Clinical trials: Neutrophils
COVID-19 Pneumonia
A Novel Parameter LIT/N That Predicts Survival in COVID-19 ICU Patients
A brisk immune response can clear a pathogen but can cause extensive collateral damage to the host. It is known that coronavirus disease 2019 (COVID-19) infection triggers a multi system inflammatory disorder which can lead to a…
- Trial name
- NCT05520918
- Testing
- the LIT test
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Gazi University
Acute Graft-versus-Host Disease
Donor Neutrophil Subsets to Predict the Risk of aGVHD
This is a prospective study to explore the association between donor neutrophil subsets and acute graft-vs.-host disease outcomes.
- Trial name
- NCT06394895
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Periodontitis
The Influence of Smoking in Periodontitis Patients, Before and After Nonsurgical Treatment
Objective: The aim of this study was to evaluate and compare the oral neutrophil numbers (ONN) in saliva, the level of matrix metalloproteinase-8 (MMP-8) in gingival crevicular fluid (GCF) and the periodontal parameters in…
- Trial name
- NCT04974502
- Testing
- Nonsurgical periodontal treatment
- Volunteers
- 40 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Gestational Diabetes Mellitus (GDM)
The Role of Breast Milk Neutrophils From Mothers With Metabolic Diseases After Nutritional Intervention. Impact on Infant Development and Response to Pulmonary Infections
This project aims at identifying variations in breast milk neutrophils among lactating mothers with gestational diabetes or obesity (objective 1), and to describe how a dietary intervention with Omega-3 fatty acids affects these…
- Trial name
- PI2222/01813 (NCT06833554)
- Testing
- Omega-3 Fatty Acids (EPA plus DHA)
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
COPD, Emphysema
Regulation of Inflammatory Mediators in Chronic Obstructive Pulmonary Disease
The aim of this study is to investigate the mechanisms whereby lung function is decreased in COPD. The hypothesis is that in diseases such as COPD, inflammatory cells including neutrophils, macrophages and lymphocytes migrate to…
- Trial name
- NCT00147095
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Imperial College London
COPD, Emphysema
Leukocyte Function in Chronic Obstructive Pulmonary Disease (COPD)
The aim of this study is to investigate the mechanisms whereby leukocytes are recruited to the lung in chronic obstructive pulmonary disease (COPD) and cause tissue destruction.
- Conditions
- COPD, Emphysema, Chronic Bronchitis
- Trial name
- NCT00147082
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Ischemic Stroke
Microclots and Neutrophil Activation as Potential Indicators for Stroke Risk and Reperfusion Failure
Stroke remains a major health burden worldwide. Many patients are severely disabled and stay in need of care. Mechanical thrombectomy has dramatically improved outcomes for stroke patients with large vessel occlusions, yet 40-50%…
- Trial name
- CLOTSAFE (NCT06530927)
- Testing
- 3D rotational digital tomography, Atomic Force Microscopy, Micro-Computertomography
- Where
- Switzerland
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Hematologic Malignancy
MPH966 for Prevention of Graft-versus-host Disease After Allogeneic Hematopoietic Stem Cell Transplantation
The purpose of this study is evaluate the safety and tolerability of MPH966, a neutrophil elastase inhibitor, and its ability to prevent graft-versus-host disease after hematopoietic stem cell transplant.
- Trial name
- NCT03986086
- Testing
- MPH966
- Where
- United States
- Sponsor
- Nelson Chao
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
The Clinical Efficacy of DFPP in Patients With AAGN
The clinical efficacy of double filtration plasmapheresis(DFPP) in patients with antineutrophil cytoplasmic autoantibody associated glomerulonephritis(AAGN).
- Trial name
- NCT02294344
- Testing
- DFPP&CTX, CTX
- Where
- China
- Volunteers
- 14 people
- Sponsor
- Zhi-Hong Liu, M.D.
Granulomatosis With Polyangiitis, Microscopic Polyangiitis
Rituximab for ANCA-associated Vasculitis (RAVE) Long-Term Follow-Up Study
Rituximab is the first drug approved by the United States Food and Drug Administration (FDA) for the treatment of patients with granulomatosis with polyangiitis (Wegener's granulomatosis) or microscopic polyangiitis.
- Trial name
- RAVELOS (NCT01586858)
- Testing
- Observational
- Where
- 8 sites in United States, Netherlands
- Volunteers
- 67 people
- Sponsor
- Johns Hopkins University
Non-small-Cell Lung Cancer
Clinical Trial for Post-marketing Evaluation of Sheng Bai Oral Liquid
The purpose of the study is to evaluate the efficacy and safety of Sheng Bai oral liquid in prevention and treatment of the decrease of neutrophilics after chemotherapy in patients with non-small-cell lung cancer.
