Clinical trials: Neurophysiology
Chronic Low Back Pain (CLBP)
Pain Neurophysiology Education in Chronic Low Back Pain
The investigators conducted a randomized controlled study including 22 patients suffering from chronic common low back pain. Patients were randomized into 2 groups: Control group received conventional rehabilitation only (11…
- Trial name
- PNE-LBP (NCT06915532)
- Testing
- Pain Neurophysiology Education, conventional rehabilitation
- Where
- Tunisia
- Volunteers
- 22 people
- Sponsor
- Hopital Charles Nicolle
Adhesive Capsulitis, Frozen Shoulder
Electrophysiologic Changes After Extended 360° Capsular Release
Frozen shoulder (adhesive capsulitis) is a condition characterized by shoulder pain and restricted range of motion, significantly impairing daily living activities.
- Trial name
- FROZEN-EMG (NCT07495306)
- Testing
- Arthroscopic 360° Capsular Release
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Acibadem University
Failed Back Surgery Syndrome (FBSS), Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine
Evaluation of Medication Tapering on the Sensitivity of the Spinal Cord Using Closed-Loop Spinal Cord Stimulation (Pilot Study)
This pilot study investigates the effects of reducing pain medication including opioids and anticonvulsants, on spinal cord sensitivity during closed-loop spinal cord stimulation (SCS).
- Conditions
- Failed Back Surgery Syndrome (FBSS), Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine, Neurophysiological Sensitivity to Spinal Cord Stimulation
- Trial name
- ECAP-MED Pilot (NCT07502612)
- Testing
- Spinal Cord Stimulation with Evoke Closed-Loop System
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Brai²n
Craniotomy, Seizures
Propofol-remifentanyl Versus Dexmedetomidine in Awake Craniotomy: Impact on Electroclinical Seizure Activity
Awake craniotomy require a cooperative patient during resection neurosurgery phase. Anesthesiologist should guarantee analgesia, sedation, nausea and vomiting prevention, while maintaining normal vital parameters.
- Conditions
- Craniotomy, Seizures, Dexmedetomidine, Propofol
- Trial name
- NCT05103735
- Testing
- Propofol
- Where
- Italy
- Volunteers
- 170 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Intracranial Hemorrhages, Prematurity
Neurophysiology and Anatomy of Severe Intraventricular Hemorrhage (IVH)
Currently, when premature infants develop severe intraventricular hemorrhage (IVH), a type of intracerebral bleed, there are no proven therapeutic interventions to prevent the devastating consequences of this event.
- Trial name
- NCT00817310
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University
Acquired Brain Injury, Traumatic Brain Injury
Pilot Trial for Adults With Acquired Brain Injury
This pilot study will compare a yoga program to a non-yoga exercise program in adults with brain injuries. The investigators will measure possible improvements in balance and heartrate.
- Conditions
- Acquired Brain Injury, Traumatic Brain Injury, Stroke
- Trial name
- RCT (NCT05793827)
- Testing
- Adapted Hatha Yoga, Low-Impact Exercise
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Colorado State University
Ischemic Stroke, Acute, Treatment Outcome
Effect of Early Versus Late Initiation of Edaravone Dexborneol on Neural Function in Patients With Acute Ischemic Stroke
The primary objective of this study was to evaluate the efficacy and safety of initiation of edaravone dextivel therapy compared with placebo in patients with acute ischaemic stroke (early and late) and to explore the optimal…
- Trial name
- EARLYS (NCT05885919)
- Testing
- Edaravone Dexborneol Concentrated Solution for injection
- Where
- 3 sites in China
- Volunteers
- 212 people
- Sponsor
- Xiangya Hospital of Central South University
Cognitive Change
Impact of Challenging Engagement on Cognition in Older Adults
The study will enroll 90 participants in the "Impact of Challenging Engagement" study and assign them to one of three groups: high-demand photography, moderate-demand photography, and active placebo.
- Trial name
- engAGE (NCT03962439)
- Testing
- High-Demand Photography, Moderate-Demand Photography, At-Home Engagement
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Chronic Pain, Living Kidney Donor
The Effect of Quadratus Lumborum (QL) Block on the Incidence of Chronic Neuropathic Pain After Retroperitoneal Laparoscopic Donor Nephrectomy: A Study on Neuroinflammation and Neurophysiology
To analyze the relationship of anterior subcostal quadratus lumborum (QL) block compared with control block on the incidence of chronic neuropathic pain at three months post-laparoscopic retroperitoneal living kidney donor.
