Clinical trials: Neurosurgical Patients, open to volunteers
Brain Blood Flow Impairment
Longitudinal Investigation of Brain Blood Flow Changes in Neurosurgical Patients
Primary study objective: Longitudinal observation of brain blood flow changes in neurosurgical patients with or without a neurosurgical intervention as compared to a healthy cohort.
- Trial name
- NCT04668261
- Testing
- Advanced imaging investigation
- Where
- Switzerland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Anxiety, Dexmedetomidine
The Impact of Dexmedetomidine Nasal Spray on Perioperative Anxiety in Neurosurgical Patients
This randomized clinical trial aims to evaluate the effect of preoperative use of dexmedetomidine nasal spray on improving perioperative anxiety levels in patients undergoing elective supratentorial tumor resection.
- Trial name
- NCT07801014
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Beijing Tiantan Hospital
Glioma, Glioblastoma
A Study for Cerebral Open Flow Microperfusion
The purpose of this study is to evaluate the safety and feasibility of intra-operative microperfusion during a planned neurosurgical resection of diseased brain parenchyma, including either an epileptic focus requiring temporal…
- Trial name
- NCT07089758
- Testing
- Cerebral open flow microperfusion
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Mayo Clinic
Postoperative Seizures After Brain Tumor Surgery
Levetiracetam for Seizure Prevention After Brain Tumor Surgery
This study aims to evaluate the efficacy and safety of levetiracetam for the prevention of postoperative seizures in adult patients undergoing supratentorial brain tumor surgery.
- Trial name
- PREVENT (NCT07239115)
- Testing
- Levetiracetam
- Where
- China
- Volunteers
- 558 people
- Sponsor
- Beijing Tiantan Hospital
Craniotomy, Neurosurgical Patients
an Analgesia-first Strategy Without Hypnotic Sedatives in Adult Patients Admitted to the Intensive Care Unit After Neurosurgical Craniotomy
Analgesia and sedation are core components of intensive care unit (ICU) care. They are used to relieve pain and anxiety, prevent harmful physiological stress responses, improve tolerance of invasive devices and mechanical…
- Trial name
- NCT06727435
- Testing
- analgesia-first strategy without hypnotic sedatives
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Beijing Tiantan Hospital
Cerebrovascular Disorders, Brain Tumours
Environmental Pollutants and Neurological Disorders
Environmental pollutants have emerged as a major global health concern, with growing evidence linking exposure to both traditional contaminants such as heavy metals (lead, mercury, cadmium, arsenic) and novel pollutants-including…
- Conditions
- Cerebrovascular Disorders, Brain Tumours, Alzheimer Dementia
- Trial name
- CLEAN (NCT07140601)
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Ageing and Geriatric Health
Study of Functional Decline and Care Pathways in Neurosurgical Patients Over 65 Years of Age
The GENEUS 1 study addresses this gap by characterizing the real-world profiles, outcomes, and care pathways of adults aged 65 years and older hospitalized in neurosurgery across France, Spain, and Portugal.
- Trial name
- GENEUS 1 (NCT07506941)
- Where
- 6 sites in France, Portugal and 1 more
- Volunteers
- 209 people
- Sponsor
- University Hospital, Toulouse
Glioblastoma (GBM)
Efficacy of Zoster Vaccination in Glioblastoma Patients
In modern practice a trimodality treatment has emerged as standard of care for histologically confirmed glioblastoma. We hypothesize that the additional vaccination against herpes zoster, after surgical resection followed by…
- Trial name
- STARGATE (NCT07546669)
- Testing
- Additional vaccination against shingles (herpes zoster), Standard of care treatment without additional vaccination
- Volunteers
- 230 people
- Sponsor
- University Hospital, Essen
T2DM Patients With Traumatic Brain Injury
Hybrid Closed-Loop System in Neurosurgical Perioperative Hyperglycemia: An Open RCT
In this study, we plan to use an open-source hybrid closed-loop artificial pancreas system and a combination of a traditional insulin pump and continuous glucose monitoring (CGM) respectively to conduct short-term intensive…
- Trial name
- NCT06909071
- Testing
- Hybrid Closed-Loop Artificial Pancreas System
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanxi Bethune Hospital
Neurosurgical Patients
COMparative Performance of General Purpose Models
To compare the performance of the Eleveld models for propofol and remifentanil on neurosurgery patients admitted to intensive care with their intraoperative performance.
- Trial name
- NCT06584097
- Where
- 2 sites in Italy
- Volunteers
- 42 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Hypotension
Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During Anesthesia
The optimal vasopressor for ensuring organ blood flow and tissue oxygen delivery during surgery remains undetermined. This study aim to compare the effects of noradrenaline vs.
