Clinical trials: Neurosurgical Patients
CNS
Intraoperative Use of I.V. Sodium Fluorescein in Suspected CNS Tumors
The FLUO.CER.TUM study is a prospective observational clinical trial conducted at the IRCCS Foundation Neurological Institute "Carlo Besta" in Milan, Italy.
- Trial name
- FLUOCERTUM (NCT07233954)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Postoperative Seizures After Brain Tumor Surgery
Levetiracetam for Seizure Prevention After Brain Tumor Surgery
This study aims to evaluate the efficacy and safety of levetiracetam for the prevention of postoperative seizures in adult patients undergoing supratentorial brain tumor surgery.
- Trial name
- PREVENT (NCT07239115)
- Testing
- Levetiracetam
- Where
- China
- Volunteers
- 558 people
- Sponsor
- Beijing Tiantan Hospital
Stress, Pain
A Randomized Controlled Trial to Assess the Impact of Live and Recorded Music-Based Interventions on Pre-operative Stress, Mood, Pain and Biomarkers, in Neurosurgical Patients (Music-STAR Trial)
The study plans to enroll a total of 132 patients. The goal of this study is to measure pre-and post-music intervention changes in patients' vital signs, serum- and plasma-level biomarkers by broad-spectrum proteomics analysis…
- Trial name
- NCT06536504
- Testing
- Steinway Spirio M recording/player piano
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- M.D. Anderson Cancer Center
Intracranial Pressure
Safety Study to Evaluate Intracranial Pressure During High Frequency Chest Wall Oscillation
The purpose of this study is to evaluate changes in intracranial pressure (ICP) during or immediately following high frequency chest wall oscillation (HFCWO) treatment with the Vest™ in neurosurgical subjects.
- Trial name
- NCT00279097
- Testing
- High Frequency Chest Wall Oscillation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hill-Rom
Neurocognitive Disorders, Postoperative Period
Pre-operative Neurocognitive Disorder and Low Near-infrared Spectrometry is Associated With Postoperative Delirium
The main goal of the investigation is to identify the incidence of cognitive dysfunction and POD in patients older than 65 years of age undergoing neurosurgical elective surgery and determine if an association between cognitive…
- Conditions
- Neurocognitive Disorders, Postoperative Period, Postoperative Complications
- Trial name
- NCT03171766
- Testing
- Mini-Mental State Examination (MMSE), Visual Analog Scale (VAS), Mini Cog test
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Centro Hospitalar do Porto
Postoperative Delirium
Remimazolam vs. Propofol: Impact on Postoperative Delirium in Neurosurgical Patients
The investigator aimed to evaluate the incidence of postoperative delirium after remimazolam-based total intravenous anesthesia (TIVA) compared to the propofol-based TIVA in patients undergoing neurosurgery.
- Trial name
- NCT06115031
- Testing
- Remimazolam, Propofol
- Where
- South Korea
- Volunteers
- 696 people
- Sponsor
- Samsung Medical Center
Neurosurgical Patients
Cardiac Autonomic Dysfunction and Perioperative Outcomes
The autonomic nervous system (ANS) is cardinal for maintaining systemic homeostasis and is pivotal for the baseline regulation and modulation of vital cardiovascular, hemodynamic, respiratory, gastrointestinal, and body…
- Trial name
- CADPONS (NCT05230641)
- Testing
- No intervention
- Where
- India
- Volunteers
- 400 people
- Sponsor
- National Institute of Mental Health and Neuro Sciences, India
Fall Patients
The Effect of The STEADI Program on Falls and Falls Prevention in Neurosurgical Patients in Jordan
The goal of this interventional study will be to evaluate the effectiveness of the STEADI Program on falls and falling prevention compared with routine falling assessment in neurosurgical patients in Jordan.
- Trial name
- NCT05815875
- Testing
- STEADI Program, Routine care
- Where
- Jordan
- Volunteers
- 70 people
- Sponsor
- King Abdullah University Hospital
Motor Cortex; Lesion, Glioma
Accelerating Motor Recovering in Patients With SMA Syndrome After Glioma Surgery by Using nrTMS
The goal of this randomized clinical controlled trial is to learn about whether neuro-navigation repetitive transcranial magnetic stimulation (nrTMS) was useful to accelerate the recovery in patients with SMA syndrome after…
- Conditions
- Motor Cortex; Lesion, Glioma, Supplementary Motor Area Syndrome
- Trial name
- NCT05803057
- Testing
- TMS stimulation treatment
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Beijing Neurosurgical Institute
Airway Management, Spine Surgery
Laryngeal Mask Use in Knee-chest Position in Lumbar Surgery in Neurosurgical Patients
Spine surgery is the most common procedure in neurosurgical setting. Some centers have chosen the patient self-position to avoid complications such as accidental extubation or loss of the iv line.
