Clinical trials: Neurosurgical Patients
Intracranial Hypertension, Traumatic Brain Injury
Invasive Versus Non-Invasive Intracranial Pressure-Guided Management in Neurosurgical Patients
Raised intracranial pressure (pressure inside the skull) is a serious complication for patients with brain injuries, strokes, or tumors. Managing this pressure is critical to prevent further brain damage.
- Conditions
- Intracranial Hypertension, Traumatic Brain Injury, Subarachnoid Haemorrhage (SAH), Intracerebral Haemorrhage
- Trial name
- NCT07853963
- Testing
- External Ventricular Drain (EVD) Placement and ICP Monitoring, Optic Nerve Sheath Diameter (ONSD) Ultrasonography
- Where
- Nepal
- Volunteers
- 40 people
- Sponsor
- Kathmandu Medical College and Teaching Hospital
Diabetes Insipidus, Neurohypophyseal, Copeptin Blood Levels
The Trend of Copeptin Levels and Its Clinical Value for Postoperative CDI in Pediatric Patients After NSI in ICU
Central diabetes insipidus (CDI),a disease caused by the decrease of AVP (a hormone involved in the control of water-electrolyte balance ) secretion and characerized by polyuria, is a common complication after neurosurgerical…
- Conditions
- Diabetes Insipidus, Neurohypophyseal, Copeptin Blood Levels, Copeptin, Neurosurgical Intervention
- Trial name
- NCT06742060
- Testing
- serum copeptin levels
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Children's Hospital of Fudan University
Cerebral Hemodynamics
Perioperative Cerebrovascular Autoregulation Monitoring in Neurosurgical Patients
One of the challenges in pediatric anesthesiology is to ensure adequate cerebral perfusion pressure to prevent cerebral ischemia or hyperemia from pressure-passive perfusion.
- Trial name
- NCT04174001
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Boston Children's Hospital
Posterior Fossa Tumor, Brain Tumor Adult
Fluid Responsiveness in Posterior Fossa Tumor Resection: PPV and CVP Guidance
To answer the question: What are the differences in intraoperative fluid administration volumes between PPV and CVP-guided strategies during posterior fossa tumor resection in the park bench position?
- Trial name
- NCT06595667
- Testing
- Pulse pressure variation, Central venous pressure
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Chiang Mai University
Subdural Hematoma
Augmented Reality for Subdural Drain Placement
This study involves using a augmented reality (AR) system to assist in the placement of a subdural evacuating portal system (SEPS).
- Trial name
- NCT06052124
- Testing
- Augmented Reality Device
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Neurosurgical Surgery, Sedo-analgesia
The Effect of the Sedo-Analgesia Protocol Applied to Intensive Care Unit Patients on Patient Outcomes
Neurosurgical interventions are a leading cause of death and disability in adults, and managing intracranial hypertension in the acute phase is a critical treatment process to prevent secondary brain injury .
- Conditions
- Neurosurgical Surgery, Sedo-analgesia, İntensive Care, Nursing Care
- Trial name
- Sedo Analgesia (NCT07148544)
- Testing
- Sedo analgesia protocol, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Cukurova University
Fluid Therapy, Brain Edema
Effects of Intraoperative GDFT on the Postoperative Brain Edema
Whether a fluid protocol aiming for protecting vital organ perfusion or fluid restriction is favorable to post-craniotomy outcomes such as brain edema remains uncertain.
- Conditions
- Fluid Therapy, Brain Edema, Brain Tumor
- Trial name
- NCT03323580
- Testing
- GDFT, traditional fluid therapy
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Beijing Tiantan Hospital
Brain Metastases
Study of Intraoperative Radiotherapy for Patients With Large Brain Metastases Treated With Neurosurgical Resection
The primary purpose of this study is to establish a maximum tolerated dose (MTD) through a dose-escalation trial using intraoperative radiotherapy (IORT) following neurosurgical resection for large brain metastases, and to…
- Trial name
- NCT04040400
- Testing
- intraoperative radiotherapy (IORT)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Louisville
Surgical Site Infection (SSI)
Effects of Intensive Glycemic Control in the Postoperative Period of Neurosurgical Patients on the Incidence of Surgical Site Infection
Surgical site infections (SSIs) are frequent complications in neurosurgical patients, often worsened by perioperative hyperglycemia.
