Clinical trials: Neuromuscular Disease Patients
Centronuclear Myopathy
Prospective Natural History Study of Patients With Myotubular Myopathy and Other CentroNuclear Myopathies
This is the 2 years extension of the prospective and longitudinal study of the natural history and functional status of patients with myotubular myopathy and other centronuclear (CNM) sponsored by Dynacure including ten…
- Trial name
- NatHis-CNM (NCT03351270)
- Testing
- Standardized strength, respiratory and motor function assessments
- Where
- 11 sites in Belgium, France and 3 more
- Volunteers
- 60 people
- Sponsor
- Institut de Myologie, France
Intermediate AMD
A Clinical Trial Evaluating the Safety and Efficacy of a New Light Combination Therapy Addressing Intermediate AMD
The proposed clinical investigation wants primary to validate the safety of the innovative light therapy approach and in second priority provide insight and confirmations on therapeutic effect.
- Trial name
- retinaSEES-PoC (NCT06557369)
- Testing
- reSEES
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Oculox Technologies SA
Muscular Dystrophy, Facioscapulohumeral
Study of SRP-1001 in Adult and Adolescent Participants With Facioscapulohumeral Muscular Dystrophy Type 1
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics of SRP-1001 in participants with facioscapulohumeral muscular dystrophy Type 1 (FSHD1).
- Trial name
- NCT06131983
- Testing
- SRP-1001 for Injection
- Where
- 16 sites in Australia, Canada and 5 more
- Volunteers
- 60 people
- Sponsor
- Sarepta Therapeutics, Inc.
Carpal Tunnel Syndrome
Short-Term Effectiveness of Ultrasound-Guided Corticosteroid Hydrodissection
Aim: Steroid injections are remarkably effective as a treatment for carpal tunnel syndrome (CTS) in the short term. The aim of this study was to determine whether hydrodissection would provide an additional clinical effect when…
- Trial name
- NCT04848324
- Testing
- Corticosteroid Hydrodissection, Corticosteroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Fibromyalgia
Serious Game for Fibromyalgia Patients
Aim: To check the applicability of LitEmotion© in people with Fibromyalgia. Design: randomized clinical trial, with pre, post and follow-up evaluation. Researchers and outcome evaluator blinded.
- Trial name
- NCT03906188
- Testing
- LitEmotion
- Where
- Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universidad de Burgos
Lumbar Radiculopathy
Effects of Myofascial Release and Nerve Flossing Technique on Pain and Disability in Patients With Lumbar Radiculopathy
Radiculopathy is a clinical condition which involves one or more nerves resulting in impaired function. The site of injury in radiculopathy is at the level of the spinal nerve root.
- Trial name
- NCT06241027
- Testing
- Nerve flossing technique, Myofascial release
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Postpolio Syndrome
Effectiveness of Transcranial Magnetic Stimulation Treatment in Patients Diagnosed With Postpolio Syndrome
This randomized, double-blind, sham-controlled trial evaluated the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex on walking capacity, fatigue, post-polio-related…
- Trial name
- NCT06926270
- Testing
- Repetitive transcranial magnetic stimulation (rTMS), Individualized home exercise program
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Ege University
Neuropathic Pain
Evaluation of an ATP-Containing Parenteral Vitamin B Complex in Patients With Symptomatic Diabetic Polyneuropathy
Epinosine B Forte ampoule is an intramuscular injectable supplement containing adenosine triphosphate (ATP), Cocarboxylase (vitamin B1 derivative), vitamin B12, and nicotinamide (vitamin B3).
- Trial name
- NCT07296354
- Testing
- adenosine triphosphate, Vitamin B Complex
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Egyptian International Pharmaceutical Industries Co
Myasthenia Gravis
Follow-up of a Cohort of Patients With Myasthenic Syndrome and COVID-19 Infection
Coronavirus disease 2019 (COVID-19), declared by the World Health Organization (WHO) as a "public health emergency of international concern" (January 31, 2020), has posed a significant threat to global health.
- Trial name
- CO-MY-COVID (NCT04695379)
- Where
- 10 sites in France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Bordeaux
Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis
Acoustic and Perceptual Markers of Dysarthria in Amyotrophic Lateral Sclerosis (ALS)
This study proposes to identify acoustic and perceptual markers related to upper motor neuron (UMN) degeneration and lower motor neuron (LMN) degeneration in the dysarthria of patients with amyotrophic lateral sclerosis (ALS)…
- Conditions
- Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis, Kennedy's Disease
- Trial name
- SPEECH-ALS (NCT03560661)
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Pain
Beneficial Effects of Self-hypnosis/Self-care for Chronic Pain Patients : a MRI and EEG Study
Chronic pain concerns one in four adults in Belgium. Fibromyalgia is an example of chronic pain and is characterized by diffused and migrant musculo-tendinous pain localized in the limbs and at an axial level.
