 sites in United States, Canada
- Volunteers
- 206 people
- Sponsor
- Acorda Therapeutics
Sarcopenic Obesity, Acupuncture Treatment
The Effect of Acupuncture on Sarcopenia and Obesity in Patients With Sarcopenic Obesity.
Sarcopenia is defined by the European Working Group on Sarcopenia in Older People (EWGSOP) as "a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength, carrying a risk of adverse outcomes…
- Conditions
- Sarcopenic Obesity, Acupuncture Treatment, Exercise
- Trial name
- Sarcopenia (NCT07797140)
- Testing
- Diet and exercise, Acupuncture
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Ayşe Ukbe Baykut
Sarcopenia in Elderly, Chronic Heart Failure
Effects of Resistance Training on Sarcopenia in Older Patients With Chronic Heart Failure
The goal of study is to evaluate the effects of an eight-week machine-based resistance training program on managing sarcopenia in older outpatients with chronic heart failure (HF) at Military Hospital 175.
- Trial name
- NCT06785168
- Testing
- Machine-based Resistance Training
- Where
- 2 sites in Vietnam
- Volunteers
- 146 people
- Sponsor
- Kieu Dang Phuong Nguyen
Muscle Fatigue, Trapezius Muscle Strain
Short Interventions to Prevent Trapezius Muscle Fatigue in Computer Work
This study is expected to demonstrate that during experimental days of seated computer work sustained and focalized low-level muscle activity contributes to the development of long-lasting fatigue effects (and thus possible…
- Trial name
- NCT03863340
- Testing
- interruptions of work tasks
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Cachexia
The Impact of Oligo-Fucoidan in Cancer Cachexia and Sarcopenia
Fucoidan also ameliorates tumour and chemotherapy-induced muscle atrophy and -related cachectic symptoms in vivo and in vitro. To evaluate the effect of fucoidan in cancer cachexia or sarcopenia in cancer patients.
- Trial name
- OFCS (NCT05623852)
- Testing
- fucoidan
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Medical University WanFang Hospital
Cirrhosis, Myosteatosis
Protocol for Muscle Attenuation Cut-offs in Cirrhosis
The goal of this observational study is to learn if new muscle attenuation cut-offs for the definition of myosteatosis can better predict survival in patients with cirrhosis.
- Conditions
- Cirrhosis, Myosteatosis, Sarcopenia, Sarcopenia in Liver Cirrhosis
- Trial name
- Myocirrhosis (NCT06593015)
- Testing
- Radiological tool for the diagnosis of myosteatosis
- Where
- Italy
- Volunteers
- 1,296 people
- Sponsor
- University of Roma La Sapienza
Liver Cirrhosis, Sarcopenia
A Study to Assess the Efficacy, Safety, and Tolerability of Oral LPCN 1148 in Male Subjects With Cirrhosis of the Liver and Sarcopenia
This is a randomized, double-blind, placebo-controlled study to assess the efficacy, safety, and tolerability of LPCN 1148 in men with cirrhosis of the liver and sarcopenia.
- Trial name
- NCT04874350
- Testing
- LPCN 1148
- Where
- 10 sites in United States
- Volunteers
- 30 people
- Sponsor
- Lipocine Inc.
Delayed Onset Muscle Soreness (DOMS), Inflammation
Effects of Immediate and Delayed Repeated Cold Exposure After Physical Exertion
The goal of this clinical trial is to learn if applying cold therapy can reduce swelling, inflammation, and pain after physical activity in adults who experience muscle soreness (Delayed Onset Muscle Soreness, or DOMS).
- Conditions
- Delayed Onset Muscle Soreness (DOMS), Inflammation, Muscle Pain, Muscle Damage
- Trial name
- NCT06813690
- Testing
- Cold Therapy with Axanova Cold Hot Pearls Maxi Pack
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
Myalgic Encephalomyelitis, Long-COVID
Low Dose Rapamycin in ME/CFS, Long-COVID, and Other Infection Associated Chronic Conditions
The goal of this observational study is to assess the clinical response and the effect of autophagy function in patients before, during and throughout oral low dose sirolimus (rapamycin) therapy.
- Trial name
- NCT06257420
- Testing
- Rapamycin
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Simmaron Research Inc.
Sciatica, Chronic Sciatica
Effects of Shockwave Therapy Versus Ultrasound Therapy Among Patients With Chronic Sciatica
Sciatica is characterized by radiating pain, functional limitations, reduced flexibility, disturbed sleep, and impaired quality of life.
