Clinical trials: Neutrophils
Hematologic Malignancy
MPH966 for Prevention of Graft-versus-host Disease After Allogeneic Hematopoietic Stem Cell Transplantation
The purpose of this study is evaluate the safety and tolerability of MPH966, a neutrophil elastase inhibitor, and its ability to prevent graft-versus-host disease after hematopoietic stem cell transplant.
- Trial name
- NCT03986086
- Testing
- MPH966
- Where
- United States
- Sponsor
- Nelson Chao
Granulomatosis, Wegener's, Microscopic Polyangiitis
Pharmacokinetic Study of Rituximab Induction Regimen in ANCA-associated Vasculitis
The aim of the investigators' study is to evaluate whether monitoring serum rituximab levels could be an interesting tool in the follow-up of ANCA-associated vasculitis patients.
- Trial name
- MONITUX (NCT02474888)
- Testing
- blood specimen
- Where
- 4 sites in France
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Vasculitis
A Study to Evaluate the Safety and Efficacy of CCX168 in Subjects With ANCA-Associated Vasculitis
The aim of this trial is to optimize the treatment to induce remission for patients with non-life-threatening anti-neutrophil cytoplasmic antibody vasculitis (AAV).
- Trial name
- NCT01363388
- Testing
- CCX168
- Where
- 44 sites in Austria, Belgium and 8 more
- Volunteers
- 67 people
- Sponsor
- Amgen
Cardiac Surgery
Neutrophil Gelatinase-associated Lipocalin as a New Biomarker to Detect Acute Kidney Injury in Postoperative Cardiac Surgery
Observational study aimed to test the ability of Neutrophil Gelatinase-associated Lipocalin (NGAL) concentration in blood and urine to predict and diagnose early acute renal failure (ARF) in patients after cardiac surgery…
- Trial name
- NCT01594788
- Where
- Spain
- Volunteers
- 340 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Breast Cancer Female
Does Type of Anesthesia Influence Inflammation Change After Breast Surgery?
The Neutrophil to Lymphocyte Ratio (NLR) is a frequently used biomarker of the systemic inflammatory response and is considered one of the most sensitive markers of inflammation.
- Trial name
- NCT04172220
- Testing
- Midazolam, PECS, Opioid-free general anesthesia
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
Prostatectomy
Comparison of Plasma Neutrophil Gelatinase - Associated Lipocalin (NGAL) Levels
The purpose of the study is to compare the effect of two surgical techniques (open vs robotic assisted) on plasma levels of NGAL (neutrophil gelatinase-associated lipocalin) after radical prostatectomy.
- Trial name
- NCT03607279
- Testing
- NGAL
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Antalya Training and Research Hospital
Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis
A Study to Assess the Mass Balance Recovery (Absorption, Distribution, Metabolism and Excretion) of [14C]CCX168 in Healthy Participants
The primary objective of this study is to perform mass balance following a single oral dose of [14C]CCX168 in healthy adult male participants.
- Trial name
- NCT06004960
- Testing
- [14C]CCX168
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Amgen
Systemic Wegener's Granulomatosis
WEGENT - Comparison of Methotrexate or Azathioprine as Maintenance Therapy for ANCA-Associated Vasculitides
Remission of ANCA-associated vasculitis can be obtained in approximately 80% of the patients with a combination of corticosteroids and cyclophosphamide. However, relapses are frequent.
- Trial name
- NCT00349674
- Testing
- Azathioprine: 2 mg/kg/day, methotrexate 0.3 mg/kg/week, to a maximum and optimal dose of 25 mg/week
- Where
- France
- Volunteers
- 126 people
- Sponsor
- Hospices Civils de Lyon
NAFLD- Non Alcoholic Fatty Liver Disease
Study of Neutrophils and Circulating Platelets in Correlation With the Activity of T Lymphocytes in Patients With NAFLD (Nonalcoholic Fatty Liver Disease)
The aim of the study is to define the relationship between neutrophils, platelets and the activity of T lymphocytes in patients with NAFLD (nonalcoholic fatty liver disease).
- Trial name
- NAFLD (NCT05358496)
- Testing
- Data collection
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of L'Aquila
Pesticide Poisoning
Cholinesterase, Amylase, Lipase and Neutrophil-to-lymphocyte Ratio in Acute Pesticide Poisoning Cases
To estimate diagnostic levels of amylase, lipase, pseudocholinestrase and neutrophili lymphocytic ratio to different pesticide poisoning.
- Trial name
- NCT05310188
- Testing
- pseudocholinesterease
- Volunteers
- 100 people
- Sponsor
- Assiut University
Neutrophil Extracellular Traps Formation
Neutrophil Extracellular Traps (NETs) Mediated Killing of Carbapenem-resistant Pseudomonas Aeruginosa.
Aim of the work: To determine the killing ability of neutrophils to ATCC 27853, carbapenem-resistant P. aeruginosa. To compare between the ability of ATCC 27853, carbapenem-resistant P. aeruginosa to induce NETs formation.
