Clinical trials: Neurosurgical Procedures
Postoperative Pain, Neurosurgery
Incidence, Risk Factors and Impact of Significant Pain in Patients Undergoing Neurosurgery
The proposed study intends to evaluate incidence of postoperative pain after neurosurgery. This study is likely to help in understanding of the magnitude of this problem in our country and inform about possible predictors which…
- Trial name
- NCT05264012
- Testing
- Neurosurgery
- Where
- India
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Mental Health and Neuro Sciences, India
Neurosurgery, Intervention
Pharmacokinetic and Pharmacodynamic Modelling of Norepinephrine in Patients Under Target Controlled Infusions (TCI) for Anaesthesia
Currently, administration of norepinephrine diluted at 5 µg/ml bolus or continuous infusion is common during sympatholysis hypotension of TCI following the elimination of hypovolemia or anesthetic overdosage.
- Trial name
- NOR-PHARM (NCT03454204)
- Testing
- Pharmacokinetic
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Brain Metastases
Pre- Versus Post-operative SRS for Resectable Brain Metastases
The purpose of this study is to determine if performing radiotherapy (SRS) prior to surgery results in better treatment outcomes than performing surgery before radiotherapy for patients with brain metastases.
- Trial name
- NCT04474925
- Testing
- Brain Surgery, Stereotactic Radiosurgery
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- AHS Cancer Control Alberta
Intracranial Neurosurgery
The Effects of Dexmedetomidine and Propofol on Cerebral Blood Flow and Brain Oxygenation During Deep Brain Stimulation
The investigators will evaluate the effects of dexmedetomidine and propofol on cerebral blood flow and brain oxygenation during Deep Brain Stimulation (DBS) surgery.
- Trial name
- NCT01200433
- Testing
- dexmedetomidine, propofol
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- The Cleveland Clinic
Perioperative Hypertension
Evaluation of Periop Biochemical Stress Factors in Craniotomy Neurosurgical Procedure With Respect to Preop Hypertension
Perioperative hypertension is commonly associated with surgical craniotomy. As the sympathetic nervous system and the renin-angiotensin-aldosterone system play a key role in the development of this hypertension, preoperative…
- Trial name
- NCT02441842
- Testing
- atenolol, lisinopril, glucose
- Volunteers
- 85 people
- Sponsor
- Milton S. Hershey Medical Center
Traumatic Brain Injury, Mild Traumatic Brain Injury
Score Predicting Lesion Development on CT Following Mild TBI
Mild traumatic brain injury (mTBI) is one of the most common reasons behind emergency department (ED) visits. A small portion of mTBI patients will develop an intracranial lesion that might require neurosurgical intervention.
- Trial name
- SELECT-TBI (NCT04995068)
- Testing
- Head CT to determine presence of traumatic intracranial lesion
- Where
- Sweden
- Volunteers
- 20,000 people
- Sponsor
- Karolinska Institutet
Obsessive-Compulsive Disorder
Effectiveness of Deep Brain Stimulation for Treating People With Treatment Resistant Obsessive-Compulsive Disorder
This study will evaluate the safety and effectiveness of deep brain stimulation in treating people with severe and otherwise treatment-resistant obsessive-compulsive disorder.
- Trial name
- NCT00640133
- Testing
- Active DBS
- Where
- 9 sites in United States
- Volunteers
- 27 people
- Sponsor
- Butler Hospital
Depression
Electrical Stimulation of the Internal Capsule for Intractable Depression
This study will evaluate the safety and efficacy of deep brain stimulation in treating people with several and otherwise treatment-resistant depression.
- Trial name
- NCT01069952
- Testing
- Deep Brain Stimulation System
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Butler Hospital
Pituitary Tumor
Effects of Total Intravenous Anesthesia With Propofol-remifentanil Versus Inhalational Anesthesia With Sevoflurane on Quality of Recovery in Patients Undergoing Transsphenoidal Surgery for Pituitary Tumor
A number of studies have compared the effects of total intravenous anesthesia(TIVA) versus inhalational anesthesia on perioperative period during transsphenoidal surgery.
- Trial name
- NCT02813044
- Testing
- total intravenous anesthesia (TIVA), inhalation anesthesia group
- Where
- South Korea
- Volunteers
- 82 people
- Sponsor
- Yonsei University
Posterior Fossa Tumor
Dexmedetomidine Use for Greater Occipital Nerve Block in Pediatric Posterior Fossa Tumor Surgery.
