Clinical trials: Neuropathy (Disorder)
Vascular Diseases, Peripheral Artery Disease
RECCORD (Recording Courses of Vascular Diseases) Registry
The RECording COurses of vasculaR Diseases registry (RECCORD registry) is an observational, prospective, multicentre, all-comers registry platform.
- Conditions
- Vascular Diseases, Peripheral Artery Disease, Claudication, Critical Limb Ischemia
- Trial name
- RECCORD (NCT03448029)
- Where
- Germany
- Volunteers
- 6,000 people
- Sponsor
- Deutsche Gesellschaft für Angiologie, Gesellschaft für Gefäßmedizin e.V.
Cardiac Amyloidosis
Cardiac Amyloidosis in Spinal Stenosis: the CASS-study
Background: A significant portion of cardiac amyloidosis patients have a 5 to 10 years prior history of spinal canal stenosis, reflecting a diagnostic red flag that should raise suspicion for amyloidosis presence.
- Trial name
- CASS (NCT04653675)
- Where
- Belgium
- Volunteers
- 105 people
- Sponsor
- AZ Sint-Jan AV
Diabetic Neuropathies, Chronic Pain
Optimization of NIBS for Diabetic Neuropathy Neuropathic Pain
The purpose of this study is to assess the effects of Transcranial Direct Current Stimulation (tDCS) in combination with Transcranial ultrasound (TUS) for the treatment of pain and functional limitations in subjects with Diabetic…
- Trial name
- NCT03625752
- Testing
- Active Comparator: Active tDCS + Active TUS
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Case Western Reserve University
Osteoarthritis
Tanezumab In Osteoarthritis Of The Hip Or Knee
The purpose of the study is to test the efficacy and safety of 2 doses of tanezumab compared to oxycodone CR and placebo in patients with osteoarthritis
- Trial name
- NCT00985621
- Testing
- tanezumab 10 mg, tanezumab 5 mg, oxycodone
- Where
- 112 sites in United States, Austria and 5 more
- Volunteers
- 614 people
- Sponsor
- Pfizer
Cubital Tunnel Syndrome, Ulnar Nerve Compression
Randomized Trial of Supercharged End-to-Side Anterior Interosseous Nerve Transfer for Severe Cubital Tunnel Syndrome
Functional motor recovery distal to a peripheral nerve lesion is predicated upon time to reinnervation of the motor end plate and the number of regenerate axons that reach the target.
- Conditions
- Cubital Tunnel Syndrome, Ulnar Nerve Compression, Ulnar Nerve Palsy, Ulnar Nerve Entrapment
- Trial name
- NCT04647058
- Testing
- Cubital tunnel release, Supercharged end-to-side (SETS) nerve transfer
- Where
- 2 sites in United States
- Sponsor
- Brigham and Women's Hospital
Amyloidosis, Amyloidosis Cardiac
NatiOnal Referral cenTEr Study of Transthyretin Amyloid Cardiomyopathy(ATTR) Patients on Tafamidis
All ATTRwt patients on tafamidis 61 mg treatment will be clinically evaluated before treatment initiation and subsequently every six months for the eligibility to continue tafamidis treatment, according to Italian Medicines…
- Conditions
- Amyloidosis, Amyloidosis Cardiac, ATTR Amyloidosis Wild Type
- Trial name
- NOTE-ATTR (NCT06251778)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Paolo Milani
Foot Ulcer, Diabetic
Assessing the Effects of ELO Water on Diabetic Foot Ulcers
This pilot study examined the effects of ELO water, a commercially-available oxygen-enriched drinking water, on wound healing in patients with diabetic foot ulcers over 12 weeks.
- Trial name
- NCT05908968
- Testing
- ELO water
- Where
- Singapore
- Volunteers
- 16 people
- Sponsor
- Changi General Hospital
Diabetic Foot Ulcer, Diabetic Foot
Use of Low-level Laser Therapy in the Treatment of Diabetic Foot Ulcers
Diabetes mellitus (DM) is currently an important cause of morbidity and mortality. Global estimates indicate that 382 million people live with diabetes (8.3%), and that number could reach 592 million in 2035.
- Trial name
- NCT04246814
- Testing
- LG1, LG2, LG3
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Federal University of Piaui
Leukemia, Lymphoma
iPSC Neurons From Adult Survivors of Childhood Cancer Who Have Persistent Vincristine-Induced Neuropathy
This observational study is designed to establish induced pluripotent stem cells (iPSCs) from childhood cancer survivors who did or did not develop persistent treatment-induced peripheral neuropathy, from which to make human…
- Trial name
- NCT02564484
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- St. Jude Children's Research Hospital
Carpal Tunnel Syndrome
Physical Therapy in the Treatment of Carpal Tunnel Syndrome
In the present investigation the pain reduction effects of a physical therapy technique will be compared to those produced by the absence of treatment, in subjects who suffer the signs and symptoms of carpal tunnel syndrome.
