Clinical trials: Neuropathy (Disorder)
Non-healing Wound, Diabetic Foot Ulcer
Use of AC5® Advanced Wound System in the Treatment of Diabetic Foot Ulcers
The purpose of this clinical evaluation is to collect and compare outcomes data from patients with UT 1A diabetic foot ulcers treated with 510K FDA cleared, commercially available self-assembling peptide, AC5®Advanced Wound…
- Trial name
- NCT06028386
- Testing
- AC5® Advanced Wound System, Fibracol Plus Collagen Dressing
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Arch Therapeutics
Carpal Tunnel Syndrome, Entrapment Neuropathy
Efficacy of Keyhole Approach to Carpal Tunnel Syndrome Under Ambulatory Strategy
Prospective controlled clinical trial in which a minimally invasive microsurgical approach was used following the keyhole principle in 55 patients and 65 hands under local anesthesia and ambulatory strategy.
- Trial name
- NCT03062722
- Testing
- keyhole approach
- Volunteers
- 55 people
- Sponsor
- Ivan Segura Duran
Diabetic Foot Ulcers (DFU), Lower Extremity Arterial Occlusion
Efficacy and Safety of Cold Atmospheric Plasma Combined With Endovascular Intervention for Diabetic Foot Ulcers With Lower Extremity Arterial Occlusion
The goal of this clinical trial is to evaluate whether cold atmospheric plasma (CAP) combined with endovascular intervention can accelerate wound healing and improve safety outcomes in patients aged 18 to 80 years with diabetic…
- Trial name
- NCT07198061
- Testing
- Cold Atmospheric Plasma (CAP), Infrapopliteal Endovascular Revascularisation, Guideline-Based Standard DFU Care
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shenyang Medical College
Alzheimer Disease
Mycose AdminiStration for HealIng Alzheimer NEuropathy (MASHIANE)
Alzheimer's disease (AD) is an irreversible, progressive brain disorder that slowly destroys memory and thinking skills, and, eventually, the ability to function independently.
- Trial name
- MASHIANE (NCT04663854)
- Testing
- Trehalose
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Mashhad University of Medical Sciences
Diabetic Foot Ulcer, Infection
Topical PluroGel PN for the Treatment of Mildly Infected Diabetic Foot Ulcers
This is an open label study of subjects who have failed Protocol PGN-1300. Adult subjects (greater than 18 years old) who present with a mildly infected diabetic foot ulcer (IDSA criteria) having full thickness (i.e., through the…
- Trial name
- NCT02119754
- Testing
- Plurogel PN
- Where
- 15 sites in United States
- Volunteers
- 15 people
- Sponsor
- PluroGen Therapeutics, Inc
Type 2 Diabetes Mellitus, Diabetic Polyneuropathy
Ultrasonographic Evaluation of Talar Cartilage Thickness in Patients With Diabetic Polyneuropathy
This study aimed to evaluate talar cartilage thickness in individuals with diabetic polyneuropathy using ultrasonography and to compare the findings with those of healthy individuals.
- Trial name
- NCT07801131
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Diabetic Foot, DFU
Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers
The purpose of this study is to evaluate the efficacy of human placental membrane products and standard of care versus standard of care alone in the management of nonhealing diabetic foot ulcers and venous leg ulcers.
- Conditions
- Diabetic Foot, DFU, Diabetic Foot Ulcer, Foot Ulcer, Diabetic
- Trial name
- BIOCAMP (NCT07089602)
- Testing
- Standard of Care DFU, Tri-Membrane Wrap™ DFU, Membrane Wrap™ DFU
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- BioLab Holdings
Non-arteritic Anterior Ischemic Optic Neuropathy (NAION), Trauma
Electric Stimulation of the Eye to Improve Vision After Trauma
Transcorneal Electrical Stimulation (TES) using the "OkuStim®" device delivers electrical impulses to damaged and/or diseased photoreceptor cells.
- Conditions
- Non-arteritic Anterior Ischemic Optic Neuropathy (NAION), Trauma, Multiple Sclerosis (MS)
- Trial name
- TES (NCT02019927)
- Testing
- Transcorneal Electrical Stimulation
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Wills Eye
Polyneuropathies
Ultrasonography in Diagnosis of Polyneuropathy
The main goal of this trial is to establish recommendations for clinical practice that enhance the reliability, accessibility and convenience of sheer wave elastography as a routine diagnostic test for diverse peripheral…
- Trial name
- NCT06390527
- Volunteers
- 120 people
- Sponsor
- University Medical Centre Ljubljana
Diabetic Peripheral Neuropathy, Chronic Pain
Safety and Efficacy of AEG33773 Versus Placebo in Patients With Painful Diabetic Peripheral Neuropathy
Two Phase 1 studies have been conducted with AEG33773 and available safety and tolerability data from these studies support further clinical development of AEG33773.
