Clinical trials: Newborn Diseases
Neonatal Sepsis
Potential Protective Effect of a Formula Supplemented With Fermented Matrices on the Risk of Developing Neonatal Sepsis
This is a multicenter, randomized, double-blind, placebo controlled trial, with parallel groups and reference group. The aim of the study was to evaluate the hypothesis that an immunonutritional strategy, based on use of…
- Trial name
- NCT04742582
- Testing
- Preterm Infants - fed fermented formula, Preterm Infants - fed standard formula, Pre-term Infants - breastfed
- Where
- Italy
- Volunteers
- 876 people
- Sponsor
- Heinz Italia SpA
Growth Hormone Deficiency, Turner's Syndrome
Evaluation of the Adherence and the Patient Acceptability of Zomacton® Treatment With the Zomajet® Vision X Device
The study is performed to collect long-term data on the treatment adherence and patient's acceptability when Zomacton®10 mg is administered with the Zomajet® Vision X device in patients with a growth hormone deficiency or…
- Trial name
- ZOMAXEPT (NCT02018172)
- Testing
- somatropin
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Ferring Pharmaceuticals
Muscular Dystrophies
Device for Breathing Frequency Monitoring in Muscular Dystrophy
Patients at risk of developing respiratory dysfunctions, such as patients with severe forms of muscular dystrophy, need a careful respiratory assessment, and periodic follow-up visits to monitor the progression of the disease.
- Trial name
- NCT04313595
- Testing
- RespirHó
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- IRCCS Eugenio Medea
Sickle Cell Disease, Chronic Pain
MUSic Therapy to Improve Quality Of Life in Sickle Cell Disease (MUSIQOLS)
The purpose of this pilot study is to investigate the effects of a 6-session music therapy protocol on the pain, mood, quality of life, coping skills, and self-efficacy of adult patients with sickle cell disease (SCD) as compared…
- Trial name
- NCT03556657
- Testing
- Music Therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University Hospitals Cleveland Medical Center
Infantile Colic
Acupuncture in Infantile Colic
The purpose of this study is to investigate whether acupuncture influences: the rate of infants who still fulfil the colic criterion after three intervention weeks the time when the infants are crying, fussing or have intense…
- Trial name
- NCT00860301
- Testing
- Acupuncture
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Lund University
Advanced Solid Tumor, Advanced Solid Malignancies
A Phase I/II Study to Evaluate the Safety, Pharmacokinetics and Efficacy of PRJ1-3024 in Subjects with Advanced Solid Tumors
This is a multicenter, open-label study to assess the safety and preliminary efficacy and to determine the maximum tolerated dose (MTD) or maximum administration dose (MAD) and recommended Phase 2 doses (RP2D) of PRJ1-3024 in…
- Trial name
- NCT05315167
- Testing
- PRJ1-3024
- Where
- 5 sites in China
- Volunteers
- 267 people
- Sponsor
- Zhuhai Yufan Biotechnologies Co., Ltd
Prostate Cancer, Prostatic Neoplasms
Safety and Efficacy Studies of Panobinostat and Bicalutamide in Patients With Recurrent Prostate Cancer After Castration
This trial is designed to investigate the safety, dosing schedule, and efficacy of the combination treatment of Panobinostat (a histone deacetylase inhibitor) and hormone therapy for recurrent prostate cancer.
- Trial name
- NCT00878436
- Testing
- Panobinostat, Bicalutamide
- Where
- 4 sites in United States
- Volunteers
- 52 people
- Sponsor
- NYU Langone Health
Hemodialysis, Virtual Reality
Effect of Virtual Reality on Cannulation-Related Procedural Pain, Distress and Comfort Level in Hemodialysis Patients
This study aimed to determine the effects of virtual reality on procedural pain, distress and comfort levels during cannulation in hemodialysis patients.
- Trial name
- Hemodialysis (NCT07281144)
- Testing
- Virtual Reality
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Tarsus University
Congenital Heart Disease in Pregnancy, Prenatal Diagnosis
The National Program for the Improvement of Management of Fetal Congenital Heart Disease in China
To investigate and evaluate the capacity of prenatal screening, diagnosis and counseling of congenital heart disease in medical institutions in China, in order to understand the current status and existing problems of prenatal…
- Conditions
- Congenital Heart Disease in Pregnancy, Prenatal Diagnosis, Fetal Echocardiography
- Trial name
- NCT05940363
- Testing
- Improvement on Prenatal Screening and Treatment Capabilities for Congenital Heart Disease with a Comprehensive Diagnosis and Treatment Program Incorporating New Technologies
- Volunteers
- 9,000 people
- Sponsor
- Beijing Anzhen Hospital
Hemophilia
Blood Flow Restriction in Improving Muscle Strength of Patients With Hemophilic Ankle Arthropathy
Background. The main physical sequela of patients with hemophilia is the development of a progressive, degenerative intra-articular lesion, known as hemophilic arthropathy).
