Clinical trials: Neutrophils
Childhood Cancer
Neutrophil Extracellular Traps Formation Post-hematopoietic Stem Cell Transplantation
Identifying the post-transplantation phase wherein neutrophils recover their ability to release NETs could shed new light on the mechanism responsible for the increased susceptibility to infection among these patients and aid in…
- Trial name
- NETs post HSCT (NCT01491230)
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Neutrophil-mediated Inflammatory Dermatoses, Inflammatory Dermatoses
Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases
This study is to identify rare, disease-causing mutations of several rare neutrophil dermatoses. To identify associations between NMID and variants in the genome next generation sequencing, mainly whole exome sequencing, will be…
- Trial name
- NEUTROSKIN (NCT05732987)
- Testing
- Analysis of samples
- Where
- Switzerland
- Volunteers
- 3,370 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Antineutrophil Cytoplasmic Antibody-associated Vasculitis
Trial of VIS954 in the Treatment of Antineutrophil Cytoplasmic Antibody-associated Vasculitis
This is a phase 2, double-blind, randomized, controlled, multicenter trial evaluating the efficacy, safety, pharmacokinetics, and pharmacodynamics of 2 VIS954 dosing regimens in patients with moderate to severe acute…
- Trial name
- NCT07904806
- Testing
- VIS954, Standard Of Care (SOC)
- Volunteers
- 75 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Eosinophilic Granulomatous Vasculitis
Efficacy and Safety of Benralizumab in EGPA Compared to Mepolizumab.
This is a randomized, double blind, active-controlled, parallel group, multicenter 52-week Phase 3 study to compare the efficacy and safety of benralizumab 30 mg versus mepolizumab 300 mg administered by subcutaneous (SC)…
- Trial name
- MANDARA (NCT04157348)
- Testing
- Benralizumab, Mepolizumab
- Where
- 50 sites in United States, Belgium and 7 more
- Volunteers
- 140 people
- Sponsor
- AstraZeneca
Eosinophilic Granulomatosis With Polyangiitis
Study of Mepolizumab-based Regimen Compared to Conventional Therapeutic Strategy in Patients With Eosinophilic Granulomatosis With Polyangiitis (E-merge)
The purpose of this study is to compare mepolizumab-based regimen to conventional therapeutic strategy for remission induction in patients with Eosinophilic Granulomatosis with Polyangiitis.
- Trial name
- E-merge (NCT05030155)
- Testing
- Mepolizumab, cyclophosphamide/azathioprine
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pancreatic Neuroendocrine Tumor
Study of Pancreatic Neuroendocrine Tumors and Carcinomas in Alsace Region
Pancreatic Neuroendocrine tumors and carcinomas (pNET) see the last year their incidence and prevalence going up. On the basis of their grade of differentiation and proliferation ratio measured Ki67 staining, there are divided…
- Trial name
- NCT04134832
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Strasbourg, France
Hemodynamic Instability, Post-induction Hypotension (PIH)
Preoperative Neutrophil-to-Albumin Ratio and Post-Induction Hemodynamic Vulnerability in Major Oncologic Surgery
This prospective observational study aims to evaluate whether the preoperative neutrophil percentage-to-albumin ratio (NPAR) is associated with post-induction hemodynamic vulnerability in adult patients undergoing elective major…
- Trial name
- NCT07804706
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Placenta Accreta Spectrum, Placenta Previa
Hematological and Coagulation Markers in Predicting Placenta Accreta Spectrum in Placenta Previa
Placenta accreta spectrum (PAS) is a serious pregnancy complication where the placenta attaches too deeply into the wall of the uterus.
