Clinical trials: Neutrophils
ANCA Associated Vasculitis, Occupational Diseases
Occupational and Environmental Origins of ANCA Vasculitis: Contribution of Data From the National Network for Vigilance and Prevention of Occupational Pathologies (RNV3P)
The main objective is to identify specific risk factors for ANCA vasculitis of occupational and/or environmental origin (exposures identified by questioning, geographical distribution of cases) from the RNV3P data.
- Conditions
- ANCA Associated Vasculitis, Occupational Diseases, Environmental Exposure
- Trial name
- ANCAPRO (NCT05416723)
- Where
- 11 sites in France
- Volunteers
- 302 people
- Sponsor
- University Hospital, Brest
ANCA-Associated Vasculitis
Pediatric ANCA Associated-vasculitis
The incidence in pediatrics is very low (about 0.5 per million according to a French study) and therefore the data on the pathology very poor, especially on the therapeutic level.
- Trial name
- PediANCA (NCT05383573)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
ANCA Associated Vasculitis
Multicenter Cohort Study of AAV in Hunan of China
This study aimed to explore the incidence of Anti-neutrophil cytoplasmic antibody (ANCA）-associated vasculitis (AAV) progression and its association with adverse consequences.
- Trial name
- NCT05315141
- Testing
- No Intervention
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xiangya Hospital of Central South University
Neutrophil, Lymphocyte
Preoperative Administration of Oral Carbohydrate Drink, Neutrophil/Lymphocyte Ratio and Postoperative Complications
This study evaluated the impact of a preoperative carbohydrate oral drink on the postoperative Neutrophil / Lymphocyte Ratio (NLR) and the incidence of postoperative complications after elective open colon surgery compared to the…
- Conditions
- Neutrophil, Lymphocyte, Postoperative Complications
- Trial name
- NCT05301985
- Testing
- preoperative nutrition
- Where
- Bosnia and Herzegovina
- Volunteers
- 60 people
- Sponsor
- Nermina Rizvanović
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Microscopic Polyangiitis
Rituximab Vasculitis Maintenance Study
Rituximab is now established as an effective drug for anti-neutrophil cytoplasmic antibody (ANCA) vasculitis following major European and US trials reported in 2010. After a time, its effect wears off and the disease can return.
- Conditions
- Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Microscopic Polyangiitis, Wegener Granulomatosis
- Trial name
- RITAZAREM (NCT01697267)
- Testing
- Rituximab, Azathioprine
- Where
- 38 sites in United States, Australia and 8 more
- Volunteers
- 188 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
ANCA Associated Vasculitis, Granulomatosis With Polyangiitis
Rituximab and Belimumab Combination Therapy in PR3 Vasculitis
Mechanistic study to assess whether dual B-cell immunotherapy by co-administration of rituximab and belimumab will result in improvements in biological endpoints, functional outcomes and clinical status compared to rituximab with…
- Trial name
- COMBIVAS (NCT03967925)
- Testing
- Belimumab, Rituximab, Prednisolone
- Where
- 6 sites in United Kingdom
- Volunteers
- 31 people
- Sponsor
- Rachel Jones
ANCA Associated Vasculitis, Maintenance Therapy
Comparison of the Efficacy of Leflunomide and Azathioprine for the Maintenance Therapy of ANCA Associated Vasculitis
This study is a prospective, open-labelled, randomized, controlled,multi-center clincial trial. The aim of this study is to verify that the remission rate of patients treated with Leflunomide is not inferior to that of patients…
- Trial name
- LEFAZAREM (NCT04737343)
- Testing
- Leflunomide, Azathioprine Tablets
- Where
- 4 sites in China
- Volunteers
- 114 people
- Sponsor
- Chinese SLE Treatment And Research Group
ANCA Associated Vasculitis, Sjogren's Syndrome
Patients With Co-occurrence of ANCA Vasculitis and Sjögren Syndrome
ANCA vasculitis and Sjögren syndrome are two rare diseases, and even more rarely associated. These two conditions have specific organ involvements, and specific follow-up.
- Trial name
- NCT04895878
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Montpellier
Neutrophil Extracellular Trap Formation, Portal Vein Tumor Thrombosis
Neutrophil Extracellular Traps as a Biomarker to Predict Portal Vein Tumor Thrombosis in Patients With Hepatocellular Carcinoma
The aim of this study was to investigate whether NETs markers can enhance predict portal vein tumor thrombosis in patients with live cirrhosis, so as to establish a novel predictor to guide clinical decision-making.
- Trial name
- NCT05040347
- Testing
- test NETs markers
- Where
- China
- Volunteers
- 68 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Neutrophil Extracellular Trap Formation, Portal Vein Thrombosis
Analysis of Neutrophil Extracellular Traps in Hypercoagulability and Portal Vein Thrombosis in Liver Cirrhosis Patients
The aim of this study was to investigate whether NETs markers can enhance procoagulant activity and predict portal vein thrombosis in patients with live cirrhosis, so as to establish a novel predictor to guide clinical…
- Conditions
- Neutrophil Extracellular Trap Formation, Portal Vein Thrombosis, Liver Cirrhosis
- Trial name
- NCT05012501
- Testing
- test NETs markers
- Where
- China
- Volunteers
- 79 people
- Sponsor
- The Affiliated Hospital of Qingdao University
ANCA Associated Vasculitis, Drug Use
Effect of Tofacitinib in Treating ANCA-associated Vasculitis
The goal of this study is to evaluate the efficacy and safety of tofacitinib 5 mg twice daily in AAV patients.
