Clinical trials: Neuropathy (Disorder)
Retinal Detachment, Optic Neuropathy
Effect of Intraocular Tamponade on Visual Perception
Intraocular tamponade used in vitrectomy operations may affects retinal function in various mechanisms.
- Conditions
- Retinal Detachment, Optic Neuropathy, Glaucoma
- Trial name
- NCT05543018
- Testing
- Electroretinogram, Vitrectomy operation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Meralgia Paresthetica
The Efficacy of High-Power Laser Therapy in Meralgia Paresthetica
The management of MP typically follows a conservative pathway, encompassing patient education, lifestyle modifications (e.g., avoidance of tight garments, weight loss), pharmacotherapy (such as neuropathic pain agents or…
- Trial name
- NCT07328360
- Testing
- High-power laser, Standard Conservative Care
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Uşak University
Carpal Tunnel Syndrome
Dextrose, Steroid, PRP: Choosing the Right Injection for CRS Relief; a RCT
USG guided injections to relieve carpal tunnel syndrome with dextrose water or steroid or PRP
- Trial name
- NCT06349824
- Testing
- injection Dextrose water, USG machine
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Sheikh Zayed Medical College
Painful Lumbar Radiculopathy, Healthy
Phase 1 Subcutaneous Single and Multiple Ascending Dose Study of BG00010 (Neublastin)
The primary objective of the study is to evaluate the safety and tolerability of a range of single intravenous (IV) and subcutaneous (SC) doses of BG00010 in healthy volunteers, and a range of multiple SC doses of BG00010 in…
- Trial name
- NCT01842126
- Testing
- BG00010 IV, BG00010 SC
- Where
- Netherlands
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Biogen
Diabetic Foot, Pedal Ulcers
Randomized, Prospective Evaluation of the Toad Brace in Plantar Ulcer Off-loading and Healing
The TOAD Medical Corporation Brace is a novel device that completely off-loads the foot and has been shown to heal ulcers at a rapid rate in preliminary experience in patients with plantar ulcers.
- Trial name
- NCT02052817
- Testing
- Optimal Medical Therapy Debridement + Toad Brace, Optimal Medical Therapy - Debridement
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Toad Medical Corporation
Open Angle Glaucoma
Near to Infrared (NIR) Light Neuroprotection in Glaucomatous Optic Neuropathy
The purpose of the study is to evaluate if near-to-infrared light stimulation can improve retinal ganglion cell function in glaucomatous patients.
- Trial name
- NCT00844389
- Testing
- Near to infrared light retinal stimulation, Green light stimulation
- Where
- Chile
- Volunteers
- 40 people
- Sponsor
- Universidad de Valparaiso
Foot Ulcer, Diabetic
The Effect of Motivational Interviewing on Treatment Adherence, Self-Efficacy, and Satisfaction in Individuals With Diabetic Foot Ulcers
The rise in diabetes incidence has led to a corresponding increase in diabetes-related complications. Diabetic foot ulcers, a severe consequence of diabetes, have substantial impacts on patients, the social environment, overall…
- Trial name
- NCT06023810
- Testing
- Watson's human care theory-based motivational interviewing method
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Okan University
Non Arteritic Ischemic Optic Neuropathy
A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)
Determine whether dalfampridine (Ampyra) can improve visual function in patients who have had nonarteritic ischemic optic neuropathy (NAION) with stable visual impairment.
- Trial name
- Ampyra (NCT01975324)
- Testing
- dalfampridine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Neuro-Ophthalmologic Associates, PC
Piriformis Syndrome
Comparative Effects of Stecco-fascial Manipulation and Rolfing Structural Integration in Patients With Piriformis Syndrome
This study aims to compare the effectiveness of Stecco Fascial Manipulation and Rolfing Structural Integration in treating Piriformis syndrome, focusing on special outcomes like pain severity and functional outcomes.
- Trial name
- Piriformis (NCT07322185)
- Testing
- Experimental: GROUP A ( Stecco fascial Manipulation), Experimental: GROUP B (Rolfing Structural Integration)
- Where
- 3 sites in Pakistan
- Volunteers
- 42 people
- Sponsor
- Danyal Ahmad
Diabetic Foot Ulcers
Omeza Products in Combination With Standard of Care for the Treatment of Diabetic Foot Ulcers
This study is to evaluate the efficacy of OCM™ used in combination with off-loading devices for the treatment of diabetic foot ulcers.
