Clinical trials: Neuropathy, Diabetic
Diabetic Cardiovascular Autonomic Neuropathy (DCAN)
Bayesian Estimation of Diagnostic Performance of Diabetic Cardiovascular Autonomic Neuropathy Without a Gold Standard
This study aimed to estimate sensitivities and specificities of diabetic cardiovascular autonomic neuropathy (DCAN) diagnostic tests using the Bayesian approach without a gold standard in another independence dataset.The…
- Trial name
- NCT02461381
- Testing
- not intervention
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shanghai Tongji Hospital, Tongji University School of Medicine
Painful Peripheral Diabetic Neuropathy
A Study to Evaluate PEMF Therapy on Experimentally Inducted Pain in Subjects With Painful Peripheral Diabetic Neuropathy
Evaluate the effectiveness of the Provant Therapy System compared to sham on pain sensitivity and nervous system response to various qualities of experimentally induced pain in the upper and lower extremities of subjects with…
- Trial name
- NCT02809911
- Testing
- Provant
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Regenesis Biomedical, Inc.
Lower Extremity Amputee, Diabetic Peripheral Neuropathy
Functional and Neuroprotective Effects of Restoring Lower Limb Sensation After Diabetic Peripheral Neuropathy
The purpose of this study is to evaluate the effectiveness of providing sensation of the missing limb to individuals with above and below the knee limb loss.
- Trial name
- NCT04658693
- Testing
- Implanted Multi contact stimulating electrode and intramuscular electromyography recording electrode
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- VA Office of Research and Development
Diabetic Foot
Fitostimoline® Hydrogel Versus Saline Gauze Dressing in Diabetic Foot Ulcers
Diabetes Mellitus (DM) is one of the most widespread metabolic diseases and the alarming rise in its prevalence worldwide poses enormous challenges.
- Trial name
- NCT05661474
- Testing
- Fitostimoline ® hydrogel group, Saline gauze group
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federico II University
Osteomyelitis, Diabetic Foot
Efficacy of Surgical Treatment of Osteomyelitis in Diabetic Foot Ulcers
Hypothesis:Surgical treatment of osteomyelitis in diabetic foot is more effective that medical treatment through antibiotherapy and leads wound healing in ulcers complicated with bone infection.Material and Methods: Randomized…
- Conditions
- Osteomyelitis, Diabetic Foot, Diabetic Foot Ulcers
- Trial name
- NCT01137903
- Testing
- Conservative surgery, Ciprofloxacin, Amoxicillin-Potassium Clavulanate Combination
- Where
- Spain
- Volunteers
- 88 people
- Sponsor
- Universidad Complutense de Madrid
Peripheral Neuropathy, Somatosensory Disorders
Sensorimotor Training for Adults With Diabetic Peripheral Neuropathy
Adults with diabetic peripheral neuropathy tend to fall more frequently than healthy population as a consequence of multiple sensorimotor and cognitive damages.
- Conditions
- Peripheral Neuropathy, Somatosensory Disorders, Sensorimotor Gait Disorder
- Trial name
- NCT05262946
- Testing
- sensorimotor training based on Feldenkrais method, foot care education, usual care
- Volunteers
- 44 people
- Sponsor
- Universidad Complutense de Madrid
Diabetic Foot Ulcer
Bioactive Smart Dressings for Diabetic Foot Ulcers: Randomized Controlled Trial
We propose a randomized controlled study to assess the efficacy of: 1. Platelet-lysate loaded sustained release thermo-gelling formulation (Platelets-SR) 2.
- Trial name
- NCT05671250
- Testing
- PRP gel and SOC-treatment, EPO/ISDN/UFH cryogel dressing, Standard of Care
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University
Diabetic Neuropathy
The Effect of Ruboxistaurin on Small Fiber Function
To determine the effect of Ruboxistaurin on small fiber function.
- Trial name
- NCT00190970
- Testing
- Ruboxistaurin
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Chromaderm, Inc.
Diabetic Foot Ulcers
Study of Safety, Tolerability, and Pharmacokinetics of Topical Selinexor (KPT-330) Diabetic Foot Ulcer (DFU) Patients
Patients with eligible diabetic foot ulcers will be screened, treated, and followed for complete ulcer closure. This is a randomized trial. All patients will receive standard-of-care treatment.
- Trial name
- NCT02367690
- Testing
- Selinexor, Standard-of-Care, Vehicle Gel
- Where
- New Zealand
- Sponsor
- Karyopharm Therapeutics Inc
Diabetic Foot Ulcer Associated With Type II Diabetes Mellitus
Effect of Stress Ball Applied During Surgical Debridement/Dressing on Pain, Distress, and Physiological Parameters in Patients With Diabetic Foot Ulcers
Diabetes mellitus (DM) is a common metabolic disease characterized by hyperglycemia, resulting from a deficiency or insufficiency of insulin.
- Trial name
- NCT07119983
- Testing
- Stress ball
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Cukurova University
Diabetic Foot, Diabetic Foot Ulcer
Effectiveness of the Autologous Adipose Tissue Harvested With SEFFICARE Method for Treatment of DFU Minor Amputation
Diabetic foot ulcers (DFU) are one of the complications of diabetes mellitus resulting from multiple causes such as neuropathy, ischemia, and infection that contribute to morbidity and amputation.
- Conditions
- Diabetic Foot, Diabetic Foot Ulcer, Amputation
- Trial name
- SEFFIDiFA (NCT05072353)
- Testing
- SEFFICARE
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Diabetic Foot Ulcer Outcome, Quality of Patient Care
The Diabetic Foot Ulcer Registry
This is an observational, longitudinal real world registry of diabetic foot ulcers created from electronic health record data obtained in the course of clinical care.
- Trial name
- DFUR (NCT02813161)
- Testing
- cellular and tissue based therapy, negative pressure wound therapy, debridement
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- U.S. Wound Registry
Diabetic Foot Ulcer
Placental Cells for Diabetic Foot Ulcers
The purpose of this research study is to test the safety of placental stem cells to treat non-healing diabetic foot ulcers.
- Trial name
- NCT07686094
- Testing
- Placenta Stem Cells
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Wake Forest University Health Sciences
Painful Diabetic Neuropathy
An Open-label follow-on Trial to Assess the Long-term Safety and Efficacy of Oral SPM 927 in Subjects With Diabetic Neuropathy
The primary objective of the trial is to assess the tolerability and safety of long-term SPM 927 administration in subjects with diabetic neuropathy.
- Trial name
- NCT00861042
- Testing
- SPM927/Lacosamide
- Volunteers
- 69 people
- Sponsor
- UCB Pharma
Diabetic Peripheral Neuropathy
Comparative Effects of Balance and Resisted Training in Diabetic Peripheral Neuropathy.
The aim of this study is to determine comparative effects of balance and resisted training on pain and balance in patients with daibetic peripheral neuropathy.
- Trial name
- NCT06303453
- Testing
- Balance exercises, Resisted exercises
- Where
- Pakistan
- Volunteers
- 58 people
- Sponsor
- Riphah International University
Diabetic Foot
Efficacy and Safety of Heberprot-P® in Patients With Advanced Diabetic Foot Ulcer in Dasman Diabetes Institute.
The purpose of this study is to assess the efficacy and safety of the intralesional administration of Heberprot-P® (human recombinant epidermal growth factor) plus the standard treatment in patients with complex diabetic foot and…
- Trial name
- NCT03239457
- Testing
- Heberprot P
- Volunteers
- 50 people
- Sponsor
- Dasman Diabetes Institute
Diabetes Foot Care
Therapeutic Effect of Electroacupuncture at Zusanli (ST-36) on Diabetic Foot Wounds
The goal of this clinical trial is to learn if electroacupuncture at the Zusanli (ST-36) can assist in the treatment of diabetic foot ulcers.
- Trial name
- EA for DFU (NCT07482137)
- Testing
- Electroacupuncture at Zusanli (ST-36)
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Zhongda Hospital
Painful Diabetic Neuropathy
A Trial to Investigate Safety and Efficacy of SPM927 in Painful Diabetic Neuropathy
The primary purpose is to investigate the safety and efficacy of SPM927 in patients with Painful Diabetic Neuropathy
- Trial name
- NCT00861445
- Testing
- SPM927/Lacosamide
- Volunteers
- 119 people
- Sponsor
- UCB Pharma
Peripheral Arterial Disease(PAD), Arterial Occlusive Disease
Follow-up Study Using Gene Therapy for Critical Limb Ischemia (NL003-CLI-III-L)
The goal of this observational study is to learn about the long-term effects of Donaperminogene Seltoplasmid Injection (NL003) in participants who have been received drug NL003 or placebo at least one dose from the parent phase…
- Conditions
- Peripheral Arterial Disease(PAD), Arterial Occlusive Disease, Arteriosclerosis Obliterans, Thromboangiitis Obliterans
- Trial name
- NCT07023965
- Testing
- NL003
- Where
- 5 sites in China
- Volunteers
- 542 people
- Sponsor
- Beijing Northland Biotech. Co., Ltd.
Diabetes, Diabetic Foot Ulcer
Medico-economical Assessment of Telemedicine During Chronic Diabetes-related Foot Wound Management
The aim of the study is to assess the cost-effectiveness of telemedicine in the care of chronic diabetic foot ulcers. Patients will be randomized into 2 groups: 1/conventional care group with iterative visits to diabetes…
- Trial name
- AIRPEDIA (NCT01814267)
- Testing
- telemedicine, conventional
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Grenoble