Clinical trials: Next Generation Sequencing
Pulmonary Infection
mNGS for Detection of Pathogens for Pulmonary Infection
Pulmonary infections remain the leading causes of morbidity and mortality among patients worldwide. Pathogen identification is crucial yet difficult for the majority of the cases.
- Trial name
- NCT03798925
- Testing
- None Intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sir Run Run Shaw Hospital
NSCLC, NSCLC Stage IV
Molecular Landscape Analysis and Clinical Implications for NSCLC Patients With Rare Mutations
Lung cancer is the most common primary cancer of the lung and is responsible for the ever increasing number of cancer-related deaths worldwide.
- Conditions
- NSCLC, NSCLC Stage IV, NSCLC, Recurrent
- Trial name
- NCT05701787
- Where
- 2 sites in China
- Volunteers
- 500 people
- Sponsor
- Shanghai Chest Hospital
ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION, Acute Myeloid Leukemia
MAC vs RIC for Transplantation in FLT3-ITD-Mutated AML Guided by UHS-NGS MRD ( FLT3 - MAC vs RIC )
This is a multicenter, open-label, 1:1 randomized non-inferiority trial with stratification. The study will enroll patients aged 18-60 years with FLT3-ITD-mutated acute myeloid leukemia (AML) who are in first complete remission…
- Trial name
- FLT3 - M vs R (NCT07904884)
- Testing
- RIC, MAC
- Where
- China
- Volunteers
- 310 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Cancer, Breast Cancer
Liquid Biopsy Evaluation and Repository Development at Princess Margaret
The objective of this protocol is to develop an institution-wide liquid biopsy protocol that will establish a common process for collecting blood and corresponding archived tumor specimens for future research studies at the…
- Conditions
- Cancer, Breast Cancer, Lung Cancer, Colon Cancer
- Trial name
- LIBERATE (NCT03702309)
- Where
- Canada
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Pancreatic Cancer
Molecularly Tailored Therapy in Advanced Pancreatic Cancer
Pancreatic cancer that has spread or cannot be removed by surgery is difficult to treat. Standard chemotherapy can slow the disease, but the cancer often starts growing again.
- Trial name
- TAILOR-PANC (NCT07802418)
- Testing
- Arm 1: Molecularly Tailored Therapy, Arms 2: Standard-of-Care Therapy, Arm 3: Standard-of-Care Observational Cohort
- Where
- 4 sites in Denmark
- Volunteers
- 1,200 people
- Sponsor
- Herlev Hospital
Infertility
A Study of Preimplantation Genetic Screening With Next Generation Sequencing Technology on Advanced Age Women
With the development of society, more and more aged pregnant women because of various reasons, their abnormality rate of egg chromosome was higher than that of young women, then the abnormality rate of embryo chromosome is higher…
- Trial name
- NCT02868528
- Testing
- chromosome screening with NGS technology
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Oropharyngeal Squamous Cell Carcinoma
The Registry Study of Genetic Alterations of Oropharyngeal Cancer in Taiwan
We will use the next-generation sequencing (NGS) technology to identify genomic alterations of Taiwanese HPV positive and negative oropharyngeal squamous cell carcinoma (OPSCC) for novel biomarker development and the study design…
- Trial name
- NCT05522881
- Where
- 7 sites in Taiwan
- Volunteers
- 410 people
- Sponsor
- National Health Research Institutes, Taiwan
Gastrointestinal Stromal Tumor (GIST)
Resistance Profiling Using Functional Imaging and Next Generation Sequencing in Refractory Gastrointestinal Stomal Tumors (GIST)
Gastrointestinal stromal tumors (GIST) are the most common malignant sarcomas of the gastrointestinal tract. Inhibitors of the mutated driver proteins KIT and PDGFRA can temporarily control disseminated GIST disease but cannot…
- Trial name
- PATHFINDERS (NCT07109024)
- Testing
- Generation of a comprehensive and single-lesion resistance profile
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Universität Duisburg-Essen
Early Childhood Caries
Investigation of Supragingival Plaque Microbiome in Early Childhood Caries
The purpose of this study was to characterize the supragingival plaque microbiome in children with early childhood caries and identify potential microorganisms associated with caries.
- Trial name
- NCT04456335
- Testing
- Collection of supragingival plaque from caries free children
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Trakya University
Myelodysplastic Syndromes
Clinical and Genomic Registry of MDS in Asia
Myelodysplastic syndrome (MDS) is a group of clonal haematopoietic stem cell disorders characterized by ineffective haematopoiesis leading to cytopenia, with a significant risk of progression to acute myeloid leukaemia (AML).
- Trial name
- NCT03169296
- Where
- Hong Kong
- Volunteers
- 2,600 people
- Sponsor
- The University of Hong Kong
Sexually Transmitted Infections (Not HIV or Hepatitis), Chlamydia Trachomatis Infection
Assess the Performance of Metagenomic Sequencing in the Diagnosis of STI (NGS-IST)
The main objective of the study will be to assess the performance of the Next-Generation-Sequencing (NGS) diagnostics of Chlamydia trachomatis and Neisseria gonorrhoeae compared to reference techniques.
