Clinical trials: Neurosurgical Procedures
Neurosurgery
Correlation of PaCO2 to the Inspired and Expired Oxygen Gradient
The purpose of this study is to evaluate whether a correlation exists between the partial pressure of carbon dioxide existing within arterial blood and the gradient between inhaled and exhaled fractions of oxygen.
- Trial name
- O2 Fraction (NCT01513213)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Swedish Medical Center
Postoperative Nausea and Vomiting
Effectiveness of Triple Therapy With Palonosetron for PON Prophylaxis
Postoperative nausea and vomiting (PONV) is a displeasing experience that distresses surgical patients during the first 24 hours after a surgical procedure.
- Trial name
- NCT02635828
- Testing
- Palonosetron 0.075 mg IV, Dexamethasone 10 mg IV, Promethazine 25 mg IV
- Volunteers
- 40 people
- Sponsor
- Ohio State University
Surgical Wound Infection
Study of the Efficacy of Preoperative Cefuroxime Prophylaxis to Prevent Surgical Site Infection in Herniated Disk Surgery
The purpose of the study is to determine whether a single, pre-operative dose of cefuroxime is effective in preventing surgical site infection in patients undergoing surgery for herniated disk
- Trial name
- NCT00530400
- Testing
- cefuroxime
- Where
- 2 sites in Switzerland
- Volunteers
- 1,369 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Parkinson Disease, Tremor, Essential
Effectiveness and Reliability of Hypnosis in Stereotaxy
In certain neurosurgical procedures, the use of a stereotaxic frame is required. It is then possible to set a precise target (depending of the type of the surgery) to be reached by the surgeon.
- Conditions
- Parkinson Disease, Tremor, Essential, Dystonia, Primary
- Trial name
- ERST (NCT03074422)
- Testing
- Hypnosis
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- University Hospital, Geneva
Patients Undergoing Elective Craniotomy
Conversion From Total Intravenous Anesthesia Technique to Desflurane Anesthesia for Long Duration Neurosurgery
Since neurological testing during neurosurgery, such as somato-sensory evoked potentials, motor-evoked potentials, auditory evoked potentials and visual evoked potentials are well maintained their wave-form reactivity with total…
- Trial name
- NCT01985854
- Testing
- Propofol, Desflurane
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- Tokyo Women's Medical University
Acute Post Operative Pain
Improvement in Postoperative Pain Outcomes
This is an observational study project aims at improving postoperative pain outcomes by evaluating the current status of postoperative pain managements in the institution.
- Trial name
- NCT05624502
- Where
- Saudi Arabia
- Volunteers
- 1,000 people
- Sponsor
- King Saud University
Spinal Cord Injuries
Transforming Research and Clinical Knowledge in Spinal Cord Injury
The overall goal of Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI) study is to determine the relationships among the clinical, neuroimaging, cognitive, genetic and proteomic biomarker…
- Trial name
- TRACK-SCI (NCT04565366)
- Where
- 5 sites in United States
- Volunteers
- 726 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cerebrospinal Fluid
Comparison of Different CSF Sampling Sites on External Ventricular Drains
The aim of the current study is to evaluate the difference between proximal and distal CSF sampling. If the characteristics of distally and proximally sampled CSF are similar or correlate well, it may be possible to only sample…
- Trial name
- CSF3S (NCT05254353)
- Testing
- Analyses of proximal and distal samples
- Where
- Belgium
- Volunteers
- 55 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Anesthesia, Spinal, Neurosurgery
Testing the Feasibility of Using Ropivacaine in Spinal Anesthesia for Patients With Lower Back Surgery
The goal of this pilot clinical trial is to test the feasibility of conducting a randomized controlled trial that will examine the use of ropivacaine in the spinal anesthesia for patients undergoing elective 1- or 2-level lower…
- Conditions
- Anesthesia, Spinal, Neurosurgery, Ropivacaine, Bupivacaine
- Trial name
- SASS (NCT05824338)
- Testing
- Spinal anesthesia for lumbar surgery: ropivacaine, Spinal anesthesia for lumbar surgery: bupivacaine, General anesthesia for lumbar surgery
- Where
- 2 sites in Canada
- Volunteers
- 45 people
- Sponsor
- Fraser Health
s100b
The Neuroprotective Effects of RPC on the Neurosurgery
The current study is designed to clarify the neuroprotective effect of remote ischemic precondtioning on the patients underwent neurosurgery.
