Clinical trials: Neuromuscular Disorder
Visual Analogue Pain Scale, Pain Measurement
Efficacy of Radiofrequency Nucleoplasty and Targeted Disc Decompression in Lumbar Radiculopathy
The aim of this study is to compare early and long term efficacy of lumbar radiofrequency nucleoplasty and targeted disc decompression in patients with lumbar radiculopathy who failed previous conventional therapy.
- Trial name
- RFNaTDD (NCT02025283)
- Testing
- Group Decompression or Group Nucleoplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Ankara University
Carpal Tunnel Syndrome, Energy Transfer Capacitative and Resistive Therapy
Effectiveness Transfer Energy Capacitive and Resistive Therapy in Patients With Carpal Tunnel Syndrome
Objective: The aim of this study was to evaluate the effect of Transfer Energy Capacitive and Resistive (TECAR) therapy on pain, symptom severity and function in patients diagnosed with carpal tunnel syndrome (CTS) based on…
- Trial name
- NCT06451094
- Testing
- US therapy, TECAR
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Amyotrophic Lateral Sclerosis
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RAG-17 in Subjects With Amyotrophic Lateral Sclerosis (ALS) With Superoxide Dismutase Type 1 (SOD1) Gene Mutation
This is a Phase 1, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RAG-17 in Subjects with Amyotrophic Lateral Sclerosis (ALS) with Superoxide…
- Trial name
- NCT06556394
- Testing
- RAG-17
- Where
- 3 sites in China
- Volunteers
- 32 people
- Sponsor
- Ractigen Therapeutics.
Autoimmune Disease, Neurologic Autoimmune Disease
Autologous Stem Cell Transplant for Neurologic Autoimmune Diseases
This phase II trial studies the side effects and how well carmustine, etoposide, cytarabine and melphalan together with antithymocyte globulin before a stem cell transplant works in treating patients with autoimmune neurologic…
- Conditions
- Autoimmune Disease, Neurologic Autoimmune Disease, Autologous Transplant Autoimmune, Multiple Sclerosis Transplant
- Trial name
- NCT00716066
- Testing
- Anti-Thymocyte Globulin, Autologous Hematopoietic Stem Cell Transplantation, Carmustine
- Where
- 3 sites in United States
- Volunteers
- 53 people
- Sponsor
- Fred Hutchinson Cancer Center
Myasthenia Gravis, Generalized
A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis
The purpose of this study is to evaluate the pharmacodynamic (PD) effect, safety, and tolerability of Povetacicept in participants with generalized myasthenia gravis (gMG).
- Trial name
- ETNA (NCT07501702)
- Testing
- Povetacicept
- Where
- 31 sites in United States, Australia and 3 more
- Volunteers
- 34 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Duchenne Muscular Dystrophy
A Study to Evaluate the Safety and Tolerability of PF-06939926 Gene Therapy in Duchenne Muscular Dystrophy
This is a first-in-human/first-in-patient, multi-center, open-label, non-randomized, ascending dose, safety and tolerability study of a single intravenous infusion of PF-06939926 in ambulatory and non-ambulatory subjects with…
- Trial name
- NCT03362502
- Testing
- PF-06939926
- Where
- 22 sites in United States
- Volunteers
- 23 people
- Sponsor
- Pfizer
Anti-MAG Neuropathy, Peripheral Nervous System Disease
Study Evaluating the Predictive Value of the Terminal Latency Index (TLI) for Treatment Response in Patients With Anti-MAG Neuropathy
"Anti-myelin-associated glycoprotein (anti-MAG) neuropathy is a rare dysimmune peripheral neuropathy, most commonly associated with an IgM monoclonal gammopathy.
- Conditions
- Anti-MAG Neuropathy, Peripheral Nervous System Disease, Anti-Myelin-Associated Glycoprotein Antibodie
- Trial name
- PREDIMAG (NCT07794137)
- Testing
- Electroneuromyography (ENMG) and Terminal Latency Index (TLI) Assessment
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Dermatomyositis
Biomarkers of Cancer-Associated Myositis
The project is about dermatomyositis (DM), an autoimmune disease characterized by inflammation in the skeletal muscles and skin. Patients with DM have an increased risk of cancer, with a cancer incidence between 5.5% and 42%.
- Trial name
- MIOSURFACE (NCT06808672)
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Cardiac Amyloidosis, Aortic Stenosis
Aortic Stenosis and Cardiac Amyloidosis
The dual pathology of aortic stenosis (AS) and cardiac amyloidosis (CA) is increasingly recognized. Even tough efforts have been undertaken to bring cohorts together, the largest cohort of AS-ATTR to date is <50 patients.