- Conditions
- Sciatica, Chronic Sciatica, Lumbar Radiculopathy
- Trial name
- NCT07710924
- Testing
- Extracorporeal Shockwave Therapy, Therapeutic Ultrasound, Conventional Physiotherapy
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- University of Lahore
Post-Herpetic Neuralgia (PHN), Neuropathic Pain
A Study Into Pain Relief Given by ASP8477 for Peripheral Neuropathic Pain (Either Post-herpetic Neuralgia or Painful Diabetic Peripheral Neuropathy) and Its Safety
The purpose of this study is to assess the painkilling efficacy of ASP8477 relative to mock (placebo) in patients that have been diagnosed with painful diabetic peripheral neuropathy or postherpetic neuralgia determined by the…
- Conditions
- Post-Herpetic Neuralgia (PHN), Neuropathic Pain, Painful Diabetic Peripheral Neuropathy (PDPN)
- Trial name
- MOBILE (NCT02065349)
- Testing
- ASP8477
- Where
- 17 sites in Czechia, Germany and 2 more
- Volunteers
- 132 people
- Sponsor
- Astellas Pharma Europe B.V.
Hereditary Sensory Neuropathy Type I
Hereditary Sensory Neuropathy Serine Trial
This is a randomised double-blind placebo-controlled trial of L-serine in Hereditary Sensory Neuropathy type 1 (HSN1) due to variants in SPTLC1/2 gene.
- Trial name
- SENSE (NCT06113055)
- Testing
- L-serine
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University College, London
Neuropathy Associated With Dysproteinaemias
Relationship Between Serum Interleukin-20 Level and Paclitaxel-associated Neuropathy
This study aims to investigate the correlation between paclitaxel-induced neuropathy and the measurement values of serum IL-20 levels at baseline and during chemotherapy in patients who will receive neoadjuvant or adjuvant…
- Trial name
- NEUROTOX (NCT05622617)
- Testing
- no intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Namik Kemal University
Stroke, Hemiplegia, Spastic
Condensed and Distributed Robotic Therapy in Spastic Stroke Post Botulinum Toxin Injection
The purpose of this project is to examine and compare the immediate and long-term effects of combined Botulinum toxin type A (BoNT-A) injection between condensed and distributed robot-assisted training (RT) programs in patients…
- Trial name
- NCT03321097
- Testing
- condensed RT group, distributed RT group
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Chang Gung Memorial Hospital
Sarcopenia
Smart Tech-Based Nutrition and Exercise for Sarcopenia Risk.
Sarcopenia, characterized by muscle loss and weakness, is a major health issue among older adults and impacts mobility and quality of life.
- Trial name
- S-TEN (NCT07230210)
- Testing
- The 12-week exercise component is delivered via the dedicated Line Bot platform. It includes three progressive exercise training videos (resistance, balance) . Participants are in
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- HSIAO MEI LAN
Spinal Cord Injuries, Spinal Cord Diseases
Impact of Peripheral Afferent Input on Central Neuropathic Pain
The overarching aim of this study is to investigate the contribution of peripheral afferent input to spontaneous and evoked central neuropathic pain after a spinal cord lesion or disease.
- Conditions
- Spinal Cord Injuries, Spinal Cord Diseases, Syringomyelia
- Trial name
- NCT05646810
- Testing
- Lidocaine (10 mg/ml), Isotonic saline
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Muscular Dystrophy, Oculopharyngeal (OPMD)
Continuation Protocol to Protocol BBCO-001
This will be a multi-center, randomized withdrawal, open-label, non-treatment concurrent control, parallel group study. Patients completing protocol BBCO-001 will be offered the opportunity to enter into this 12-month randomized…
- Trial name
- HOPEMD (NCT02328482)
- Testing
- Tehalose 30gr
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Bioblast Pharma Ltd.
Inactivity, Physical, Treatment Adherence and Compliance
VR vs. Conventional Cycling Exercise for Geriatric Inpatient Physical Activation
The aim of this study is to investigate whether virtual reality assisted stationary cycling exercise results in more physical activity than conventional unsupervised stationary cycling exercise.
- Conditions
- Inactivity, Physical, Treatment Adherence and Compliance, Hospital Acquired Condition, Sarcopenia
- Trial name
- NCT05123638
- Testing
- Virtual reality cycling exercise, Unsupervised stationary cycling exercise
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Bispebjerg Hospital
Whiplash Associated Disorders (WAD), Whiplash
Neuromuscular Mechanisms Underlying Poor Recovery From Whiplash Injuries
This study is investigating whether changes in the shape and size of bodily muscles and spinal cord anatomy can influence recovery rates following a motor vehicle collision (MVC).
- Trial name
- NCT02157038
- Testing
- Pedometer, MRI
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Northwestern University