- Trial name
- NCT06441708
- Testing
- No intervention
- Volunteers
- 50 people
- Sponsor
- Assiut University
ANCA Associated Vasculitis
Efficacy and Safety for Rituximab Combined With Telitacicept in the Treatment of ANCA-associated Vasculitis (TTCAAVREM)
This study is a prospective, open-labelled, randomized, controlled, single-center clinical trial. The aim of this study is to investigate the remission rate of patients treated with Telitacicept combined with Rituximab in…
- Trial name
- NCT05962840
- Testing
- Telitacicept
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chinese SLE Treatment And Research Group
Renal Failure
ROLE OF URINARY BIOMARKER NEUTROPHIL GELATINASE ASSOCIATED LIPOCALCIN (NGAL) IN EARLY PREDICTION OF AKI IN CIRRHOSIS OF LIVER
Kidney dysfunction is a complex and common event in patients with liver cirrhosis. Although novel treatments have shown some promising results , acute kidney injury remains a major complication of decompensated liver cirrhosis…
- Trial name
- NGAL (NCT05161910)
- Testing
- Biomarkers
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Asian Institute of Gastroenterology, India
Pulmonary Fibrosis
Pilot Study of Pirfenidone in Pulmonary Fibrosis With Anti-myeloperoxydase Antibodies
The purpose of this study is to determine wether pirfenidone is safe and effective in the treatment of pulmonary fibrosis with anti-myeloperoxydase (MPO) antibodies or pulmonary fibrosis with anti-MPO associated vasculitis.
- Trial name
- PIRFENIVAS (NCT03385668)
- Testing
- Pirfenidone
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
the Prognostic Value of Pre-treatment NLR in Patients With Locally Advenced Rectal Cancer and Post-treatment
The Prognostic Impact Of The Neutrophil To Lymphocyte Ratio In Patients With Locally Advanced Rectal Cancer
In this study, we aim to investigate the prognostic value of pre-treatment NLR in patients with locally advenced rectal cancer and post-treatment
- Trial name
- NCT05673343
- Volunteers
- 100 people
- Sponsor
- Assiut University
Infection
Hyperbaric Oxygen, Neutrophil-oxidative Burst, and Cytokines
In this small pilot study, participants (patients and healthy volunteers) will have blood drawn before and after the study intervention (hyperbaric chamber session or normal pressure oxygen breathing.
- Trial name
- O2B (NCT02563678)
- Testing
- Hyperbaric Oxygen, Hyperbaric Air/Oxygen, Normobaric oxygen
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Intermountain Health Care, Inc.
Acute Renal Failure, Sepsis
Angiotensin in Septic Kidney Injury Trial
The purpose of this study is to determine the effect of a systemic infusion of angiotensin II on haemodynamics and urine output in critically ill patients with severe sepsis/septic shock and acute renal failure.
- Conditions
- Acute Renal Failure, Sepsis, Septic Shock
- Trial name
- ASK-IT (NCT00711789)
- Testing
- Angiotensin II
- Where
- 2 sites in Australia
- Volunteers
- 12 people
- Sponsor
- Austin Health
Cardiorenal Syndrome
Accuracy of Urinary NGAL in Predicting CardioRenal Syndrome in Acute Heart Failure at Emergency - CYNDERELA-HF Study
Rationale: Heart Failure (HF) elevated prevalence in Brasil and the world; 20-30% AHF patients develop CardioRenal Syndrome (CRS) type 1; Worsening Renal Failure (WRF) is a prognostic marker of mortality in Acute HF;NGAL is a…
- Trial name
- CYNDERELA-HF (NCT01364636)
- Where
- Brazil
- Volunteers
- 180 people
- Sponsor
- Pro-Cardiaco Hospital
Congenital Heart Disease, Tetralogy of Fallot
Prognostic Value of NLR, TLR, and ALC in Predicting ToF Primary Repair Outcome
Tetralogy of Fallot (ToF) were cyanotic congenital heart disease with chronic hypoxia which increases the risk of exacerbated inflammatory response in ToF primary repair.
- Conditions
- Congenital Heart Disease, Tetralogy of Fallot, Neutrophil-lymphocyte Ratio, Absolute Lymphocyte Count
- Trial name
- NCT05976204
- Testing
- ToF primary repair
- Where
- Indonesia
- Volunteers
- 501 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
ANCA-associated Vasculitis
Clinical Trial to Evaluate Safety and Efficacy of CCX168 in ANCA-Associated Vasculitis
The aim of this trial is to test the safety and efficacy of two dose regimens of the complement C5a receptor CCX168 in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).
- Trial name
- NCT02222155
- Testing
- CCX168 10 mg, twice daily, plus cyclophosphamide/rituximab plus glucocorticoids, CCX168 30 mg, twice daily, cyclophosphamide/rituximab plus glucocorticoids
- Where
- 43 sites in United States, Canada
- Volunteers
- 42 people
- Sponsor
- Amgen