Clinical trials: Neutrophils
ANCA-Associated Vasculitis (AAV)
Avacopan Added to Standard-of-care Therapy in ANCA-associated Vasculitis With Severe Kidney Involvement
ANCA-associated vasculitis (AAV) is a rare auto-immune disease, with high mortality in the absence of treatment. There is still an unmet need to define new treatment strategies to reduce drug side effects, as well as to reverse…
- Trial name
- REVERSE (NCT07373262)
- Testing
- Avacopan
- Where
- 30 sites in France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Toulouse
COVID-19
Effect Of Calcitriol On Neutrophil To Lymphocytes Ratio And High Sensitivity C-Reactive Protein Covid-19 Patients
This research is a study that compares the administration of calcitriol with the outcomes of COVID-19 patients
- Trial name
- NCT05765617
- Testing
- Calcitriol
- Where
- Indonesia
- Volunteers
- 16 people
- Sponsor
- Universitas Sebelas Maret
Chronic Granulomatous Disease
Modified Stem Cell Transplantation Procedure for Treating Chronic Granulomatous Disease
This study will investigate the safety and effectiveness of a new stem cell transplant procedure for treating chronic granulomatous disease (CGD) in patients with active infection.
- Trial name
- NCT00006417
- Testing
- Stem cell transplantation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Covid19
Involvement of Polymorphonuclear Neutrophils and Platelets in Severe Form of COVID-19
The main objective is to quantify the population of reverse migrating neutrophils in patients with COVID-19.
- Trial name
- NeutroVID (NCT04930757)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
STEMI
NLR AND CRP Useful as Cost-Effective Preliminary Prognostic Markers in ST-Elevation Myocardial Infarction
Acute myocardial infarction (AMI) is a serious and fatal cardiovascular emergency and considered the leading cause of mortality worldwide.
- Trial name
- NCT06491667
- Testing
- CBC, C-reactive protein
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Chronic Obstructive Airway Disease, Healthy Volunteers
Regulation of the Release of Inflammatory Mediators From Blood Leukocytes
Chronic obstructive pulmonary disease (COPD for short) involves inflammation inside the air passages of the lungs. This inflammation might be partly responsible for the shortness of breath, cough and susceptibility to chest…
- Trial name
- NCT00180765
- Testing
- Up to 100ml blood will be taken by venupuncture.
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Imperial College London
Pre-Eclampsia
Vital Mechanism of NETs Formation vs. Suicidal Mechanism of NETs Formation During Normal Pregnancy and Preeclampsia
Formation of neutrophil extracellular traps (NETs) is a process of activation of neutrophils, which then generate filaments containing DNA, enzymes and extracellular histones.
- Trial name
- GrossNETs (NCT05470712)
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Vasculitis, Wegener's Granulomatosis
Comparison of Treatments to Maintain Disease Remission in Patients With Wegener's Granulomatosis and Related Vasculitis Syndromes
This study will compare the safety and effectiveness of two drugs-methotrexate and mycophenolate mofetil (MPM)-in preventing disease recurrence in patients with Wegener's granulomatosis and related inflammatory blood vessel…
- Trial name
- NCT00004567
- Testing
- Mycophenolate Mofetil
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Knee Surgery With Tourniquet
Effect of Spinal or Sevoflurane Anesthesia on Neutrophil Activation During Knee Surgery With Pneumatic Tourniquet
Aim of study : Assessement of neutrophil activation during ischemia reperfusion associated with tourniquet use for total knee arthroplasty.
- Trial name
- NCT03470363
- Testing
- Sevoflurane Volatile Liquid, Bupivacaine / SUFentanil
- Volunteers
- 40 people
- Sponsor
- University of Liege
Acute Kidney Injury
Acute Normovolemic Hemodilution on Urine Neutrophil Gelatinase-associated Lipocalin Levels
Acute normovolemic hemodilution (ANH) is performed as a blood conservation technique during surgical procedures with high risk for significant blood loss.
- Trial name
- NCT05349292
- Testing
- ANH
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
The Clinical Efficacy of DFPP in Patients With AAGN
The clinical efficacy of double filtration plasmapheresis(DFPP) in patients with antineutrophil cytoplasmic autoantibody associated glomerulonephritis(AAGN).
