Clinical trials: Neurosurgery
Spinal Dural Defect, Cerebrospinal Fluid Leakage
Dural Medical Adhesive for Watertight Sealing in Dural Repair
This is a prospective, multicenter, single-blind, randomized controlled superiority clinical trial of dural medical adhesive for watertight sealing after primary spinal dural repair to prevent cerebrospinal fluid (CSF) leakage.
- Conditions
- Spinal Dural Defect, Cerebrospinal Fluid Leakage, Spinal Neurosurgery
- Trial name
- NCT07754344
- Testing
- Dural medical adhesive, Standard dural reinforcement surgery
- Where
- 6 sites in China
- Volunteers
- 141 people
- Sponsor
- Medprin Regenerative Medical Technologies Co., Ltd.
Recurrent Glioblastoma
Improving Tumor Treating Fields Treatment for Brain Cancer Patients With Skullremodeling Surgery (Neurosurgery)
The aim of this trial is to test a new potential treatment, skullremodeling surgery (SR-surgery) combined with tumor treating fields (TTFields), for patients with first recurrence of malignant brain tumor (first recurrence of…
- Trial name
- OptimalTTF-2 (NCT04223999)
- Testing
- Skullremodeling surgery, Control
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Anders Rosendal Korshøj
Ascorbic Acid, Neurosurgical Procedures
Effect of Vitamin C on Postoperative Pulmonary Complications After Intracranial Tumor Surgery
The goal of this clinical trial is to investigate the effect of perioperative administration of vitamin C on postoperative pulmonary complications, with the aim of providing a safe and effective medication regimen for the…
- Conditions
- Ascorbic Acid, Neurosurgical Procedures, Humans, Ventilator-Induced Lung Injury
- Trial name
- NCT06421688
- Testing
- Ascorbic acid, Saline
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Qianfoshan Hospital
Brain Tumor, Hydrocephalus
Linking Digital Smartphone Behaviour With Brain Function
This study will thus examine daily behaviour based on smartphone use and link it to the neurological and neuropsychological status as well as to neuroradiological studies that are part of the clinical routine.
- Conditions
- Brain Tumor, Hydrocephalus, Arteriovenous Malformations
- Trial name
- SmartSurgery (NCT03516162)
- Testing
- There is no study-specific intervention
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Brain Metastases
Intraoperative Radiotherapy After the Resection of Brain Metastases
INTRAMET examines prospectively the effectiveness of an intraoperative radiotherapy immediate after the surgical resection of brain metastases.
- Trial name
- INTRAMET (NCT03226483)
- Testing
- Intraoperative Radiotherapy
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Universitätsmedizin Mannheim
Neurosurgical Procedures, Neurosurgical Patients
Prolonged Mechanical Ventilation in Neurosurgical Patients:
The study was carried out at the neurosurgical operating theater and neurosurgical intensive care unit, Maharaj Nakorn Chiang Mai University-Hospital.
- Conditions
- Neurosurgical Procedures, Neurosurgical Patients, Prolonged Mechanical Ventilation
- Trial name
- NCT06591624
- Testing
- Prolonged Mechanical Ventilation, remain intubation after surgery
- Where
- Thailand
- Volunteers
- 340 people
- Sponsor
- Chiang Mai University
Brain Neoplasms
Improving Surgical Outcomes in Patients With Low Grade Gliomas Using Advanced Pre- and Intra-operative MRI
This aim of this study is to improve the outcomes for patient with gliomas undergoing neurosurgery by maximising the extent of resection whilst minimising neurological morbidity.
- Trial name
- NCT02884947
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- University College, London
Neurosurgery, Orthopedic Surgery
Impact of Tranexamic Acid on Red Blood Cell Transfusion in Spinal Surgery
Spinal surgery may be associated with substantial blood loss which often requires erythrocyte transfusion. Transfusion of red blood cells (RBC) is not free of adverse events and has been associated with increased risks of…
- Conditions
- Neurosurgery, Orthopedic Surgery, Red Blood Cell Transfusion
- Trial name
- NCT01258010
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 99 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Spontaneous Subarachnoid Hemorrhage
Time to Specialized Admission in Case of Severe Brain Haemorrhage.
Spontaneous subarachnoid haemorrhages (SAH) are a particularly severe type of stroke with a tendency to affect younger individuals than other types of stroke.
- Trial name
- NCT03786068
- Where
- Denmark
- Volunteers
- 262 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Intracranial Aneurysm
The Helsinki Unruptured Intracranial Aneurysm Quality of Care Study
A research-initiated prospective cohort study with the aim to assess the effectivity, safety and long-term outcomes after surgical and endovascular treatment of unruptured intracranial aneurysms.
