Clinical trials: Neuromuscular Physiology
Spinal Muscular Atrophy
Responsiveness and Validation Study of MFM-20 in SMA Patients Treated With Nusinersen
The Motor Function Measure (MFM), a reliable tool assessing motor function and its progression in most neuromuscular diseases, is widely used in France in many teams.
- Trial name
- RetroNusiMFM (NCT04644393)
- Where
- 8 sites in France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Pediatric Obesity, Lower Extremity Biomechanics
Training Induced Reduction of Lower-limb Joint Loads During Locomotion in Obese Children
Childhood obesity is one of the most critical and accelerating health challenges throughout the world. It is a major risk factor for developing varus/valgus misalignments of the knee joint.
- Trial name
- NCT02545764
- Testing
- Strength and neuromuscular exercise programme
- Where
- Austria
- Volunteers
- 48 people
- Sponsor
- St. Pölten University of Applied Sciences
Geriatrics, Exercise Therapy
Comparison of Neuromuscular and Aquatic Exercise Programs on Fall Risk and Physical Function in Geriatrics
Objective: The aim of this study is to compare neuromuscular and aquatic Exercise programs on fall risk and physical function in geriatrics.
- Conditions
- Geriatrics, Exercise Therapy, Fall, Physical Functional Performance
- Trial name
- NE-AEinGR (NCT06300281)
- Testing
- Neuromuscular Exercise, Aquatic Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Alanya Alaaddin Keykubat University
Spasticity as Sequela of Stroke
EXOPULSE Mollii Suit, Motor Function & Stroke (EXOSTROKE)
Spasticity is a common and debilitating complication in neurological conditions such as multiple sclerosis, cerebral palsy, and stroke.
- Trial name
- EXOSTROKE (NCT06702163)
- Testing
- EXOPULSE MOLLII SUIT (active)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Institut De La Colonne Vertebrale Et Des Neurosciences
Diaphragmatic Dysfunction, Muscle Weakness
Recovery of Diaphragmatic Function After Neuromuscular Blockade and Sugammadex
The effect of neuromuscular blocking agents (NMBA, e.g. rocuronium) on respiratory muscle activity is well known. However, since the availability of sugammadex, to our knowledge, no study has been conducted to evaluate the effect…
- Conditions
- Diaphragmatic Dysfunction, Muscle Weakness, Muscle Fatigue
- Trial name
- SUDIA (NCT01962298)
- Testing
- sugammadex 2mg/kg, neostigmine, sugammadex 4mg/kg
- Where
- Belgium
- Volunteers
- 75 people
- Sponsor
- University Hospital, Antwerp
Carpal Tunnel Syndrome (CTS)
Electrophysiological and Functional Recovery After Carpal Tunnel Release
Carpal tunnel syndrome occurs when the median nerve is compressed at the wrist. It can cause pain, numbness, tingling, reduced hand strength, and difficulty performing daily activities.
- Trial name
- ELECTRO-CTS (NCT07803939)
- Testing
- Primary Carpal Tunnel Release Surgery
- Volunteers
- 100 people
- Sponsor
- Istanbul Medipol University Hospital
Stroke
Impact of Gait Training on Lower Extremity Motor Function and Balance Performance in Stroke Survivors.
This randomized clinical trial evaluates and compares the effectiveness of three physiotherapy-based rehabilitation strategies in improving gait, motor function, balance, and independence in individuals recovering from stroke.
- Trial name
- NCT07066319
- Testing
- Gait Training with Proprioceptive Neuromuscular Facilitation (PNF), Gait Training with Conventional Physiotherapy, Combined PNF and Conventional Physiotherapy (without direct gait training)
- Where
- Pakistan
- Volunteers
- 99 people
- Sponsor
- University of Lahore
Sarcopenia, Aging
Dual-benefits of Aerobic and Resistance Training
This study evaluates the effect of three different exercise strategies on physical function in older adults. Participants will be randomly assigned to one of three exercise groups: resistance training, moderate-intensity…
- Conditions
- Sarcopenia, Aging, Disability Physical
- Trial name
- DART (NCT03978572)
- Testing
- Resistance Training, Moderate-Intensity Continuous Cycling, High-Intensity Interval Cycling
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ohio University
Neuromuscular Disease
Respiratory Muscle Strength in Patients With NMD
The purpose of this study is to determine if inspiratory muscle strength training (IMST) will impact maximal inspiratory pressure and pulmonary function in patients with neuromuscular disease.
- Trial name
- RMST (NCT01555905)
- Testing
- Threshold PEP or IMT device Phillips-Respironics
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Florida
Lumbar Radiculopathy, Lumbar Spinal Stenosis
The Impact of Contrast Media Used in Epidural Steroid Injections on Thyroid Function Tests
This study is aim to disclose the effect of contrast media, which used in epidural steroid injections, on the parameters of thyroid function tests (TFTs). The patients who underwent an epidural steroid injection were included.
- Conditions
- Lumbar Radiculopathy, Lumbar Spinal Stenosis, Cervical Radiculopathy, Cervical Stenosis
- Trial name
- NCT05404412
- Testing
- Epidural Steroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people
- Sponsor
- Marmara University
Sarcopenia
β-glucan and Exercise on Musculoskeletal Function in Sarcopenic Adults
The investigators will conduct a randomized, double-blind, placebo-controlled study to investigate the effects of Aureobasidium pullulans produced β-glucan and regular combined exercise on muscle strength, muscle mass, muscle…
- Trial name
- NCT06629805
- Testing
- Aureobasidium pullulans produced β-glucan
- Where
- South Korea
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Diabetic Neuropathies, Rehabilitation
Comparative Effects of Reactive Balance Training and Task-Oriented Training on Postural Stability in Patients With Diabetic Peripheral Neuropathy
Diabetic peripheral neuropathy (DPN) is a common complication of prolonged hyperglycemia that damages peripheral nerves, leading to impaired sensory function, increased fall risk, and reduced quality of life.
- Conditions
- Diabetic Neuropathies, Rehabilitation, Reaction Time, Activities of Daily Living
- Trial name
- NCT07827417
- Testing
- Reactive Balance Training, TASK ORIENTED TRAINING
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Foundation University Islamabad
Stroke, Healthy Adults
Comparison of Effects of Mirror Therapy Combined With Neuromuscular Electrical Stimulation or Binaural Beats Stimulation on Cortical Excitability, Heart Rate Variability and Lower Limb Motor Function in Patients With Stroke
This study aims to compare the effects of mirror therapy combined with either neuromuscular electrical stimulation or binaural beat stimulation on post-stroke lower limb motor function recovery.
- Trial name
- NCT06011018
- Testing
- Mirror Therapy, Mirror Therapy + Electrical Stimulation, Mirror Therapy + Binaural Beat
- Where
- Taiwan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Healthy Older Adults
Acute Cardiovascular and Neuromuscular Responses to Walking With Blood Flow Restriction (BFR) in Older Adults
The goal of this clinical trial is to explore how walking combined with different levels of partial blood flow restriction (BFR) affects cardiovascular, neuromuscular, and movement (kinematic) variables in older adults.
- Trial name
- NCT07275138
- Testing
- Walking
- Where
- 2 sites in Portugal, Spain
- Volunteers
- 20 people
- Sponsor
- Universidade da Coruña
Cerebral Palsy (CP)
Effect of rESWT Session Frequency on Spasticity and Function Assessed by Sonoelastography in Children With Cerebral Palsy
Spasticity is a major contributor to functional limitations in children with cerebral palsy. Radial extracorporeal shock wave therapy (rESWT) has emerged as a non-invasive method for reducing spasticity; however, the optimal…
- Trial name
- CP-rESWT-FREQ (NCT07476690)
- Testing
- Real radial extracorporeal shock wave therapy (rESWT), Conventional physical therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Inclusion Body Myositis
Monitoring Biomarker for Detecting Change in Physical Activity and Limb Function in Inclusion Body Myositis Over Time
Inclusion-Body Myositis (IBM) results in weakness and the deterioration of distal arm muscles, the symptoms of which are currently assessed through expert examination at clinical visits.
- Trial name
- NCT06153108
- Testing
- PAMSys pendant PAMSys wrist sensors
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Kansas Medical Center
Motor Neuropathy, Sensory Neuropathy
Short-term Evaluation of Motor and Sensory Function in Post-COVID-19 Patients
SARS-COV-2 infection reframed medical knowledge in many aspects, yet there is still a lot to be discovered. our aim is to evaluate neurological impact of covid-19; if there is any.
- Trial name
- NCT05721040
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Neuromuscular Diseases
Bulbar Function in Neuromuscular Patients
The main objective is prospectively study the upper airways function in an adult population of neuromuscular patients. The main measurement will be the evolution of tongue strength recorded each year during annual clinical…
- Trial name
- ORDEG (NCT02097368)
- Testing
- tongue strength measurement, respiratory function measurement, swallowing tests
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Neuromuscular Control, Balance
Acute Impact of Static, Dynamic, and Proprioceptive Exercises on Proprioception, Strength, Balance, and Explosive Power
The purpose of this randomized controlled trial is to compare the acute effects of static stretching, dynamic stretching, and proprioceptive exercises on proprioception, muscle strength, balance, and explosive power in young…
- Conditions
- Neuromuscular Control, Balance, Musculoskeletal Function
- Trial name
- SSDSPE-RCT (NCT07320027)
- Testing
- Static Stretching Exercise Group, Dynamic Stretching Exercise Group, Proprioceptive Exercise Group
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Konya Necmettin Erbakan Üniversitesi
Knee Osteoarthritis
Effectiveness of Exercise Plus Pain Neuroscience Education on Brain Function in Knee Osteoarthritis
A three-arm randomized controlled trial will be conducted. Fifty-nine participants with KOA will be recruited in a 1:1:1 ratio. Assessor, and statistician will be blinded to group allocation.
- Trial name
- NCT06482970
- Testing
- Neuromuscular exercise plus pain neuroscience education, Neuromuscular exercise
- Volunteers
- 57 people
- Sponsor
- Universidad Santo Tomas, Chile