- Trial name
- NCT00866489
- Testing
- remote preconditioning
- Volunteers
- 70 people
- Sponsor
- Xijing Hospital
Dural Defect, Cerebrospinal Fluid Leak
Immiseal™ Dural Sealant Post-Market Registry Study
This is a multicentre, prospective, open-label, single-arm, observational, post-market clinical follow-up registry study designed to observe the safety and performance of the Immiseal™ Dural Sealant System when used as an adjunct…
- Conditions
- Dural Defect, Cerebrospinal Fluid Leak, Neurosurgical Procedures
- Trial name
- NCT07651826
- Where
- Latvia
- Volunteers
- 85 people
- Sponsor
- Medprin Regenerative Medical Technologies Co., Ltd.
Cranial Neurosurgery
Heart Rate Variability and Processed EEG Features as Predictors of Postoperative Outcomes After Cranial Neurosurgery
Patients undergoing cranial neurosurgery face a high-risk postoperative period, particularly during emergence from anesthesia and early recovery in the post-anesthesia care unit (PACU).
- Trial name
- HERO-PACU (NCT07443072)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Ventilator-induced Lung Injury
Intraoperative Lung-Protective Ventilation in Neurosurgery
The purpose of this study is to explore the effectiveness of lung-protective ventilation during general anesthesia for neurosurgical procedures on postoperative pulmonary outcome, compared with traditional ventilation.
- Trial name
- NCT02386683
- Testing
- lung-protective ventilation
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Capital Medical University
Glioma
Registry Study on Epidemiological and Biological Disease Profile as Well as Clinical Outcome in Patients With Low Grade Gliomas
The LoG-Glio-Registry is based on a network of german hospitals gathering radiological, clinical, epidemiological and molecular data on all patients diagnosed with a low grade glioma.
- Trial name
- LoG-Glio (NCT02686229)
- Testing
- no interventions
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University of Ulm
Deep Brain Stimulation, Parkinson Disease
Consensus Statements on Deep Brain Stimulation in Patients With Parkinson's Disease
Deep brain stimulation (DBS) has become a cornerstone therapy for advanced Parkinson's disease (PD), showing superior outcomes over best medical treatment in randomized clinical trials.
- Trial name
- DBS_Consensus (NCT07173660)
- Testing
- Delphi study
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Trigeminal Neuralgia, Microvascular Decompression
Impact of Teflon Technique on Recurrence After Microvascular Decompression for Trigeminal Neuralgia
The study aims to see if shredded Teflon placed away from the trigeminal nerve is equally effective in pain control in Trigeminal Neuralgia while minimizing the risks of pain recurrence due to granuloma formation when this…
- Conditions
- Trigeminal Neuralgia, Microvascular Decompression, Teflon
- Trial name
- NCT07046247
- Testing
- Microvascular decompression for trigeminal neuralgia
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- University of Valencia
Brain Tumor
Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures
The objective of the study is to assess safety of panitumumab-IRDye800 in pediatric patients undergoing brain surgery to remove suspected tumors.
- Trial name
- NCT04085887
- Testing
- Panitumumab-IRDye800, Pinpoint-IR9000 endoscopic/handheld device, Explorer Air camera
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stanford University
Neurosurgery, Mechanical Ventilation
Lung and Heart USG for Predicting Weaning in Neurosurgical Patients
Ultrasonography is a commonly used diagnostic and procedural adjunctive modality in intensive care. Weaning of neurosurgical patients off ventilatory support is a critical procedure, fraught with risks of hypoxia and hypercapnia.
- Conditions
- Neurosurgery, Mechanical Ventilation, Extubation
- Trial name
- NCT03580993
- Testing
- Lung Ultrasound
- Where
- India
- Volunteers
- 27 people
- Sponsor
- National Institute of Mental Health and Neuro Sciences, India
Pain, Postoperative, Neurosurgery
Preemptive Infiltration With Betamethasone and Ropivacaine for Postoperative Pain in Laminoplasty or Laminectomy
Laminoplasty and laminectomy have been used for decades for the treatment of intraspinal space occupying lesions, spinal stenosis, disc herniation, injuries, etc.
- Trial name
- NCT04153396
- Testing
- The Treatment group, The Control group
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Beijing Tiantan Hospital
Perioperative Hypertension
Evaluation of Periop Biochemical Stress Factors in Craniotomy Neurosurgical Procedure With Respect to Preop Hypertension
Perioperative hypertension is commonly associated with surgical craniotomy. As the sympathetic nervous system and the renin-angiotensin-aldosterone system play a key role in the development of this hypertension, preoperative…
- Trial name
- NCT02441842
- Testing
- atenolol, lisinopril, glucose
- Volunteers
- 85 people
- Sponsor
- Milton S. Hershey Medical Center