Clinical trials: Neutrophils
Rheumatoid Arthritis
Study of the Functional Status Neutrophils in Rheumatoid Arthritis Patients to Identify New Biomarkers of Response to Anti-TNFalpha Therapy
The goal of this interventional pathophysiological exploratory, cohort, prospective, with a 6-month follow-up study is to characterize phenotypic and functional alterations of PolyMorphonuclear Neutrophils as well as…
- Trial name
- NeutroARTherap (NCT05802719)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Type 2 Diabetes
Post-extraction Wound Healing in Patients With Type 2 Diabetes
The purpose of this study is to evaluate clinical healing after dental extraction and the occurrence of surgical complications in patients with type 2 diabetes and compare with non-diabetic patients or control, taking into…
- Trial name
- PEWHPD (NCT01091909)
- Testing
- Dental extractions
- Where
- Brazil
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia
Flow Cytometric Analysis of Peripheral Blood Neutrophil Myeloperoxidase Expression and Myelodysplastic Syndromes
Myelodysplastic syndromes (MDS) constitute a heterogeneous group of clonal bone marrow neoplasms that predominate in the elderly, with a median age at diagnosis of 70 years.
- Trial name
- MPO-MDS-PILOT (NCT03363399)
- Testing
- Flow cytometry analysis of neutrophil myeloperoxidase expression
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Grenoble
ANCA Associated Vasculitis, Maintenance Therapy
Comparison of the Efficacy of Leflunomide and Azathioprine for the Maintenance Therapy of ANCA Associated Vasculitis
This study is a prospective, open-labelled, randomized, controlled,multi-center clincial trial. The aim of this study is to verify that the remission rate of patients treated with Leflunomide is not inferior to that of patients…
- Trial name
- LEFAZAREM (NCT04737343)
- Testing
- Leflunomide, Azathioprine Tablets
- Where
- 4 sites in China
- Volunteers
- 114 people
- Sponsor
- Chinese SLE Treatment And Research Group
Primary Immune Deficiency Disorder, Periodontitis
Investigation of Dental Health in Children With Neutrophil Defects: A Clinical Study
Title: Investigation of neutrophil defects associated with periodontal disease and tooth loss in children. A clinical study. Objectives: The primary objective of this study is: To investigate presence of periodontal disease and…
- Trial name
- GOSH (NCT03069079)
- Testing
- Oral hygiene advice, non surgical periodontal treatment
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Queen Mary University of London
Spontaneous Bacterial Peritonitis
MPV and NLR as Predictors of SBP Diagnosis
The aim of the study is to investigate the clinical utility of mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) as diagnostic markers for spontaneous bacterial peritonitis (SBP).
- Trial name
- NCT04775420
- Testing
- Measurement of mean platelet volume (MPV) and blood neutrophil to lymphocyte ratio (NLR)
- Where
- Egypt
- Volunteers
- 332 people
- Sponsor
- Sohag University
Malnutrition, Colorectal Cancer
Nutrition for Colorectal Cancer Patients and Neutrophil Functions
Hypercatabolism and immune suppression are frequently seen in patients with malignancy. Preoperative nutritional state is an important factor in determining surgical and postoperative complications because the preoperative…
- Trial name
- NCT01831310
- Testing
- Standard (Kabiven), Standard-Glutamine, Standard-Omega 3 fatty acid
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Kocaeli University
COVID-19, Mild to Moderate
COVID-19 Study at the Russian Clinical and Research Center of Gerontology of the Pirogov RNRMU
This is a retrospective observational cohort study. About 1000 hospital charts of adult patients admitted to the hospital with mild-to-moderate COVID-19 from February to August 2020 were analyzed to evaluate the inflammatory…
- Trial name
- NCT05302947
- Testing
- Baricitinib Oral Tablet, Tocilizumab Injection, Netakimab
- Where
- 2 sites in Russia
- Volunteers
- 154 people
- Sponsor
- Pirogov Russian National Research Medical University
Anaphylactic Shock to Neuro-Muscular Blocking Agents (NMBA)
Role of Neutrophil Activation in Anaphylaxis to Neuro-Muscular Blocking Agents
In about 10% of preoperative anaphylactic reactions to Neuro-Muscular Blocking Agents (NMBA) (114 patients analyzed at the BICHAT Hospital), a classical mechanism (mast cell- and IgE-dependent) is not identified.
- Trial name
- NASA (NCT01637220)
- Testing
- Blood volume collected specifically for this study
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Pancreatitis, Organ Failure, Multiple
Safety, Tolerability and Performance of the NucleoCapture Extracorporeal Therapeutic Apheresis Device in the Reduction of Circulating cfDNA/NETs in Subjects With Pancreatitis
This is a single-centre, randomised-controlled, open-label, feasibility study to assess the safety, tolerability and performance of the NucleoCapture extracorporeal apheresis device in the reduction of circulating cell-free DNA…
- Trial name
- NUC-SAP1 (NCT06566638)
- Testing
- NucleoCapture device
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Antineutrophilic Cytoplasmic Antibody (ANCA)- Associated Vasculitis (AAV), Idiopathic Inflammatory Myositis (IIM)
A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease
This is a phase 1 study designed to evaluate the safety, pharmacokinetics (PK), and anti-B-cell activity of FT819 following treatment with or without auxiliary medicinal product (AMP) in participants with moderate-to-severe…
- Conditions
- Antineutrophilic Cytoplasmic Antibody (ANCA)- Associated Vasculitis (AAV), Idiopathic Inflammatory Myositis (IIM), Systemic Sclerosis (SSc), Systemic Lupus Erythematosus (SLE)
- Trial name
- NCT06308978
- Testing
- FT819, Fludarabine, Cyclophosphamide
- Where
- 21 sites in United States, France and 2 more
- Volunteers
- 244 people
- Sponsor
- Fate Therapeutics
Atheroma; Myocardial
Plaque Erosion Prospective Study ii
Plaque erosion is associated with myocardial infarction (MI) in about 30% of cases and may require a different management approach to plaque rupture.
