Clinical trials: Neuromuscular Disorder
Cervical Radiculopathy
Ultrasound Guided Transcutaneous Pulsed Radiofrequency for Cervical Radiculopathy
Cervical radiculopathy (CR) is a painful condition caused by irritation of the cervical nerve roots, often leading to neck, shoulder, and arm pain, sometimes with numbness or weakness.
- Trial name
- NCT07207356
- Testing
- true transcutaneous pulsed radiofrequency
- Where
- Taiwan
- Volunteers
- 32 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Chinese Version, Fibromyalgia
Chinese Version of Fibromyalgia Criteria and Severity Scales Study
Up to now, there is no Chinese version of fibromyalgia diagnosis criteria and severity assessment scales. The aim of this study is to translate, adapt, and validate the Chinese version of the 2011 modification of the 2010 ACR…
- Conditions
- Chinese Version, Fibromyalgia, Diagnosis, Fibromyalgia Impact Questionnaire
- Trial name
- NCT03381131
- Where
- China
- Volunteers
- 327 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Low Back Pain
Effects of Bilateral Asymmetrical Limbs Proprioceptive Neuromuscular Facilitation on Multifidus Muscle in CLBP.
The low back pain is a leading cause to limit individual functional activities worldwide and 60%-80% of adults are probable to get low back pain at least once in life time.
- Trial name
- NCT04206137
- Testing
- Group A (PNF rhythmic initiation group ), Group B (Swiss ball exercises)
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- University of Karachi
Stroke, Proprioceptive Disorders
Combined Effects of PNF and Electrical Muscle Stimulation on Spasticity and Hand Function in Stroke Patients.
To determine the combined effects of proprioceptive neuromuscular facilitation and electrical muscle stimulation on spasticity and hand function in stroke patients.
- Conditions
- Stroke, Proprioceptive Disorders, Balance; Distorted
- Trial name
- NCT05916872
- Testing
- experimental group, control group
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Respiration Disorders, Neuromuscular Disease
Evaluation of Vital Capacity
Respiratory failure is the most common cause of death in neuromuscular diseases. The aim of this research is to evaluate the thoracopulmonary recruitment by comparison of inspiratory vital capacity (VC ins)and…
- Trial name
- CVassist (NCT02022072)
- Testing
- measures of assisted vital capacity by a mechanical insufflation/exsufflation (Cough Assist®)
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Muscle Atrophy, Disuse Atrophy (Muscle) of Lower Leg
The Regulation of Human Skeletal Muscle Mass by Contractile Perturbation
It is well known that periods of weight training lead to increases in skeletal muscle size and strength. In contrast, periods of inactivity such as bed rest or immobilization result in losses of skeletal muscle size and strength.
- Trial name
- HYPAT (NCT03046095)
- Testing
- Unilateral Resistance Exercise, Immobilization
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- McMaster University
Diabetic Neuropathy, Painful
A Study for Treatment of Pain in Patients With Diabetic Neuropathy.
The purpose of this study is to test whether a new treatment will be safe and effective in treating pain. Patients with diabetic peripheral neuropathy will be included.
- Trial name
- NCT00785577
- Testing
- Pregabalin, LY545694 21 mg, LY545694 49 mg
- Where
- 13 sites in United States, Mexico and 1 more
- Volunteers
- 273 people
- Sponsor
- Eli Lilly and Company
Complex Regional Pain Syndrome, Sciatica
[18F]FTC-146 PET/MRI in Healthy Volunteers and in CRPS and Sciatica
Chronic pain can result from injured or inflamed nerves, as occurs in people suffering from sciatica and CRPS. These nerve injuries or regions of nerve irritation are often the cause of pain in these conditions, but the current…
- Trial name
- NCT02753101
- Testing
- [18F]-FTC-146
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Stanford University
Osteoporosis, Sarcopenia
Bone Microstructure by Using HR-pQCT in Long Courses After Gastrectomy
Osteoporosis after gastrectomy, which is characterized by both the loss of bone mass and the deterioration of bone architecture, is a serious complication in the long course after gastrectomy.
- Conditions
- Osteoporosis, Sarcopenia, Gastric Cancer
- Trial name
- NCT03251430
- Testing
- gastrectomy
- Where
- Japan
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Kobayashi Shinichiro
Myasthenia Gravis, Generalized
The Safety and Efficacy of S103 in the Treatment of Refractory Generalized Myasthenia Gravis
This study is a single-center, open-label, single-arm, dose-exploration study to evaluate the safety and preliminary effectiveness of BCMA CAR-T（S103） in the treatment of refractory, generalized myasthenia gravis.