- Trial name
- NCT07826247
- Volunteers
- 130 people
- Sponsor
- Assiut University
Sepsis, Intensive Care (ICU)
Investigation of the Relationship Between MD, MLR and NLR With APRs in Sepsis in the ICU
The aim of this study is to investigate, in patients admitted to the intensive care unit either for reasons other than sepsis who subsequently develop sepsis or with a primary diagnosis of sepsis, whether monocyte distribution…
- Conditions
- Sepsis, Intensive Care (ICU), Acute Phase Biomarkers
- Trial name
- NCT07537179
- Testing
- Monocyte Distribution
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Oguz Gundogdu
Urinary Bladder Cancer, Urinary Bladder Neoplasm
Neutrophils to Lymphocytes Ratio in Predicting the Response to BCG in Non-muscle Invasive Bladder Cancer
There is a relation between inflammatory cells and the prognosis of tumors (cancer colon, renal, liver, and urinary bladder). In this study, the investigators will link the Neutrophils to Lymphocytes ratio to the response to…
- Conditions
- Urinary Bladder Cancer, Urinary Bladder Neoplasm, BCG, Trans Urethral Resection of a Bladder Tumor
- Trial name
- NCT05946369
- Testing
- Neutrophil to lymphocyte ratio
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Ain Shams University
Prematurity, Histologic Chorioamnionitis
Infant Immune Response to Bacterial Infection
This study will examine the response of white blood cells to bacterial infection in blood taken from the umbilical cords of newly delivered infants.
- Trial name
- NCT00546195
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Neoplasms, Neutropenia
Profiling Neutrophil Counts in Patients on Chemotherapy
The purpose of this trial is to observe the changes in white cell counts in patients with cancer during chemotherapy and to determine if changes in the white cell count in the early days during chemotherapy can be used as a…
- Conditions
- Neoplasms, Neutropenia, Febrile Neutropenia
- Trial name
- NCT02806557
- Testing
- Home finger-prick capillary blood count monitoring
- Volunteers
- 200 people
- Sponsor
- University of Leeds
Covid19
Involvement of Polymorphonuclear Neutrophils and Platelets in Severe Form of COVID-19
The main objective is to quantify the population of reverse migrating neutrophils in patients with COVID-19.
- Trial name
- NeutroVID (NCT04930757)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vasculitis
Clinical Trial of Mycophenolate Versus Cyclophosphamide in ANCA Vasculitis
The purpose of this study is to investigate whether mycophenolate mofetil is effective as treatment for new cases of ANCA associated vasculitis.
- Trial name
- MYCYC (NCT00414128)
- Testing
- mycophenolate mofetil, cyclophosphamide
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Neutrophil Extracellular Traps Formation
Neutrophil Extracellular Traps (NETs) Mediated Killing of Carbapenem-resistant Pseudomonas Aeruginosa.
Aim of the work: To determine the killing ability of neutrophils to ATCC 27853, carbapenem-resistant P. aeruginosa. To compare between the ability of ATCC 27853, carbapenem-resistant P. aeruginosa to induce NETs formation.
- Trial name
- NCT06441708
- Testing
- No intervention
- Volunteers
- 50 people
- Sponsor
- Assiut University
Rheumatic Disease
Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder Arthroplasty
The purpose of this study is to assess the incidence of rheumatologic flares, changes in pain scores (VAS), changes in functional outcomes (PROMIS), wound complications, surgical site infections, and return trips to the operating…
- Trial name
- NCT07138898
- Testing
- Methotrexate, Sulfasalazine, Hydroxychloroquine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- NYU Langone Health
Liver Diseases
Mechanisms of Inflammatory Liver Injury
White blood cells can cause liver damage if they inappropriately accumulate in the liver in large numbers. Such an event can occur if an individual's blood is exposed to endotoxin, a substance released from the cell walls of many…
- Trial name
- NCT00011284
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Pneumonia, Bronchiolitis
Neutrophil Monocyte Lymphocyte Ratios in Pediatric Chest Infections
This prospective cohort study aims to evaluate neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and neutrophil-to-monocyte ratio in children with lobar pneumonia, bronchiolitis, and bronchopneumonia compared with…
- Trial name
- NCT07888049
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
COVID-19
Effect of N-Acetylcysteine on Neutrophil Lymphocyte Ratio And Length of Stay In COVID-19 Patients
This research is a study that compares the administration of N-acetylcysteine at various doses with the outcomes of COVID-19 patients, namely the neutrophil-to-lymphocyte ratio and length of stay.
- Trial name
- NCT05658549
- Testing
- N-acetyl cysteine
- Where
- Indonesia
- Volunteers
- 120 people
- Sponsor
- Universitas Sebelas Maret
Covid19
Bedside Assessment of Immune Function in Patients With Covid-19
Covid-19 is a global pandemic causing unprecedented morbidity and mortality in the general population. It appears to have a greater effect on the elderly or those with underlying health problems but is not exclusively confined to…
- Trial name
- LITCOME (NCT06879548)
- Where
- United Kingdom
- Sponsor
- Barts & The London NHS Trust