Clinical trials: Neuromuscular Disease Patients
Muscle Wasting, Non Small Cell Lung Cancer
Phase III Study of the Effect of GTx-024 on Muscle Wasting in Patients With Non-Small Cell Lung Cancer (NSCLC)
The purpose of this study is to determine if the investigational drug GTx-024 can help subjects with non-small cell lung cancer increase physical function and maintain or gain muscle, also called "lean body mass".
- Trial name
- NCT01355484
- Testing
- GTx-024
- Where
- 27 sites in United States
- Volunteers
- 321 people
- Sponsor
- GTx
Femoral Neuropathy
Femoral Neuropathy After Anterior Cruciate Ligament Reconstruction: Femoral Nerve Block vs Patient-controlled Analgesia (PCA)
Femoral neuropathy after anterior cruciate ligament reconstruction with femoral nerve block may be as high as 24% at 6 postoperative weeks when evaluated prospectively and systematically through a clinical neurological and an…
- Trial name
- NCT01321138
- Testing
- Femoral nerve block, PCA morphine
- Where
- Switzerland
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Complication of Dialysis, Chronic Kidney Disease
Efficacy of Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation in Hemodialysis Patients
The purpose of this study is to examine the effect of 6 months of daily beta-hydroxy beta-methylbutyrate (HMB) supplementation on the physical function and the health of bones, arteries and heart in hemodialysis patients.
- Conditions
- Complication of Dialysis, Chronic Kidney Disease, Muscle Loss, End Stage Renal Disease
- Trial name
- NCT01837238
- Testing
- HMB
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Illinois at Urbana-Champaign
Stroke, Pain
MRP Verses PNF on Pain, Foot Drop, Gait and Functional Mobility in Hemiplegic Patients.
This single blinded randomized control study aimed to determine the comparative effectiveness of two rehabilitation approaches for improving pain, foot drop, gait, and functional mobility in patients with hemiplegia.
- Conditions
- Stroke, Pain, Gait, Drop Foot, Foot Drop
- Trial name
- CEMRA-PNF (NCT06539247)
- Testing
- Motor Relearning Program with Electrical Muscle Stimulation (MRA + EMS), Proprioceptive Neuromuscular Facilitation Technique with Electrical Muscle Stimulation (PNF + EMS)
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- University of Lahore
Diabetic Peripheral Neuropathy (DPN)
Far-Infrared Socks for Neuropathic Pain and Nerve Function in Diabetic Patients
This study aims to evaluate the effectiveness of far-infrared radiation (FIR) emitting socks in improving neuropathic pain, nerve conduction, and quality of life in patients with diabetic peripheral neuropathy (DPN).
- Trial name
- FIR-DPN (NCT06880484)
- Testing
- Far-Infrared Radiation (FIR) Socks
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- TC Erciyes University
Neuropathy, Neuropathy, Diabetic
Photobiomodulation Therapy and Nerve Density for Patients With Diabetic or Chemotherapy-associated Neuropathy
This study seeks to determine if photobiomodulation (PBM, or low level laser light) affects the growth and distribution of nerves int he skin.
- Conditions
- Neuropathy, Neuropathy, Diabetic, Neuropathy Toxic
- Trial name
- NCT03195868
- Testing
- Realief Therapy
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Minnesota
Spinal Muscular Atrophy
Longitudinal Data Collection in Pediatric and Adult Patients With Spinal Muscular Atrophy in Latin America
The natural history of SMA patients has changed, due to the improvements in treatment and technological advances. The systematic collection of data from routine clinical practice in multiple Latin American countries, harmonized…
- Trial name
- RegistrAME (NCT05475691)
- Where
- 18 sites in Argentina, Brazil and 4 more
- Volunteers
- 361 people
- Sponsor
- Hospital Israelita Albert Einstein
Neuromuscular Blockade, Chronic Obstructive Pulmonary Disease
Comparison of Time to Extubation Using Sugammadex or Neostigmine
A prospective blinded randomized clinical trial to compare time to extubation using Sugammadex versus Neostigmine/glycopyrrolate as reversal agents after use of neuromuscular blockade agents in an outpatient bronchoscopy suite.
- Trial name
- NCT04606901
- Testing
- neostigmine/glycopyrrolate, sugammadex
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Temple University
Amyotrophic Lateral Sclerosis (ALS)
Study on the Safety and Efficacy of RAG-21 in the Treatment of Amyotrophic Lateral Sclerosis Patients With FUS Gene Mutations
Amyotrophic lateral sclerosis (ALS) is a chronic progressive neurodegenerative disease that remains incurable, with limited existing therapies or drugs available. Familial ALS can be caused by mutations in various genes.
- Trial name
- RAG-21-FUS-ALS (NCT07080801)
- Testing
- RAG-21
- Volunteers
- 6 people
- Sponsor
- Beijing Tiantan Hospital
ALS (Amyotrophic Lateral Sclerosis)
ALS Reversals - Lunasin Regimen
This is a 12-month, widely inclusive, largely virtual, single-center, open-label pilot trial utilizing a historical control group.
