Clinical trials: Neuromuscular Disease Patients
Carpal Tunnel Syndrome (CTS)
Radial Pressure Wave Therapy With or Without Parameter Modulation for Carpal Tunnel Syndrome.
This study aims to evaluate the clinical effects of radial pressure wave therapy in patients with a confirmed diagnosis of mild to moderate carpal tunnel syndrome.
- Trial name
- RPWT in CTS (NCT07070661)
- Testing
- Fixed-Dose Radial Pressure Wave Therapy., Modulated-Dose Radial Pressure Wave Therapy.
- Where
- Mexico
- Volunteers
- 44 people
- Sponsor
- Armando Tonatiuh Avila Garcia
Neuropathy, AIDS
Safety and Preliminary Evidence of Efficacy of Escalating Doses of Dimiracetam in AIDS Patients With Painful Neuropathy
One hundred consenting AIDS patients suffering from treatment induced painful neuropathy will be blindly randomize to Active and Placebo groups (ratio A/P = 3/2 and will receive increasing oral doses of dimiracetam starting from…
- Trial name
- NCT01135251
- Testing
- dimiracetam, sugar pill
- Where
- South Africa
- Volunteers
- 116 people
- Sponsor
- Neurotune AG
Stroke
Effects of tDCS on Quadriceps Strength After Stroke
Previous studies show that one session of tDCS allow to improve muscle strength in hemiparetic patients in anodal condition. We test a new electrods configuration : a anodale stimulation opposite to the cortical representation…
- Trial name
- tDCS(HE) (NCT02109796)
- Testing
- transcranial Direct current stimulation
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Amyotrophic Lateral Sclerosis (ALS)
Safety, Tolerability, and Pharmacodynamic Exploration of Orelabrutinib in Patients With Amyotrophic Lateral Sclerosis (ALS)
This is a single-center, open-label, dose-escalation, investigator-initiated pilot study to evaluate the safety, tolerability, dose-limiting toxicity (DLT), and pharmacodynamic signals of orelabrutinib in patients with…
- Trial name
- NCT07875972
- Testing
- Orelabrutinib
- Volunteers
- 12 people
- Sponsor
- Liu Qing
Spinal Muscular Atrophy 1
Long-Term Follow-up Study for Patients From AVXS-101-CL-101
This is a long term, safety follow up study of patients in the AVXS-101-CL-101 gene replacement therapy clinical trial for SMA Type 1 delivering onasemnogene abeparvovec-xioi.
- Trial name
- START (NCT03421977)
- Testing
- Onasemnogene Abeparvovec-xioi
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Novartis Gene Therapies
Lambert Eaton Myasthenic Syndrome
A Phase 3 Study of Amifampridine Phosphate in Patients With Lambert Eaton Myasthenic Syndrome (LEMS)
A Phase 3 study to evaluate the efficacy and safety of Amifampridine Phosphate in patients with Lambert-Eaton Myasthenic Syndrome (LEMS).
- Trial name
- NCT01377922
- Testing
- Amifampridine Phosphate
- Where
- 14 sites in United States, France and 6 more
- Volunteers
- 38 people
- Sponsor
- Catalyst Pharmaceuticals, Inc.
Cervical Radiculopathy
Effect of Manual Therapy on Sensory Features in Patients With Cervical Radiculopathy
Background \& Purpose: Cervical radiculopathy is a neurological disorder, which commonly results because of nerve compression. There are different types of physical therapy interventions that are used for cervical radiculopathy.
- Trial name
- NCT03328351
- Testing
- manual therapy, Superficial soft tissue massage
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 28 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Fibromyalgia
Effectiveness of Pain Neuroscience Education and Strength Training in Fibromyalgia
The main goal of this study is to get to know if applying both, pain neuroscience education (PNE) plus strength training (ST) will reduce the pain of fibromyalgia (FM).
- Trial name
- PNE-ST-FM (NCT04855851)
- Testing
- PAIN NEUROSCIENCE EDUCATION AND STRENGTH TRAINING, USUAL CARE
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Manuel Rebollo Salas
FAP, Familial Amyloid Polyneuropathy
Efficacy and Safety of Inotersen in Familial Amyloid Polyneuropathy
The purpose of this study is to evaluate the efficacy and safety of inotersen given for 65 weeks in participants with Familial Amyloid Polyneuropathy (FAP).