- Trial name
- NCT00891683
- Testing
- AEG33773 oral dosing
- Where
- 20 sites in United States, Bulgaria and 2 more
- Volunteers
- 128 people
- Sponsor
- Aegera Therapeutics
Diabetic Foot Ulcers (DFU), Nutrition Assessment
Nutritional Status in Adults With Diabetic Foot Ulcers
This feasibility and pilot study has two aims. The primary aim is to assess the feasibility of collecting clinical, nutritional, and functional data among adults with diabetic foot ulcers (DFUs) who are treated at an outpatient…
- Conditions
- Diabetic Foot Ulcers (DFU), Nutrition Assessment, Malnutrition (Calorie), Ulcer Foot
- Trial name
- NutriDFU-P (NCT07621770)
- Testing
- Protein supplementation and nutrition education
- Volunteers
- 30 people
- Sponsor
- Hvidovre University Hospital
Dysautonomia
Autonomic Cardiovascular Neuropathy in Recently Diagnosed DM2 Patients (ACNDM2)
The investigators are studying the initial autonomic alterations in participants recently diagnosed with DM2 and in those patients classified as Pre-Diabetes, mainly focused on the baroreceptor sensitivity and on the peripheral…
- Trial name
- ACNDM2 (NCT02931773)
- Testing
- Task Force® Monitor
- Where
- Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Diabetes Mellitus, Diabetic Peripheral Neuropathy
Immunonutrition for Diabetic Foot Ulcers
Diabetes-induced peripheral neuropathy can lead to the development of diabetic foot ulcers (DFUs), which can have a devastating effect on patients' lives and can lead to life threatening infection, amputations, and even death.
- Conditions
- Diabetes Mellitus, Diabetic Peripheral Neuropathy, Diabetic Foot Ulcer
- Trial name
- NCT05281562
- Testing
- Lovaza, L-Arginine Powder, Vitamin C
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Prisma Health-Midlands
Acute Myelogenous Leukemia, Myelodysplastic Syndrome
Dose Escalation/ Expansion Study of CA-4948 as Monotherapy in Patients With Acute Myelogenous Leukemia (AML) or Myelodysplastic Syndrome (MDS)
This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with AML or higher- risk Myelodysplastic Syndrome (hrMDS).
- Trial name
- NCT04278768
- Testing
- Emavusertib, Venetoclax
- Where
- 32 sites in United States, Czechia and 6 more
- Volunteers
- 366 people
- Sponsor
- Curis, Inc.
Amyloid Cardiomyopathy
Genistein in trAnSthyretin recePtor Amyloid caRdiomyopathy
This Phase 1b/2a study aims to investigate the safety and efficacy of genistein in patients with Transthyretin (TTR) Amyloidosis.
- Trial name
- GASPAR (NCT06634108)
- Testing
- Genistein
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Diabetic Foot
A Randomized Trial on Platelet Rich Plasma Versus Saline Dressing of Diabetic Foot Ulcers
New treatments for persistent DFU have emerged, among which are the bioengineered skin substitutes, extracellular matrix proteins products, matrix metalloproteinases modulators, and growth factor therapy.
- Trial name
- NCT04090008
- Testing
- PRP gel, Saline dressing
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Mansoura University
Lymphocytic Leukemia, Chronic, Lymphoma, Small Lymphocytic
Duvelisib With Obinutuzumab in Patients With CLL/SLL Previously Treated With a BTKi (SYNCHRONY)
To evaluate the safety, pharmacokinetics, and pharmacodynamics of Duvelisib (IPI-145) in combination with obinutuzumab in patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma previously treated with a BTKi.
- Trial name
- NCT02292225
- Testing
- IPI-145 (duvelisib), Obinutuzumab
- Where
- 7 sites in United States, Canada
- Volunteers
- 3 people
- Sponsor
- SecuraBio
Diabetic Foot Ulcer
A Clinical Intervention Study of Tangningtongluo on Diabetic Foot Ulcer
Purpose and significance:With the increasing incidence of Diabetes mellitus (DM), the incidence rate of Diabetic Foot (DF) is raised.
- Trial name
- NCT05145140
- Testing
- Standardized Western Medicine Treatment, Tangningtongluo tablet and cream, Tangningtongluo tablet
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Affiliated Hospital of Nantong University
Charcot-Marie-Tooth Disease, Type IA, Charcot-Marie-Tooth Disease Type 2A
Muscle MRI in Charcot Mary Tooth Disease: a Prospective Cohort Study
This cohort study (participants with CMT and control participants) has two parts (Part 1: CMT1A cohort; Part2: CMT1B, CMT2A and CMTX1 cohort) and is proposed to take place over 3 years across three sites.
- Conditions
- Charcot-Marie-Tooth Disease, Type IA, Charcot-Marie-Tooth Disease Type 2A, Charcot-Marie-Tooth Disease, Type IB, Charcot-Marie-Tooth Disease, Type X
- Trial name
- NCT03550300
- Where
- United Kingdom
- Volunteers
- 130 people
- Sponsor
- University College, London
Diabetic Polyneuropathy
Study of Physical Therapy in Patients With Diabetic Polyneuropathy
Sensorimotor diabetic polyneuropathy is a common and serious complication of longstanding diabetes mellitus. The therapeutic options are limited (pain therapy, antidepressants, physical measures using direct current such as two…
- Trial name
- NCT05622630
- Testing
- Four-cell bath, Gravel bath
- Where
- Germany
- Volunteers
- 68 people
- Sponsor
- Paracelsus Harz Clinic Bad Suderode.
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