Clinical trials: Neuromuscular Function
Steinert's Disease
Compare Train and 3D-4D Left Ventricular Systolic Function in Subjects Suffering From Dystrophy and Healthy Subjects
Steinert's disease is an orphan disease. The prognosis of patients with this disease is conditioned by cardiac involvement. Search an early stage alterations in contractile function in subjects suffering from dystrophy would…
- Trial name
- NCT02930408
- Testing
- electrocardiogram, Echocardiography
- Volunteers
- 70 people
- Sponsor
- Poitiers University Hospital
Spinal Cord Injuries, Muscle Atrophy
Characterization of the Changes in the Signalling Pathways During Spinal Cord Injury-induced Skeletal Muscle Atrophy
Atrogin-1 and muscle RING finger-1 are skeletal muscle specific genes, with ubiquitin ligase activities, that are upregulated during muscle atrophy in mice.
- Trial name
- NCT01470950
- Testing
- Motionmaker
- Where
- 2 sites in Switzerland
- Volunteers
- 28 people
- Sponsor
- Clinique Romande de Readaptation
Neuromuscular Performance, Balance and Function
Immediate and Delayed Effects of Kinesio Taping on the Neuromuscular Performance
The purpose of this study is analyze the immediate and late effects of the application of KT in neuromuscular performance of the quadriceps in postural balance and function of the lower limb of healthy subjects.
- Trial name
- IDEKTNP (NCT02431910)
- Testing
- Functional elastic tape
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio Grande do Norte
Lumbar Radiculopathy
Mulligan BLR Versus Mulligan TSLR Versus Neural Mobilization n Patient With Lumber Radiculopathy
The goal of this study is to compare the effectiveness of mulligan traction Straight Leg Raise and mulligan's bent leg rise and neural mobilization to conventional therapies in order to assess which treatment is more successful…
- Trial name
- NCT05258214
- Testing
- Mulligan Bent Leg Raise, Mulligan Traction Straight Leg Raise, Neural Mobilization
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Induction of Anaesthesia, Muscle Relaxants
Developing a Physiology-Pharmacodynamic Model of Rocuronium Dose and Cardiac Output to Investigate the Onset Time of Neuromuscular Relaxation
After a patient is put to sleep, a breathing tube is often placed through the larynx (voice box) into the trachea (windpipe). To place a breathing tube requires the muscles of the jaw, voice box, and diaphragm to be relaxed.
- Conditions
- Induction of Anaesthesia, Muscle Relaxants, Rocuronium
- Trial name
- NCT07168252
- Testing
- Rocuronium dosing
- Volunteers
- 32 people
- Sponsor
- Clare Hayes-Bradley
Cervical Radiculopathy
Effect of Kinetic Control Retraining on Neck Proprioception and Functional Outcome in Patients With Cervical Radiculopathy
The aim of this study is to investigate the effect of kinetic control retraining on neck proprioception and functional outcome in patients with cervical radiculopathy.
- Trial name
- NCT06803134
- Testing
- Selected physical therapy program, Kinetic control retraining
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Cairo University
Chronic Pain, Spasticity as Sequela of Stroke
Closed Loop Spinal Cord Stimulation for Neuromodulation of Upper Motor Neuron Lesion Spasticity
Spasticity is characterized by increased muscle tension and is a classic consequence of upper motor neuron (UMN) damage in the central nervous system, such as from stroke or trauma.
- Conditions
- Chronic Pain, Spasticity as Sequela of Stroke, Upper Motor Neuron Lesion
- Trial name
- CLONUS (NCT06384170)
- Testing
- Spinal Cord Stimulation- Closed loop
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Sarcopenia
Effect of Ursolic Acid of Loquat Extract on Function of Muscle
This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of Ursolic Acid of Loquat Extract for treatment of muscle function improvement with relatively health adults.
- Trial name
- NCT02401113
- Testing
- UA group
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Sarcopenia
Clinical Trial of Astaxanthin Formulation With Exercise in Sarcopenia Elderly
The primary objective of this trial is to evaluate the effect of oral administration of an Astaxanthin formulation compared to placebo after one month alone and after an additional 3 months of exercise training on mitochondrial…
- Trial name
- NCT03368872
- Testing
- Astaxanthin formulation, Exercise training
- Where
- 2 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Astavita, Inc.
Lumbar Radiculopathy, Lumbar Spinal Stenosis
The Impact of Contrast Media Used in Epidural Steroid Injections on Thyroid Function Tests
This study is aim to disclose the effect of contrast media, which used in epidural steroid injections, on the parameters of thyroid function tests (TFTs). The patients who underwent an epidural steroid injection were included.