- Trial name
- NCT04329247
- Testing
- Median nerve neural mobilization
- Where
- Venezuela
- Volunteers
- 74 people
- Sponsor
- Universidad Europea de Madrid
Hereditary Spastic Paraplegia, Primary Lateral Sclerosis
Spastic Paraplegia - Centers of Excellence Research Network
The Spastic Paraplegia - Centers of Excellence Research Network (SP-CERN) is a collaborative research consortium dedicated to advancing the understanding, diagnosis, and treatment of hereditary spastic paraplegia (HSP) and…
- Conditions
- Hereditary Spastic Paraplegia, Primary Lateral Sclerosis, SPG4, SPG5A
- Trial name
- SP-CERN (NCT06553976)
- Where
- 11 sites in United States
- Volunteers
- 100 people
- Sponsor
- Boston Children's Hospital
Diabetic Foot, Staphylococcal Infections
Standard Treatment Associated With Phage Therapy Versus Placebo for Diabetic Foot Ulcers Infected by S. Aureus
The primary objective of this study is to compare the efficacy of standard treatment associated with a topical anti-staphylococcal bacteriophage cocktail versus standard treatment plus placebo for diabetic foot ulcers…
- Trial name
- PhagoPied (NCT02664740)
- Testing
- Topical anti-Staphylococcus bacteriophage therapy
- Where
- 6 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Carpal Tunnel Syndrome
Dual Task During Exercise for Carpal Tunnel Release
The aim of this study will be to evaluate the effect of the dual task on hand motor performance, pain, functionality and psychosocial factors in patients with carpal tunnel syndrome undergoing surgery.
- Trial name
- DTCTR (NCT05593952)
- Testing
- Dual task, Single task
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- University of Valencia
Amyloid Cardiomyopathy
Amyloidosis TTR Flow Reserve Evaluation
Anginal symptoms and signs of ischemia have been reported in some patients with cardiac amyloidosis (TTR) without obstructive epicardial coronary artery disease (CAD).
- Trial name
- AMYTRE (NCT05103943)
- Testing
- SPECT MPI
- Where
- 4 sites in France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Diabetic Foot
Cost-effectiveness Evaluation of Two 10% Urea Creams in Patients With Diabetic Foot Syndrome
Randomised, double-blind, cost-effectiveness clinical trial of two 10% urea creams purchased in pharmacies and supermarkets in patients with diabetic foot syndrome.
- Trial name
- NCT05588258
- Testing
- Participants were given the 10% urea cream purchased in pharmacy or supermarket as appropriate after randomisation and their foot skin quality was assessed by validated questionnaire.
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Universidad Complutense de Madrid
Carpal Tunnel Syndrome
Investigation of the Efficiency of Radial Extracorporeal Shock Wave Therapy at Different Pulses in Carpal Tunnel Syndrome
Different parameters have been used in studies investigating the efficacy of extracorporeal shock wave therapy in the treatment of carpal tunnel syndrome.
- Trial name
- NCT06321276
- Testing
- extracorporeal shockwave therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Ahi Evran University Education and Research Hospital
Leber Hereditary Optic Neuropathy (LHON)
Gene Therapy Clinical Trial for the Treatment of Leber's Hereditary Optic Neuropathy Associated With ND4 Mutations
The objective of this clinical study is to evaluate the safety and efficacy of NR082 in the treatment of LHON caused by mitochondrial ND4 gene mutation.
- Trial name
- NCT05293626
- Testing
- NR082 Injection, Injection needle
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Neurophth Therapeutics Inc
Carpal Tunnel Syndrome
Preoperative Gabapentine for Carpal Tunnel
The purpose of this study was to evaluate the postoperative analgesic effect of preoperative gabapentine for carpal tunnel syndrome surgery.
- Trial name
- NCT01632215
- Testing
- Gabapentine, Sugar pill
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Carpal Tunnel Syndrome, Electromyography
Comparison of the Efficacy of High Intensity Laser Therapy and Low Level Laser Therapy in the Carpal Tunnel Syndrome
Carpal tunnel syndrome is the most common entrapment neuropathy and is frequently encountered in clinical practice. Although there is no standard protocol for its treatment, conservative treatment methods are preferred.
- Conditions
- Carpal Tunnel Syndrome, Electromyography, Low-Level Laser Therapy, Ultrasound Imaging
- Trial name
- NCT06219876
- Testing
- low level laser treatment, High intensity laser treatment, wrist splint
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Ankara City Hospital Bilkent
Diabetic Foot Ulcers (DFU), Lower Extremity Arterial Occlusion
Efficacy and Safety of Cold Atmospheric Plasma Combined With Endovascular Intervention in Patients With Diabetic Foot Ulcers and Lower Extremity Arterial Occlusion
Critical limb ischemia is the end-stage manifestation of peripheral arterial disease (PAD), frequently presenting as ischemic rest pain, ulceration, or gangrene.
- Trial name
- PROSPECT (NCT07073040)
- Testing
- Cold atmospheric plasma (CAP), Successful infrapopliteal angioplasty
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Shenyang Medical College
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