- Trial name
- NCT05417425
- Testing
- Omeza collagen matrix, Omeza lidocaine lavage, Omeza skin protectant
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Omeza, LLC
Carpal Tunnel Syndrome (CTS)
PRP Versus Saline Hydrodissection for CTS RCT
This single-center, single-blind, randomized controlled trial compared two injectates used for ultrasound-guided hydrodissection of the median nerve in adults with carpal tunnel syndrome: autologous platelet-rich plasma (PRP) and…
- Trial name
- NCT07904650
- Testing
- Autologous platelet-rich plasma, Normal Saline (0.9% Sodium Chloride), Ultrasound-guided median nerve hydrodissection
- Where
- Poland
- Volunteers
- 21 people
- Sponsor
- Medical University of Lodz
Carpal Tunnel, Carpal Tunnel Syndrome
Efficacy of Electroacupuncture in Carpal Tunnel Syndrome
The aim of this clinical study is to assess the effectiveness of electroacupuncture in reducing the severity of symptoms, in improving limb function, in improving the aesthetic and motor conduction of the median nerve and in…
- Conditions
- Carpal Tunnel, Carpal Tunnel Syndrome, Pain, Pain Syndrome
- Trial name
- NCT04603274
- Testing
- 8 sessions of electroacupuncture to the upper limb with carpal tunnel syndrome
- Where
- 2 sites in Greece
- Volunteers
- 25 people
- Sponsor
- Aretaieion University Hospital
Diabetic Peripheral Neuropathy, Diabetes Mellitus Type 2
Photobiomodulation for Diabetic Peripheral Neuropathy
Diabetic peripheral neuropathy (DPN) is a common complication of long-term diabetes, affecting approximately 50 percent of patients.
- Trial name
- PBMT-DPN (NCT07613489)
- Testing
- Photobiomodulation Therapy
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- University of Faisalabad
Overactive Bladder
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients
Aims: To evaluate changes in levels of ADRB3, ROCK2, and GEF which have key roles in the adrenergic and cholinergic pathways of contraction-relaxation harmony in voiding physiology, and to investigate the diagnostic potential of…
- Trial name
- NCT04626960
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Scapholunate Advanced Collapse (SLAC), Scapholunate Crystalline Advanced Collapse (SCAC)
The KinematX Midcarpal Total Wrist Arthroplasty Registry
The goal of this observational study is to learn about functional and patient reported outcomes in patient undergoing total wrist replacement with the KinematX total wrist replacement study.
- Conditions
- Scapholunate Advanced Collapse (SLAC), Scapholunate Crystalline Advanced Collapse (SCAC), Scaphoid, Trapezium, and Trapezoid Advanced Collapse (STTAC), Carpal Tunnel Syndrome (CTS)
- Trial name
- NCT05719935
- Testing
- KinematX total wrist arthroplasty system
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Extremity Medical
Leber's Hereditary Optic Neuropathy (LHON)
Post Authorisation Safety Study With Raxone in LHON Patients
This study is a multicentre, prospective, non-interventional post-authorisation safety study (PASS) of the clinical outcomes for patients with LHON treated with Raxone®. No medication will be provided as part of this study.
- Trial name
- PAROS (NCT02771379)
- Testing
- Idebenone
- Where
- 26 sites in Austria, France and 4 more
- Volunteers
- 229 people
- Sponsor
- Santhera Pharmaceuticals
Cancer, Breast Cancer
Assessment of Paclitaxel-Induced Neuropathy
The purpose of this study is to collect clinical data, blood samples, and self reported symptoms from patients that experience unusually severe neuropathy after treatment with paclitaxel.
- Conditions
- Cancer, Breast Cancer, Ovarian Cancer
- Trial name
- NCT01953159
- Testing
- Blood Collection, Patient Questionnaires
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Carpal Tunnel Syndrome, Median Neuropathy, Carpal Tunnel
Role of Inflammation in Carpal Tunnel Syndrome
This study aims to investigate the role of inflammation in carpal tunnel syndrome (CTS) using a prospective cohort study design.
- Trial name
- NCT05852288
- Testing
- Inflammatory markers
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ahram Canadian University
Diabetic Neuropathy
The Effect of Ruboxistaurin on Small Fiber Function
To determine the effect of Ruboxistaurin on small fiber function.
- Trial name
- NCT00190970
- Testing
- Ruboxistaurin
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Chromaderm, Inc.
Charcot Neuroarthropathy
Contact Cast Versus Posterior Slab as Offloading Modality for Charcot Neuroarthropathy
Charcot neuroarthropathy (CN) is a condition in diabetic patients characterized by foot swelling, redness, and a temperature difference exceeding 2˚C compared to the other foot.
- Trial name
- NCT06573554
- Testing
- Total Contact Cast, Posterior Slab
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
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