- Trial name
- Brain Sugar (NCT07548112)
- Testing
- Intensive glycemic control, Hypokalemia Prevention Protocol During IV Insulin Therapy, Glucose-Supported Intravenous Insulin Infusion Protocol
- Volunteers
- 572 people
- Sponsor
- University of Sao Paulo
Critical Illness
The Diagnosis and Incidence of Critical Illness Polyneuromyopathy in Medical and Neurosurgical ICU Patients
This study plans to learn more about whether simpler diagnostic tests can be used to identify the development of acute neuromuscular loss of function in patients with critical illness and respiratory failure receiving mechanical…
- Trial name
- NCT02634658
- Testing
- Muscle Ultrasound, Nerve Conduction Study, Electromyography
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
Sovra and Intra Tentorial Lesions
Reliability of BIS Monitoring in Neurosurgical Patients
The aim of the study is to assess the reliability of Bispectral Index (BIS Vista , Covidien) in neurosurgical patients . BIS values at Loss of Consciousness (LOC), Post Intubation (PI) and Return of Consciousness (ROC) in…
- Trial name
- NCT01483547
- Testing
- Bispectral Index (BIS Vista, Covidien)
- Where
- Italy
- Volunteers
- 405 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Brain Tumors
Frailty as a Predictor of Neurosurgical Outcomes in Brain Tumor Patients
Frailty as an adjunct to preoperative assessment of neurosurgical patients has never been evaluated. This study aims to determine if frailty predicts neurosurgical complications in brain tumor patients and enhances current…
- Trial name
- NCT02530749
- Where
- United States
- Volunteers
- 265 people
- Sponsor
- University of Colorado, Denver
Mechanical Ventilation Complication, Neurological Complication
The Cerebral-Respiratory Interaction During Spontaneous Breathing Ventilation in Neurosurgical Patients (CeRes-SB)
Mechanical ventilation (MV) is a life-saving supportive therapy and one of the most common interventions implemented in intensive care.
- Conditions
- Mechanical Ventilation Complication, Neurological Complication, Respiratory Complication
- Trial name
- CeRes-SB (NCT05363098)
- Testing
- Mechanically ventilated neurosurgical patients
- Volunteers
- 30 people
- Sponsor
- Uppsala University
Hypertension on Emergence
Proseal Laryngeal Mask Airway or Endotracheal Tube for Emergence From Neuroanesthesia
Extubation and emergence from anesthesia lead to systemic and cerebral hemodynamic changes that can cause cerebral edema and hemorrhage.
- Trial name
- NCT01718470
- Testing
- Endotracheal tube, LMA
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Ricard Valero
Brain Metastases
Dose-staged Gamma Knife Radiosurgery Versus Microsurgical Resection
Background. Brain metastases (BM) are the most common intracranial tumor and occur in 20-40% of all oncological patients. The most common primary cancer in brain metastases is lung cancer, followed by melanoma, breast cancer…
- Trial name
- NCT04857905
- Testing
- Microsurgical resection, Gamma Knife radiosurgery
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Glioblastoma, Recurrent Glioblastoma
Recurrent GBM Treated With Neurosurgical Resection and IORT Using the Xoft Axxent eBx System and Bevacizumab
The purpose of this trial is to assess the overall survival of patients treated with the Xoft Axxent eBx System and post-radiation adjuvant Bevacizumab for single-fraction IORT following maximal neurosurgical resection of…
- Conditions
- Glioblastoma, Recurrent Glioblastoma, GBM, Recurrent GBM
- Trial name
- IORT (NCT04681677)
- Testing
- Radiation: Intra-operative Radiation Therapy - IORT, Bevacizumab
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Xoft, Inc.
Blood Pressure
Correlation Between Dorsalis Pedis and Radial Arterial Invasive Blood Pressures During Anesthesia Induction in Neurosurgical Patients
Anesthesiologists need to understand the specific difference between dorsalis pedis arterial(DPA) pressure and the more commonly used radial arterial(RA) pressure When blood pressure monitoring at DPA.
- Trial name
- NCT04469751
- Testing
- invasive blood pressure monitoring
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University
Esketamine, Pregabalin
Esketamine Combined With Pregabalin on Acute Postoperative Pain in Patients Undergoing Resection of Spinal Neoplasms.
Postsurgical pain is now known to be one of the most common and difficult-to-treat complications of surgery. severe postoperative pain can significantly impair patients' quality of life, social functioning and contribute to…
- Conditions
- Esketamine, Pregabalin, Acute Postoperative Pain, Neurosurgical Procedures
- Trial name
- NCT05096468
- Testing
- S-ketamine and pregabalin
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Beijing Tiantan Hospital
Hydrocephalus in Children, Epilepsy
Myelin Imaging Changes In Patients With Neurosurgical Diseases
Investigate myelin alterations in patients with neurosurgical diseases
- Conditions
- Hydrocephalus in Children, Epilepsy, Craniosynostoses, Traumatic Brain Injury
- Trial name
- McDESPOT (NCT03698838)
- Testing
- McDESPOT
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Memorial Healthcare System
Hypotension
Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During Anesthesia
The optimal vasopressor for ensuring organ blood flow and tissue oxygen delivery during surgery remains undetermined. This study aim to compare the effects of noradrenaline vs.
- Trial name
- IMPACT (NCT06083948)
- Testing
- Noradrenalin, Phenylephrine
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- University of Aarhus