Clinical trials: Next Generation Sequencing
Musculoskeletal Infection, Acute Hematogenous Osteomyelitis
Next-Generation Sequencing for Pathogen Detection and Quantification in Children With Musculoskeletal Infections
The purpose of this study is to evaluate the use of a blood test: Karius® plasma-based next-generation sequencing test (Karius Test), to see if we can detect and measure the infection causing agent in children with…
- Conditions
- Musculoskeletal Infection, Acute Hematogenous Osteomyelitis, Septic Arthritis, Osteomyelitis
- Trial name
- KDG-002 (NCT03846804)
- Testing
- Karius Test
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Indiana University
Adenocarcinoma, Adenocystic Carcinoma
The Registry of Oncology Outcomes Associated With Testing and Treatment
This study is to collect and validate regulatory-grade real-world data (RWD) in oncology using the novel, Master Observational Trial construct. This data can be then used in real-world evidence (RWE) generation.
- Conditions
- Adenocarcinoma, Adenocystic Carcinoma, Anal Cancer, Appendix Cancer
- Trial name
- ROOT (NCT04028479)
- Testing
- Biomarker Testing (L), Systemic Treatment (T), Patient Reported Outcomes (P)
- Where
- 2 sites in United States
- Volunteers
- 167 people
- Sponsor
- Taproot Health
Microbiome, Metagenomic Next Generation Sequencing
Norovirus Prevalence and Fecal Microbiome Characterization Through Metagenomic and Metatranscriptomic Analyses
The goal of this clinical trial is to characterize the fecal microbiome composition (including bacteria, archaea, viruses, fungi, and parasites) in fecal samples collected from travelers (including occupational travelers, leisure…
- Conditions
- Microbiome, Metagenomic Next Generation Sequencing, Norovirus Infection
- Trial name
- METATRAV (NCT07866469)
- Testing
- Characterization the fecal microbiome composition in travelers
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Hematologic Malignancies
Matching Patients With Hematologic Malignancy to Adequate Clinical Trials
A molecular profile of a patient with hematologic malignancy, for whom standard-of-care had failed, is identified using next generation sequencing.
- Trial name
- NCT02758080
- Testing
- Matching on the basis of molecular analysis, Matching on the basis of physician's choice
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Seoul National University Hospital
Catheter-Related Infections
Analysis of Microbial Biofilms in Peripheral Venous Catheters and Their Implication in Infectious Risk
Peripheral venous catheters (PVCs) are the most commonly used intravascular medical devices in healthcare establishments. Although essential in patient care, PVCs represent a significant risk factor for nosocomial infections, as…
- Trial name
- KTBIO (NCT07258862)
- Testing
- Inflammatory catheters: catheter removed because of infection at insertion site, Non-inflammatory catheters: catheter removed because it is no longer relevant to keep it in place
- Where
- 2 sites in France
- Volunteers
- 250 people
- Sponsor
- Hôpital NOVO
Infertility, Preimplantation Genetic Screening
Investigating the Cryopreserved Blastocyst's ImplantatiOn Potential After Genetic Screening
This is a two-arm parallel group randomized controlled trial at the Department of Reproductive Medicine at Ghent University Hospital.
- Trial name
- BIOPS (NCT03173885)
- Testing
- Preimplantation Genetic Screening
- Where
- Belgium
- Volunteers
- 56 people
- Sponsor
- University Hospital, Ghent
Subfertility
Preimplantation Genetic Testing for Aneuploidy of Polar Bodies
This study intends to randomly group the patients with advanced maternal age and poor ovarian response, and the study group will undergo polar body biopsy, and the next-generation sequencing(NGS) technology will be used to…
- Trial name
- NCT04538560
- Testing
- polar body biopsy
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Cerebral Small Vessel Diseases, Cadasil
Taiwan Associated Genetic and Nongenetic Small Vessel Disease
The TAG-SVD enrolled patients with clinical and neuroimaging features of cerebral small vessel disease (CSVD). All enrolled patients will receive next-generation sequence (NGS) with probes designed to target five candidate CSVD…
- Conditions
- Cerebral Small Vessel Diseases, Cadasil, HTRA1-Related Autosomal Dominant Cerebral Angiopathy, COL4A1-Related Brain Small Vessel Disease With Haemorrhage
- Trial name
- TAG-SVD (NCT05473637)
- Testing
- MRI
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Refractory Solid Tumors, Next Generation Sequencing
MyCustom:Prospective Master Protocol Trial on Precision Medicine Treatment for Refractory Solid Tumors
The MyCustom study is a investigator initiated trial(IIT), prospective real-world clinical research project, a genetic biomarker-driven "basket" (tissue-type agonistic) study.