- Conditions
- FAP, Familial Amyloid Polyneuropathy, TTR, Transthyretin
- Trial name
- NCT01737398
- Testing
- Inotersen
- Where
- 24 sites in United States, Argentina and 8 more
- Volunteers
- 173 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Neuromuscular Blockade, Arthroplasty, Replacement, Hip
Reversal of Neuromuscular Blockade With Sugammadex or Usual Care in Hip Fracture Surgery or Joint (Hip/Knee) Replacement (P07038)
This study will assess the effect of reversal of neuromuscular blockade with sugammadex compared with reversal according to usual care (neostigmine or spontaneous reversal) on the incidence of post-surgical bleeding events and on…
- Conditions
- Neuromuscular Blockade, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Blood Coagulation
- Trial name
- NCT01422304
- Testing
- Sugammadex, neostigmine and glycopyrrolate or atropine
- Volunteers
- 1,198 people
- Sponsor
- Merck Sharp & Dohme LLC
Bodily Distress Disorder Moderate, Bodily Distress Disorder Severe
Internet-based Treatment for Patients Suffering From Severe Functional Somatic Disorders
The aim of this multi-center, two-armed, randomized controlled trial is to assess the effect of a novel internet-based therapist-assisted treatment program "One step at a time" designed for the treatment of patients with moderate…
- Conditions
- Bodily Distress Disorder Moderate, Bodily Distress Disorder Severe, Fibromyalgia, Chronic Fatigue Syndrome
- Trial name
- OneSTEP (NCT05525598)
- Testing
- "One step at a time", "Get started"
- Where
- Denmark
- Volunteers
- 166 people
- Sponsor
- University of Aarhus
Adhesive Capsulitis
PNF Technique in Adhesive Capsulitis
Adhesive capsulitis is painful movement restricted condition linked with pain, restricted range of motion and difficulty in performing daily life activities. Multiple treatment options are there for its treatment.
- Trial name
- NCT05151783
- Testing
- conventional physiotherapy, PNF technique
- Volunteers
- 48 people
- Sponsor
- University of Lahore
Back Pain, Neuralgia
Evaluation of Spinal Cord Stimulation Pulse Rate On Clinical Outcomes
Clinical study to estimate the optimal frequency for stimulation of the spinal cord to achieve relief from back pain.
- Trial name
- PROCO (NCT02549183)
- Testing
- Boston Scientific PRECISION Spinal Cord Stimulator System
- Where
- 3 sites in United Kingdom
- Volunteers
- 22 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Duchenne Muscular Dystrophy
Open Label Extension Study of HT-100 in Patients With DMD
This study is designed to provide 6-months continuous dosing with the study medication, called HT-100, on participants who successfully completed the predecessor study (HALO-DMD-01).
- Trial name
- NCT01978366
- Testing
- HT-100
- Where
- 5 sites in United States
- Volunteers
- 17 people
- Sponsor
- Processa Pharmaceuticals
Fibromyalgia
Vagus Nerve Stimulation in Fibromyalgia
Vagus nerve stimulation is thought to reduce sympathetic nerve outflow and so can improve sympathetic hyperactivity in fibromyalgia patients.
- Trial name
- NCT06237595
- Testing
- Vagus nerve stimulation, Medical treatment, Combined vagus nerve stimulation and medical treatment
- Where
- Egypt
- Volunteers
- 87 people
- Sponsor
- Kasr El Aini Hospital
Sarcopenia, Muscular Atrophy
The Effects of Home-based Physical Activity Telemonitoring Program in Patients With Heart Failure and Muscle Wasting
Introduction： Muscle wasting is a serious complication that affects a large proportion of patients with heart failure (HF). Muscle wasting is a strong predictor of frailty and reduced survival in HF patients.
- Conditions
- Sarcopenia, Muscular Atrophy, Wasting Syndrome, Heart Failure
- Trial name
- NCT05588375
- Testing
- home-based physical activity telemonitoring program
- Where
- Taiwan
- Volunteers
- 118 people
- Sponsor
- Far Eastern Memorial Hospital
Fibromyalgia, Depression
Testing Interventions for Patients With Fibromyalgia and Depression
Chronic pain is a major health problem. It causes high economic and social costs around the world and severely impairs the quality of life of those who suffer from it. Chronic pain and major depression frequently co-occur.
- Trial name
- NCT03207828
- Testing
- Behavioral activation, Usual care
- Where
- Chile
- Volunteers
- 90 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Diabetes Type 2, Diabetic Neuropathies
High vs Low Dose Vitamin D in Patients With Diabetic Peripheral Neuropathy
Aim. To assess the effect of different doses of vitamin D supplementation on peripheral neuropathy in patients with type 2 diabetes mellitus (T2DM).
- Conditions
- Diabetes Type 2, Diabetic Neuropathies, Vitamin D Deficiency
- Trial name
- NCT04377399
- Testing
- Vitamin D
- Where
- Russia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Fabry Disease
Dosing Study of Replagal in Patients With Fabry Disease
This study will determine the safety and effectiveness of increasing Replagal infusions in certain patients with Fabry disease. Replagal is a genetically engineered form of Alpha-galactosidase A, an enzyme that normally breaks…
- Trial name
- NCT00068107
- Testing
- Replagal
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Baylor Research Institute
Double Crush Syndrome, Earthquake
The Role of Ultrasonography in the Diagnosis of Double Crush Syndrome
The Role of Ultrasonography in Detecting Additional Peripheral Nerve Injuries Overshadowed by Clinical and Electrodiagnostic Data in Patients with Peripheral Nerve Injury After the February 6, 2023 Earthquake
- Conditions
- Double Crush Syndrome, Earthquake, Peripheral Nerve Injuries
- Trial name
- NCT06539871
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Marmara University
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