Clinical trials: Neuromuscular Diseases
Diabetic Peripheral Neuropathy
A Study Of The Analgesic (Pain-Relief) Effects Of Tanezumab In Adult Patients With Diabetic Peripheral Neuropathy
The purpose of this study is to determine the effectiveness and safety of the investigational drug, tanezumab, in adult patients with painful diabetic peripheral neuropathy.
- Trial name
- NCT01087203
- Testing
- Tanezumab
- Where
- 48 sites in United States
- Volunteers
- 73 people
- Sponsor
- Pfizer
Post-Operative Nausea and Vomiting, Breast Cancer
Intraoperative Acupoint Stimulation to Prevent Post-Operative Nausea and Vomiting (PONV)
The goal of this clinical research study is to learn if light electrical stimulation to the wrist area during surgery is feasible in women having breast surgery.
- Trial name
- NCT02473042
- Testing
- Electrical Stimulation, Zofran, Dexamethasone
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- M.D. Anderson Cancer Center
Small Fiber Neuropathy, Idiopathic Peripheral Neuropathy
IVIg for Small Fiber Neuropathy With Autoantibodies TS-HDS and FGFR3
The objective of this study is to develop a rationale for the selective treatment of small fiber neuropathy with immune globulin (IVIG) in the appropriate patients.
- Trial name
- NCT03401073
- Testing
- Intravenous immunoglobulin, 0.9% Sodium Chloride
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Beth Israel Deaconess Medical Center
Duchenne Muscular Dystrophy
Stacking Exercises Aid the Decline in FVC and Sick Time
Duchenne Muscular Dystrophy is complicated by weak breathing muscles and lung infections. "Lung volume recruitment" is a technique performed using a face mask or mouthpiece and a hand-held resuscitation bag to stack breaths…
- Trial name
- STEADFAST (NCT01999075)
- Testing
- Lung Volume Recruitment (LVR), Conventional Treatment
- Where
- 9 sites in Canada
- Volunteers
- 70 people
- Sponsor
- Children's Hospital of Eastern Ontario
Physical Disability
A Community Wellness Program for Adults Living With Long-term Physical Disability
For people living with long-term physical disabilities, such as spinal cord injury or multiple sclerosis, middle-age (45-64) is a period of great vulnerability for losses in function and participation.
- Trial name
- EW-D (NCT03653390)
- Testing
- EnhanceWellness for Disability (EW-D), Wellness Education
- Where
- United States
- Volunteers
- 516 people
- Sponsor
- University of Washington
Neurofibromatosis 1, Plexiform Neurofibroma (PN)
Efficacy and Safety of Selumetinib in Adults With NF1 Who Have Symptomatic, Inoperable Plexiform Neurofibromas
A global study to demonstrate the effectiveness of selumetinib in participants with NF1 who have symptomatic, inoperable plexiform neurofibromas.
- Trial name
- KOMET (NCT04924608)
- Testing
- Selumetinib
- Where
- 34 sites in United States, Australia and 11 more
- Volunteers
- 145 people
- Sponsor
- AstraZeneca
Duchenne Muscular Dystrophy
Open-label Extension of the HOPE-2 Trial
This Phase 2, multi-center, open-label extension trial will provide deramiocel (CAP-1002) to subjects that were enrolled in the HOPE-2 trial and completed 12 months of follow-up.
- Trial name
- HOPE-2-OLE (NCT04428476)
- Testing
- Deramiocel (CAP-1002)
- Where
- 5 sites in United States
- Volunteers
- 13 people
- Sponsor
- Capricor Inc.
Neuropathic Pain
A Study to Investigate the Analgesic Efficacy of AZD2423 Compared With Placebo After 28 Days Treatment in Patients With Painful Diabetic Polyneuropathy
A study to investigate the analgesic efficacy of AZD2423 compared with placebo after 28 days treatment in patients with painful diabetic polyneuropathy.
- Trial name
- NCT01201317
- Testing
- AZD2423
- Where
- 20 sites in United States, Canada
- Volunteers
- 134 people
- Sponsor
- AstraZeneca
Neuralgia, Postherpetic, Diabetic Neuropathy
Neuropathic Pain Syndrome Patient Study (MK-0000-072)
The purpose of this study is to determine the best way to conduct clinical trials in patients with neuropathic pain (nerve pain). This study will see if generic pregabalin has any effect on neuropathic pain.