- Trial name
- NCT02709330
- Testing
- Lunasin Regimen, Historical control
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Richard Bedlack, M.D., Ph.D.
Diabetic Polyneuropathy
Differential Air Pressure Technology for Treatment of Diabetic Elderly Patients
Aging can be defined as sequential deterioration that occurs in elderly people including weakness, loss of mobility, decline of physical capabilities, increase susceptibility to disease and many other age-related physiological…
- Trial name
- NCT04620265
- Testing
- Antigravity treadmill training 100% weight bearing, Antigravity treadmill training 75% weight bearing, Antigravity treadmill training 50% weight bearing
- Where
- Saudi Arabia
- Volunteers
- 110 people
- Sponsor
- Umm Al-Qura University
Fibromyalgia
Acupuncture for Fibromyalgia
Fibromyalgia is the second most common autoimmune rheumatic diseases with clinical manifestations of widespread pain, fatigue and accompanied cognitive and emotional disturbances.
- Trial name
- NCT02583334
- Testing
- Verum acupuncture (30# acupuncture needle)
- Where
- 2 sites in Taiwan
- Volunteers
- 158 people
- Sponsor
- China Medical University Hospital
Pulmonary Disease, Chronic Obstructive (COPD)
Inspiratory Flow Rates Achieved by the COPD Patients Through Breezhaler®, Ellipta® and Handihaler® Inhaler Devices
The purpose of this study was to compare dynamic inspiratory flow rates achieved by a population of Chronic Obstructive Pulmonary Disease (COPD) patients through the Breezhaler®, Ellipta® and Handihaler® dry powder inhaler (DPI)…
- Trial name
- NCT02596009
- Testing
- Breezhaler®, Ellipta®, Handihaler®
- Where
- 5 sites in Argentina
- Volunteers
- 97 people
- Sponsor
- Novartis Pharmaceuticals
Major Depression, Fibromyalgia
Agomelatine in Depressed Patients With Fibromyalgia
Depression and unrefreshed sleep are frequent in patients with fibromyalgia. Agomelatine is a new antidepressant with sleep-promoting properties.
- Trial name
- NCT01731899
- Testing
- agomelatine
- Where
- Spain
- Volunteers
- 27 people
- Sponsor
- Universidad de Granada
Sciatica
"The Lived Experience of Investigations for Sciatica"
This will be an exploratory study, using semi-structured interviews to explore patients' experiences of undergoing investigations for Sciatica (leg pain referred from the lower back).
- Trial name
- NCT02512081
- Testing
- No intervention applied
- Volunteers
- 14 people
- Sponsor
- University of Southampton
Obstructive Sleep Apnea
Impact of Sugammadex vs. Neostigmine Reversal on Post-Operative Recovery and Complications
Sugammadex or neostigmine are given at the end of the surgery to reverse neuro muscular blocking drugs (NMBD). This study will evaluate whether reversal of NMBD with sugammadex is associated with faster recovery than neostigmine…
- Trial name
- Sugammadex (NCT03679611)
- Testing
- Sugammadex Sodium, Neostigmine
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
MELAS Syndrome, Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS)
A Study to Assess TTI-0102 vs Placebo in MELAS Patients
This is a randomized, double-blind, placebo-controlled study. Prior to treatment, patients will undergo a screening visit. If eligible, each subject will return for a Day 1 visit and will receive their first dose of…
- Trial name
- NCT06644534
- Testing
- TTI-0102
- Where
- 2 sites in France, Netherlands
- Volunteers
- 9 people
- Sponsor
- Thiogenesis Therapeutics, Inc.
Stiff Person Syndrome
A Study Investigating Intravenous Human Normal Immune Globulin 10% in Adults With Stiff Person Syndrome
The purpose of this study is to evaluate the efficacy and safety of QIVIGY (Intravenous Human Normal Immune Globulin 10%) compared with placebo in adult participants with stiff person syndrome (SPS).
- Trial name
- NCT07552987
- Testing
- Kedrion IVIg 10%, Human Albumin
- Volunteers
- 38 people
- Sponsor
- Kedrion S.p.A.
SMA - Spinal Muscular Atrophy, Gene Therapy
Gene Replacement Therapy Clinical Trial for Participants With Spinal Muscular Atrophy Type 1
Phase 3 pivotal US trial studying open-label intravenous administration of onasemnogene abeparvovec-xioi in spinal muscular atrophy (SMA) Type 1 participants.
- Trial name
- STR1VE (NCT03306277)
- Testing
- Onasemnogene Abeparvovec-xioi
- Where
- 16 sites in United States
- Volunteers
- 22 people
- Sponsor
- Novartis Gene Therapies
Neuralgia, Postherpetic
Effect of Opioids in Neuropathic Pain in Postherpetic Patients
Postherpetic neuralgia (PHN) is often associated with pain and sensory changes and is the leading type of neuropathic pain in modern clinical pain research.
- Trial name
- VHPRG-HDRPH (NCT01102101)
- Testing
- Remifentanil
- Where
- 2 sites in Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna