Clinical trials: Neuron Disease, Motor
Amyotrophic Lateral Sclerosis (ALS)
Testing Pulse Stimulation to Improve Motor Function in People With ALS: A Pilot Study
The goal of this clinical trial is to assess the efficacy of TPS of the motor cortex on biomarkers and clinical endpoints in patients with ALS.
- Trial name
- TPS4ALS (NCT06681610)
- Testing
- Transcranial Pulse Stimulation
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Parc de Salut Mar
Amyotrophic Lateral Sclerosis (ALS)
Developing New Ways to Detect Respiratory Impairment Early in ALS
The goal of this observational study is to develop new ways to detect early changes associated with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.
- Trial name
- NCT07844590
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Amyotrophic Lateral Sclerosis
Efficacy and Safety of Plasma Exchange With Albumin in Patients With Amyotrophic Lateral Sclerosis
Pilot, phase II, prospective, open-label, uncontrolled study of plasma exchange with 5% albumin in 10 subjects having a definite, possible, or probable diagnosis of Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- NCT02479802
- Testing
- Albumin
- Where
- Spain
- Volunteers
- 13 people
- Sponsor
- Instituto Grifols, S.A.
Amyotrophic Lateral Sclerosis, Frontotemporal Dementia
Phenotype, Genotype & Biomarkers in ALS and Related Disorders
The goals of this study are: (1) to better understand the relationship between the phenotype and genotype of amyotrophic lateral sclerosis (ALS) and related diseases, including primary lateral sclerosis (PLS), hereditary spastic…
- Conditions
- Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Primary Lateral Sclerosis, Hereditary Spastic Paraplegia
- Trial name
- NCT02327845
- Where
- 15 sites in United States, Germany and 1 more
- Volunteers
- 708 people, healthy volunteers welcome
- Sponsor
- University of Miami
Motor Neuron Disease, Benign Fasciculation-Cramp Syndrome
Serial Fasciculation Measurements in Motor Neurone Disease
Patients with motor neurone disease (MND) typically experience relentless motor decline and die within three years of symptom onset from respiratory muscle weakness.
- Trial name
- NCT03809845
- Testing
- High-density surface electromyography
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- King's College Hospital NHS Trust
Amyotrophic Lateral Sclerosis, Fasciculation
Study to Evaluate Safety & Efficacy of FLX-787-ODT to Treat Fasciculations in Tongue and Appendicular Muscle in Adult Subjects With ALS
The FLX-787-107 study will determine how well FLX-787-ODT works to reduce fasciculations in patients with Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- NCT03334786
- Testing
- FLX-787-ODT
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Flex Pharma, Inc.
Amyotrophic Lateral Sclerosis, Neurodegenerative Diseases
Quantitative Measurement of Nutritional Substrate Utilization in Patients With Amyotrophic Lateral Sclerosis (ALS)
The work of Nau et. al (Nau KL, Bromberg MB, Forshew DA, Katcha Vl. Individuals with amyotrophic lateral sclerosis are in caloric balance despite losses in mass.
- Trial name
- NCT00714220
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Drexel University College of Medicine
Amyotrophic Lateral Sclerosis (ALS)
A Patient-tailored Genetic/Biomarker/iPSC Combined Approach in ALS - PERMEALS
Amyotrophic Lateral Sclerosis (ALS) is a severe and incurable neurodegenerative disease of motor neurons with a dramatic socio-economic impact on the national health system.
- Trial name
- PERMEALS (NCT06917924)
- Testing
- lumbar puncture
- Where
- 4 sites in Italy
- Volunteers
- 200 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Breast Cancer
Bicalutamide Plus Aromatase Inhibitors in ER(+)/AR(+)/HER2(-) Metastatic Breast Cancer
This study is aim to evaluate the efficacy and safety of bicalutamide and aromatase inhibitor in ER(+)/AR(+)/HER2(-) metastatic breast cancer patients who have disease progression after treatment of an aromatase inhibitor.
- Trial name
- BETTER (NCT02910050)
- Testing
- Bicalutamide, Aromatase Inhibitor
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Xu fei
Amyotrophic Lateral Sclerosis (ALS)
A Study to Evaluate the Performance of a Diagnostic Test in ALS
Prospective multicenter study of subjects who were recently diagnosed with amyotrophic lateral sclerosis (ALS) or another neurodegenerative disease (including spinal cord diseases, muscle diseases and neurological diseases such…
- Trial name
- NCT02759913
- Testing
- Lumbar puncture
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Iron Horse Diagnostics, Inc.
Amyotrophic Lateral Sclerosis
Contribution of Diaphragmatic Ultrasound for Monitoring Diaphragmatic Function in Patients With Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a rare neuromuscular disease that occurs in adults. It is characterized by a progressive degeneration of the first and second motor neurons leading to muscle failure.
