Clinical trials: Neuropsychiatric Disorders
Global Developmental Delay
Virtual Reality and Neuropsychiatric Rehabilitation in Patients With Global Developmental Delay.
Global Developmental Delay is a disorder characterized by failure achievement of expected milestones in different areas of psychomotor development before 5 years of age.
- Trial name
- NCT05879952
- Testing
- TAU + BTsN session, TAU
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Colorectal Cancer
Longitudinal Study of Symptoms in Colorectal Cancer
The goal of this research study is to learn more about the pain and/or other symptoms that patients may experience within five years from CRC diagnosis.
- Trial name
- NCT00777192
- Testing
- Questionnaires
- Where
- United States
- Volunteers
- 509 people
- Sponsor
- M.D. Anderson Cancer Center
Aging, Dementia
Exploring Use of Companion Robot Pets for Older Adults in Care Homes
This study will assess the use and impact of the affordable 'Joy for All' robot pets for older people with and without dementia living in the care homes in South West England.
- Conditions
- Aging, Dementia, Neuropsychiatric Symptoms, Wellbeing
- Trial name
- NCT04168463
- Testing
- Two Joy for All robots (one cat and one dog)
- Where
- United Kingdom
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Psychiatric Disorder, Benzodiazepine-Related Disorders
Impact of Long Term of Benzodiazepine Use on Psychiatric Manifestation
Benzodiazepines are usually a secondary drug of abuse-used mainly to augment the high received from another drug or to offset the adverse effects of other drugs.
- Trial name
- NCT04792658
- Testing
- Detailed interview with personal demographic data, Intelligence assessment using the Arabic version of the Wechsler Adult Intelligence Scale (WAIS), The Arabic version of the Structured Interview for the Five-Factor Personality Model (SIFFM)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Mild Cognitive Impairment, Behavioral Symptoms
The Moderating Roles of Social Support, Coping Resources and Personality and Mediating Role of Self-esteem on the Impact of Cognitive Deficit on Neuropsychiatric Symptoms Among Persons With Mild Cognitive Impairment: A Mixed-method Sequential Explanatory Design
This is a sequential mixed study to test the hypothesized models with seven hypotheses of the relationship between cognitive deficit (subject and objective) and neuropsychiatric symptoms (NPS) among persons with mild cognitive…
- Trial name
- NCT04085107
- Testing
- Face-to-face interviews
- Where
- Hong Kong
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Mental Disorder
Neuropsychiatric Effects of Interferon-Alpha and Ribavirin
Use of the drug interferon-alpha (IFN-A), is associated with frequent and well characterized side effects like neurotoxicity. Neurotoxicity can cause symptoms of depression, agitation, anxiety, and/or confusion.
- Trial name
- NCT00001547
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Institute of Mental Health (NIMH)
PANS, PANDAS
Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS): Clinical Characterization and Prospective Course
This study is a brief (3 month) longitudinal study following children between the ages of 4-16 years old who have been diagnosed with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS).
- Trial name
- NCT04382716
- Testing
- No intervention
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Minnesota
COVID-19-Associated Encephalitis, Long COVID
Longterm Influence of Pediatric Long COVID Syndrome
We enroll pediatric patients who were diagnosed COVID-19 for main observation target. We will perform brain MRI and neuropsychiatric evaluation 4-6 months after COVID-19 diagnosed.
- Trial name
- NCT05566392
- Testing
- Brain MRI
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Multiple Sclerosis, Alzheimer's Disease
PET Brain Imaging in Multiple Sclerosis, Alzheimer's Disease, and Other Neurological and Neuropsychiatric Diseases
The specific aims of the study are: Primary: To determine the presence and regional distribution of microglial activation, as assessed by Fluorine-18 (18F) labeled "Peripheral Benzodiazepine Receptor 06" (PBR06) -PET, in subjects…
- Trial name
- MAPET (NCT02649985)
- Testing
- [F-18]PBR06, [C-11]PBR28
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Impulse Control Disorder
Remission of ICD by Switching Dopamine Agonist to Levodopa/Carbidopa
The purpose of this study is to see whether the ICDs(Impulse Control Disorder) are improved and neuropsychiatric traits related to ICD are changed or not when switching dopamine agonist to levodopa/carbidopa in patients with…
- Trial name
- REIN-PD (NCT01683253)
- Testing
- Levodopa/Carbidopa(200mg/50mg), Dopaminergic Agonists
- Where
- 5 sites in South Korea
- Volunteers
- 150 people
- Sponsor
- Sandoz
Multiple Sclerosis
Cortical Inhibition in Patients With Multiple Sclerosis
1. To investigate the relationship between corticospinal inhibition and clinical, psychological, and cognitive features in MS patients. 2.
