Clinical trials: Next Generation Sequencing
Coronavirus Disease (COVID-19)
To Access the Egyptian COVID-19 Whole Genome by NGS and Compare to the International Worldwide Database
This is an exploratory study that will be performed on confirmed positive COVID-19 samples to identify the dominant viral genome strain in Egyptians using next generation sequencing (NGS).
- Trial name
- Strain (NCT04346043)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Gastritis, Atrophic, Gastric Cancer
System Biology of Spleen Deficiency Syndrome
Spleen Deficiency Syndrome(SDS)is a widely researched issue, but due to the limitations of the research methods, the scientific mechanism of SDS is biased and not comprehensive.
- Trial name
- SBSDS (NCT02915393)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Beijing University of Chinese Medicine
Intellectual Disability
Genome Sequencing Strategies for Genetics Diagnosis of Patients With Intellectual Disability
Introduction : Intellectual Disability (ID) is the most common cause of referral in the pediatric genetic centers and is characterized by an extreme genetic heterogeneity corresponding to a myriad of rare diseases that…
- Trial name
- DEFIDIAG (NCT04154891)
- Testing
- Whole Genome Sequencing
- Where
- 14 sites in France
- Volunteers
- 3,825 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Functional Dyspepsia
Duodenal Microbiota in Functional Dyspepsia
The goal of this observational study is to assess the type of duodenal microbiota and duodenal microbiome in in FD patients compared to control group.
- Trial name
- NCT06326918
- Testing
- Duodenal mucosal brushing, Duodenal mucosal biopsy
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- King Chulalongkorn Memorial Hospital
Neoplastic Syndromes, Hereditary, Cancer
Cancer Predisposition Testing by Family-based Whole-genome Sequencing (WGS) in Every Child With Newly Diagnosed Cancer
Assessment of the utility of family-based (trio) whole-genome sequencing for cancer predisposition testing in sequential newly diagnosed paediatric and adolescent cancer patients
- Conditions
- Neoplastic Syndromes, Hereditary, Cancer, Genetic Predisposition to Disease
- Trial name
- PREDICT (NCT04903782)
- Testing
- Family-based whole genome sequencing
- Where
- 3 sites in Australia
- Volunteers
- 270 people
- Sponsor
- Sydney Children's Hospitals Network
Mendelian Disorders, Genetic Disorder
Delineation of Novel Monogenic Disorders in the United Arab Emirates Population
The study aims to identify novel monogenic phenotypes from specific pedigrees and discover the underlying causal genetic variant using genetic sequencing (Sanger and/or Next Generation Sequencing - Panel/WES/WGS) methodologies in…
- Conditions
- Mendelian Disorders, Genetic Disorder, Novel Mutation, Hereditary Disorder
- Trial name
- NCT03589079
- Testing
- Sanger and/or Next Generation Sequencing (NGS)
- Where
- United Arab Emirates
- Volunteers
- 150 people
- Sponsor
- Imperial College London Diabetes Centre
Melanocytic Nevi, Melanoma (Skin Cancer)
Reflectance Confocal Microscopy and Molecular Correlation in Atypical Melanocytic Lesions
This observational, prospective cohort study aims to evaluate the diagnostic relevance of Reflectance Confocal Microscopy (RCM) features in atypical melanocytic lesions scheduled for surgical excision, and to correlate these…
- Conditions
- Melanocytic Nevi, Melanoma (Skin Cancer), Next Generation Sequencing (NGS)
- Trial name
- NCT07277920
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Modena and Reggio Emilia
Classical Hodgkin Lymphoma
European Project for ctDNA Detection as a Biomarker for Non-invasive Therapy Monitoring in Paediatric Classical Hodgkin Lymphoma
Classical Hodgkin lymphoma (cHL) accounts for 15% of all cases of cancer in children and adolescents and represents the first cause of cancer during adolescence.
- Trial name
- EURHOLY (NCT07356882)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Infection
Massively Parallel Sequencing to Identify Microbiological Organisms in Bronchoalveolar Lavage Fluid
Patients who are post hematopoietic stem cell transplantation who require a bronchoalveolar lavage (BAL) for standard clinical car will have extra fluid collected and sent for massively parallel sequencing to see if it is as…
- Trial name
- NCT03995030
- Testing
- massively paralleled sequencing
- Volunteers
- 10 people
- Sponsor
- New York Medical College
Pancreas Cyst
DNA-mutation Analysis in Cyst Fluid of Suspected Intraductal Papillary Mucinous Neoplasia of the Pancreas
Diagnostic tools are needed to identify mucinous cysts for further evaluation or follow-up respectively to identify cysts with HGD or invasive cancer at an early stage for surgical resection.
