Clinical trials: Neurotoxicity Syndrome
Neurotoxicity, Unspecified Adult Solid Tumor, Protocol Specific
Nerve Changes in Patients Who Are Undergoing Chemotherapy or Biological Therapy for Cancer
RATIONALE: Learning about the effects of chemotherapy and biological therapy on nerve function may help doctors plan treatment and help patients live more comfortably.
- Trial name
- NCT00281853
- Testing
- management of therapy complications
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Case Comprehensive Cancer Center
Parkinson Disease, Dyskinesia, Medication-Induced
Efficacy, Safety and Pharmacokinetic Study of CPL500036 in Patients with Levodopa Induced Dyskinesia
The aim of the study is to determine potential anti-dyskinetic properties of CPL500036 (PDE10A inhibitor) in Parkinson disease patients suffering from levodopa Induced dyskinesia.
- Trial name
- NCT05297201
- Testing
- CPL500036 - low dose, CPL500036 - high dose
- Where
- 16 sites in Poland, Ukraine
- Volunteers
- 105 people
- Sponsor
- Celon Pharma SA
Cancer, Breast Cancer
Assessment of Paclitaxel-Induced Neuropathy
The purpose of this study is to collect clinical data, blood samples, and self reported symptoms from patients that experience unusually severe neuropathy after treatment with paclitaxel.
- Conditions
- Cancer, Breast Cancer, Ovarian Cancer
- Trial name
- NCT01953159
- Testing
- Blood Collection, Patient Questionnaires
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Central Nervous System Lymphoma
Using a Novel Functional MRI Technique to Evaluate for Neurotoxicity
The purpose of this study is to test resting state functional Magnetic Resonance Imaging (rsfMRI) scans to see if rsfMRI scans are better than the standard task based fMRI scans at diagnosing or monitoring central nervous system…
- Trial name
- NCT03342586
- Testing
- Resting State fMRI (rsfMRI), Auditory Attention and Executive Functions Test, Memory Test
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer
Neuroprotective Effect of Neurotropin on Chronic OXA-induced Neurotoxicity in Stage II and Stage III CRC Patients
Oxaliplatin is effective in adjuvant and first-line colorectal cancer chemotherapy. Oxaliplatin-induced severe chronic neurotoxicity is the main dose-limiting adverse event.
- Trial name
- NCT07320950
- Testing
- Neurotropin
- Where
- China
- Volunteers
- 333 people
- Sponsor
- Sun Yat-sen University
Lymphoma, Leukemia
Cognitive Aftereffects of Neurotoxicity in Children and Young Adults With Relapsed/Refractory Hematologic Malignancies Who Receive CAR T-cell Therapy
Background: CAR T-cell therapy is a promising new treatment for blood cancers. During treatment, a person s T-cells are genetically changed to kill cancer cells.
- Trial name
- NCT05237986
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Neurotoxicity, Neurotoxicity Syndromes
Assessing DCog Short for Neurotoxicity in CAR-T
The aim of this study is to determine the effectiveness of DCog Short, a self-reporting, iPad-based application tool, in assessing neurotoxicity in participants undergoing CAR-T cell therapy.
- Conditions
- Neurotoxicity, Neurotoxicity Syndromes, Hematologic Malignancy, Immune Effector Cell Associated Neurotoxicity Syndrome
- Trial name
- NCT07403812
- Testing
- DCog Short
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Beth Israel Deaconess Medical Center
Lymphoma, Lymphoma, B-Cell
Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell Lymphoma
This research study combines 2 different ways of fighting disease: antibodies and T cells. Both antibodies and T cells have been used to treat patients with cancers, and both have shown promise, but neither alone has been…
- Conditions
- Lymphoma, Lymphoma, B-Cell, Immune System Diseases, Immunoproliferative Disorders
- Trial name
- NCT03696784
- Testing
- iC9-CAR19 T cells, Bendamustine, Fludarabine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Metastatic Gastric Cancer
Study Evaluating Neurotoxicity in Patients With Metastatic Gastro Intestinal Cancer Taking Phycocare® or Placebo During Oxaliplatin Based Chemotherapy
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most frequent side effects caused by antineoplastic agents, with a prevalence from 19% to over 85%.
- Trial name
- PROPERTY (NCT05025826)
- Testing
- Phycocare
- Where
- 8 sites in France
- Volunteers
- 73 people
- Sponsor
- Nantes University Hospital
Infection Resistant to Multiple Drugs
Prospective Observational Pilot-study for the Evaluation of the Nephro- an Neurotoxicity in the Anti-infectious Therapy With Inhalative Colistin Therapy for Patients With Ventilator-associated Pneumonia (VAP)
Multi-Drug resistant pathogens (MDR) are reported worldwide with increasing incidence, especially in intensive care settings. One of the drugs which are effective against MDRs, is colistin (polymyxin E).
