Clinical trials: Next Generation Sequencing
Loosening, Prosthesis
Identification of Infections in Hip Arthroplasty Loosening.
Recent data showed that the rate of periprosthetic infections in patients undergoing a hip arthroplasty revision for aseptic loosening is higher than what can be ascertained with conventional methods.
- Trial name
- NCT04773054
- Testing
- Microbiological analysis of periprosthetic tissue, Histological analysis of periprosthetic tissue, Characterization of tissue microbiota
- Where
- Italy
- Volunteers
- 11 people
- Sponsor
- Istituto Ortopedico Rizzoli
Breast Neoplasm Female, Therapeutics
Clinical Value of Next Generation Sequencing in Endocrine Therapy for Advanced Hormone Receptor Positive/HER-2 Negative Breast Cancer
To determine the landscape of gene mutation before and after endocrine therapy, to search for molecular markers of endocrine therapy efficacy, and to explore the clinical value of using NGS detection of ctDNA to guide precise…
- Conditions
- Breast Neoplasm Female, Therapeutics, Mutation
- Trial name
- NCT03786575
- Testing
- Next Generation Sequencing (NGS) detection
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College
Multiple Myeloma
Elimination of Minimal Residual Disease After Transplant
This is a single-center, single-arm, phase II study that will enroll multiple myeloma (MM) patients with persistent bone marrow minimal residual disease (MRD) post autologous stem cell transplant (ASCT) irrespective of the…
- Trial name
- EMAT (NCT05690984)
- Testing
- Dexamethasone, Isatuximab, Lenalidomide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical College of Wisconsin
Acute Encephalitis, Acute Myelitis
Acute Infectious Encephalitis and Myelitis in Guadeloupe by New Generation Sequencing
: Encephalitis or myelitis is defined as the inflammatory or infectious involvement of the cerebral parenchyma or spinal cord. When an infectious origin is suspected, the germ is not always identified.
- Trial name
- EMAI-NGS (NCT07251049)
- Where
- Guadeloupe
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Microbial Colonization, Burns
Understanding the Burn Wound Microbiome: Comparing Traditional Wound Cultures to Next Generation Sequencing Technology
The purpose of this investigation is to better understand the wound microbiome in burn wounds and the role it plays in outcomes and complications related to treatment.
- Trial name
- NCT05275335
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Familial Pulmonary Fibrosis
GEN-FPF: Genetic Exploration of Familial Pulmonary Fibrosis
Pulmonary fibrosis (PF) is a progressive lung disease marked by tissue scarring and impaired breathing. Familial pulmonary fibrosis (FPF) makes up 10-20% of PF cases and shares features with idiopathic PF (IPF), but the genetic…
- Trial name
- GEN-FPF (NCT07251725)
- Where
- Italy
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Staphylococcus Aureus, Next Generation Sequencing
MSSA and MRSA Screening in Patients Undergoing Elective TJA: the Benefits of Next-generation Sequencing
The aims of this study were to evaluate the diagnostic performance of molecular and culture techniques in S. aureus screening using paired nasal and groin swabs, to determine, if any, discrepancy between the diagnostic techniques…
- Conditions
- Staphylococcus Aureus, Next Generation Sequencing, Total Joint Arthroplasty
- Trial name
- NCT04574752
- Testing
- next generation sequencing
- Where
- United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Hodgkin Lymphoma
Cell-free Tumor DNA as Minimal Residual Disease in Hodgkin Lymphoma Patients
Molecular analysis identifies residual disease by overcoming the sensitivity of imaging methods and therefore has the potential for integrating with therapy provided by FDG-PET alone.
- Trial name
- NCT05254821
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- Federico II University
Intellectual Disability
Targeted Next Generation Sequencing and Intellectual Disability
The purpose is to determine the benefit of next generation sequencing (NGS) targeted on genes involved in intellectual disability for etiologic diagnosis of intellectual disabilities.