- Conditions
- Chronic Pain, Living Kidney Donor, Quadratus Lumborum Block, Laparoscopic Donor Nephrectomy
- Trial name
- NCT07037992
- Testing
- injection of local anesthesia solution, Injection of normal saline
- Where
- Indonesia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Ankle Injuries
Neurophysiology of Ankle Instability
Chronic ankle instability (CAI) is a common debilitating orthopedic condition that disrupts physical function and decreases quality of life. Not all CAI is the same.
- Trial name
- NCT06576687
- Testing
- Physical Rehabilitation
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Parkinson Disease
Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation
The study aims to investigate cognitive impairment associated with Deep Brain Stimulation (DBS) in Parkinson's Disease patients, with a focus on identifying neurophysiology biomarkers of DBS associated cognitive changes.
- Trial name
- NCT05933681
- Testing
- Neural recordings and stimulation
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Vanderbilt University Medical Center
Alzheimer Disease
40Hz tACS in Treating Cognitive Function and Modulating Neurophysiology of Patients With Alzheimer's Disease
Gamma brain activity is crucial for cognitive function and intra-brain communication. Gamma frequency stimulation via transcranial alternating current stimulation(tACS) might alleviate memory deficits on both animal models of…
- Trial name
- NCT05723172
- Testing
- active tACS
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- Che-Sheng Chu
Neuroscience, Movement Disorders
Metabotropic Receptors For Glutamate Type 3 In Parkinson's
Parkinson's disease (PD) is characterized by bradykinesia, rigidity, and tremor. Several scientific pieces of evidence, based on the use of kinematic techniques, have allowed quantifying objectively the alterations of the…
- Trial name
- NCT03998787
- Testing
- Neurophysiological assessment
- Volunteers
- 40 people
- Sponsor
- Neuromed IRCCS
Neurodevelopmental Disorders
Individual Neurophysiological Sensory Profiles in People With and Without Neurodevelopmental Disorders
The goal of this observational study is to evaluate intra-individual neurophysiological variability in children and adults with and without NeuroDevelopmental Disorders (NDD), for several sensory modalities and types of…
- Trial name
- SensAUry (NCT07542977)
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Stroke
Clinical Predictors of Rehabilitation-induced Arm Recovery After Stroke: Longitudinal Cohort Study
Clinical predictors of rehabilitation-induced arm recovery after stroke are still missing since literature provides evidence mainly on the spontaneous recovery path.
- Trial name
- NeuroPro (NCT05423119)
- Testing
- conventional therapy
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Chronic Low Back Pain
Efficacy of Education on Neurophysiology of Pain Combined to Hypnosis in Patients With Chronic Low Back Pain
Although education on neurophysiology of pain improves disability, there are limited effects in pain intensity. Hypnosis is an approach that has proven useful in pain intensity and psychosocial aspects in some chronic pain…
- Trial name
- NCT02638753
- Testing
- education, education combined with hypnosis
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Universidade Cidade de Sao Paulo
Parkinson Disease
Neurophysiology of Reward Signaling in Parkinson's Disease
The goal of this study is to learn more about the brain activity underlying Parkinson's disease risk taking and reward seeking behaviors.
- Trial name
- NCT07409207
- Testing
- Neurophysiology recordings, Neural stimulation
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Vanderbilt University Medical Center
Stroke
Structurally Reorganizing Motor Cortex in Stroke Patients Through Hebbian-type Stimulation
Stroke is a leading cause of morbidity in the United States but identification of treatment strategies to improve outcome is limited by the incomplete understanding of the mechanisms of recovery.
- Trial name
- NCT01569607
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Cathrin Buetefisch
Neck Pain
Pain Neurophysiology Education and Exercise for Adolescents With Chronic Idiopathic Neck Pain
This study compared the effectiveness of pain neurophysiology education and neck/shoulder exercises with no intervention in adolescents with chronic idiopathic neck pain (CINP).
- Trial name
- NCT02827994
- Testing
- neurophysiology of pain education and exercises
- Volunteers
- 43 people
- Sponsor
- Aveiro University
Usher Syndrome, Cochlear Implantation
Auditory Neural Function in Implanted Patients With Usher Syndrome
Usher syndrome (USH) causes extensive degeneration in the cochlear nerve (CN), especially in CN fibers innervating the base of the cochlea.
- Trial name
- NCT04906135
- Testing
- Experimental manipulation of stimulation parameters
- Where
- 4 sites in United States
- Volunteers
- 29 people
- Sponsor
- Ohio State University