Clinical trials: Neuropathic Bladder
Neurogenic Bladder
Study of Autologous Neo-Bladder Construct in Subjects With Neurogenic Bladder Following Spinal Cord Injury
Subjects with neurogenic bladder secondary to spinal cord injury that is refractory to medical treatment and requires augmentation cystoplasty will be enrolled.
- Trial name
- NCT00512148
- Testing
- Autologous neobladder construct
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Tengion
Neurogenic Bladder Dysfunction Nos, Spinal Cord Injury
Botox-A Injection to Improve Bladder Function in Early Spinal Cord Injury (#H-20344)
The purpose of this study is to see what the effect of Botox has on bladder function for those who have recently suffered spinal cord injury.
- Trial name
- NCT00711087
- Testing
- BOTOX-A, Saline injection
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Baylor College of Medicine
Urinary Tract Infections, Spinal Cord Injuries
Gentamicin Bladder Instillations to Prevent Urinary Tract Infections in Patients With Spinal Cord Injury
A non-randomized study evaluating the efficacy of intravesical gentamicin on the occurrence rate of urinary tract infections and bladder complications in patients after spinal cord injury (SCI), and to assess its effectiveness in…
- Conditions
- Urinary Tract Infections, Spinal Cord Injuries, Spinal Cord Diseases, Neurogenic Bladder
- Trial name
- NCT03503513
- Testing
- Gentamicin Sulfate
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Michigan
Bladder, Neurogenic
Study to Evaluate the Efficacy and Safety of Tamsulosin in Children With Neurogenic Bladder
Aim of this study is to evaluate the efficacy and safety of a range of doses of tamsulosin hydrochloride as treatment in children with an elevated detrusor leak point pressure associated with a known neurological deficit
- Trial name
- NCT00796614
- Testing
- tamsulosin hydrochloride
- Where
- 52 sites in United States, Belgium and 11 more
- Volunteers
- 231 people
- Sponsor
- Boehringer Ingelheim
Bladder, Neurogenic
PK/PD, Long-term Safety and Efficacy of Tamsulosin Treatment in Children With Neurogenic Bladder
Aims of this study is to characterize the pharmacokinetic/pharmacodynamic profile and evaluate the safety, efficacy and tolerability, of tamsulosin hydrochloride as treatment in children with a neuropathic bladder, over the…
- Trial name
- NCT00340704
- Testing
- tamsulosin hydrochloride
- Where
- 72 sites in United States, Belgium and 12 more
- Volunteers
- 143 people
- Sponsor
- Boehringer Ingelheim
Multiple Sclerosis, Neurogenic Bladder
Vaginal Estriol in Multiple Sclerosis
Study to evaluate the efficiency of vaginal estriol, as a treatment for urogenital symptoms in female patients with RRMS. The secondary objective is to evaluate the potential role of vaginal estriol in re-myelination in RRMS…
- Trial name
- NCT03774407
- Testing
- vaginal estriol
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Texas Tech University Health Sciences Center
Urinary Tract Infections, Bladder, Neurogenic
A Biochip for Rapid Diagnosis of Complicated Urinary Tract Infection
The purpose of this proposal is clinical validation of an electrochemical biochip for rapid pathogen identification and antibiotic susceptibility determination.
- Trial name
- NCT00591240
- Where
- United States
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Parkinson's Disease, Neurogenic Bladder
Safety and Efficacy of botulinumA Toxin (BotoxA) for Treatment of Neurogenic Bladder of Parkinson's Disease
The basic nerve deficit of Parkinson's disease (PD) leads to lower urinary tract symptoms of frequency, urgency and urge urinary incontinence. Lower urinary tract symptoms tend to occur at more advanced stages of PD.
- Conditions
- Parkinson's Disease, Neurogenic Bladder, Urinary Incontinence, Clostridium Botulinum Toxin Adverse Reaction
- Trial name
- NCT01421719
- Testing
- Cystoscopic injection of Botox into the urinary bladder
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Overactive Bladder, Urinary Urge Incontinence
Reduction of Bladder Injection Pain With Belladonna Opiate Suppository
The purpose of this study is to test whether using belladonna \& opiate suppositories (B\&Os) can improve patient discomfort during Onabotulinumtoxin A (BoNT) injection into the bladder for treatment of overactive bladder…
- Conditions
- Overactive Bladder, Urinary Urge Incontinence, Urinary Bladder, Neurogenic, Painful Bladder Syndrome
- Trial name
- ROBIN (NCT02600715)
- Testing
- Onabotulinumtoxin A (BoNT), belladonna, Morphine
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Edgar LeClaire, MD
Neurogenic Bladder, Multiple Sclerosis
Brain Targets in Patients With Bladder Emptying Difficulties
The goal of this study is to identify brain centers specifically associated with "initiation of voiding" in patients with neurogenic bladder dysfunction.
- Conditions
- Neurogenic Bladder, Multiple Sclerosis, Voiding Dysfunction
- Trial name
- NCT03574610
- Testing
- Transcranial Rotating Permanent Magnet Stimulator (TRPMS)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- The Methodist Hospital Research Institute
Chronic Spinal Cord Injury, Neurogenic Bladder
Reducing Anticholinergic Bladder Medication Use in Spinal Cord Injury With Home Neuromodulation
The purpose of this study is to determine the efficacy of home transcutaneous tibial nerve stimulation (TTNS) in spinal cord injury(SCI) and to determine the impact on quality of life using TTNS at home
- Trial name
- TTNS-RCT (NCT04074616)
- Testing
- High Dose, Low dose
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas Health Science Center, Houston
Spinal Cord Injury, Neurogenic Bladder
Multifaceted Treatment of Catheter-related Urinary Tract Infection
The specific objective of this clinical trial is to demonstrate that a multifaceted approach for treatment for catheter-related urinary tract infection (UTI) in patients with spinal cord injury is effective and feasible.
- Conditions
- Spinal Cord Injury, Neurogenic Bladder, Urinary Tract Infection
- Trial name
- NCT00732238
- Testing
- Shortened course of antibiotic therapy, Standard Therapy
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- US Department of Veterans Affairs
Neurogenic Urinary Bladder
Alfuzosin Treatment in Children and Adolescents With Neurogenic Urinary Bladder Dysfunction
The primary objective of the study was to evaluate the efficacy of Alfuzosin in comparison to Placebo on the detrusor Leak Point Pressure (LPP) in children and adolescents 2-16 years of age with elevated detrusor LPP of…
- Trial name
- ALFACHIN (NCT00549939)
- Testing
- Alfuzosin
- Where
- 18 sites in United States, Bulgaria and 16 more
- Volunteers
- 172 people
- Sponsor
- Sanofi
Neurogenic Bladder Dysfunction
Chronic Electrical Stimulation to Reduce Bladder Hyperreflexia
Bladder spasms after spinal cord injury (SCI) can result in incontinence, urinary tract infections, kidney damage, trigger dangerous increases in blood pressure and decrease independence and quality of life.
- Trial name
- NCT03472599
- Testing
- Genital Nerve Stimulation
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- VA Office of Research and Development
Neurogenic Bladder
Augmentation Cystoplasty Using an Autologous Neo-Bladder
Subjects with neurogenic bladder secondary to spina bifida refractory to medical treatment will be enrolled. The hypothesis is that augmentation cystoplasty using an autologous neo-bladder construct will significantly increase…
- Trial name
- NCT00419120
- Testing
- Autologous neo bladder construct
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Tengion
Multiple Sclerosis, Lower Urinary Tract Symptoms
Central Nervous System Changes Following OnabotulinumtoxinA Injection in the Bladder
The purpose of this research study is to evaluate higher neural changes following intra-detrusor injection of Onabotulinumtoxin-A (BTX-A) in patients with Multiple Sclerosis (MS).
- Conditions
- Multiple Sclerosis, Lower Urinary Tract Symptoms, Neurogenic Bladder, Detrusor, Overactive
- Trial name
- NCT03033355
- Testing
- Intra-detrusor injection of Onabotulinumtoxin-A
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The Methodist Hospital Research Institute
Lower Urinary Tract Symptoms
A Pilot Study to Assess Effects of Self-Administered Nitrous Oxide (SANO) on Urodynamic Study (UDS) Parameters
A urodynamic study (UDS) is a common procedure done to learn more about the cause of urinary symptoms. For some patients, UDS can be associated with anxiety or discomfort.
- Trial name
- NCT05883332
- Testing
- Self-Administered Nitrous Oxide, Oxygen
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Chronic Spinal Cord Injury, Neurogenic Bowel
Home Neuromodulation of the Neurogenic Bladder in Chronic Spinal Cord Injury With Transcutaneous Tibial Nerve Stimulation
Determine the safety, feasibility, compliance, and efficacy of a daily home TTNS protocol in chronic SCI provided by self or caregiver for 4 weeks.
- Trial name
- HomeTTNS (NCT03458871)
- Testing
- 4-week TTNS home-based protocol
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- The University of Texas Health Science Center, Houston
Pain, Neuropathic, Epilepsy
Cancer in Patients With Gabapentin (GPRD)
High doses of gabapentin are associated with pancreatic acinar cell tumors in rats, but there has been no post marketing pancreatic carcinogenicity signal with gabapentin as reported by spontaneous reports in AERS or in the…
- Conditions
- Pain, Neuropathic, Epilepsy, Renal Pelvis Cancer, Pancreatic Cancer
- Trial name
- NCT01236053
- Testing
- Gabapentin prescriptions
- Volunteers
- 2,323,608 people
- Sponsor
- GlaxoSmithKline
Detrusor Hyperreflexia
A Study Evaluating Oxybutynin in Patients With Neurogenic Overactive Bladder Associated With a Neurological Condition
This study will evaluate the efficacy and safety of an anticholinergic drug treatment administered by transdermal patch to treat overactive bladder in adults who have spinal cord injury.
- Trial name
- NCT00224029
- Testing
- Oxybutynin transdermal system
- Where
- 6 sites in United States
- Volunteers
- 24 people
- Sponsor
- Watson Pharmaceuticals