Clinical trials: Neuromuscular Disorder
Specific Advanced Solid Tumors
Study of ACR-2316 in Specific Advanced Solid Tumors
This is a first in-human, Open-label Phase 1/2 study to assess the safety and activity of ACR-2316 for the treatment of subjects with specific, histologically confirmed, locally advanced, recurrent or metastatic solid tumors.
- Trial name
- NCT06667141
- Testing
- ACR-2316
- Where
- 15 sites in United States
- Volunteers
- 100 people
- Sponsor
- Acrivon Therapeutics
Acute Sciatica, Pain
Comparative Effects of Neural Mobilization and Muscle Energy Technique in Sciatic Patients
In this study, investigator will see the effects of neural mobilization in comparison to the muscle energy technique in the patients suffering from sciatica.
- Trial name
- NCT04875741
- Testing
- Neural mobilization, Muscle energy technique
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- University of Lahore
Pain, Chronic Pain
Efficacy and Tolerability of Lidocaine Plaster for Treatment of Long-term Local Nerve Pain
The purpose of this trial is to investigate the efficacy and safety of lidocaine 5% medicated plaster in localized chronic post-operative neuropathic pain in comparison to placebo plaster.
- Conditions
- Pain, Chronic Pain, Neuropathic Pain, Postoperative Pain
- Trial name
- NCT01752322
- Testing
- Lidocaine 5% medicated plaster
- Where
- 42 sites in Austria, Belgium and 6 more
- Volunteers
- 444 people
- Sponsor
- Grünenthal GmbH
Myasthenia Gravis
A Study of RVT-1401 in Myasthenia Gravis (MG) Patients
The purpose of the current study is to assess safety/tolerability and key pharmacodynamic (PD) effects that are considered to be associated with clinical benefit (reduction of total IgG and anti-AChR-IgG) in Myasthenia Gravis…
- Trial name
- NCT03863080
- Testing
- RVT-1401
- Where
- 20 sites in United States, Canada
- Volunteers
- 17 people
- Sponsor
- Immunovant Sciences GmbH
Paramyotonia Congenita, Nondystrophic Myotonia
Using MRI in Patients With Non-dystrophic Myotonia to Access Muscle Contractility
The aim of this project is (1) to investigate whether or not structural muscle abnormalities could be a consequence of the disorder and (2) to provide further clinical description of this rare phenotype.
- Trial name
- NCT04808388
- Testing
- MRI
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Neuromuscular Diseases
Comparison of Two Methods of Adjusting the Mechanical In-Exsuflation in Neuromuscular Adult Patients
In the context of neuromuscular diseases, the weakness of the respiratory muscles makes difficult to manage periods of congestion due to a less effective cough.
- Trial name
- EXSUFLOW (NCT03355105)
- Testing
- Objective adjustment of the MI/E exsuflation pressure and evaluation of cough effort, Subjective adjustment of the MI/E exsuflation pressure and evaluation of cough effort
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Limb Girdle Muscular Dystrophy
Evolution of the Functional and Muscular State of Patients With Muscular Dystrophy 2A Belts
Limb girdle muscular dystrophies were originally defined as a postnatal progressive muscle disease, which begins and primarily affects the pelvic and scapular muscles.
- Trial name
- CALNATHIS (NCT06390566)
- Testing
- calpaïnopathies
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma
SF1126 in Recurrent or Progressive SCCHN and Mutations in PIK3CA Gene and/or PI-3 Kinase Pathway Genes
The purpose of this study is to test the good and bad effects of an experimental drug called SF1126. This drug is being tested in patients whose cancer has not been controlled by available standard therapies and who have certain…
- Trial name
- NCT02644122
- Testing
- SF1126
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Ezra Cohen
Cervical Radiculopathy
Association Between Neck Disability Index Categories and Multidirectional Range of Motion in Patient With Cervical Radiculopathy
This study aims to investigate the association between NDI categories (None, Mild, Moderate, Severe) and ROM in six directions: flexion, extension, right and left side bending, and right and left rotation.