- Trial name
- NCT06129331
- Testing
- Amyloid-specific treatment, No amyloid-specific treatment
- Where
- 2 sites in Austria, United Kingdom
- Volunteers
- 300 people
- Sponsor
- Medical University of Vienna
Fibromyalgia
Tools for the Differential Diagnosis of Fibromyalgia Based on Cognitive Tasks
The goal of this observational study is to test for behavioural and neurophysiological biomarkers in fibromyalgia patients. The main questions it aims to answer are: Is there a measurable decline in working memory? Could these…
- Trial name
- NCT05910372
- Testing
- Color Comparison Task, N-back Task
- Where
- Argentina
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Peripheral Neuropathies, Peripheral Neuropathy Due to Chemotherapy
Balance4Mobility: Effects of Walkasins Use in Individuals With Peripheral Neuropathy and Balance Problems
The goal of this clinical trial is to is to test whether Walkasins can help people with peripheral neuropathy maintain their balance better.
- Conditions
- Peripheral Neuropathies, Peripheral Neuropathy Due to Chemotherapy, Peripheral Neuropathy With Type 2 Diabetes, Balance Control in Elderly
- Trial name
- NCT06959277
- Testing
- Walkasins, Fall Prevention Training
- Where
- 6 sites in United States
- Volunteers
- 200 people
- Sponsor
- RxFunction Inc.
Myasthenic Crisis, Upper Respiratory Infection
Incidence and Risk of Influenza in Myasthenic Patients
Upper respiratory infection , including influenza, may exacerbate the symptoms of myasthenia gravis (MG), which is an autoimmune disease that causes muscle weakness and, in some cases, can precipitate a myasthenic crisis In the…
- Trial name
- NCT03884777
- Volunteers
- 400 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Fatigue Syndrome, Chronic, Myalgic Encephalomyelitis
Oral Melatonin Plus Zinc Supplementation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)
The purpose of this study is to evaluate the effects of oral melatonin plus zinc supplementation in relieving self-reported fatigue in CFS/ME
- Trial name
- MELATOZINC (NCT03000777)
- Testing
- melatonin plus zinc
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Laboratorios Viñas, S.A.
Cancer, Skin Fibroblasts
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome
Background: Nicotinamide riboside (NR) is a vitamin B3 dietary supplement. It may help improve muscle function, that may in turn may improve a person s exercise capacity.
- Conditions
- Cancer, Skin Fibroblasts, Muscle Weakness
- Trial name
- NCT03789175
- Testing
- Nicotinamide Riboside (NR)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Molar, Third
Pain and Trismus Control in Third Molar Surgery: Ibuprofen, Ketamine, and Their Combination
The goal of the clinical trial is to compare the efficacy of ibuprofen, ketamine, and their combination in managing postoperative pain and trismus following third molar surgery.
- Trial name
- NCT05923775
- Testing
- Impacted third molar surgey
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Cihan Topan
Disease of Respiratory System
Application of Low-dose Muscle Relaxants in Bronchoscopic Interventional Procedures
The purpose of this clinical trial is to observe the use of low-dose muscle relaxants in bronchoscopy intervention surgeries, compared with no muscle relaxants, in terms of the satisfaction of tracheal tube insertion after…
- Trial name
- NCT07035301
- Testing
- Lidocaine Intravenous Infusion, Remimazolam Tosilate, Remifentanil
- Where
- China
- Volunteers
- 153 people
- Sponsor
- Harbin Medical University
Postpoliomyelitis Syndrome
Arm Cycling to Improve Fitness in Polio Survivors
The aim of this study is to investigate the effect of upper limb cardiovascular training on fitness, energy cost of walking, fatigue and pain in polio survivors.
- Trial name
- NCT01271530
- Testing
- Upper Limb Ergometry
- Where
- Ireland
- Volunteers
- 55 people
- Sponsor
- Royal College of Surgeons, Ireland
Head and Neck Cancer, Oral Cancer
Rehabilitation Outcomes in Head and Neck Survivors
Head and neck cancer is prevalent in Taiwan, and oral cancer is the most common location. Patients with advanced stage of the disease need extensive tumor excision with neck dissection.
- Trial name
- HNC (NCT03206242)
- Testing
- Physiotherapy
- Where
- Taiwan
- Volunteers
- 65 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke
Effect of Neural Constraints on Movement in Stroke
This study investigates the effects of Tizanidine on the voluntary movement controls of the arms of participants who have had a stroke and have not had a stroke by measuring medication-induced changes in upper extremity…
- Trial name
- ENCMS (NCT06666673)
- Testing
- Tizanidine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Amyotrophic Lateral Sclerosis
Geometrical Facial Deformation According to Posture in Amyotrophic Lateral Sclerosis
The measurement of the facial deformation according to the body posture will be conducted by 3D scanning for each posture after marking the landmarks on the face.
- Trial name
- NCT04798183
- Testing
- 3-dimensional scan
- Where
- South Korea
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
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