The goal of this clinical trial is to evaluate the effects of ultrasound-guided versus blind greater occipital nerve block (GONB), with or without Dexmedetomidine as an adjuvant, in pediatric patients undergoing posterior fossa…
- Trial name
- NCT07878156
- Testing
- Bupivacaine 0.25%, Dexmedetomidine 1mcg/kg, Blind greater occipital nerve block
- Where
- Egypt
- Volunteers
- 260 people
- Sponsor
- Children's Cancer Hospital Egypt 57357
Nervous System Neoplasms
Protective Ventilation in Neurosurgery, a Pilot Study
The purpose of this study is to assess the effect size and variability of dural tension measured as intracranial pressure (ICP) below the dura of the surgical field in patients undergoing elective supra-tentorial surgery for…
- Trial name
- NeuroVentOR (NCT02450019)
- Testing
- Traditional to protective ventilation, Protective to traditional ventilation
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS San Raffaele
Cerebrospinal Fluid Leak
The EVICEL® Neurosurgery Phase III Study
The objective of this study is to evaluate the safety and efficacy of EVICEL® Fibrin Sealant (Human) for use as an adjunct to sutured dural repair in cranial surgery.
- Trial name
- NCT02457546
- Testing
- EVICEL Fibrin Sealant, Hydrogel sealant
- Where
- 26 sites in United States, Australia and 4 more
- Volunteers
- 234 people
- Sponsor
- Ethicon, Inc.
Acromegaly
Preoperative Lanreotide Treatment in Acromegalic Patients With Macroadenomas
Previous studies addressing preoperative somatostatin analogs (SSA) treatment and subsequent surgical cure rates are conflicting, reporting a benefit, or no difference between groups.
- Trial name
- NCT00993356
- Testing
- Preoperative lanreotide treatment, Transsphenoidal surgery
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Delirium, Eras
Rehabilitation Intervention on Prevention of Postoperative Delirium
1. A questionnaire on "Cognition and Attitudes of Nurses on Postoperative Deafness in Neurosurgical Patients" was initially formed through reference literature and expert opinions.
- Trial name
- NCT03949114
- Testing
- Evaluation, nursing care, rehabilitation
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pediatric, Neurosurgery
Remimazolam and Emergence Delirium in Pediatrics
Emergence delirium is a common complication in pediatrics undergoing neurosurgery. Previous study showed that a single bolus of remimazolam was associated with lower incidence of postoperative agitation.
- Conditions
- Pediatric, Neurosurgery, Sevoflurane Anesthesia, Remimazolam
- Trial name
- NCT07046364
- Testing
- Remimazolam, Normal Saline
- Where
- 2 sites in China
- Volunteers
- 248 people
- Sponsor
- Peking University First Hospital
Dural Defect, Cerebrospinal Fluid Leak
Immiseal™ Dural Sealant Post-Market Registry Study
This is a multicentre, prospective, open-label, single-arm, observational, post-market clinical follow-up registry study designed to observe the safety and performance of the Immiseal™ Dural Sealant System when used as an adjunct…
- Conditions
- Dural Defect, Cerebrospinal Fluid Leak, Neurosurgical Procedures
- Trial name
- NCT07651826
- Where
- Latvia
- Volunteers
- 85 people
- Sponsor
- Medprin Regenerative Medical Technologies Co., Ltd.
VR-based Informed Consent
Virtual Reality for Patient Informed Consent in Neurosurgery
The goal of this randomized controlled trial is to evaluate benefits of VR (virtual reality)-based patient informed consent in neurosurgery regarding subjective patient comprehension, patient-doctor relationship and anxiety.
- Trial name
- NCT06627426
- Testing
- VR-based patient informed consent
- Where
- Switzerland
- Volunteers
- 34 people
- Sponsor
- University Hospital, Basel, Switzerland
Central Nervous System Infections
Meropenem Penetration Across BBB in Patients With CNS Infection and Optimization of Meropenem Treatment
A prospective, open-label study investigated the pharmacokinetic profile of meropenem in patients with post-neurosurgical central nervous system (CNS) infection, especially its BBB penetration into cerebrospinal fluid (CSF).
- Trial name
- NCT02506686
- Testing
- Meropenem
- Volunteers
- 82 people
- Sponsor
- Huashan Hospital