- Trial name
- NCT07152522
- Testing
- cross sectional observational
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Neurofibromatosis
Clinical Trial of Pirfenidone in Adult Patients With Neurofibromatosis 1
The study is a phase II, open label trial of oral Pirfenidone in 24 adult patients with neurofibromatosis type 1. Pirfenidone is a new, broad-spectrum anti-fibrotic drug, with proven in vitro and in vivo negative effects on…
- Trial name
- NCT00754780
- Testing
- Pirfenidone
- Volunteers
- 24 people
- Sponsor
- Mayo Clinic
Traumatic Brain Injury
Effects of Intranasal Nerve Growth Factor for Traumatic Brain Injury
Traumatic bain injury(TBI) remains a hidden epidemic involving individuals affected predominantly at a young age who in the most severe cases remain with permanent physical,psychological and cognitive deficits.This study will…
- Trial name
- NCT01212679
- Testing
- nerve growth factor, nomral saline
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Jinling Hospital, China
Diabetic Neuropathy
A Nutritional Intervention for Diabetic Neuropathy
The purpose of this study is to assess whether, in individuals with diabetic neuropathy, a low-fat, vegan diet in combination with a vitamin B12 supplement improves pain, sensation and other subjective symptoms, more effectively…
- Trial name
- NCT01690962
- Testing
- Vegan diet and vitamin B12 supplement, Vitamin B12 supplement
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Physicians Committee for Responsible Medicine
Cerebral Palsy Spastic Hemiplegic
Improving Hand Movements in Kids With One-Sided Arm Stiffness Cerebral Palsy Through Motion Minder Therapy (MoMT)
Motion Minder Therapy is a targeted intervention for fine motor skill challenges in spastic hemiplegic cerebral palsy children, emphasizing affordability, particularly in middle-income countries like India.
- Trial name
- MoMT (NCT06560281)
- Testing
- Motion Minder Therapy (MoMT)
- Where
- 2 sites in India
- Volunteers
- 10 people
- Sponsor
- Saveetha University
Carpal Tunnel Syndrome
Cross-Cultural Adaptation and Psychometric Validation of the Turkish Version of Atroshi-Lyrén 6-item Symptoms Scale
This study aims to develop Turkish version of the Atroshi-Lyrén 6-item symptoms scale (A-L scale) and to perform validity and reliability evaluations.
- Trial name
- NCT05970692
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ilke KARA
Carpal Tunnel
Assessing the Comparability of 2D and 4D Ultrasound Measurements
Investigators will recruit 20 healthy volunteers between the ages of 18 and 80, who have no history of carpal tunnel syndrome or wrist injury.
- Trial name
- NCT02666911
- Testing
- 4D Ultrasound, 2D ultrasound
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Desmoplastic Small Round Cell Tumor, Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Donor Stem Cell Transplant After Chemotherapy for the Treatment of Recurrent or Refractory High-Risk Solid Tumors in Pediatric and Adolescent-Young Adults
This phase II trial investigates side effects and how well donor stem cell transplant after chemotherapy works in treating pediatric and adolescent-young adults with high-risk solid tumor that has come back (recurrent) or does…
- Conditions
- Desmoplastic Small Round Cell Tumor, Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Recurrent Desmoplastic Small Round Cell Tumor, Recurrent Malignant Peripheral Nerve Sheath Tumor
- Trial name
- NCT04530487
- Testing
- Allogeneic Hematopoietic Stem Cell Transplantation, Cyclosporine, Etoposide
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- M.D. Anderson Cancer Center
Cerebral Palsy, Muscle Contracture
The Muscle in Cerebral Palsy; Sarcomere Length in Vivo and Microscopic Characterization of Biopsies.
Cerebral palsy (CP) is a motor impairment due to a brain malformation or a brain lesion before the age of two. Spasticity, hypertonus in flexor muscles, dyscoordination and an impaired sensorimotor control are cardinal symptoms.
- Conditions
- Cerebral Palsy, Muscle Contracture, Spasticity, Muscle
- Trial name
- CPMuscleSL (NCT05518565)
- Testing
- No intervention
- Where
- 3 sites in Sweden
- Volunteers
- 150 people
- Sponsor
- Eva Ponten
COPD, Muscle Weakness
Feasibility of Strength Training in Patients Hospitalized Due to COPD
To examine the feasibility of progressive unilateral knee-extension strength training using ankle weight cuffs in patients hospitalized due to acute exacerbation in COPD
- Trial name
- NCT01981200
- Testing
- Resistance training in AECOPD
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Frederikssunds Hospital, Denmark
Myotonic Dystrophy
DM1 Heart Registry - DM1 Respiratory Registry
Myotonic dystrophy type 1 (DM1) is the most frequent neuromuscular disease in adults. DM1 patients have an impaired prognosis (mean age of death <60 years) due to cardiac and respiratory complications.
- Trial name
- DM1-Heart-R (NCT01136330)
- Where
- France
- Volunteers
- 914 people
- Sponsor
- Institut de Myologie, France
Facial Pain, Comorbidity
Somatosensory Investigation of Orofacial Pain Patients
Orofacial pain, specially neuropathic orofacial pain, is a challenge of diagnosis and treatment in orofacial pain. It is associated with sensory abnormalities.With increasing life expectancy of the population is more and more…
- Conditions
- Facial Pain, Comorbidity, Neuralgia
- Trial name
- QST (NCT02910336)
- Testing
- Quantitative Sensory Testing
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
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