- Trial name
- NCT06958939
- Testing
- Dose level 1 group, Dose level 2 group, Dose level 3 group
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Ting Chang, MD
Fibromyalgia
Prevalence of Fibromyalgia in Israel
The prevalence of fibromyalgia syndrome in the Israeli population is of importance fro planning resource allocation of medical expenditure as well as for identifying demographic and ethnic differences of this unique population…
- Trial name
- NCT01203865
- Where
- Israel
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Sarcopenia
Evaluation of Sarcopenia in Women in Different Stages of Life and in Hormonal Therapy or Not
The three-year interventional study has the following objectives: The study aims to assess the prevalence of sarcopenia in menopausal women receiving hormone replacement therapy or not compared with pre-menopausal women.
- Trial name
- NCT06792201
- Testing
- SARC-F, Handgrip test, Chair stand test
- Where
- Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Poliomyelitis
A Study to Evaluate Safety and Immunogenicity of tOPV in 1 to 5 Years and at 6 Weeks of Age
The purpose of this study is to assess the safety (serious adverse events [SAEs]), and severe adverse events [AEs] (grade 3 according to CTCAE 4.03) after one dose of SABIN tOPV in 1-5 year-old children and three doses of SABIN…
- Trial name
- T2-ABMG (NCT02580201)
- Testing
- Oral Polio Vaccine
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Fidec Corporation
Stroke, Hemiparesis
Neuromuscular and Biomechanical Control of Lower Limb Loading in Individuals With Chronic Stroke
Stroke is the leading cause of long-term disability in the U.S. Individuals with hemiparesis due to stroke often have difficulty bearing weight on their legs and transferring weight from one leg to the other.
- Trial name
- NCT03694028
- Testing
- Limb Loading, Conventional Training
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Maryland, Baltimore
Fibromyalgia (FM), Quantitative Sensory Testing
Investigation of Pain Modulation Phenotypes in Female Patients With Fibromyalgia
Fibromyalgia is characterized by altered pain processing, including impaired descending pain inhibition and central sensitization.
- Conditions
- Fibromyalgia (FM), Quantitative Sensory Testing, Central Sensitization, PRESSURE PAIN THRESHOLD
- Trial name
- NCT07640607
- Testing
- Quantitative Sensory Tests(QST) protocol, Clinical Scales
- Volunteers
- 82 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Fibromyalgia
Evaluation of Adherence of Women With Fibromyalgia to Walking Prescriptions
Although there are many studies evaluating adherence to supervised walking programs in patients with fibromyalgia (FM), there are limited studies evaluating adherence to unsupervised walking programs.
- Trial name
- NCT05996692
- Testing
- Evaluation of adherence to walking prescriptions
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Dermatomyositis
An Extension Study for Participants Who Have Completed the Treatment Period of a Qualifying Parent Study
The purpose of this research study is to evaluate the long-term safety, and tolerability of PF-06823859 study drug in adult participants with Dermatomyositis (DM) from a qualifying study.
- Trial name
- NCT05192200
- Testing
- Anti-Beta Interferon (PF-06823859)
- Where
- 25 sites in United States, Hungary and 2 more
- Volunteers
- 24 people
- Sponsor
- Pfizer
Neuropathic Pain, PTSD
The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD
This study is aimed to evaluate outpatient ketamine infusion within a military chronic neuropathic pain population and its effect on PTSD. Currently, this is a pilot study with 30 participants.
- Trial name
- NCT06414356
- Testing
- Ketamine, Magnesium sulfate, Ketamine + Magnesium sulfate
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Margaux M. Salas, PhD
Pudendal Neuralgia
Evaluation of the Efficacy of Therapeutic Infiltrations of the Pudendal Nerve, Performed Under Neurostimulation on Pain, 1 Month After an Infiltration of Local Anaesthetic, in the Treatment of Pudendal Neuralgia.
Pudendal neuralgia (PN) is a chronic nerve compression syndrome causing neuropathic pain. Treatment includes medication, infiltration and decompressive surgery.
- Trial name
- EPHI-DACI (NCT06872437)
- Testing
- Lidocaine Injectable Solution, Saline Solution for Block
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Cirrhosis, Sarcopenia
Prevalence of Sarcopenia and Undernutrition in Patients With Cirrhosis and Abdominal Hernia
The study evaluates whether sarcopenia influences the prevalence of abdominal hernias in patients with cirrhosis.
- Conditions
- Cirrhosis, Sarcopenia, Malnutrition, Hernia, Abdominal
- Trial name
- NCT03458845
- Testing
- Computed Tomography Scan
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- University of Sao Paulo
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