- Trial name
- NCT03820531
- Testing
- Next Generation Sequencing, CEA and lipase, Cytology
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Theresienkrankenhaus und St. Hedwig-Klinik GmbH
Infective Endocarditis
Clinical Metagenomics of Infective Endocarditis
Infective endocarditis (IE) is an infection of cardiac valves. IE mainly involves bacteria, more rarely fungi. IE is an uncommon diseases with an estimated incidence of 1-12 cases per 100,000 inhabitants per year.
- Trial name
- Meta-ENDO (NCT03199287)
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Geneva
Preimplantation Diagnosis
Feasibility Study of Preimplantation Genetic Diagnosis for Single-gene Disorders
Preimplantation Genetic Diagnosis (PGD) for monogenic diseases is usually performed by multiplex PCR combining polymorphic microsatellites familial analysis and, where possible, couple-specific mutation detection.
- Trial name
- NCT02502214
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Infertility
Next Generation Sequencing Screening for Embryonic Ploidy Status
To evaluate the benefits of using next generation sequencing to assess embryonic aneuploidy. All viable blastocysts will be biopsied and cryopreserved for future transfer.
- Trial name
- nexgen (NCT02032264)
- Testing
- Comprehensive Chromosome Screening, Morphologically Best
- Where
- United States
- Volunteers
- 309 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Gonorrhea, Neisseria Gonorrhea
Metagenomic Analysis of the Pharynx in High Risk Partners
The Neisseria gonorrhoea (NG) epidemic in England is at the highest level in one hundred years of public health records. The World Health Organisation has listed NG as one of the top five bacterial infections globally because of…
- Conditions
- Gonorrhea, Neisseria Gonorrhea, Neisseria Meningitidis, Metagenomic Next Generation Sequencing
- Trial name
- NCT07671014
- Volunteers
- 100 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Lynch Syndrome
Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Patients Meeting Chinese Lynch Syndrome Criteria
The purpose of this study is to find out the proportion of patients diagnosed with Lynch syndrome in colorectal cacner patients meeting Chinese Lynch syndrome criteria.
- Trial name
- NCT03046849
- Testing
- next-generation sequencing
- Where
- 3 sites in China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Solid Tumors, Metastatic Disease
CPCT-02 Biopsy Protocol
A major challenge for researchers in cancer care is to expedite the development of new therapeutics and the Center for Personalized Cancer Treatment (a collaboration of the Dept.
- Trial name
- CPCT-02 (NCT01855477)
- Testing
- Histological biopsy procedure
- Where
- Netherlands
- Volunteers
- 6,927 people
- Sponsor
- Foundation CPCT
Rare Diseases, Genetic Predisposition
Diagnostic Value of Exome/ Genome Sequencing, Conventional Methods in Rare Diseases and Familial Tumor Syndromes
For the retrospective data analysis, patients with genetic diseases of any age and, if available, other family members, for whom genetic analyzes were carried out between 10/2016 and 12/2020, should be included.
- Trial name
- EXGEFATU (NCT04731857)
- Testing
- Retrospective data analysis
- Where
- Germany
- Volunteers
- 12,000 people
- Sponsor
- University Hospital Tuebingen
Microbial Colonization, Viral Infection
Follow-up of the Nasal Microbiome and Viral Infections in Newborns Hospitalised in Neonatology.
The goal of this interventional study is to learn about nasal microbiome and viral infections in newborns hospitalised in neonatology.
- Conditions
- Microbial Colonization, Viral Infection, Neonatal Infection
- Trial name
- NEOBIOME (NCT05717283)
- Testing
- Nasal swab
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Caen
Lung Cancer
EBUS-TBNA vs Transbronchial Mediastinal Cryobiopsy for Adequacy of Next Generation Sequencing
This is a multi-center clinical trial evaluating the effect of transbronchial mediastinal cryobiopsy for its ability to improve the likelihood of obtaining tissue sufficient for molecular analysis.
- Trial name
- FROSTBITE-3 (NCT06105801)
- Testing
- Endobronchial ultrasound with transbronchial needle aspiration, Bronchoscopy, Cryobiopsy
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Tuberous Sclerosis Complex
Dermatologic Patterns of Tuberous Sclerosis Patients and Somatic Mutation Relationship
Tuberous Sclerosis is a rare genetic disorder that affects about one in 15,000 individuals. It is part of the phacomatoses: a germline mutation of the gene Tuberous Sclerosis Complex 1 (TSC1) or TSC2 causes a protein dysfunction…
- Trial name
- NCT04112537
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Montpellier