- Trial name
- NCT03413358
- Testing
- Sheng Bai oral liquid, Platinum-based two medicine (carboplatin / cisplatin) .
- Where
- China
- Volunteers
- 240 people
- Sponsor
- BeiJing Yijiayi Medicine Techonoloy Co., Ltd.
Allogeneic Granulocyte Donation
Improving White Blood Cell Collection From Healthy Donors
Background: White blood cells called granulocytes help the body fight infection. People who have had chemotherapy or bone marrow transplants may have very low numbers of these cells.
- Trial name
- NCT01553214
- Testing
- Filgrastim, Dexamethasone
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
ANCA-associated Vasculitis
Avacostar - (PASS)
The Avacostar PASS is a non-interventional, multi-national, prospective cohort study that will collect data from 2 cohorts of patients: those treated with avacopan for active severe AAV, and a second cohort treated with a…
- Trial name
- Avacostar (NCT05897684)
- Where
- 35 sites in Germany, United Kingdom
- Volunteers
- 507 people
- Sponsor
- Vifor Fresenius Medical Care Renal Pharma
Sinus Disease, EGPA - Eosinophilic Granulomatosis With Polyangiitis
Effectiveness on Sino-Nasal Symptoms Of Mepolizumab 300
OBJECTIVES The primary objective of this study is evaluating the reduction of dimension of nasal polyps measured with Nasal Polyp Endoscopic Score (NPS) The secondary objective is to evaluate the improvement in nasal symptoms and…
- Conditions
- Sinus Disease, EGPA - Eosinophilic Granulomatosis With Polyangiitis, Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps
- Trial name
- MEPO300REAL (NCT07592104)
- Testing
- Mepolizumab 300 mg
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Spontaneous Bacterial Peritonitis
MPV and NLR as Predictors of SBP Diagnosis
The aim of the study is to investigate the clinical utility of mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) as diagnostic markers for spontaneous bacterial peritonitis (SBP).
- Trial name
- NCT04775420
- Testing
- Measurement of mean platelet volume (MPV) and blood neutrophil to lymphocyte ratio (NLR)
- Where
- Egypt
- Volunteers
- 332 people
- Sponsor
- Sohag University
Neuro-Oncology, MRI Imaging
Mechanistic Study of SPARC-Mediated Regulation of Neutrophil Extracellular Trap Formation in the Brain Metastatic Microenvironment of Breast Cancer
The objective of this observational study is to investigate the characteristics of the tumor microenvironment in patients with brain tumors using multi-modal magnetic resonance imaging (MRI).
- Conditions
- Neuro-Oncology, MRI Imaging, Tumor Immune Microenvironment
- Trial name
- NCT07185646
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Xiangya Hospital of Central South University
Systemic Lupus Erythematosus, Systemic Sclerosis
Clinical Study on Targeted CD19CAR-T Therapy for Autoimmune Diseases
This is an open-label, investigator-initiated clinical trial (IIT) aimed at evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of RD06-04 in patients with active SLE, SSc, AAV, IIM, and pSS
- Conditions
- Systemic Lupus Erythematosus, Systemic Sclerosis, ANCA Associated Vasculitis, Idiopathic Inflammatory Myopathies
- Trial name
- NCT06549296
- Testing
- RD06-04 CART Cell Injection
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Nanjing Bioheng Biotech Co., Ltd.
Vasculitis
A Study to Evaluate the Safety and Efficacy of CCX168 in Subjects With ANCA-Associated Vasculitis
The aim of this trial is to optimize the treatment to induce remission for patients with non-life-threatening anti-neutrophil cytoplasmic antibody vasculitis (AAV).
- Trial name
- NCT01363388
- Testing
- CCX168
- Where
- 44 sites in Austria, Belgium and 8 more
- Volunteers
- 67 people
- Sponsor
- Amgen
Hemorrhagic Shock
Effect of Remote Ischemic Conditioning on Trauma Patients With Hemorrhagic Shock
The purpose of the study is to evaluate whether remote ischemic conditioning is a safe and effective intervention to prevent the development of inflammation and coagulopathy in trauma patients with hemorrhagic shock.
- Trial name
- NCT02071290
- Testing
- Pneumatic tourniquet
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
Burnout Syndrome, Neutrophil-Lymphocyte Ratio
Music Therapy on Neutrophyl Lymphocytes Ratio, Interleukin 6 and Interleukin 10 Levels of Burnout Syndrome
Burnout Syndrome (BOS) can be defined as a state of stress both physically and psychically due to the burden and stressor of high work. The prevalence of BOS in health workers varies between 25-75% globally.
- Conditions
- Burnout Syndrome, Neutrophil-Lymphocyte Ratio, Interleukin-6, Interleukin-10
- Trial name
- NCT05750160
- Testing
- music therapy
- Where
- Indonesia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia