Clinical trials: Neuropathic Pain, open to volunteers
Neuropathic Pain, Nociplastic Pain
Evolution of Different Sensitivity Levels in Patients With Chronic Neuropathic Pain in the Pelvi-perineal Region After Treatment With High-concentration Capsaicin Patches
The primary objective of this study will be to demonstrate a change in pain sensitization parameters before and after the application of the high-concentration capsaicin patch.
- Trial name
- CAPSASENS (NCT07660510)
- Testing
- Quantitative Sensory Testing and questionnaires
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Neuropathic Pain
Safety, Tolerability, and Pharmacokinetics of ASCT-83 in Healthy Adults
The goal of this clinical trial is to learn if ASCT-83 is safe and well-tolerated and measure how ASCT-83 is absorbed, distributed, and eliminated from the body over time. The study will be conducted in healthy adults.
- Trial name
- NCT07363395
- Testing
- ASCT-83
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Alcamena Stem Cell Therapeutics
Neuropathic Pain, Chronic Pain
Analgesic Effectiveness of Capsaicin 8% Cutaneous Patch in Children
This study concerns children aged to 12 to 17-years with local chronic neuropathic pain after trauma or surgery. It is a multicentric randomized controlled superiority trial in parallel arms : experimental arm: Capsaicin 8%…
- Trial name
- CAPSAPED (NCT05997979)
- Testing
- Capsaicin 8% patch, Hydrocolloid dressing
- Where
- 10 sites in France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Brest
Spinal Cord Injuries, Chronic Pain
Development of a Pain Rehabilitation Program for Chronic Pain After SCI
Pain rehabilitation programs are essential for optimal treatment of chronic pain and are usually based on the biopsychosocial model.
- Conditions
- Spinal Cord Injuries, Chronic Pain, Neuropathic Pain, Interprofessional Team Collaboration
- Trial name
- NCT07634796
- Testing
- multi-modality pain management
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Umeå University
Neuropathic Pain, Chronic Postsurgical Pain
Efficacy of an Intraoperative Periradicular Application of Platelet Rich Fibrin (PRF) on the Intensity of Residual Post-surgical Neuropathic Pain After a Surgery for Disc Herniation
The prevalence of post-surgical lumbar neuropathic radiculopathy is approximately 30%. Poor response to the treatments recommended for neuropathic pain, namely antidepressants and/or gabapentinoids, requires the development of…
- Trial name
- NeuroPRF (NCT05196503)
- Testing
- Treatment
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Neuropathic Pain Management
tACS for Neuropathic Pain Management After SCI
The overall goal is to investigate the effectiveness of a novel intervention - transcranial alternating current stimulation (tACS) for neuropathic pain management in people after spinal cord injury.
- Trial name
- NCT06029075
- Testing
- tACS 10Hz, tACS 20Hz
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- The University of Texas Health Science Center, Houston
Neuropathic Pain
Brain Connectivity Changes With Spinal Cord Stimulation and Treatment of Chronic Pain: A Resting State NIRS/EEG Study
This study aims to assess how use of spinal cord stimulation for the treatment of chronic pain impacts brain structure and function.
- Trial name
- NCT05811312
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Diabetic Peripheral Neuropathic Pain
Evaluation of Efficacy and Safety of VX-993 for Pain Associated With Diabetic Peripheral Neuropathy
The purpose of this study is to evaluate the efficacy, safety, and tolerability of VX-993 in participants with pain associated with Diabetic Peripheral Neuropathy (DPN)
- Trial name
- NCT06619860
- Testing
- VX-993, Pregabalin
- Where
- 47 sites in United States, Canada and 4 more
- Volunteers
- 300 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Chronic Neuropathic Pain
Safety and Tolerability Study of ST-503 for Refractory Pain Due to Peripheral Neuropathy (Small Fiber Predominant, SFN)
This research is being done to study a possible treatment for refractory pain due to small fiber neuropathy (SFN). ST-503 is intended to deliver a modified copy of the gene which will ideally repress Nav1.7 tissue-related pain…
- Trial name
- NCT06980948
- Testing
- ST-503
- Where
- 11 sites in United States
- Volunteers
- 27 people
- Sponsor
- Sangamo Therapeutics
Patients With Taxane-induced Chronic Neuropathic Pain
Chemotherapy Induced Peripheral Neuropathy by Taxanes and Capsaicin 8%.
The goal of this study is to compare the evolution of the density of small nerve fibers assessed with skin biopsies at the foot between two groups of patients with taxane-induced chronic neuropathic pain matched for sex and age…
- Trial name
- capsaNeP (NCT07602387)
- Testing
- Capsaicin 8% Patch, antidepressants (tricyclics and serotonin reuptake inhibitor SRIs), antiepiletics, lidocaine patches, and neurostimulation
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospital Ambroise Paré Paris
Spinal Cord Injuries, Pain, Neuropathic
Pain Phenotyping in Patients With Neuropathic Pain After Spinal Cord Injury
The development of neuropathic pain is one of the most debilitating sequels after a spinal cord injury (SCI). The overall aim of this study is to investigate potential underlying pathophysiological mechanisms of neuropathic pain…
- Conditions
- Spinal Cord Injuries, Pain, Neuropathic, Nociceptive Pain, Neuropathy
- Trial name
- NCT06443281
- Testing
- Neurophysiology, Cardiovascular test, Experimental pain paradigms
- Where
- Switzerland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Spinal Cord Injury, Neuropathic Pain
Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Neuropathic Pain Following Spinal Cord Injury
This pilot randomized, double-blind, sham-controlled clinical investigation will evaluate the feasibility and safety of a 30-day home-based transcutaneous auricular vagus nerve stimulation (taVNS) intervention in adults with…
- Trial name
- NCT07588711
- Testing
- Active Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Calcitonin, Neuropathic Pain
Calcitonin Therapy on Incidence and Severity of Neuropathic Pain After Spinal Cord Injury
This prospective randomized double blinded study will be conducted to evaluate the effect of early pharmacologic intervention with calcitonin on the incidence or the severity of neuropathic pain after spinal cord injury
- Conditions
- Calcitonin, Neuropathic Pain, Spinal Cord Injury
- Trial name
- NCT05805683
- Testing
- Calcitonin
- Where
- Egypt
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Tanta University
Frozen Shoulder, Adhesive Capsulitis
USG-Guided Shoulder Injections in Frozen Shoulder
Frozen shoulder (adhesive capsulitis) is characterized by pain and a progressive restriction of both active and passive shoulder range of motion, significantly impairing daily activities and quality of life.
- Conditions
- Frozen Shoulder, Adhesive Capsulitis, Shoulder Pain, Nociplastic Pain
- Trial name
- NCT07493213
- Testing
- USG-guided suprascapular nerve block, USG-Guided suprascapular nerve block plus subacromial injection.
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Konya Beyhekim Training and Research Hospital
Frozen Shoulder, Adhesive Capsulitis
Efficacy of Chemically Distinct Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Pain Phenotypes in Adhesive Capsulitis
Patients aged 18-75 years who present to a tertiary rehabilitation hospital with shoulder pain and restricted range of motion, and who consent to participate, will be included in the study.
- Conditions
- Frozen Shoulder, Adhesive Capsulitis, Shoulder Pain, NSAID (Non-Steroidal Anti-Inflammatory Drug)
- Trial name
- NCT07493226
- Testing
- Propionic acid deriaves, acetic acid derivatives, oxicam derivatives
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Konya Beyhekim Training and Research Hospital
Neuropathic Pain, Plantar Fasciitis
Efficacy of Extracorporeal Shockwave Therapy on Plantar Fasciitis in Patients With Peripheral Neuropathy
This study aims to evaluate the efficacy of extracorporeal shockwave therapy (ESWT) in reducing pain and improving functional outcomes for patients with neuropathy-associated plantar fasciitis.
- Trial name
- NCT07587255
- Testing
- Extracorporeal shockwave therapy (ESWT)
- Volunteers
- 114 people
- Sponsor
- National Taiwan University Hospital
Neuropathic Pain, Chemotherapy-induced Peripheral Neuropathy (CIPN)
Efficacy of Spinal Cord Stimulation in Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent and debilitating side effect of many cancer treatments. It affects 28 to 48% of patients receiving chemotherapy.
- Conditions
- Neuropathic Pain, Chemotherapy-induced Peripheral Neuropathy (CIPN), Cancer-related Pain
- Trial name
- CHEMOSTIM (NCT07579611)
- Testing
- Spinal cord stimulation (FAST mode)
- Where
- France
- Volunteers
- 68 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Neuropathic Pain
rTMS Efficacy Coupled With Mirror Therapy
Neuropathic pain is particularly difficult to treat with classic first-line drugs. Neuromodulation techniques using repetitive transcranial magnetic stimulation (rTMS) are useful alternative, but there is a need to improve their…
- Trial name
- STIRM (NCT04867187)
- Testing
- Repetitive transcranial magnetic stimulation (rTMS), Mirror therapy using virtual reality
- Where
- 2 sites in France
- Volunteers
- 64 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Drug-resistant Neuropathic Pain
Non-invasive Personalized Transcranial Cortical Neurostimulation for Pain Relief
Neuropathic pain is a public health problem with less than 50% of patients being relieved by drug treatments. Surgically implanted motor cortex stimulation represents an invasive therapeutic solution capable of relieving a…
- Trial name
- PERSOSTIM (NCT06209645)
- Testing
- tDCS (Transcranial Direct Current Stimulation), tACS (Transcranial Alternating Current Stimulation)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Painful Diabetic Neuropathy (PDN), Diabetic Neuropathy
Efficacy and Feasibility of BurstDR SCS in Painful Diabetic Neuropathy
This prospective, single-arm clinical study evaluates the therapeutic efficacy and feasibility of BurstDR spinal cord stimulation (SCS) using Abbott's Proclaim XR and Eterna systems in patients with painful diabetic neuropathy…
- Conditions
- Painful Diabetic Neuropathy (PDN), Diabetic Neuropathy, Neuropathic Pain, Chronic Pain
- Trial name
- ABBT DPN (NCT07250828)
- Testing
- BurstDR Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- TriCity Research Center