- Conditions
- Neuralgia, Postherpetic, Diabetic Neuropathy, Painful Small-Fiber Neuropathy, Idiopathic Distal Sensory Polyneuropathy
- Trial name
- NCT00570310
- Testing
- Comparator: pregabalin
- Volunteers
- 104 people
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Obstructive Pulmonary Disease
Neuromuscular Electrical Stimulation in Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to elucidate whether combination of usual pulmonary rehabilitation and neuromuscular electrical stimulation of quadriceps may improve exercise capacity in patients affected by chronic obstructive…
- Trial name
- NCT00677690
- Testing
- neuromuscular electrical stimulation (NMES)
- Where
- Italy
- Volunteers
- 83 people
- Sponsor
- Fondazione Salvatore Maugeri
Fibromyalgia, FMS
Light Treatment to Improve Symptom Management of Fibromyalgia Syndrome
The purpose of this study is to determine the effect a morning light treatment has on improving physical function, pain intensity, and pain sensitivity in people with fibromyalgia syndrome (FMS).
- Trial name
- NCT03794908
- Testing
- Light therapy A (Bright) via the Re-Timer®, Light therapy B (Dim) via the Re-Timer®
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Michigan
Myotonic Dystrophy 1
Study of Tideglusib in Adolescent and Adult Patients With Myotonic Dystrophy
The purpose of this study is to determine whether Tideglusib is safe and efficacious in the treatment of adolescents and adults with congenital and juvenile-onset Myotonic Dystrophy.
- Trial name
- NCT02858908
- Testing
- Tideglusib
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- AMO Pharma Limited
Neuropathic Pain
Clinical Management of Neuropathic Pain With Ramelteon
This proposal is to conduct a double-blinded, randomized, placebo-controlled, crossover clinical study to examine the hypothesis that ramelteon would reduce pain score and improve functional status in subjects with neuropathic…
- Trial name
- NCT00753623
- Testing
- Ramelteon
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts General Hospital
Complex Regional Pain Syndrome
Safety of Intravenous Neridronic Acid in CRPS
The aim of this trial was to investigate the safety of intravenous neridronic acid in patients with complex regional pain syndrome (CRPS).
- Trial name
- NCT02972359
- Testing
- Neridronic acid
- Where
- 46 sites in United States, Germany
- Volunteers
- 580 people
- Sponsor
- Grünenthal GmbH
Sarcopenia
Integrated Physical Training With Protein Diet in Older Adults With Sarcopenia Symptoms.
Sarcopenia is the major health concern and common consequence of COVID-19 in the aging population. Moreover, this clinical condition has not been considered in usual physical rehabilitation practice, and its optimal protein…
- Trial name
- NCT05224453
- Testing
- Physical training and high protein diet, Physical training and low protein diet
- Where
- Saudi Arabia
- Volunteers
- 76 people
- Sponsor
- Prince Sattam Bin Abdulaziz University
Multiple Sclerosis, Spasticity
Developing and Testing a Comprehensive MS Spasticity Management Program
This is a study to determine the impact of education and specific lower extremity stretches for MS-related spasticity. The study will evaluate the acceptance and efficacy of education and stretching using a randomized controlled…
- Trial name
- NCT02170779
- Testing
- Spasticity: Take Control, Usual care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Amyotrophic Lateral Sclerosis
A Phase 2 Study to Evaluate AL001 in C9orf72-Associated ALS
A phase 2 double-blind, placebo-controlled study of AL001 in participants with C9orf72-associated ALS.
- Trial name
- NCT05053035
- Testing
- AL001
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- Alector Inc.
Metabolic Syndrome, Autonomic Neuropathy
Metabolic Syndrome and Fall Risk
Obesity and the metabolic syndrome (MetS) are rapidly growing problems. Individuals with the MetS are at risk for not only future chronic diseases, but they have a higher prevalence of neuropathy, including cardiac autonomic…
- Trial name
- NCT02633891
- Testing
- Balance exercise, Standard care
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- VA Office of Research and Development
Neuralgia,Postherpetic
Safety and Efficacy of Gabapentin in Postherpetic Neuralgia
Gabapentin and pregabalin are treatments for some types of neuropathic pain, including postherpetic neuralgia (PHN). However, these treatments usually need to be taken 3 times a day for effective pain control.
- Trial name
- NCT00636636
- Testing
- Gabapentin Extended Release tablets
- Where
- 39 sites in United States, Argentina and 1 more
- Volunteers
- 452 people
- Sponsor
- Depomed
Sarcopenia, Geriatric
Effect Of Ophiochepalus Striatus Extract On Serum IGF-1 And IL-6 Levels In Elderly Patients With Sarcopenia
The goal of this Clinical Trial is to analyze effect of Ophiochepalus striatus extract on serum IGF-1 and IL-6 levels in elderly patients with sarcopenia. The main questions it aims to answer are: 1.
- Conditions
- Sarcopenia, Geriatric, Muscle Mass, Muscle Strength
- Trial name
- NCT05869383
- Testing
- Ophiochepalus striatus extract
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Universitas Sriwijaya
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.