Clinical trials: Neuromuscular Disease Patients
Spinal Muscular Atrophy
Holter of Movement in Patients with SMA Undergoing Treatment.
Acti-SMA is a multi-centric academic study. It aims to monitor the progress of patients with spinal muscular atrophy under treatment with Spinraza° or risdiplam.
- Trial name
- NCT04888702
- Testing
- Actimyo
- Where
- 3 sites in Belgium, Romania
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Amyotrophic Lateral Sclerosis
Video-Based Proprioceptive Exercise Program in ALS
In the project, it was aimed to evaluate the proprioceptive system in the disease, which is still mysterious and therefore has no curative treatment under current conditions, and to examine the effects of the video-based…
- Trial name
- ALS (NCT07292545)
- Testing
- video based exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Tarsus University
Anesthesia, Pain
A Comparison of US and Evoked Motor Response-guided Placement of Continuous Femoral Nerve Block Following TKA
The purpose of this study is to determine which technique for catheter placement in continuous femoral nerve block (FNB) is most successful - guidance with (1) ultrasound or (2) nerve stimulation and ultrasound.
- Conditions
- Anesthesia, Pain, Nerve Pain, Knee Arthroplasty
- Trial name
- NCT03121976
- Testing
- Ultrasound, Ultrasound + Nerve Stimulation
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- Sunnybrook Health Sciences Centre
Sarcopenia, Colon Cancer
Preoperative Sarcopenia and Surgical Outcomes in Colorectal Cancer Patients
Colorectal cancer is the third most common malignant neoplasm worldwide and the fourth leading cause of cancer-related deaths. Muscle mass loss in oncology patients is most often the result of cancer-related malnutrition.
- Conditions
- Sarcopenia, Colon Cancer, Rectal Cancer, Surgical Outcomes
- Trial name
- NCT06698289
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Mersin University
Trismus, Radiation-induced Fibrosis
Physiotherapy for Radiation-induced Trismus
The purpose of this study is to assess the effect of two protocols of physiotherapeutic exercises in the maintenance and/or increase of the mandibular range of movement in patients suffering from head and neck cancer (HNC) who…
- Trial name
- NCT02094690
- Testing
- Therabite, Hyperboloid
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Neuromuscular Diseases
Oscillation and Lung Expansion (OLE) Therapy for Treatment of Neuromuscular Disease (NMD) Patients
The study will be a non-randomized open label pilot study comparing a retrospective control period to an active treatment period with oscillation and lung expansion (OLE) therapy.
- Trial name
- NCT05366010
- Testing
- Oscillation and Lung Expansion (OLE) therapy
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Baxter Healthcare Corporation
Sarcopenia, Malnutrition
Nutritional Therapy in Patients at Risk for Malnutrition and Sarcopenia in Pulmonary Rehabilitation
Malnutrition and sarcopenia (muscle wasting) are common in health care settings and represent a health and economic burden due to associated increased mortality and prolonged hospital stays.
- Trial name
- NCT05096013
- Testing
- individual nutritional therapy
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Thimo Marcin
Myasthenia Gravis (MG)
Talquetamab in Patients With Refractory Generalized Myasthenia Gravis
Myasthenia Gravis (MG) is a chronic autoimmune disease mediated by pathogenic antibodies. Approximately 10%-15% of patients present with refractory status, defined as having an inadequate response to existing therapies or an…
- Trial name
- NCT07499323
- Testing
- Talquetamab
- Volunteers
- 2 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Neuromuscular Diseases, Scoliosis
Evaluation of the Feasibility of Remote Monitoring of Mechanical In-exsufflation Devices in Paralytic and Neuromuscular Patients Treated at Home.
The implementation of an mechanical in-exsufflator device (MI-E) requires specific expertise because it is a complex device that requires fine-tuning of the settings according to different clinical situations to optimize its…
- Trial name
- TELE-INEX (NCT05723289)
- Testing
- MI-E Telemonitoring
- Where
- France
- Volunteers
- 10 people
- Sponsor
- KerNel Biomedical
Muscular Dystrophy, Duchenne
An Open-Label Extension Study for Patients With Duchenne Muscular Dystrophy Who Participated in Studies of SRP-5051 (Vesleteplirsen)
The purpose of this extension study is to evaluate the safety, tolerability, and pharmacokinetics of repeat administrations of SRP-5051 (vesleteplirsen) in participants with Duchenne muscular dystrophy (DMD) who participated in…
- Trial name
- NCT03675126
- Testing
- SRP-5051
- Where
- 8 sites in United States, Canada
- Volunteers
- 15 people
- Sponsor
- Sarepta Therapeutics, Inc.