- Trial name
- NCT06030869
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Tianjin Medical University Second Hospital
Multiple Myeloma
A Study of Venetoclax and ABBV-838 Combination Therapy With Dexamethasone in Participants With Multiple Myeloma Whose Cancer Has Come Back or Had No Response to Recent Cancer Treatment
This is an open-label, multicenter clinical trial designed to evaluate the safety and potential efficacy of venetoclax and ABBV-838 combination therapy with dexamethasone in participants with relapsed or refractory multiple…
- Trial name
- NCT02951117
- Testing
- Venetoclax, ABBV-838, Dexamethasone
- Where
- 3 sites in Australia
- Sponsor
- AbbVie
Parapneumonic Effusion
Metagenomic Study in Parapneumonic Effusion
Objective: To identify known and unknown bacterial pathogens in patients with pleural infections using a combination of conventional culture and next-generation sequencing approaches.
- Trial name
- NCT05394220
- Testing
- 16S rRNA gene amplicon sequencing
- Where
- Hong Kong
- Volunteers
- 115 people
- Sponsor
- Chinese University of Hong Kong
Coronary Artery Disease, Myocardial Infarction
Premature Coronary Artery Disease - Clinical and Molecular Genetic Aspects
Since finishing the sequencing of the human genome in 2003, genetic research in coronary artery disease (CAD) and other complex traits have developed dramatically.
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Atherosclerosis
- Trial name
- PIHS (NCT02146872)
- Where
- Denmark
- Volunteers
- 400 people
- Sponsor
- Aarhus University Hospital Skejby
Rare Diseases, Genetic Predisposition
Diagnostic Research in Patients With Rare Diseases - Solving the Unsolved Rare Diseases
The DiRiP study will enroll patients (n = 3500) with unclear rare diseases and suspected genetic reasons. In group 1 (n = 500) subjects are clinically characterized in the context of outpatient/ inpatient standard care at the UKT…
- Trial name
- DiRiP-RD (NCT03491280)
- Testing
- NGS Diagnostic
- Where
- Germany
- Volunteers
- 5,500 people
- Sponsor
- University Hospital Tuebingen
Lymphoma, Large B-Cell, Diffuse
Non-invasive Tumor Immunoglobulin Gene Next Generation Sequencing (IgNGS) in Diffuse Large B Cell Lymphoma (DLBCL)
This study will evaluate IgNGS at different time points in newly diagnosed DLBCL patients homogeneously treated (RCHOP) to address its correlation with conventional techniques (i.e., positron emission tomography/computed…
- Trial name
- NCT04237168
- Testing
- IgNGS from circulating tumor DNA
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cystic Fibrosis
Perceptions of the CF Screening Protocol Incorporating NGS
Newborn bloodspot screening (from now on referred to as screening) for cystic fibrosis (CF) became part of the national screening programme in 2007. Screening for CF is also well established internationally.
- Trial name
- NCT06299566
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- King's College London
Human Papillomavirus
Multi-site HPV Screening by High-throughput Sequencing in Patients With Chronic HPV-HR Infection Followed by Gynecology
The main risk of developing cervical cancer is the persistence of an High risk human papillomavirus (HPV-HR) infection, the mechanisms of which are still not understood.
- Trial name
- DEP-HPV (NCT04901351)
- Testing
- Smear
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Adenocarcinoma of Lung
Comparative Genomic Profiling of Lung Adenocarcinoma in Asians and Caucasians: A Propensity Matched Analysis
Lung adenocarcinomas (LUADs) from Asian ancestry are reported to have different genomic architectures compared with LUADs from Caucasian ancestry.
- Trial name
- NCT04692935
- Volunteers
- 450 people
- Sponsor
- Jun Wang
Solid Organ Malignancies
Neural Network-based Treatment Decision Support Tool in Patients With Refractory Solid Organ Malignancies
DRUID is a treatment decision support tool combining predictive models and public databases related to multi-gene markers, drug response screens, gene essentiality and clinical status of drugs to provide drug recommendations…
- Trial name
- DRUID (NCT05719428)
- Testing
- DRUID AI Program
- Where
- Singapore
- Volunteers
- 37 people
- Sponsor
- National University Hospital, Singapore
COVID-19
NGS Diagnostic in COVID-19 Hosts - Genetic Cause Relating to the Course of Disease Progression
In this study (i) the host genome to identify susceptibility regions of infection, inflammation, and host defense, (ii) host response to Severe Acute Respiratory Syndrome-Corona-Virus-2 (SARS-CoV-2) infection, and (iii) viral…
- Trial name
- COVID-19 NGS (NCT04364828)
- Testing
- Whole Genome Analysis, T-cell receptor (TCR) repertoire, SARS-CoV-2 viral composition
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University Hospital Tuebingen
Metastatic Colorectal Cancer
Technical Optimization of Detection of KRAS, BRAF and NRAS Mutations on Tumor DNA Circulating in Metastatic Colorectal Cancer
The objective of this study is to optimize the search by next-generation sequencing (NGS) mutations in the KRAS, BRAF and NRAS on circulating tumor DNA and compare the genetic profiles obtained with those from tumors embedded in…
- Trial name
- CircuLOR-1 (NCT02827565)
- Testing
- KRAS, NRAS et BRAF mutation analysis from circulating plasma DNA
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Institut de Cancérologie de Lorraine