- Trial name
- PEPSii (NCT04701385)
- Testing
- Optical Coherence Tomography (OCT)
- Where
- United Kingdom
- Volunteers
- 33 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Ocular Discomfort, Ocular Inflammation
Effects of Xiidra on Closed Eye Tear Film Leukocytes in Dry Eye Disease
Every night during sleep, there is an accumulation of white blood cells in the closed eye. The closed eye white blood cells are predominantly neutrophils, but there is a small population (3%) of T cells.
- Conditions
- Ocular Discomfort, Ocular Inflammation, Dry Eye, Contact Lens Complication
- Trial name
- NCT03408015
- Testing
- Lifitegrast
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Prostate Infection, Prostate Disease
The Relationship Between Serum PSA Levels and WBC, Delta Neutrophil Index (DNI) and Other Hematological Parameters
Purpose: To find the correlation between hemogram parameters and Delta Neutrophil Index(DNI) and Serum PSA in patients presenting with the diagnosis of acute prostatitis.
- Conditions
- Prostate Infection, Prostate Disease, Prostate Cancer
- Trial name
- NCT05399940
- Testing
- Serum PSA,Delta Neutrophil Index(DNI),WBC
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Hisar Intercontinental Hospital
Pancreatic Cancer, Gastric Cancer
Evaluation of NETs in Patients With Solid Cancers Associated With a High Risk of Venous Thromboembolic Events
Venous Thromboembolic Events (ETVs) are the second leading cause of death (9.2% of causes of death) in cancer patients after tumor progression (1).
- Conditions
- Pancreatic Cancer, Gastric Cancer, Colorectal Cancer
- Trial name
- Flownet (NCT04294589)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neutrophil, Phyllanthus Abnormis Poisoning
To Exam the Effects of Phyllanthus Niruri Extracts on Human Neutrophils
To exam the effects of Phyllanthus niruri extracts(corilagin, phyllanthin and brevifolin) on human neutrophils
- Trial name
- NCT05206058
- Testing
- venipuncture
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Chronic Myeloid Leukemia (CML)
Study of CD38 and CD56 in Chronic Myeloid Leukemia
Chronic myeloid leukemia is a myelo-proliferative neoplasm characterized by abnormal proliferation of myeloid cells. There is an accumulation of mature granulocytes in the blood and bone marrow.
- Trial name
- NCT07740603
- Testing
- cd 38 and cd 56
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sohag University
Autoimmune Diseases, Systemic Lupus Erythematosus
Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA U CAR-T Cell Injection for the Treatment of Relapsed/Refractory Autoimmune Diseases
A single arm, open-label pilot study is designed to determine the safety and effectiveness of anti-CD19/BCMA U CAR T cells in patients with autoimmune diseases. 60 patients are planned to be enrolled in the dose-escalation trial.
- Conditions
- Autoimmune Diseases, Systemic Lupus Erythematosus, Systemic Sclerosis, Primary Sjögren Syndrome
- Trial name
- NCT07246096
- Testing
- anti-CD19/BCMA U CAR T cells
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Changhai Hospital
Breast Cancer, Breast Neoplasm Female
Targeting Stress-Driven Inflammatory and Angiogenic Pathways With Brief ACT to Enhance Neoadjuvant Chemotherapy Response in Locally Advanced Breast Cancer
This clinical trial aims to learn whether a brief psychological therapy called Brief Acceptance and Commitment Therapy (Brief-ACT) can improve the effectiveness of neoadjuvant chemotherapy in patients with locally advanced breast…
- Conditions
- Breast Cancer, Breast Neoplasm Female, Locally Advanced Breast Cancer (LABC), Locally Advanced Breast Cancer
- Trial name
- NCT07570368
- Testing
- Brief Acceptance and Commitment Therapy, Standard Counseling, Neoadjuvant Chemotherapy
- Volunteers
- 54 people
- Sponsor
- Universitas Airlangga
Postoperative Pain, Abdominal Surgery by Laparotomy
Rectus Sheath Block as an Adjunct to General Anesthesia for Midline Laparotomy Pain
This study evaluates whether adding an ultrasound-guided rectus sheath block (RSB) to general anesthesia can improve pain control after midline laparotomy.
- Trial name
- RSB-MIDLINE (NCT07393763)
- Testing
- Ultrasound-guided rectus sheath block
- Where
- Indonesia
- Volunteers
- 46 people
- Sponsor
- Udayana University