- Conditions
- Airway Management, Spine Surgery, Prone Position
- Trial name
- NCT02162368
- Where
- Spain
- Volunteers
- 358 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Glioblastoma, GBM
Recurrent GBM With Maximal Neurosurgical Removal and Treatment With IORT
The purpose of this study is to assess the safety and efficacy of the Xoft Axxent eBx System when used for single-fraction IORT for recurrent Glioblastoma.
- Conditions
- Glioblastoma, GBM, Recurrent GBM
- Trial name
- NCT04763031
- Testing
- Intra-operative Radiation Therapy - IORT
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Parkridge Medical Center
Neurosurgical Procedures, Neurosurgical Patients
Prolonged Mechanical Ventilation in Neurosurgical Patients:
The study was carried out at the neurosurgical operating theater and neurosurgical intensive care unit, Maharaj Nakorn Chiang Mai University-Hospital.
- Conditions
- Neurosurgical Procedures, Neurosurgical Patients, Prolonged Mechanical Ventilation
- Trial name
- NCT06591624
- Testing
- Prolonged Mechanical Ventilation, remain intubation after surgery
- Where
- Thailand
- Volunteers
- 340 people
- Sponsor
- Chiang Mai University
Glioblastoma (GBM)
Efficacy of Zoster Vaccination in Glioblastoma Patients
In modern practice a trimodality treatment has emerged as standard of care for histologically confirmed glioblastoma. We hypothesize that the additional vaccination against herpes zoster, after surgical resection followed by…
- Trial name
- STARGATE (NCT07546669)
- Testing
- Additional vaccination against shingles (herpes zoster), Standard of care treatment without additional vaccination
- Volunteers
- 230 people
- Sponsor
- University Hospital, Essen
Postoperative Acute Kidney Injury
Postoperative Acute Kidney Injury in Patients Undergoing Prolonged Neurosurgical Operations
Postoperative Acute Kidney Injury in Patients Undergoing Prolonged Neurosurgical Operations
- Trial name
- NCT03486184
- Testing
- Cystatin-C
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Brain Injuries, Brain Trauma
Evaluation of qSOFA in Neurosurgical Patients
The aim of the study is to look if Quick Sequential Organ Failure Assessment Score score in detecting a eary Sepsis is afflicted by neurosurgical disorders
- Conditions
- Brain Injuries, Brain Trauma, Subarachnoid Hemorrhage
- Trial name
- NCT04265404
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Goethe University
Ventilator-Associated Pneumonia (VAP), Intensive Care Unit (ICU) Patients
Pulmonary Microbiota Changes and Clinical Outcomes in Neurosurgical ICU Patients With Artificial Airways
After neurosurgery, many patients need to stay in the intensive care unit (ICU) and use a breathing machine (mechanical ventilation) because of issues like decreased consciousness, weak breathing, or poor airway protection.
- Conditions
- Ventilator-Associated Pneumonia (VAP), Intensive Care Unit (ICU) Patients, Microbiome Dysbiosis
- Trial name
- NCT07129174
- Where
- 3 sites in China
- Volunteers
- 220 people
- Sponsor
- Jian-Xin Zhou
Ageing and Geriatric Health
Study of Functional Decline and Care Pathways in Neurosurgical Patients Over 65 Years of Age
The GENEUS 1 study addresses this gap by characterizing the real-world profiles, outcomes, and care pathways of adults aged 65 years and older hospitalized in neurosurgery across France, Spain, and Portugal.
- Trial name
- GENEUS 1 (NCT07506941)
- Where
- 6 sites in France, Portugal and 1 more
- Volunteers
- 209 people
- Sponsor
- University Hospital, Toulouse
Brain Tumor, Vascular Lesion
Factor XIII and Pulmonary Embolism in Neurosurgical Patients
Two studies (Gerlach et al. 2000; Gerlach et al. 2002) described the impact of factor XIII on the risk of prospective hemorrhage for patients undergoing craniotomy.
- Conditions
- Brain Tumor, Vascular Lesion, Factor XIII Deficiency, Pulmonary Embolism
- Trial name
- NCT01106937
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Craniotomy, Brain Surgery
The Efficacy of Intravenous Acetaminophen During Perioperative Neurosurgery Period
This is a prospective randomized double blinded trial study involving 128 patients undergoing any craniotomy procedure at Evanston Hospital. The patients will be randomized by the sealed envelope technique.
- Trial name
- NCT01739699
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Endeavor Health
Intensive Care (ICU)
Role of Lung Ultrasound in Weaning From Mechanical Ventilation in Postoperative Neurosurgical ICU Patients
The aim of this study is to demonstrate the role of lung ultrasound in weaning from mechanical ventilation in neurosurgical ICU patients compared to the ordinary tools as chest X-ray , ABG, rapid shallow breathing index…
- Trial name
- NCT03921112
- Testing
- lung ultrasound, routine tools
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Ain Shams University