- Conditions
- Lumbar Radiculopathy, Lumbar Spinal Stenosis, Cervical Radiculopathy, Cervical Stenosis
- Trial name
- NCT05404412
- Testing
- Epidural Steroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people
- Sponsor
- Marmara University
Myotonic Dystrophy 1
Home-based Training and Supplementation in DM1 Patients
Myotonic dystrophy type 1 (DM1) is a rare genetic disease that affects about 1 in 2100 people. Patients diagnosed with DM1 present with many symptoms, however, their muscles are mainly affected.
- Trial name
- DM1HBET (NCT05848830)
- Testing
- Mult-ingredient supplement, Concurrent exercise training
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McMaster University
Frailty Syndrome, Sarcopenia
Design and Validation of FEXO: A Playful Exercise Program for Institutionalized Frail Older Adults
This multicenter randomized controlled trial aims to evaluate the effectiveness of a playful multicomponent exercise intervention (FEXO - Fun Exercise for Older Adults) on intrinsic capacity, frailty, and functional health in…
- Trial name
- FEXO-FRAIL (NCT07133581)
- Testing
- FEXO (Fun Exercise for Older Adults)
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University
Fibromyalgia
Impact of Inclusion of a Therapy Dog Visit as Part of the Fibromyalgia Treatment Program
In this study the investigators hypothesize that the presence of a Mayo Clinic certified therapy dog will provide additional benefits above typical therapy for patients suffering from fibromyalgia currently enrolled in the Mayo…
- Trial name
- NCT03042728
- Testing
- Dog Interaction, Human Interaction
- Where
- 2 sites in United States
- Volunteers
- 229 people
- Sponsor
- Mayo Clinic
fMRI, ACL Injury
Study of Functional Magnetic Resonance Signal Variations in Patients Undergoing Anterior Cruciate Ligament Reconstruction With the Application of a Dedicated Neuromotor Training
Lower limb injuries represent the majority of sports-related injuries, with knee injuries being among the most common. In particular, anterior cruciate ligament (ACL) injuries are considered highly devastating and…
- Conditions
- fMRI, ACL Injury, Rehabilitation Exercise, Neuromuscular Control
- Trial name
- ACL-fMRI-TNMT (NCT07097077)
- Testing
- Effect of targeted neuromotor training in patients undergoing ACL reconstruction on the volumetric activation of cerebral cortex regions during fMRI.
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Stefano Zaffagnini
Amyotrophic Lateral Sclerosis, ALS Functional Ration Scale
Tamoxifen Treatment in Patients With Motor Neuron Disease
The aim of this study is to survey the effect of Tamoxifen in motor neuron disease (MND) patients, amyotrophic lateral sclerosis (ALS) with regular riluzole usage. TDP-43 is related to ALS.
- Conditions
- Amyotrophic Lateral Sclerosis, ALS Functional Ration Scale, TAR-DNA-binding Protein-43, Tamoxifen
- Trial name
- NCT02166944
- Testing
- tamoxifen 40 mg daily for one year
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Chronic Pain, Opioid Use
Neuroimaging of Opioid Phase (OPAL)
The purpose of this study is to compare activity in the brains of female adults with chronic pain and/or opioid use, and healthy female adults that may help to develop new and targeted treatments for adults with chronic pain and…
- Trial name
- OPAL (NCT05905419)
- Testing
- Opioid Phase
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Duke University
Shin Splint
Effects of Autogenic Inhibition and Reciprocal Inhibition in Amateur Football Players With Shin Splints.
This randomized controlled trial aims to compare the effectiveness of Autogenic Inhibition and Reciprocal Inhibition in treating shin splints among amateur footballers aged 18-30 from SA Gardens Football Club, Lahore.
- Trial name
- NCT06501430
- Testing
- Heating Therapy, Manual Soft tissue Release
- Where
- Pakistan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Diabetic Foot, Diabetic Neuropathies
Peripheral Protective Sensation in Type 2 Diabetes Mellitus
The aim of our study was to investigate the effect of sole sensation on peripheral muscle strength, functional capacity, balance and physical activity level in individuals with Type 2 Diabetes Mellitus.
- Trial name
- NCT05904262
- Testing
- Foot Sole Sensation Evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Istanbul Kent University
Stroke, Proprioceptive Disorders
Combined Effects of PNF and Electrical Muscle Stimulation on Spasticity and Hand Function in Stroke Patients.
To determine the combined effects of proprioceptive neuromuscular facilitation and electrical muscle stimulation on spasticity and hand function in stroke patients.
- Conditions
- Stroke, Proprioceptive Disorders, Balance; Distorted
- Trial name
- NCT05916872
- Testing
- experimental group, control group
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Irritable Bowel, Fibromyalgia
Psychiatric Disorders and Functional Somatic Disorders
The objectives of this study are: Firstly, to investigate the association between psychiatric disorders and functional somatic disorder (FSD).
- Conditions
- Irritable Bowel, Fibromyalgia, Chronic Fatigue Syndrome, Bodily Distress Syndrome
- Trial name
- NCT06006715
- Volunteers
- 7,493 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital