Clinical trials: Neuroprotection
Aortic Stenosis, Cerebral Ischaemic Injury
Perioperative Intensive Statin Therapy for Neuroprotection in TAVR（PISTNT）
Transcatheter aortic valve replacement (TAVR) has become the most anticipated treatment method in the cardiovascular field in recent years, experiencing rapid development.
- Trial name
- PISTNT (NCT07087379)
- Testing
- Intensive statin treatment
- Volunteers
- 500 people
- Sponsor
- Pan Xiangbin
Acute Brain Injury, Transcutaneous Vagus Nerve Stimulation
The Role of Transcutaneous Vagus Nerve Stimulation in Treatment of Acute Brain Injury
Acute brain injury is a major global health problem associated with high mortality and morbidity, limited therapeutic options, prolonged hospital stays, and long-term disability that significantly impairs quality of life and…
- Conditions
- Acute Brain Injury, Transcutaneous Vagus Nerve Stimulation, Neuromodulation, Immunomodulation
- Trial name
- NCT07384845
- Testing
- transcutaneous vagus nerve stimulation (tVNS)
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- Clinical Hospital Centre Zagreb
Cerebrovascular Accident
Field Administration of Stroke Therapy - Magnesium (FAST-MAG) Trial
The goal of this study is to evaluate the effectiveness and safety of field-initiated magnesium sulfate in improving the long-term functional outcome of patients with acute stroke.
- Trial name
- FAST-MAG (NCT00059332)
- Testing
- Magnesium Sulfate, Normal Saline
- Where
- United States
- Volunteers
- 1,700 people
- Sponsor
- Jeffrey L. Saver
Hypoxic-ischemic Encephalopathy
Neonatal Erythropoietin in Asphyxiated Term Newborns
The purpose of this study is to determine the safety and pharmacokinetics of moderate to high doses of erythropoietin in newborn infants with birth asphyxia.
- Trial name
- NEAT (NCT00719407)
- Testing
- erythropoietin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, San Francisco
Ischemic Cerebrovascular Disease, Acute Ischemic Stroke
Efficacy and Safety of Calculus Bovis Sativus (CBS) for Ischemic Cerebral Vascular Disease (CBSinICVD)
The most common cause of death for Chinese patients is ischemic cerebrovascular diseases(ICVD), particularly cerebral infarction.
- Conditions
- Ischemic Cerebrovascular Disease, Acute Ischemic Stroke, Cerebral Small Vessel Diseases
- Trial name
- NCT06474507
- Testing
- Calculus bovis sativus (CBS)
- Where
- 2 sites in China
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Hypoxic Ischaemic Encephalopathy
Xenon and Cooling Therapy in Babies at High Risk of Brain Injury Following Poor Condition at Birth
This study examines the effect of inhaled xenon gas in the treatment of newborn infants with hypoxic-ischemic encephalopathy (HIE) in combination with cooling, which is the standard treatment for this condition.
- Trial name
- CoolXenon3 (NCT02071394)
- Testing
- Xenon gas, Whole body cooling
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospitals Bristol and Weston NHS Foundation Trust
Relapsing-remitting Multiple Sclerosis
Sunphenon Epigallocatechin-gallate (EGCg) in Relapsing-remitting Multiple Sclerosis (SuniMS Study)
Hypothesis: Sunphenon, a green tea extract containing 95% egcg, given daily as oral medication over a period of 18 months has anti-inflammatory and neuroprotective properties in patients with relapsing-remitting multiple…
- Trial name
- SuniMS (NCT00525668)
- Testing
- epigallocatechin-gallate (Sunphenon)
- Where
- 2 sites in Germany
- Volunteers
- 120 people
- Sponsor
- Charite University, Berlin, Germany
Hypoxic Ischemic Encephalopathy
Safety and Efficacy of Topiramate in Neonates With Hypoxic Ischemic Encephalopathy Treated With Hypothermia
The purpose of this study is to determine whether the administration of topiramate to newborns with hypoxic-ischemic encephalopathy potentiates the neuroprotective effect of treatment with hypothermia.
- Trial name
- NeoNATI (NCT01241019)
- Testing
- Topiramate in newborns with hypoxic ischemic encephalopathy treated with therapeutic hypothermia
- Where
- 2 sites in Italy
- Volunteers
- 64 people
- Sponsor
- Meyer Children's Hospital IRCCS
Cardiac Arrest, Return of Spontaneous Circulation
Post-CA Neuroprotection With Magnesium
The purpose of this pilot interventional study is to collect preliminary data on administering magnesium sulfate as a neuroprotective medication in patients who achieved Return of Spontaneous Circulation (ROSC) following Cardiac…
- Trial name
- NCT06455514
- Testing
- Magnesium Sulfate, Saline
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- NYU Langone Health
Glaucoma, Neuroprotection
Effect of Fixed Combination Citicoline Homotaurine and Pyrroloquinoline Quinone on Pattern-electroretinogram in Glaucoma
The goal of this clinical trial is to examine the effect of the fixed combination Citicoline 500 mg, Homotaurine 50 mg, Pyrroloquinoline quinone (PQQ) disodium salt (Neuprozin Mito®) on pattern electroretinogram (PERG) in…
- Trial name
- NCT06431113
- Testing
- Citicoline 500 mg plus Homotaurine 50 mg plus Pyrroloquinoline quinone (Neuprozin Mito® )
- Where
- 2 sites in Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Perinatal Asphyxia
Melatonin for Neuroprotection Following Perinatal Asphyxia
The aim of this study is to examine the effect of combining melatonin to whole body cooling on the brain injury and outcome of neonates following perinatal asphyxia.
- Trial name
- NCT02071160
- Testing
- Melatonin
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Tanta University
Open Angle Glaucoma, Primary Open Angle Glaucoma
Topical Insulin for Glaucoma (TING2)
This study evaluates the safety and preliminary efficacy of topical sterile human insulin eye drops (EYED-002) in patients with open-angle glaucoma.
- Conditions
- Open Angle Glaucoma, Primary Open Angle Glaucoma, Low Tension Glaucoma, Pigmentary Glaucoma
- Trial name
- NCT07619482
- Testing
- EYED-002 Low Dose (721 U/mL topical insulin), EYED-002 High Dose (1442 U/mL topical insulin), EYED-002 (highest tolerated dose, 12-month)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Stanford University
Ischemic Stroke
Superselective Citicoline and Verapamil for Ischemic Neuroprotection and Greater Effective Response
This is a phase 1, blinded-outcome, randomized, placebo controlled study to investigate the safety and feasibility of super-selective intra-arterial administration of verapamil and citicoline immediately following successful…
- Trial name
- SCAVINGER (NCT02823106)
- Testing
- Verapamil and Citicoline
- Where
- United States
- Sponsor
- Justin Fraser
Multiple Sclerosis
A Study of the MIND Diet for Persons With Multiple Sclerosis
This study will assess the impact of a MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet on brain health and MS symptoms.
- Trial name
- NCT06992115
- Testing
- Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet, Small Group
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Primary Open Angle Glaucoma (POAG), Open-Angle Glaucoma
A Study Investigating Oral Semaglutide in People with Open-Angle Glaucoma
The aim of this clinical trial is to investigate whether oral semaglutide can be used to treat open-angle glaucoma. The main question it aims to answer is: Does oral semaglutide safely improve inner retinal function in patients…
- Conditions
- Primary Open Angle Glaucoma (POAG), Open-Angle Glaucoma, Glaucoma
- Trial name
- ABSALON (NCT06792422)
- Testing
- Oral semaglutide
- Where
- Denmark
- Volunteers
- 126 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Age-Related Macular Degeneration
Effect of Saffron Supplementation on Macular Cone-mediated Function in Age-related Macular Degeneration
This is a pilot interventional study whose aim is to determine the effect of a dietary supplementation with a Crocus Sativus extract, Saffron, on macular cone-mediated function in patients with early age-related macular…
- Trial name
- safAMD (NCT00951288)
- Testing
- Saffron
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Catholic University of the Sacred Heart
Acute Stroke, Ischemic Stroke, Acute
The Prehospital Administration of Normobaric Oxygen in Suspected Stroke
The primary purpose of this study is to explore the feasibility and safety of normobaric oxygen therapy (NBO) under pre-hospital condition in patients with suspected stroke.
- Trial name
- NO SUSPENSION (NCT05351073)
- Testing
- NBO
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Capital Medical University
Neonatal Respiratory Failure
Hypothermia During ECMO to Decrease Brain Injury
Newborn infants with severe respiratory failure are treated with extracorporeal membrane oxygenation (ECMO), a modified form of cardiopulmonary bypass.
- Trial name
- NCT01675388
- Testing
- Hypothermia
- Where
- United States
- Sponsor
- Sood, Beena G., MD, MS
Multiple Sclerosis, Optic Neuritis
Neuroprotection and Repair in Optic Neuritis
The primary aim of this open-label pilot trial is to estimate the treatment effect of 100 mg of oral minocycline twice daily for 90 days, initiated within 30 days of onset of ON, on functional and structural optic nerve recovery…
- Trial name
- Mino in ON (NCT01073813)
- Testing
- Minocycline
- Volunteers
- 6 people
- Sponsor
- University of Calgary
Cardiac Arrest, Hypoxic Ischemic Brain Injury
TIBOHCA: Safety, Tolerability and Pharmacokinetics of 2-Iminobiotin (2-IB) After OHCA
Following successful cardiopulmonary resuscitation (CPR) after out of hospital cardiac arrest (OHCA), 50% of patients admitted to the Intensive Care Unit (ICU) die.
- Trial name
- TIBOHCA (NCT02836340)
- Testing
- 2-Iminobiotin
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)