Clinical trials: Newborn Diseases
Vitiligo Vulgaris, Psoriasis
PALLAS Laser for Skin Diseases
The primary objective of this study is to get clinical experiences with the PALLAS laser in the treatment of skin conditions that respond well to UV light (vitiligo, psoriasis, alopecia areata, atopic dermatitis).
- Conditions
- Vitiligo Vulgaris, Psoriasis, Alopecia Areata, Atopic Dermatitis
- Trial name
- PALLAS-UV (NCT07250997)
- Testing
- UVB laser treatment
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Szeged University
Bicuspid Aortic Valve Disease, Thoracic Aortic Disease in Patients With a Bicuspid Aortic Valve
International Bicuspid Aortic Valve Consortium (BAVCon)
Bicuspid aortic valve (BAV) disease is the most frequent congenital cardiac malformation, occurring in 0.5-1.2% of the US population.
- Trial name
- BAVCon (NCT01980797)
- Where
- 12 sites in United States, Canada and 3 more
- Volunteers
- 6,464 people
- Sponsor
- Boston University
Rett Syndrome
ANAVEX2-73 Study in Pediatric Patients With Rett Syndrome
ANAVEX2-73-RS-003 is a Phase 2/3, double-blind, randomized, placebo-controlled dose escalation safety, tolerability and efficacy study in patients 5-17 years of age with RTT using endpoints including multiple clinical and…
- Trial name
- EXCELLENCE (NCT04304482)
- Testing
- ANAVEX2-73 oral liquid
- Where
- 12 sites in Australia, Canada and 1 more
- Volunteers
- 92 people
- Sponsor
- Anavex Life Sciences Corp.
Hemophilia A
Safety,Efficacy and Pharmacokinetics Evaluation of SCT800 in Previously Treated Paediatric Patients With Severe Haemophilia A.
This study is a multicenter phase III uncontrolled open-label trial to evaluate the efficacy,safety and pharmacokinetics of SCT800 in regular prophylaxis and perioperative treatment in patients (<12 years old) with severe…
- Trial name
- NCT03947320
- Testing
- Recombinant Human Coagulation FVIII
- Volunteers
- 70 people
- Sponsor
- Sinocelltech Ltd.
Gastroesophageal Reflux Disease (GERD)
Phase 3/Safety & Efficacy of Esomeprazole in Infants
The purpose of this study is to look at the improvement of a once a day dose of esomeprazole for reducing the signs and symptoms of infants with gastroesophageal reflux disease (GERD).
- Trial name
- NCT00468559
- Testing
- Open Label Run In Esomeprazole, Double Blind Esomeprazole
- Where
- 25 sites in United States, France and 2 more
- Volunteers
- 98 people
- Sponsor
- AstraZeneca
Hypobetalipoproteinemia
HYPOCHOL : A Genetically-based Strategy to Identify New Targets in Cholesterol Metabolism
The aim of this study is to identify new targets in cholesterol metabolism thanks to a genetically-based strategy.
- Trial name
- HYPOCHOL (NCT02354079)
- Testing
- hypobetalipoproteinemia genetic and genotypic screening
- Where
- France
- Volunteers
- 435 people
- Sponsor
- Nantes University Hospital
Eczema, Atopic Dermatitis
A Herbal Compound for Eczema
The goal of this interventional clinical trial study is to compare ZAX.1400.EC.02 and placebo in Eczema patients. The main question it aims to answer is: Can treatment with ZAX.1400.EC.02 for 3 weeks improve clinical signs of…
- Conditions
- Eczema, Atopic Dermatitis, Inflammation
- Trial name
- NCT06758752
- Testing
- ZAX.1400.EC.02
- Where
- Iran
- Volunteers
- 110 people
- Sponsor
- Fasa University of Medical Sciences
Respiratory Distress Syndrome (&Amp; [Hyaline Membrane Disease])
Early Surfactant Administration at FiO₂ >0.25 Under NIPPV for RDS in Very Preterm Infants
This multicenter randomized controlled trial investigates whether initiating pulmonary surfactant (PS) at a lower oxygen threshold (FiO₂ >0.25) during nasal intermittent positive pressure ventilation (NIPPV) for very preterm…
- Trial name
- NCT07100652
- Testing
- Threshold FiO₂
- Where
- China
- Volunteers
- 384 people
- Sponsor
- Jiulongpo No.1 People's Hospital
Hemophilia A
Once-A-Day Prophylaxis for Youth and Young Adults With Severe Hemophilia A
The primary objective of this study is to test the feasibility of a large-scale clinical trial of once-daily prophylaxis. The secondary objectives are to collect clinical efficacy outcomes so that we can better plan a large-scale…
- Trial name
- NCT00717626
- Testing
- Kogenate FS, Advate, or Humate-P, Recombinate, Helixate FS
- Where
- 3 sites in Canada
- Volunteers
- 14 people
- Sponsor
- The Hospital for Sick Children
Syringomyelia, Chiari Malformation
Development of a Patient-reported Outcome Measure for Chiari Malformation and Syringomyelia
Chiari malformation corresponds to the herniation of cerebellar tonsils into the foramen magnum resulting in obstruction of cerebrospinal fluid circulation, which may eventually lead to the formation of an intramedullary cavity…
- Trial name
- BCS-score (NCT06011226)
- Testing
- focus groups, questionnaire
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atopic Dermatitis
A Phase II Study of HY209 Gel for Atopic Dermatitis Patients (Shaperon)
A Randomized, Double-blinded, Placebo-controlled, Parallel, Multi-Center Phase II Clinical Study to Evaluate the Efficacy and Safety of HY209 gel for Patients with Atopic Dermatitis
- Trial name
- NCT04530643
- Testing
- HY209 0.3%, HY209 0.5%
- Where
- 3 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- Shaperon
Hypospadias and Epispadias
Comparison of Pudendal Nerve Block and Caudal Block for Hypospadias in Young Children
The purpose of this randomized blinded prospective study is to compare the analgesic efficacy and duration of a Pudendal Nerve Block (PNB) to a Caudal Block (CB) for pediatric patients, ages 6 months to 2 years, undergoing…
- Trial name
- NCT03145415
- Testing
- Caudal block, Bilateral Pudendal block
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Gastrointestinal Stromal Tumors, Small-cell Lung Cancer
A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit
This open-label clinical trial will evaluate the safety and tolerability of NN3201 in subjects with advanced and/or metastatic solid tumors known to express c-Kit.
- Conditions
- Gastrointestinal Stromal Tumors, Small-cell Lung Cancer, Adenoid Cystic Carcinoma, Uveal Melanoma
- Trial name
- NCT06805825
- Testing
- NN3201
- Where
- 5 sites in United States
- Volunteers
- 67 people
- Sponsor
- Novelty Nobility, Inc.
Cleft Lip and Palate
Weigh Easy: Simplifying Home Weight Monitoring for Infants
This single-site, experimental, pilot study in infants identified from 0 - 3 months of age who present to the Cleft and Craniofacial Clinic with a cleft lip and/or palate will compare weight outcomes of infants who used the Weigh…
- Trial name
- NCT04384276
- Testing
- The Weigh Easy System, Retrospective Control
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Tourette's Syndrome, Attention Deficit Hyperactivity Disorder
Study of Clonidine on Sleep Architecture in Children With Tourette's Syndrome (TS) and Comorbid ADHD
In the present study, we examine the question "Will day-time aggression in children improve when their night-time sleep is treated with pharmacological intervention (i.e.
- Trial name
- NCT00152750
- Testing
- APO-clonidine
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Haemophilia
Validation of a Specific Measure for Assessment of Compliance With Treatment in Patients With Hemophilia
Research project for validation of a questionnaire on compliance to treatment in patients with hemophilia. It is intended to validate the American VERITAS-PRO scale according to the international methodology validation…
- Trial name
- NCT02582450
- Testing
- Patients with haemophilia
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Real Fundación Victoria Eugenia
Hereditary Angioedema
CSL312 (Garadacimab) in the Prevention of Hereditary Angioedema Attacks
This is a multicenter, double-blind, randomized, placebo-controlled, parallel-arm study to investigate the efficacy and safety of subcutaneous administration of CSL312 (garadacimab) in the prophylactic treatment of hereditary…
- Trial name
- NCT04656418
- Testing
- CSL312
- Where
- 28 sites in United States, Canada and 5 more
- Volunteers
- 64 people
- Sponsor
- CSL Behring
Turner Syndrome
Characterization of Hepatopathy in Turner Syndrome: Analysis of Determinants
The present study is therefore aimed at investigating the prevalence of hepatic alterations (laboratory and imaging) in adult patients with TS and generating hypothesissto the possible etiopathogenetic factors most involved, as…
- Trial name
- NCT06794190
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Primary Ciliary Dyskinesia, Cystic Fibrosis
Respiratory Function, Exercise Capacity and Peripheral Muscle Strength Among Patients With CF, PCD and Healthy Children
The aim of this study is to compare pulmonary function, respiratory muscle strength, exercise capacity and peripheral muscle strength of patients with CF, PCD and healthy childrens.
- Trial name
- NCT04161313
- Testing
- Measurement of functional capacity, pulmonary function test, Functional capacity
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Ventricular Septal Defect
Cera™ VSD Occluder Post Market Clinical Follow-up
The objective of this post-market registry is to assess the safety and performance of the Lifetech Cera™ VSD occluder in a real-world and on-label fashion.
- Trial name
- NCT05939713
- Testing
- Cera™ VSD occluder implantation
- Where
- 8 sites in Taiwan
- Volunteers
- 152 people
- Sponsor
- Cardiac Children's Foundation Taiwan
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