Clinical trials: Neuromuscular Disease Patients
Pain, Neck, Cervical Radiculopathy
Are Stabilization Exercises Effective After Epidural Steroid Injection in Patients With Cervical Radiculopathy?
Cervical radiculopathy was first described in 1943 by researchers named Semmes and Murphy, years later than lumbosacral radiculopathy.
- Conditions
- Pain, Neck, Cervical Radiculopathy, Pain, Radiating
- Trial name
- NCT05307211
- Testing
- Cervical Interlaminar Epidural Steroid Injection, Neck Stabilization Exercises, Neck and Scapular Stabilization Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Marmara University
Fibromyalgia, Chronic Pain
Efficacy of Psychological Therapy in Chronic Pain and Fibromyalgia
Today, one of the most important challenges of the health system is the attitude towards chronic disorders. That implies changing from a health structure established for the treatment of acute diseases to a continued care system.
- Trial name
- DOLORTRATPSI (NCT03992612)
- Testing
- control group: usual medical care, MBPM- Mindfulness-Based Pain Management
- Where
- Spain
- Volunteers
- 112 people
- Sponsor
- University of the Basque Country (UPV/EHU)
Fibromyalgia
Effectiveness of Exercise and Patient-centred Education on Fibromyalgia
This study aims to compare the effects of an eight-week exercise and patient-centred education programme with eight-week exercise alone programme on disability, pain intensity, health-related quality of life and patient global…
- Trial name
- NCT04220567
- Testing
- Experimental: Exercise and Patient-centred education, Active Comparator: Exercise
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Instituto Politécnico de Setúbal. Escola Superior de Saúde.
Amyotrophic Lateral Sclerosis
Safety and Efficacy of TRO19622 as add-on Therapy to Riluzole Versus Placebo in Treatment of Patients Suffering From ALS
The purpose of the assay is to assess the safety and the efficacy of TRO19622 330 mg QD as add-on therapy to riluzole 50 mg bid in the treatment of patients suffering from ALS, as compared to placebo, assessed by the 18-month…
- Trial name
- MITOTARGET (NCT00868166)
- Testing
- Olesoxime, Riluzole
- Where
- 15 sites in Belgium, France and 3 more
- Volunteers
- 512 people
- Sponsor
- Hoffmann-La Roche
Generalized Myasthenia Gravis, MG - Myasthenia Gravis
An Open-label Study to Investigate the Clinical Efficacy of Different Dosing Regimens of Efgartigimod IV in Patients With Generalized Myasthenia Gravis
The purpose of this open-label study is to investigate the efficacy, safety, and tolerability of a continuous regimen of efgartigimod compared with a cyclic regimen in participants with Generalized Myasthenia Gravis (gMG).
- Conditions
- Generalized Myasthenia Gravis, MG - Myasthenia Gravis, gMG
- Trial name
- ADAPT NXT (NCT04980495)
- Testing
- Efgartigimod IV
- Where
- 39 sites in United States, Austria and 9 more
- Volunteers
- 69 people
- Sponsor
- argenx
Fibromyalgia, Neck Pain
Kinesiophobia in Patients With Fibromyalgia Syndrome and Chronic Neck Pain
Kinesiophobia which is described as fear of movement reduces physical activity levels and increases the risk of chronic pain. The investigators consider that kinesiophobia levels are higher in patients with fibromyalgia syndrome…
- Conditions
- Fibromyalgia, Neck Pain, Healthy
- Trial name
- NCT03778801
- Testing
- kinesiophobia
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aksaray University Training and Research Hospital
Neuralgia, Failed Back Surgery Syndrome
High Voltage VS Standard Voltage Radiofrequency in a Patient With Failed Back Surgery Syndrome
Postoperative lumbar spine pain syndrome (FBSS) refers to patients who have undergone surgery for lumbar spine disease one or more times and still have intractable lumbosacral pain after surgery, with or without lower limb…
- Trial name
- NCT05563636
- Testing
- standard pulsed radio frequency (PRF), high-voltage long-term pulsed radio frequency (PRF)
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Fibromyalgia
Qigong Exercise May Benefit Patients With Fibromyalgia
The long-term goal of our research program is to develop an effective and cost-saving mind-body therapy to help patients with FM.
- Trial name
- NCT01333566
- Testing
- Intervention Group
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Kansas Medical Center
Lumbar Radiculopathy, Radicular Low Back Pain
R³ Rehab Pathway Versus Usual Care After Lumbar Radicular Surgery
The R³ trial is a multicentre cluster randomized controlled trial evaluating an evidence-based, person-centred rehabilitation pathway for patients undergoing lumbar surgery for radicular pain.
- Trial name
- R³ (NCT07313566)
- Testing
- R³ Rehabilitation Pathway
- Where
- 16 sites in Belgium
- Volunteers
- 480 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Postherpetic Neuralgia
Leech Therapy for Postherpetic Neuralgia
The purpose of this study is to investigate, whether leech therapy for the treatment of postherpetic pain improves pain and sensory function.