- Conditions
- Sexually Transmitted Infections (Not HIV or Hepatitis), Chlamydia Trachomatis Infection, Neisseria Gonorrhoeae Infection, Mycoplasma Genitalium Infection
- Trial name
- NGS-IST (NCT05581160)
- Testing
- Assess the Performance of Metagenomic Sequencing in the Diagnosis of STI (NGS-IST)
- Where
- 2 sites in France
- Volunteers
- 332 people
- Sponsor
- Institut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'Ba
Diffuse Large B Cell Lymphoma
Real-Time Monitoring of Circulating Tumor DNA and Study of Prognostic Factors in Patients Treated With CAR-T Cells
The purpose of this study is to demonstrate that it is possible to report in real time (less than 3 weeks) to the hematologist the results of the molecular minimal residual disease (MRD) based on blood circulating tumor DNA…
- Trial name
- RT-CAR (NCT05675982)
- Testing
- CAR-T cells monitoring
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Henri Becquerel
Lung Cancer
Dynamic Monitoring Circulating Tumor DNA in Surgical Patients With Lung Cancer
This study aims to promote the rational use of liquid biopsy in the clinical detection of lung cancer. Lung cancer is a malignant tumor with high morbidity and mortality worldwide.
- Trial name
- LUNGCA (NCT03317080)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- West China Hospital
Triple Negative Breast Cancer
Next-Generation Sequencing-based Germline and Somatic Genetic Testing in Triple-negative Breast Cancer
For patients with triple negative breast cancer, implementation of genetic testing in decision making might impact both risk management for the patient and her family, but also, importantly, therapeutic management.
- Trial name
- PERSONA (NCT03920488)
- Where
- Italy
- Volunteers
- 264 people
- Sponsor
- European Institute of Oncology
Lyme Disease, Pediatric Infectious Disease
Next Generation Sequencing Detection of Lyme Disease
Next Generation Sequencing is capable of sequencing millions of small strands of DNA from a single blood sample, potentially improving its sensitivity compared to PCR testing, which only detects predetermined larger strands of…
- Conditions
- Lyme Disease, Pediatric Infectious Disease, Erythema Migrans, Lyme Arthritis
- Trial name
- NCT03505879
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Malaria, Falciparum Malaria
Malaria Molecular Surveillance in Mozambique (Phase 2)
Mozambique is among the ten countries with the highest burden of malaria worldwide, with an estimated 10.3 million cases in 2021.
- Conditions
- Malaria, Falciparum Malaria, Malaria in Pregnancy
- Trial name
- GenMoz2 (NCT06529237)
- Testing
- LDH-based malaria rapid diagnostic test, Malaria rapid diagnostic test
- Where
- Mozambique
- Volunteers
- 18,750 people, healthy volunteers welcome
- Sponsor
- Centro de Investigacao em Saude de Manhica
Non Hodgkin Lymphoma
Assessment of the Minimal Residual Disease in DLBCL From Cell-free Circulating DNA by NGS
This is a prospective descriptive monocentric study whose purpose is to describe the clonal evolution of the mutational pattern in cfDNA of a cohort of patients with Diffuse Large B-Cell Non-Hodgkin Lymphomas (DLBCL) before…
- Trial name
- LymphoSeq (NCT02339805)
- Testing
- next generation sequencing, Fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG-PET)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Henri Becquerel
Familial Lipomatosis, Very Rare Dermatologic Diseases
Identification of Mutations Responsible for Rare Familial Skin Diseases by Next Generation Sequencing
The primary purpose of the protocol is to use next generation sequencing to identify pathogenic variants in genes involved in very rare skin diseases.
- Trial name
- DERMA-SEQ (NCT02509650)
- Where
- 2 sites in France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Rheumatic Heart Disease
RhEumatiC Heart diseAse Genetics
Rheumatic fever (RF) is an autoimmune disease that is mediated by the cellular and humoral immune response that follows an untreated pharyngeal Streptococcus pyogenes infection.
- Trial name
- RECHARGE (NCT02118818)
- Testing
- Next generation sequencing
- Where
- Rwanda
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Gastritis
A Relevance Study Between the Result of Clinical Drug Intervention and Next-generation Sequencing Technology Focused on Refractory Helicobacter Pylori Infection
Approximately 50% of people in the world are infected with H. pylori, and its eradication rate fail to exceed 80% and even fails into an unacceptable range.Various risk factors for infection include lower socioeconomic status…
- Trial name
- NCT02806674
- Testing
- The eradication times of the patients, The result of 13C-urea breath test after treatment
- Where
- 4 sites in China
- Volunteers
- 1,845 people
- Sponsor
- The University of Hong Kong-Shenzhen Hospital