Clinical trials: Neuromuscular Disease Patients
HR+ HER2- Breast Cancer
Sapanisertib and Serabelisib (PIKTOR) in Various Combinations in Patients With HR+/HER2- Advanced/Metastatic Breast Cancer
The study is a Phase 1b/2, multi-center, open-label, dose escalation trial evaluating the safety and preliminary efficacy of sapanisertib and serabelisib (PIKTOR) with fulvestrant and/or other anticancer therapies in participants…
- Trial name
- NCT07558733
- Testing
- Serabelisib, Sapanisertib, Fulvestrant
- Where
- 7 sites in United States
- Volunteers
- 32 people
- Sponsor
- Faeth Therapeutics
Amyotrophic Lateral Sclerosis
Blood-Brain Barrier Opening Using MR-Guided Focused Ultrasound in Patients With Amyotrophic Lateral Sclerosis
The purpose of this study is to evaluate the safety, tolerability, and feasibility of Blood-Brain Barrier (BBB) opening using transcranial MRI-guided focused ultrasound in conjunction with an intravenous ultrasound contrast agent…
- Trial name
- NCT03321487
- Testing
- Blood-Brain Barrier opening with MRgFUS
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- InSightec
Chronic Obstructive Pulmonary Disease Severe, Muscle Weakness
Additional Manual Therapy Over Inspiratory Muscle Training in COPD
The benefits of inspiratory muscle training(IMT) in patients with chronic obstructive pulmonary disease(COPD) were reported.But in severe COPD patients, benefit from IMT may be limited.There is need for further research in new…
- Trial name
- NCT04533516
- Testing
- Manual therapy technics, Inspiratory Muscle Training
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istinye University
Juvenile Idiopathic Arthritis, Rheumatic Diseases
Low-energy Laser Applications in Patients With Juvenile Idiopathic Arthritis
This study endeavored to evaluate the auxiliary effect of low-energy laser therapy (LLT) on pain, muscle performance, fatigue, and functional ability in children with juvenile idiopathic arthritis (JIA).
- Conditions
- Juvenile Idiopathic Arthritis, Rheumatic Diseases, Chronic Knee Pain, Fatigue
- Trial name
- NCT05031104
- Testing
- Physical Exercise, Physical Exercise plus Low-energy Laser Therapy
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Cairo University
Amyotrophic Lateral Sclerosis, ALS
A Study of Protein Metabolism, Microbiome and Investigational Probiotic Use in Patients With ALS
ALS, also known as "Lou Gehrig's" disease, is a neurodegenerative disease which is fatal. Treatment for ALS is limited and currently consists of primary symptom relief or support.
- Trial name
- NCT03324399
- Testing
- probiotic
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Avera McKennan Hospital & University Health Center
Antibody-mediated Rejection, NMO Spectrum Disorder
Biorepository and Registry for Plasma Exchange Patients
Patients who have immune mediated diseases commonly undergo plasma exchange (PLEX) procedures to remove pathological substances, typically believed to be antibodies.
- Conditions
- Antibody-mediated Rejection, NMO Spectrum Disorder, TTP, CIDP
- Trial name
- NCT05004493
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Charles M Knudson
Sarcopenia
Characterization of the Nutritional Status in the Patient With Liver Cirrhosis
In the subgroup of patients with sarcopenia, regardless of their body mass index, we want to verify the real impact of nutritional supplements with branched chain amino acids on the standard treatment based on nutritional…
- Trial name
- NCT04073693
- Testing
- Branched chain amino acids (BRCA)
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Puerta de Hierro University Hospital
Fibromyalgia
QOL Efficacy of Adapted Physical Activity for Patients With Fibromyalgia
Fibromyalgia affects at least 4% of the population. This chronic painful pathology is a source of social exclusion with a major impact on professional activity; To our knowledge, no study has demonstrated with sufficient evidence…
- Trial name
- NCT03640806
- Testing
- PHYSICAL ACTIVITY
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Stroke, Spasticity
Static Versus Dynamic Splints for Wrist Spasticity in Stroke Patients
The goal of this clinical trial is to evaluate whether different types of wrist-hand splints can reduce wrist flexor spasticity in subacute hemiplegic stroke patients.
- Conditions
- Stroke, Spasticity, Hemiplegia, Post Stroke Recovery
- Trial name
- NCT07301606
- Testing
- Static Wrist-Hand Splint, Dynamic Wrist-Hand Splint
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- University of Lahore
Fibromyalgia
Effects of Blue-enriched White Light Therapy in Patients with Fibromyalgia
Fibromyalgia is a chronic condition with an unclear etiology. The syndrome includes symptoms such as chronic musculoskeletal pain, cognitive dysfunctions, fatigue, sleep disorders, and circadian rhythm disturbances.