- Trial name
- LOKALE (NCT01894347)
- Testing
- TDM, Monitoring of Neuro-and Nephropathology
- Where
- Germany
- Volunteers
- 9 people
- Sponsor
- Charite University, Berlin, Germany
Childhood Leukemia Survivors
N-PhenoGENICS: Neurocognitive-Phenome, Genome, Epigenome and Nutriome In Childhood Leukemia Survivors
To find possible therapeutic targets to help prevent long-term brain and behavioural side effects in survivors of childhood leukemia that may have been caused by chemotherapy (Treatment-Related late Adverse Neuro-Cognitive…
- Trial name
- NPG (NCT01913093)
- Where
- Canada
- Volunteers
- 204 people
- Sponsor
- The Hospital for Sick Children
Lymphoma, Myeloma
Multimodal Telerehabilitation in Patients Undergoing CAR-T Cell Immunotherapy
The proposed multimodal telerehabilitation model allows a rehabilitation therapy team to set up individualized rehabilitation plans using a web-based care management portal and monitor patient progress online.
- Conditions
- Lymphoma, Myeloma, Cytokine Release Syndrome, Immune Effector Cell Associated Neurotoxicity Syndrome
- Trial name
- NCT07390071
- Testing
- Home Automated Telemanagement (HAT) Patient Unit
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Utah
Neurotoxicity Syndromes
A Pilot Study of Dextromethorphan for the Prevention and Treatment of Methotrexate Neurotoxicity
The purposes of this study are to find out whether dextromethorphan can prevent the short or long-term neurologic side effects of methotrexate, and whether dextromethorphan can improve symptoms of short-term neurologic side…
- Trial name
- NCT00176553
- Testing
- Dextromethorphan
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Syndrome, Manganese Neurotoxicity
Effects of Thoracolumbar Stabilization Versus Spinal Decompression Exercises on Maigne's Syndrome
The study was conducted to compare the effect of thoracolumbar stabilization exercises versus spinal decompression exercises on pain, range of motion, disability and posture in patients with maigne's syndrome.
- Trial name
- NCT07426900
- Testing
- Lumbothoracic stabilization exercises, Spinal decompression exercises, Standardized physical therapy treatment
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Neurotoxicity, Unspecified Adult Solid Tumor, Protocol Specific
Nerve Function in Older Diabetic Patients Who Are Undergoing Chemotherapy for Metastatic Solid Tumors
RATIONALE: Learning about the side effects of chemotherapy may help plan treatment and may help patients live more comfortably. PURPOSE: This clinical trial is studying nerve function in older diabetic patients who are undergoing…
- Trial name
- NCT00263861
- Testing
- management of therapy complications
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Case Comprehensive Cancer Center
Alcoholism
Baclofen to Prevent Agitation in Alcohol Addicted Patients in ICU
Background: Alcohol is the leading psychoactive substance consumed in France, with about 15 million regular consumers. The National institute on Alcohol Abuse and Alcoholism (NIAAA) considers alcohol abuse to be more than 14…
- Trial name
- BACLOREA (NCT02723383)
- Testing
- BACLOFEN
- Where
- 18 sites in France
- Volunteers
- 314 people
- Sponsor
- Nantes University Hospital
Alcohol Withdrawal Delirium
Treatment Of Alcohol Withdrawal Syndrome: Dexmedetomidine Vs Diazepam In A Hospital O'horán
The cessation of alcohol consumption of people suffering from alcohol abuse frequently leads to the development of an alcohol withdrawal syndrome (AWS).
- Trial name
- NCT03877120
- Testing
- Dexmedetomidine 0.004 MG/ML, Diazepam Injectable Solution
- Where
- Mexico
- Volunteers
- 2 people
- Sponsor
- Centro Medico Nacional La Raza, IMSS
Breast Neoplasm
Adjusting the Dose of Therapeutic Exercise to Prevent Neurotoxicity Due to Anticancer Treatment (ATENTO)
The purpose of this study is to determine whether a multimodal program based on therapeutic exercise and vagal activation techniques for newly diagnosed breast cancer women has better results in terms of neurotoxicity prevenion…
- Trial name
- ATENTO (NCT04583124)
- Testing
- ATENTO-B, ATENTO-T
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Universidad de Granada