- Conditions
- ANCA Associated Vasculitis, Drug Use, JAK-STAT Pathway Deregulation
- Trial name
- NCT04973033
- Testing
- Tofacitinib
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shanghai Zhongshan Hospital
ANCA Associated Vasculitis
the Application of Diffusion Tensor Imaging in the Evaluation of Peripheral Neuropathy in ANCA Associated Vasculitis
1. Include qualified 50 ANCA-associated vasculitis(AAV) patients; and the first 27 patients will be divided into 3 groups with different diffused tension image (DTI) parameters and to choose the best strategy； 2.
- Trial name
- NCT04923074
- Testing
- diffusion tensor imaging(DTI) evaluation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Neurocognitive Disorders, Neutrophil-Lymphocyte Ratio
NLR and PRL in Neurocognitive Disorders
Preliminary evidence suggest a possible relationship between Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio (PLR) and perioperative neurocognitive disorders (NCD).
- Conditions
- Neurocognitive Disorders, Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio
- Trial name
- NCT04736290
- Testing
- NLR, PLR
- Where
- Greece
- Volunteers
- 288 people
- Sponsor
- University of Thessaly
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Microscopic Polyangiitis
Low-dose Glucocorticoid Vasculitis Induction Study
Previous reports suggested conventional immunosuppressants such as cyclophosphamide could not reduce glucocorticoid dose in remission induction in ANCA-associated vasculitis because of lower remission rate and higher relapse…
- Conditions
- Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Microscopic Polyangiitis, Wegener Granulomatosis
- Trial name
- LoVAS (NCT02198248)
- Testing
- Rituximab, Glucocorticoids
- Where
- 17 sites in Japan
- Volunteers
- 140 people
- Sponsor
- Chiba University
Neutrophil Chemotactic Response
Influence of Lifestyle Factors on Neutrophil Migration Pilot Study
This study will determine how common lifestyle practices affect the behavior of neutrophils (a type of immune cell) at shorter time scales than previously possible.
- Trial name
- NCT02411318
- Testing
- Exercise, ProLab 200mg caffeine capsule, Ethanol ingestion
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
ANCA-associated Vasculitis
MICRO-RNAs OF NEUTROPHILS IN RENAL ANTINEUTROPHIL CYTOPLASMIS ANTIBODY (ANCA) -ASSOCIATED VASCULITIS
Activation of neutrophils by ANCA ("Anti-Neutrophil Cytoplasm Antibodies") and subsequent microvascular endothelial cell damage is the main feature of ANCA-associated vasculitis (AAV), a severe autoimmune disease that often…
- Trial name
- MINERVA (NCT02954705)
- Testing
- Non interventional study
- Where
- France
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Granulomatosis With Polyangiitis (Wegener's) (GPA), Microscopic Polyangiitis (MPA)
Plasma Exchange and Glucocorticoids for Treatment of Anti-Neutrophil Cytoplasm Antibody (ANCA) - Associated Vasculitis
The purpose of this study is to determine whether plasma exchange as well as immunosuppressive therapy are effective in reducing death and end-stage renal disease (ESRD).
- Trial name
- PEXIVAS (NCT00987389)
- Testing
- Plasma Exchange, No Plasma Exchange, Glucocorticoids [Standard Dose]
- Where
- 98 sites in United States, Australia and 13 more
- Volunteers
- 704 people
- Sponsor
- University of Pennsylvania
Vasculitis
Prevention of Relapses in Proteinase 3 (PR3)-Anti-neutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis
Treatment of patients with PR3-ANCA-associated vasculitis consists of two phases: remission induction with highly effective, but also relatively toxic, drugs and, secondly, after remission is achieved, maintenance therapy with…
- Trial name
- NCT00128895
- Testing
- azathioprine
- Where
- 8 sites in Netherlands
- Volunteers
- 131 people
- Sponsor
- University Medical Center Groningen
Neutrophil Extracellular Traps; Antiphospholipid Antibody-induced Pregnancy Loss
Neutrophil Extracellular Traps Mediate Antiphospholipid Antibody-induced Pregnancy Loss
1. Establish a multi-platform detection system for neutrophil extracellular traps in blood and tissues, and evaluate the detection performance; 2.
- Trial name
- NCT03735108
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shanghai First Maternity and Infant Hospital
Multiple Trauma, Sepsis
The Role of Post-traumatic Inhibition of the Innate and Adaptive Immune System in the Development of Infectious Complications in Severely Injured Patients
Patients admitted to the Intensive Care Unit after severe injury are prone to suffer from infectious complications and even sepsis.
- Conditions
- Multiple Trauma, Sepsis, Innate Immune Response, Disorder of Neutrophils
- Trial name
- POSEIDON (NCT03489577)
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- UMC Utrecht