- Trial name
- IMPACT (NCT06083948)
- Testing
- Noradrenalin, Phenylephrine
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- University of Aarhus
Moderate-to-Severe Traumatic Brain Injury
Comparing Sedatives for Intracranial Pressure Control in Traumatic Brain Injury
The goal of this clinical trial is to compare the effects of propofol, midazolam, and dexmedetomidine on intracranial pressure control and clinical outcomes in adults with moderate-to-severe traumatic brain injury undergoing…
- Trial name
- ICP-TBI (NCT07678216)
- Testing
- propofol, midazolam, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 210 people
- Sponsor
- Aswan University
Diabetes Insipidus, Neurohypophyseal, Copeptin Blood Levels
The Trend of Copeptin Levels and Its Clinical Value for Postoperative CDI in Pediatric Patients After NSI in ICU
Central diabetes insipidus (CDI),a disease caused by the decrease of AVP (a hormone involved in the control of water-electrolyte balance ) secretion and characerized by polyuria, is a common complication after neurosurgerical…
- Conditions
- Diabetes Insipidus, Neurohypophyseal, Copeptin Blood Levels, Copeptin, Neurosurgical Intervention
- Trial name
- NCT06742060
- Testing
- serum copeptin levels
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Children's Hospital of Fudan University
Neurosurgery, Delirium - Postoperative
Electroencephalogram Predicts Post-operative Delirium
The goal of this observational study is to investigate the predictive value of sub-hairline electroencephalography (EEG) during anesthesia recovery for postoperative delirium (POD).
- Conditions
- Neurosurgery, Delirium - Postoperative, Brain Tumor Adult
- Trial name
- EPOD (NCT06894238)
- Testing
- Sub-hairline EEG Monitoring
- Where
- 2 sites in China
- Volunteers
- 137 people
- Sponsor
- Beijing Sanbo Brain Hospital
Pressure Injuries
Effect of Positioning Protocol on Skin Pressure Injury and Shoulder Traction Pain in Neurosurgical Patients
This study evaluates a modified lateral decubitus positioning method designed to prevent pressure injuries and reduce shoulder traction pain in patients undergoing neurosurgical procedures under general anesthesia.
- Trial name
- NCT07791056
- Testing
- Modified Lateral Decubitus Positioning Protocol, Conventional Lateral Decubitus Positioning
- Where
- China
- Volunteers
- 80 people
- Sponsor
- General Hospital of Ningxia Medical University
Stress, Pain
A Randomized Controlled Trial to Assess the Impact of Live and Recorded Music-Based Interventions on Pre-operative Stress, Mood, Pain and Biomarkers, in Neurosurgical Patients (Music-STAR Trial)
The study plans to enroll a total of 132 patients. The goal of this study is to measure pre-and post-music intervention changes in patients' vital signs, serum- and plasma-level biomarkers by broad-spectrum proteomics analysis…
- Trial name
- NCT06536504
- Testing
- Steinway Spirio M recording/player piano
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- M.D. Anderson Cancer Center
Subarachnoid Hemorrhage in Adult Patients
Sphenopalatine Block in Headache in Patients With Non-traumatic Subarachnoid Hemorrhage
Non-traumatic SAH, linked in 85% of cases to the rupture of an intracranial aneurysm, is a serious stroke affecting young people. Half of all survivors suffer cognitive impairment.
- Trial name
- SATURN (NCT06735261)
- Testing
- Sphenopalatine Ganglion Block using 2% lidocaine
- Volunteers
- 70 people
- Sponsor
- University Hospital, Grenoble
CNS
Intraoperative Use of I.V. Sodium Fluorescein in Suspected CNS Tumors
The FLUO.CER.TUM study is a prospective observational clinical trial conducted at the IRCCS Foundation Neurological Institute "Carlo Besta" in Milan, Italy.
- Trial name
- FLUOCERTUM (NCT07233954)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Ventilator-Associated Pneumonia (VAP), Intensive Care Unit (ICU) Patients
Pulmonary Microbiota Changes and Clinical Outcomes in Neurosurgical ICU Patients With Artificial Airways
After neurosurgery, many patients need to stay in the intensive care unit (ICU) and use a breathing machine (mechanical ventilation) because of issues like decreased consciousness, weak breathing, or poor airway protection.
- Conditions
- Ventilator-Associated Pneumonia (VAP), Intensive Care Unit (ICU) Patients, Microbiome Dysbiosis
- Trial name
- NCT07129174
- Where
- 3 sites in China
- Volunteers
- 220 people
- Sponsor
- Jian-Xin Zhou
Surgical Site Infection (SSI)
Effects of Intensive Glycemic Control in the Postoperative Period of Neurosurgical Patients on the Incidence of Surgical Site Infection
Surgical site infections (SSIs) are frequent complications in neurosurgical patients, often worsened by perioperative hyperglycemia.
- Trial name
- Brain Sugar (NCT07548112)
- Testing
- Intensive glycemic control, Hypokalemia Prevention Protocol During IV Insulin Therapy, Glucose-Supported Intravenous Insulin Infusion Protocol
- Volunteers
- 572 people
- Sponsor
- University of Sao Paulo