- Trial name
- HUIQE (NCT06147102)
- Testing
- Surgery, Endovascular
- Where
- Finland
- Volunteers
- 173 people
- Sponsor
- Helsinki University Central Hospital
Supratentorial Neoplasms, Brain Tumor, Primary
Comparison of Stroke Volume Variation-guided Normovolemic and Restrictive Fluid Management During Craniotomy: a Randomized Controlled Trial
Fluid management during neurosurgery presents a special clinical agenda. Volume overload can have detrimental effects on intracranial pressure by increasing either cerebral blood volume or hydrostatically driven cerebral edema…
- Conditions
- Supratentorial Neoplasms, Brain Tumor, Primary, Craniotomy
- Trial name
- NCT02113358
- Testing
- Intravenous colloid bolus with Voluven
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Tumor, Cerebral Ventricle, Tumor, Cerebellar
Post Market Clinical Follow-Up Study on the Performance and Safety of Lyoplant®
Retrospective, single center, single arm PMCF study on the performance and safety of Lyoplant® used for the replacement and extension of connective tissue structures in neurosurgery.
- Conditions
- Tumor, Cerebral Ventricle, Tumor, Cerebellar, Aneurysm Cerebral, Trauma, Brain
- Trial name
- LYOPLACE (NCT05441618)
- Testing
- Lyoplant®
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Aesculap AG
Anesthesia Awareness
Manual Versus Targer-controll Infusion in Reduction of Awareness and Dreaming
This study compares manual total intravenous anesthesia (TIVA) and target-controll infusion (TCI) in reduction of awareness and dreaming, and the haemodynamical stability during operation.
- Trial name
- NCT03476213
- Testing
- Group TCI, Group TIVA
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- University Hospital Hradec Kralove
Neurosurgery
Correlation of PaCO2 to the Inspired and Expired Oxygen Gradient
The purpose of this study is to evaluate whether a correlation exists between the partial pressure of carbon dioxide existing within arterial blood and the gradient between inhaled and exhaled fractions of oxygen.
- Trial name
- O2 Fraction (NCT01513213)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Swedish Medical Center
Ischemic Stroke
SOLITAIRE™ FR With the Intention For Thrombectomy (SWIFT) Study
The purpose of this study is to demonstrate substantial equivalence of the SOLITAIRE™ FR Revascularization Device (SOLITAIRE™ Device) with a legally marketed device, MERCI Retrieval System® (MERCI® Device).
- Trial name
- SWIFT (NCT01054560)
- Testing
- SOLITAIRE™ Device, MERCI® Device
- Where
- 2 sites in United States
- Volunteers
- 144 people
- Sponsor
- Medtronic Neurovascular Clinical Affairs
Brain Tumor Adult, Brain Tumor Benign
Comparison of Skin Closure Techniques in Oncological Neurosurgical Procedures: Intradermal Running Suture Versus Transdermal Interrupted Sutures
The purpose of this study is to compare two commonly used methods of closing the skin after surgery for an intracranial tumor. Skin closure is one of the most important steps in neurosurgical procedures, as it has a major…
- Conditions
- Brain Tumor Adult, Brain Tumor Benign, Meningioma, Glioma
- Trial name
- NEURO-SUTURE (NCT07413796)
- Testing
- Absorbable running intradermal suture, Non-absorbable interrupted transdermal suture
- Where
- Poland
- Volunteers
- 382 people
- Sponsor
- Medical University of Warsaw
Treatment Resistant Depression
Deep Brain Stimulation for Treatment Resistant Depression With the Medtronic Activa PC+S
The goal of this study is to use the Activa Primary Cell + Sensing (PC+S) device to study Latent Field Potential (LFP) in the brains of people with Treatment Resistant Depression (TRD) before and during active stimulation.
- Trial name
- NCT01984710
- Testing
- Medtronic Activa PC+S System
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Emory University
Glioblastoma, Brain Tumors
Assessment of Early Post-operative Nuclear Imaging in Neurosurgery: a Safety and Feasibility Study in Patients Operated for Glioblastoma
This clinical trial aims to evaluate the feasibility and safety of early post-operative brain PET-MRI imaging in adult patients who have undergone surgery for suspected glioblastoma.
- Conditions
- Glioblastoma, Brain Tumors, Brain Imaging
- Trial name
- EARLYBRAINPET (NCT07274397)
- Testing
- Early post-operative brain PET-MRI with 18F-DOPA and Gadolinium
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Beta Emitting Accurate Monitored Systems
Brain Stem Hemorrhage, Robotic Surgical Procedures
A Multicenter, RAndomIzed, coNtrolled, umBrella Trial fOr Minimally Invasive Neurosurgery With AI-assisted Robotic guidanCe for Hemorrhagic Stroke
The purpose of this clinical trial is to observe the improvements in clinical symptoms and imaging outcomes for brainstem hemorrhage using robot-assisted stereotactic puncture, evaluate the clinical efficacy and safety of this…
- Trial name
- RAINBOW-BSH (NCT06459427)
- Testing
- Robot-assisted minimally invasive puncture and aspiration surgery, Standard medical management
- Where
- 15 sites in China
- Volunteers
- 142 people
- Sponsor
- Yanbing Yu
Neurologic Complication, Neurosurgery
The Potential Impact of Clindamycin on Neurosurgery Patients.
A prospective, open-label, single center, controlled trial. 44 patients that underwent neurosurgery or presented meningitis signs, for whom Clindamycin add-on therapy to assess its effect on neurological complication in relation…
- Trial name
- NCT06068673
- Testing
- Clindamycin 600 mg, standard regimen
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Damanhour University