Peripheral Neuropathy
Pilot Study Investigating the Use of the ReBuilder to Treat Chemotherapy Induced Peripheral Neuropathy in Patients With Breast Cancer
The purpose of this study is to investigate the effect of the ReBuilder in the treatment of individuals with breast cancer and chemotherapy induced peripheral neuropathy.
- Trial name
- NCT02606110
- Where
- United States
- Sponsor
- Eastern Regional Medical Center
Herpes Zoster
A Study Exploring Efficacy of Peginterferon in Patients With Herpes Zoster
To evaluate the efficacy, optimal dose and efficacy trend of multiple subcutaneous injections of peginterferon α1b in patients with herpes zoster, and provide support for phase III clinical trials.
- Trial name
- NCT05492591
- Testing
- Peginterferon α1b, Peginterferon α1b with valacyclovir, Valacyclovir
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Institute Of Biological Products
Vitamin D Deficiency, Peripheral Neuropathy
Vit D and Peripheral Neuropathy in Taxane Naive Patients
To evaluate the efficacy of vit D supplement in cancer patients which receive taxane drugs with vit D deficiency and complaining from Peripheral neuropathy
- Trial name
- NCT05852496
- Testing
- Vitamin D
- Volunteers
- 60 people
- Sponsor
- Assiut University
Spinal Cord Injuries (SCI), Chronic Pain
Virtual Reality-Based Hypnotherapy for Pain, Sleep, and Mood in Spinal Cord Injury
The goal of this clinical trial is to learn whether virtual reality (VR)-based hypnotherapy, added to conventional physiotherapy, improves pain, sleep, mood, and quality of life in adults with chronic spinal cord injury.
- Conditions
- Spinal Cord Injuries (SCI), Chronic Pain, Neuropathic Pain, Sleep Disturbance
- Trial name
- HypnoVR-SCI (NCT07846410)
- Testing
- Virtual Reality-Based Hypnotherapy, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Effects of Long Term Ventilation Support on the Quality of Life of ALS Patients and Their Families
Amyotrophic lateral sclerosis (ALS) is a serious rapidly progressive disease of the nervous system. The average survival from the time of diagnosis is two to three years.
- Conditions
- Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Nervous System Diseases, Spinal Cord Diseases
- Trial name
- ALS-LTMV (NCT05744310)
- Testing
- Long term mechanical ventilation support, No long term mechanical ventilation support
- Where
- 9 sites in Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Muscle Weakness, Mechanical Ventilation Complication
Cycling Exercise in Mechanical Ventilation
Prolonged critical illness renders survivors with increased long-term morbidity associated with high healthcare costs. Muscle weakness and fatigue are reported as the main contributors to long-term poor functional outcomes.
- Trial name
- NCT03581760
- Testing
- Cycling Exercise, Conventional Physiotherapy
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital Ostrava
Polymyositis, Dermatomyositis
Efficacy and Tolerability of BAF312 in Patients With Polymyositis and Dermatomyositis
This study determined the efficacy, safety, tolerability and the PK profile of BAF312, a novel immunomodulator, in polymyositis and dermatomyositis patients who were not responsive to traditional immunosuppressive and/or…
- Trial name
- NCT01148810
- Testing
- BAF312
- Where
- 6 sites in United States, Czechia and 3 more
- Volunteers
- 18 people
- Sponsor
- Novartis Pharmaceuticals
Charcot-Marie-Tooth Disease Type 1A
Phase III Trial Assessing the Efficacy and Safety of PXT3003 in CMT1A Patients (PLEO-CMT)
The purpose of this study is to determine whether PXT3003 is effective and safe in the treatment of Charcot-Marie-Tooth disease - Type 1 A (CMT1A).
- Trial name
- PLEO-CMT (NCT02579759)
- Testing
- PXT3003 dose 1, PXT3003 dose 2
- Where
- 30 sites in United States, Belgium and 6 more
- Volunteers
- 323 people
- Sponsor
- Pharnext S.C.A.
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Efficacy and Safety Study of I10E in Treatment of Patients With CIDP
Primary objective: To assess the efficacy of I10E in improving the disability of patients with CIDP. Secondary objective: To assess the safety of I10E in patients with CIDP.
- Trial name
- PRISM (NCT02293460)
- Testing
- I10E
- Where
- 33 sites in France, Italy and 4 more
- Volunteers
- 44 people
- Sponsor
- Laboratoire français de Fractionnement et de Biotechnologies
Chronic Disease
Integrative Therapy of Chronic Diseases
The observational study aims to investigate the extent to which a two-week stay in an internal medicine clinic for integrative medicine and naturopathy results in an improvement of complaints, impairments, quality of life…
- Trial name
- InteChron (NCT04927403)
- Testing
- multimodal integrative naturopathic therapy concept
- Where
- 3 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- Universität Duisburg-Essen
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