- Trial name
- NCT06261593
- Testing
- Blood flow restriction
- Where
- Spain
- Volunteers
- 31 people
- Sponsor
- Investigación en Hemofilia y Fisioterapia
Huntington Disease
28-Day Study of SAGE-718 on Functioning Capacity in Participants With Huntington's Disease
The primary purpose of this study is to assess the magnitude of the baseline difference between participants with early Huntington's Disease (HD) and healthy participants (HP) with respect to measures of cognitive performance.
- Trial name
- NCT05358821
- Testing
- SAGE-718
- Where
- 14 sites in United States, Canada
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Supernus Pharmaceuticals, Inc.
Atopic Dermatitis
Narrow-band (NB)-UVB vs. Bath-PUVA and NB-UVB Plus Salt Water Baths in Atopic Dermatitis
In this controlled crossover study we aim to compare the efficacy of narrow-band UVB (NB-UVB) with bath-PUVA and NB-UVB plus salt water baths in atopic dermatitis.
- Trial name
- NCT01402414
- Testing
- NB-UVB, Bath-PUVA, NB-UVB plus salt water baths
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Ruhr University of Bochum
Graves' Ophthalmopathy
Retinal Oxygen Saturation in Patients With Graves' Ophthalmopathy and in Normal People
Find if the retinal function is affected in both the nonsevere and the severe stage of Graves' ophthalmopathy (GO) by comparing the retinal oxygen saturation of GO patients with that of normal people.
- Trial name
- NCT02290704
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Prematurity, Very Low Birth Weight
The Safety Evaluation of Silver Alginate (Algidex™) Dressing in Very Low Birth Weight (VLBW) Infants
The purpose of this study is to test the safety of silver alginate (Algidex™) dressing in VLBW infants in preparation for a large efficacy trial.
- Trial name
- NCT00593684
- Testing
- Silver Alginate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor Research Institute
Intrahepatic, Cholestasis
Reduction of Neonatal Parenteral Nutrition Associated Cholestasis Through Lipid Emulsions
Parenteral nutrition associated cholestasis (PNAC) is a common complication of prolonged and exclusive parenteral nutrition (PN).
- Trial name
- NCT02633384
- Testing
- SMOFlipid, Lipofundin
- Volunteers
- 52 people
- Sponsor
- Centro Hospitalar de Lisboa Central
Cardiomyopathy, Dilated
Early Treatment With Candesartan vs Placebo in Genetic Carriers of Dilated Cardiomyopathy (EARLY-GENE Trial)
Prospective, multicenter, randomized, placebo-controlled, double-blind clinical trial to evaluate safety and efficacy of candesartan in the prevention of the development of Dilated Cardiomyopathy (DCM) in genetic carriers of a…
- Trial name
- EARLY-GENE (NCT05321875)
- Testing
- Candesartan
- Where
- Spain
- Volunteers
- 320 people
- Sponsor
- Cristina Avendaño Solá
Vitamin c, Thalassemia Major
Role of Vitamin C to Augment Iron Chelation With DFP or DFX
role of Vit C to Augment iron chelation with DFP or DFX in thalassemic patients.
- Conditions
- Vitamin c, Thalassemia Major, Iron Chelation
- Trial name
- NCT02083575
- Testing
- Vitamin C, Defriprone, deferisarox, deferiprone , deferesarox
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Sickle Cell Anemia
Gum Arabic as Fetal Hemoglobin Agent in Sickle Cell Anemia
The purpose of this study is to determine whether Gum Arabic is effective as fetal hemoglobin inducing agent for sickle cell anemia patients.
- Trial name
- NCT02467257
- Testing
- Gum Arabic
- Where
- Sudan
- Volunteers
- 47 people
- Sponsor
- Al-Neelain University
Neural Tube Defects, Folic Acid Deficiency
Using Iodized Salt to Improve Serum Folate, B12 and Iron Levels
Question: How effective is fortified iodized salt in increasing serum concentrations of folate, B12 and iron among non-pregnant and non-lactating women of reproductive age? Hypothesis: Micronutrient fortified iodized salt can…
- Conditions
- Neural Tube Defects, Folic Acid Deficiency, Spina Bifida, Anencephaly-Spina Bifida
- Trial name
- NCT06904612
- Testing
- Micronutrient fortified iodized salt
- Where
- 2 sites in United States, India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hydrocephalus and Neuroscience Institute
Autosomal Dominant Polycystic Kidney Disease
The Safety and Efficacy of Catheter-based Renal Denervation Using the Vessix™ Renal Denervation System in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Patients With Severe Debilitating Pain
This study will test the safety and efficacy of the Vessix Renal Denervation system in the reduction of pain in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD).
- Trial name
- NCT02746419
- Testing
- Vessix
- Sponsor
- University of Chicago
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