- Trial name
- ZoHir (NCT01744522)
- Testing
- Leech therapy
- Where
- Germany
- Volunteers
- 6 people
- Sponsor
- Universität Duisburg-Essen
Guillain-Barré Syndrome
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab in Participants With Guillain-Barré Syndrome (GBS)
The purpose of this study is to evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of crovalimab compared with placebo as an add-on therapy to intravenous immunoglobulin (IVIg) in participants with severe GBS.
- Trial name
- NCT05494619
- Testing
- Crovalimab, Intravenous immunoglobulin therapy
- Sponsor
- Hoffmann-La Roche
Neuralgia,Postherpetic
Safety and Efficacy of Gabapentin in Postherpetic Neuralgia
Gabapentin and pregabalin are treatments for some types of neuropathic pain, including postherpetic neuralgia (PHN). However, these treatments usually need to be taken 3 times a day for effective pain control.
- Trial name
- NCT00636636
- Testing
- Gabapentin Extended Release tablets
- Where
- 39 sites in United States, Argentina and 1 more
- Volunteers
- 452 people
- Sponsor
- Depomed
Sarcopenia
Evaluation of Frailty in Patients With Fibrosing Interstitial Lung Diseases: Prognostic and Therapeutic Impact
Fibrosing interstitial lung diseases (ILDs), with idiopathic pulmonary fibrosis being the most common form, primarily affect older individuals and have a poor prognosis, with a median survival of 3 to 5 years.
- Trial name
- FRAPID (NCT07004595)
- Testing
- Evaluation of patient frailty
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Nantes University Hospital
Neuralgia, Postherpetic
Dose Ranging Trial to Determine the Safety and Efficacy of EMA401 in Patients With PHN
The study is a randomized, double blind, placebo-controlled, parallel-group comparison (two dose levels of EMA401 versus a placebo group), of safety and efficacy in patients with postherpetic neuralgia.
- Trial name
- NCT02426411
- Testing
- EMA401 200 mg, EMA401 600 mg
- Sponsor
- Spinifex Pharmaceuticals Pty Ltd
Spinal Muscular Atrophy
A Study to Assess the Efficacy, Safety and Pharmacokinetics of Nusinersen (ISIS 396443) in Infants With Spinal Muscular Atrophy (SMA)
The primary objective is to examine the clinical efficacy of multiple doses of nusinersen (ISIS 396443) administered intrathecally to participants with Infantile-Onset Spinal Muscular Atrophy (SMA).
- Trial name
- NCT01839656
- Testing
- nusinersen
- Where
- 4 sites in United States, Canada
- Volunteers
- 21 people
- Sponsor
- Biogen
Pruritus, Psychogenic Skin Disease
Psychogenic and Neurogenic Components in Patients With Psychogenic or Neuropathic Pruritus
Scientific research on pruritus is in intensive development, with significant advances in understanding its pathophysiology. The causes of pruritus are very huge; they can be classified into different categories; we can find…
- Conditions
- Pruritus, Psychogenic Skin Disease, Neuropathic Pain, Itch
- Trial name
- PRURINEURO (NCT05024851)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Brest
Amyotrophic Lateral Sclerosis
Contralateral R1 in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting both upper and lower motor neurons. Electroneuromyography is an important tool for the diagnosis.
- Trial name
- MOTOBLINK (NCT06206629)
- Testing
- blink reflex evaluation
- Where
- 2 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Lumbar Radiculopathy
Comparing of Using Patient Imaging and Virtual Reality-based Simulation Prior to Lumbar Transforaminal Injections
This study aims to evaluate the impact of pre-procedure training using a 3D simulator, based on lumbar CT images, on the success rate and efficiency of lumbar transforaminal steroid injections in patients who are expected to be…
- Trial name
- NCT06643572
- Testing
- Virtual reality simulator
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Korea University Anam Hospital
Peripheral Neuropathy, Diabetes Mellitus
IVIg for Demyelination in Diabetes Mellitus
The purpose of this study is to determine whether intravenous immunoglobulin (IVIg) is an effective intervention for patients with diabetes, peripheral neuropathy, and demyelination on nerve conduction studies.
- Conditions
- Peripheral Neuropathy, Diabetes Mellitus, Chronic Inflammatory Demyelinating Polyneuropathy
- Trial name
- IDIDM (NCT02372149)
- Testing
- 10% intravenous immunoglobulin (IVIg), 0.9% sodium chloride
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Toronto
Critical Illness, Intensive Care (ICU) Myopathy
Early Goal-Directed Nutrition in ICU Patients - EAT-ICU Trial
An increasing number of patients survive critical illness and intensive care, but describe having impaired physical function several years after discharge as a consequence of extensive loss of muscle mass.
- Conditions
- Critical Illness, Intensive Care (ICU) Myopathy, Muscle Wasting, Loss of Physical Function
- Trial name
- EAT-ICU (NCT01372176)
- Testing
- Early Goal-Directed Nutrition, ASPEN-guidelines
- Where
- Denmark
- Volunteers
- 203 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
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