- Trial name
- NCT04263324
- Testing
- Self-hypnosis/self-care
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- University of Liege
Cervical Cancers
The Effects of Immunonutrition Therapy on Locally Advanced Cervical Cancer Patients
The goal of this open-label randomized control trial is to study the effect of immunonutrition in locally advanced cervical cancer (LACC) with standard concurrent chemoradiotherapy.
- Trial name
- NCT06349148
- Testing
- enteral immunonutrition, standard oral enteral nutrition
- Where
- China
- Volunteers
- 50 people
- Sponsor
- SHUANG ZHENG JIA, PhD
Amyotrophic Lateral Sclerosis, Frontotemporal Dementia
A Phase 2a Study of TPN-101 in Patients With C9ORF72 ALS/FTD
This is a Phase 2a study to assess the the safety and tolerability of TPN-101 in patients with Amyotrophic Lateral Sclerosis (ALS) and/or Frontotemporal Dementia (FTD) Associated with Hexanucleotide Repeat Expansion in the…
- Trial name
- NCT04993755
- Testing
- TPN-101, 400 mg/day
- Where
- 19 sites in United States, Belgium and 3 more
- Volunteers
- 42 people
- Sponsor
- Transposon Therapeutics, Inc.
Myasthenia Gravis
Hematopoietic Stem Cell Therapy for Patients With Refractory Myasthenia Gravis
MG may be neonatal, congenital, or autoimmune. Neonatal MG arises from transplacental transfer of ACh receptor antibodies from a mother with autoimmune MG to the fetus.
- Trial name
- NCT00424489
- Testing
- Hematopoietic Stem Cell Transplantation, Cyclophosphamide, ATG (rabbit)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Northwestern University
Neuromuscular Diseases
Bulbar Function in Neuromuscular Patients
The main objective is prospectively study the upper airways function in an adult population of neuromuscular patients. The main measurement will be the evolution of tongue strength recorded each year during annual clinical…
- Trial name
- ORDEG (NCT02097368)
- Testing
- tongue strength measurement, respiratory function measurement, swallowing tests
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Carpal Tunnel Syndrome
Dual Task During Resistance Training in CTR
Carpal tunnel syndrome (CTS) is a highly prevalent peripheral compressive neuropathy of the upper extremity. CTS is characterised by the presence of pain, tingling sensations and paraesthesia in the median nerve territory.
- Trial name
- DTRTCTR (NCT05592184)
- Testing
- Exercise
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- University of Valencia
Postherpetic Neuralgia
A Study To Compare Pregabalin/PF-00489791 Combination Versus Pregabalin Alone In Post-Herpetic Neuralgia
Pregabalin is an alpha-2 delta ligand approved for the treatment of neuropathic pain, however, not all patients will respond to this drug.
- Trial name
- NCT00599638
- Testing
- pregabalin, pregabalin/PF-00489791
- Where
- 39 sites in United States
- Volunteers
- 72 people
- Sponsor
- Pfizer
Efficacy and Safety
Efficacy and Safety of Deep Cervical Lymph Node-vein Bypass Surgery in ALS Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, affects motor neurons, causing progressive muscle atrophy and weakness.
- Trial name
- NCT06351735
- Testing
- Deep cervical lymph node-vein bypass surgery
- Volunteers
- 3 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Carpal Tunnel Syndrome
COMET-AOA: Median Nerve Stiffness in Mild-Moderate CTS With OMT & Conservative Therapy
To evaluate and quantify changes in the elasticity and shear wave modulus (stiffness) of the median nerve in patients diagnosed with mild to moderate carpal tunnel syndrome following osteopathic manipulative therapy.
- Trial name
- COMET-AOA (NCT06150443)
- Testing
- Osteopathic manipulative treatment (OMT), Conservative treatment
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Kettering Health Network
Duchenne Muscular Dystrophy
Validity and Reliability of the 6 Minute Pegboard Ring Test
This study aimed to investigate the validity and reliability of 6PBRT in individuals with DMD and its applicability on these patients.
- Trial name
- NCT06174025
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Çağtay Maden
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.