- Trial name
- NCT07128160
- Testing
- Clinical and Demographic Assessment, Corticospinal Inhibition Assessment, Radiological Assessment
- Volunteers
- 50 people
- Sponsor
- Assiut University
Obsessive-Compulsive Disorder, Treatment Resistant Disorders
Rituximab for Obsessive-compulsive Disorder. (RITS-PO-2019)
This study evaluates the addition of rituximab to 12 patients diagnosed with treatment resistant obsessive-compulsive disorder in an open trial.
- Trial name
- NCT03983031
- Testing
- Rituximab
- Where
- 2 sites in Sweden
- Volunteers
- 11 people
- Sponsor
- Region Örebro County
Dementia, Neurocognitive Disorders
Effectiveness and Cost-Effectiveness of Robot Therapy With the Paro Robot in People Living With Dementia
The purpose of this study is to evaluate the effectiveness and cost-effectiveness of group robot therapy with the PARO therapy robot in terms of quality of life and neuropsychiatric symptoms in people living with dementia in…
- Conditions
- Dementia, Neurocognitive Disorders, Mild Cognitive Impairment
- Trial name
- NCT05884424
- Testing
- PARO Therapy Robot
- Where
- 15 sites in Spain
- Volunteers
- 123 people
- Sponsor
- Instituto de Mayores y Servicios Sociales (IMSERSO)
Toxoplasmosis in Neuropsychiatric Disorders
Toxoplasma Gondii Seroprevalence Among Children With Some Neuropsychiatric Disorders
Toxoplasma gondii is recognized as being involved in the etiology of various psychotic disorders including epilepsy and ADHD (Markovitz et al.,2015).
- Trial name
- NCT06980298
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sohag University
Cadmium Exceeds the Standard
Study on Neuropsychiatric Behavior in Cadmium-exposed People
This study hypothesized that excessive cadmium is related to clinical pain, depression, and cognitive impairment, and that related indicators will improve after cadmium is eliminated.
- Trial name
- NCT06572566
- Testing
- Non-invasive examination and assessment.
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Jianersheng (Zhuhai) Pharmaceutical Technology Co., Ltd.
Huntington Disease
Assessing Efficacy of Neuropsychiatric Assessment and Treatment Protocols in Huntington's Disease Patients
Phase A: Recruit 50 patients with HD, and their caregivers, to complete a neuropsychiatric and quality of life battery of scales at baseline.
- Trial name
- NCT03417583
- Testing
- Protocol Intervention Group
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Intracranial Aneurysm
Supraphysiologic Insulin to Improve Outcomes After Surgical Treatment of Unruptured Cerebral Aneurysms
We hypothesize that in patients undergoing surgical treatment of unruptured intracranial aneurysms, the increase in blood sugar as a result of surgical stress is detrimental to outcome, as measured by blood levels of proteins…
- Trial name
- NCT00615381
- Testing
- Insulin
- Where
- United States
- Sponsor
- Northwestern University
Dementia
Tailored Activity Program-Veterans Affairs
The Tailored Activity Program - Veterans Administration is a Phase III efficacy trial designed to reduce behavioral symptoms in Veterans with dementia living with their caregivers in the community.
- Trial name
- NCT01357564
- Testing
- Tailored Activity Program, Attention Control
- Where
- United States
- Volunteers
- 322 people
- Sponsor
- VA Office of Research and Development
Type 2 Diabetes Mellitus, Non-Proliferative Diabetic Retinopathy
Blood-retinal Barrier Imaging and Neuropsychiatric Sequela in Type 2 Diabetes Mellitus
In Type 2 Diabetes mellitus patients we will: 1. quantify vasculopathy and blood-retinal barrier (BRB) leakage 2. measure blood-brain barrier (BBB) permeability and neuroanatomical changes 3.
- Conditions
- Type 2 Diabetes Mellitus, Non-Proliferative Diabetic Retinopathy, Diabetic Macular Edema
- Trial name
- NCT01107132
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Soroka University Medical Center
HIV Infections
The Neuropsychiatric Evaluation of HIV-Positive and Negative Drug Using Individuals: Study 215
The lack of success in treating substance abuse may be contributed to by a limited understanding of the clinical neurobiology of drug abuse.
- Trial name
- NCT01034800
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)