- Trial name
- NCT04504721
- Testing
- light therapy
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Cervical Radiculopathy
Spinal Mobilization and PNF Comparison on Pain, Disability in Patients With Cervical Radiculopathy
As in this modern era of digitalization; mobile phones, touch pads and computers devices use is increasing, neck pain that radiates into upper limb is also becoming common due to such devices long term use in bad postures or…
- Trial name
- NCT06866821
- Testing
- SMWAM's and PNF C-R Technique, PNF C-R Technique and PT Protocol
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Spinal Muscular Atrophy
Real-World Use of Novel Treatments in Patients With Spinal Muscular Atrophy (SMA): A Multi-Site Retrospective Chart Review of Pediatric SMA Patients Outside of the United States
This global, retrospective, non-interventional, medical chart review (MCR), descriptive study collected patient-level data in regions outside the US.
- Trial name
- NCT06178393
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Novartis Pharmaceuticals
Critical Illness, Dysphagia
MuScle WastIng and DysphaGia iN CriticAlly IlL Patients (SIGNAL)
The goal of this study is to find out how muscle wasting in the mouth and throat affects swallowing (dysphagia) in adults who are critically ill and being treated in intensive care units.
- Conditions
- Critical Illness, Dysphagia, Muscle Wasting in Critically Ill, Swallowing Disorders
- Trial name
- SIGNAL (NCT07076524)
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- Barts & The London NHS Trust
Critical Illness, Covid19
Body Composition Study in Critically Ill Patients-Extended to COVID-19
Muscle loss (ultrasound quadricep muscle) and muscle strength (handgrip and knee extension strength) will be compared between COVID-19 and non COVID-19 critically ill patients.
- Conditions
- Critical Illness, Covid19, Muscle Atrophy, Muscle Strength
- Trial name
- COVID-MUSCLE (NCT04849624)
- Testing
- No Intervention
- Where
- Malaysia
- Volunteers
- 59 people
- Sponsor
- University of Malaya
Myotonic Dystrophy 1
Effect of MYODM on Quality of Life, Fatigue and Hypersomnia in Patients With Myotonic Dystrophy Type 1
The purpose of this study is to determine whether MYODM (formulated composition containing Theobroma cacao supplemented with caffeine (caffeine/theobromine ratio1/1.85, w/w) is effective in the treatment of excessive daytime…
- Trial name
- NCT04634682
- Testing
- MYODM
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Myogem Health Company, S.L.
Fibromyalgia
Effects of Box Breathing Exercise in Patients With Fibromyalgia
Fibromyalgia is a chronic condition that can cause widespread pain, sleep problems, fatigue, gastrointestinal symptoms, and reduced comfort.
- Trial name
- NCT07722923
- Testing
- Box Breathing Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Artvin Coruh University
Lumbar Radiculopathy
Efficacy of Combining Mulligan Spinal Mobilization With Leg Movement and Mechanical Lumbar Traction in Lumbar Radiculopathy
Lumbar radiculopathy (LR), often caused by disc herniation, results in significant pain, disability, and reduced quality of life.
- Trial name
- NCT07573124
- Testing
- Spinal Mobilization with Leg Movement (SMWLM), Mechanical Lumbar Traction, Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Khyber Medical University Peshawar
Piriformis Syndrome
Comparative Effects of Post Facilitation Stretch and Active Release Technique in Female Patients With Piriformis Syndrome.
This clinical study aimed to compare the effectiveness of Post-Facilitation Stretch (PFS) and Active Release Technique (ART) on pain, disability, quality of life, and range of motion of hip internal and external rotation in…
- Trial name
- NCT07547059
- Testing
- Post Facilitation Stretch, Active Release Technique
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Ibadat International University, Islamabad
ALSFTD, ALS (Amyotrophic Lateral Sclerosis)
Effects of Probiotics in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia Spectrum Disorder (ALS-FTDSD) Patients
The aim of this study is to assess the impact of a probiotic formulation on participants with ALS-FTDSD. It is hypothesized that participants given the probiotics will have different lipid profiles compared to participants…
- Conditions
- ALSFTD, ALS (Amyotrophic Lateral Sclerosis), Frontal Temporal Dementia (FTD)
- Trial name
- PROBIOTIC (NCT06051123)
- Testing
- Probiotic
- Where
- 3 sites in Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Diabetic Foot
Effect of Subtalar and Talocrural Joint Mobilization on Foot Ranges and Posture in Diabetic Patients
The aim of this research is to determine the Effects of mobilizations on foot ranges and posture in people with Type 2 Diabetes Mellitus. Randomized controlled trials will be done at Dr.
- Trial name
- NCT05922280
- Testing
- subtalar and talo-crural mobilization, International Working Group of the Diabetic Foot care guidelines
- Where
- Pakistan
- Volunteers
- 41 people
- Sponsor
- Riphah International University
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