- Trial name
- NCT02294344
- Testing
- DFPP&CTX, CTX
- Where
- China
- Volunteers
- 14 people
- Sponsor
- Zhi-Hong Liu, M.D.
Anesthesia Techniques, Percutaneous Nephrolithotomy
Effects of Spinal vs General Anesthesia on Systemic Inflammation in PCNL
This observational study aims to compare the effects of spinal and general anesthesia on perioperative systemic inflammatory response in patients undergoing percutaneous nephrolithotomy (PCNL).
- Conditions
- Anesthesia Techniques, Percutaneous Nephrolithotomy, Systemic Inflammation
- Trial name
- PCNL-ANES-INF (NCT07326670)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Rheumatoid Arthritis
A Study of the Effects of RoActemra/Actemra (Tocilizumab) on Neutrophils in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Biologic and/or Non-biologic DMARDs.
This open-label, single arm study will assess the effect of RoActemra/Actemra (tocilizumab) on neutrophils and monitor safety and benefit-risk of RoActemra/Actemra treatment in patients with active rheumatoid arthritis who have…
- Trial name
- NCT01195272
- Testing
- tocilizumab [RoActemra/Actemra]
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Hoffmann-La Roche
Neonatal SEPSIS
The Role of Neutrophil CD64 and Soluble Triggering Receptor Expressed on Myeloid Cells 1 in Neonatal Sepsis
Neonatal sepsis (NS) is a rather serious but relatively common health problem. Despite recent advances in the treatment of neonatal infection, mortality and comorbidities remain high.
- Trial name
- NCT03795285
- Testing
- Expression of neutrophil CD64
- Volunteers
- 50 people
- Sponsor
- Assiut University
Melanoma, Surgery
Perioperative Examination of Inflammatory Markers in Relation to Sentinel Lymph Node Biopsy in Patients With Melanoma; a Pilot Study
We want to test if an association between sentinel lymph node biopsy (SLBN) and a systemic inflammatory response can be made.
- Trial name
- NCT05817149
- Testing
- Blood samples
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Aalborg University Hospital
Neutrophil, Lymphocyte
Preoperative Administration of Oral Carbohydrate Drink, Neutrophil/Lymphocyte Ratio and Postoperative Complications
This study evaluated the impact of a preoperative carbohydrate oral drink on the postoperative Neutrophil / Lymphocyte Ratio (NLR) and the incidence of postoperative complications after elective open colon surgery compared to the…
- Conditions
- Neutrophil, Lymphocyte, Postoperative Complications
- Trial name
- NCT05301985
- Testing
- preoperative nutrition
- Where
- Bosnia and Herzegovina
- Volunteers
- 60 people
- Sponsor
- Nermina Rizvanović
Sepsis Newborn
Is Neutrophil to Lymphocyte Ratio a Prognostic Factor of Sepsis in Newborns With Operated Congenital Heart Disease
The use of neutrophil lymphocyte ratio is useful for the detection of infection status in newborns after surgery
- Trial name
- NCT03923543
- Testing
- Neutrophil to lymphosit ratio
- Volunteers
- 60 people
- Sponsor
- Firat Ergin
Granulomatosis With Polyangiitis
Natural History of Granulomatosis With Polyangiitis: Clinical and Genetic Biomarkers of Airway Disease NoAAC PR-03 Study
The ultimate goal of this prospective natural history study is to define the natural history of the obstructive airway manifestations of Granulomatosis with polyangiitis (GPA).
- Trial name
- NoAAC PR-03 (NCT03182049)
- Testing
- Airway assessment, Rheumatology assessment
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
OSA
Impact of Intermittent Hypoxia on Neutrophil Extracellular Traps
This prospective observational study will enroll 60 moderate-to-severe OSA patients (AHI≧15/hour, 30 obese [BMI>=27] \& 30 non-obese [BMI<27]) and 40 age-, gender-, BMI-matched controls without OSA.
- Trial name
- NCT05485688
- Testing
- sleep apnea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Acute Kidney Injury
NGAL As An Aid for the Diagnosis of Acute Kidney Injury in Intensive Care
Acute Kidney Injury (AKI) is a common and severe complication in critically ill patients which is associated with increased morbidity and mortality as well as high costs of medical care.
- Trial name
- NCT02121470
- Where
- 4 sites in United States
- Volunteers
- 252 people
- Sponsor
- BioPorto Diagnostics