- Trial name
- ALSUS (NCT05352958)
- Testing
- Diaphragmatic ultrasound, Electro-physiological exploration of the diaphragm
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Amyotrophic Lateral Sclerosis, Dysphagia
Fatigue in Patients With Amyotrophic Lateral Sclerosis
Expiratory muscle strength training (EMST) is an emerging palliative intervention for prolonging pulmonary and swallow function in patients with amyotrophic lateral sclerosis (PALS), but it is unknown whether EMST may result in…
- Conditions
- Amyotrophic Lateral Sclerosis, Dysphagia, Dyspnea, Respiration Disorders
- Trial name
- NCT04468191
- Testing
- Experimental expiratory muscle strength training (EMST)
- Where
- United States
- Sponsor
- Cara Donohue
Amyotrophic Lateral Sclerosis
Efficacy and Safety of Cyclophosphamide in Amyotrophic Lateral Sclerosis
The goal of this clinical trial is to learn whether cyclophosphamide (CTX) combined with standard treatment can slow disease progression in adults with amyotrophic lateral sclerosis (ALS).
- Trial name
- CORTEX-ALS (NCT07834450)
- Testing
- Cyclophosphamide, Riluzole
- Volunteers
- 60 people
- Sponsor
- Huashan Hospital
Spinal Muscular Atrophy
A Study to Learn About the Effect of Higher Doses of Nusinersen (BIIB058) Given as Injections to Participants With Spinal Muscular Atrophy (SMA) Who Were Previously Treated With Risdiplam (ASCEND)
In this study, researchers will learn more about the use of a higher dose of nusinersen (BIIB058) in participants with spinal muscular atrophy (SMA).
- Trial name
- ASCEND (NCT05067790)
- Testing
- Nusinersen
- Where
- 22 sites in United States, Germany and 3 more
- Volunteers
- 45 people
- Sponsor
- Biogen
Amyotrophic Lateral Sclerosis
A Pilot Study of the Utility of 3D Printed Masks for ALS Subjects
Non-invasive ventilation (NIV) is an important therapy for patients with a number of neurological diseases. Specifically, NIV has been shown to be an effective treatment for people with amyotrophic lateral sclerosis (ALS, also…
- Trial name
- NCT03519880
- Testing
- Custom Mask Interface
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Michigan
Amyotrophic Lateral Sclerosis, Sialorrhea
Study of Myobloc in the Treatment of Sialorrhea (Drooling) in Patients With Amyotrophic Lateral Sclerosis (ALS)
The purpose of this study is to determine the safety and efficacy of Myobloc in ALS patients who are having excessive drooling. The primary goal of the study is to determine if the patient perceives a benefit from the Myobloc in…
- Trial name
- NCT00125203
- Testing
- Botulinum toxin type B (Myobloc), Injection of salivary glands
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Amyotrophic Lateral Sclerosis (ALS)
Rasagiline in Subjects With Amyotrophic Lateral Sclerosis (ALS)
ALS is a disorder that weakens motor strength and lung function. Rapid loss of motor neurons in the brain and spinal cord of ALS patients causes the symptoms of increasing weakness and loss of muscle function.
- Trial name
- NCT01786603
- Testing
- Rasagiline
- Where
- 10 sites in United States
- Volunteers
- 80 people
- Sponsor
- Richard Barohn, MD
Spinal Muscular Atrophy
Holter of Movement in Patients with SMA Undergoing Treatment.
Acti-SMA is a multi-centric academic study. It aims to monitor the progress of patients with spinal muscular atrophy under treatment with Spinraza° or risdiplam.
- Trial name
- NCT04888702
- Testing
- Actimyo
- Where
- 3 sites in Belgium, Romania
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Chronic Pain, Spasticity as Sequela of Stroke
Closed Loop Spinal Cord Stimulation for Neuromodulation of Upper Motor Neuron Lesion Spasticity
Spasticity is characterized by increased muscle tension and is a classic consequence of upper motor neuron (UMN) damage in the central nervous system, such as from stroke or trauma.
- Conditions
- Chronic Pain, Spasticity as Sequela of Stroke, Upper Motor Neuron Lesion
- Trial name
- CLONUS (NCT06384170)
- Testing
- Spinal Cord Stimulation- Closed loop
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Amyotrophic Lateral Sclerosis
Memantine Therapy in Amyotrophic Lateral Sclerosis
Tau, a protein in the cerebrospinal fluid CSF is believed to be elevated in amyotrophic lateral sclerosis (ALS) patients. The investigators believe that Tau is truly a marker of increased neuronal death from any disease process.
- Trial name
- TAME (NCT01020331)
- Testing
- Memantine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Phoenix Neurological Associates, LTD
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