- Trial name
- NGS-DI (NCT02889068)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Central Hospital, Nancy, France
Acute Lymphoblastic Leukemia, Adult B-Cell, Chronic Lymphocytic Leukemia
The clonoSEQ® Watch Registry
This is a prospective, multicenter, observational study of adult patients with a diagnosis of acute lymphoblastic leukemia (ALL), multiple myeloma (MM), chronic lymphocytic leukemia (CLL), or non-Hodgkin lymphoma (NHL).
- Conditions
- Acute Lymphoblastic Leukemia, Adult B-Cell, Chronic Lymphocytic Leukemia, Multiple Myeloma, Non-hodgkin Lymphoma
- Trial name
- NCT04545333
- Testing
- clonoSEQ Assay
- Where
- 14 sites in United States
- Volunteers
- 465 people
- Sponsor
- Adaptive Biotechnologies
Intrahepatic Cholangiocarcinoma
Next Generation Sequencing in Intrahepatic Cholangiocarcinoma
The aim of the present study is to perform a comprehensive molecular characterization of intrahepatic cholangiocarcinoma (ICC) in patients exposed to well-known or putative risk factors (such as asbestos) for this malignancy, in…
- Trial name
- EtherBil (NCT02184871)
- Testing
- exposure to different risk factors and molecular assessment
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- University of Bologna
Solid Tumor, Metastatic Cancer
A Study to Examine the Clinical Value of Comprehensive Genomic Profiling Performed by Belgian NGS Laboratories: a Belgian Precision Study of the BSMO in Collaboration With the Cancer Centre
The project, called "BALLETT" (Belgian Approach of Local Laboratory Extensive Tumor Testing), has a double goal: (1) show the relevance of broad molecular profiling to improve oncological patients care, (2) demonstrate that broad…
- Trial name
- BALLETT (NCT05058937)
- Testing
- Comprehensive genomic profiling
- Where
- 12 sites in Belgium
- Volunteers
- 936 people
- Sponsor
- The Belgian Society of Medical Oncology
Solid Tumor, Adult
Personalized Therapy of Molecular Tumor Board Participation With the Guidance of Next Generation Sequencing
This study seeks to evaluate the clinical value of the personalized therapy model with the guidance of Molecular Tumor Board (MTB) after Next Generation Sequencing(NGS), and to track patient outcomes.
- Trial name
- NCT03929653
- Testing
- Personalized therapy model with Molecular Tumor Board and Next Generation Sequencing
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Tianjin Medical University Second Hospital
Increased Nuchal Translucency in the First Trimester of Pregnancy
Metatranscriptomic Next Generation Sequencing in First Trimester Trophoblast With Increased Fetal Nuchal Translucency (METAHCN)
The study is based on the hypothesis that increased nuchal translucency may be associated with a materno fetal infection and that the pathogen responsible for this infection could be identify with metatranscriptomic…
- Trial name
- METAHCN (NCT05388968)
- Testing
- Metatranscriptomic, Specific microbiologic diagnosis
- Where
- France
- Volunteers
- 78 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Euploid Embryos
Embryo Aneuploidies and Morphokinetics in Ovarian Stimulated and Non Stimulated IVF Cycles
The purpose of this study is to compare the number of euploid embryos obtained per metaphase II oocyte in unstimulated (modified natural cycles) and stimulated IVF cycles.
- Trial name
- AMOS (NCT03128580)
- Where
- 3 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Lysosomal Storage Diseases
NGS-Based Genetic Approach to Identify Rare Lysosomal Storage Disorders in Patients With Neurological Manifestations
LYSO-NEXT uses genetic sequencing to identify undiagnosed lysosomal storage disorders in adults with unexplained neurological symptoms.
- Trial name
- LYSO-NEXT (NCT07863479)
- Testing
- NGS-based genetic testing
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Soft Tissue Sarcoma Adult, Undifferentiated Pleomorphic Sarcoma
Prospective Identification of Predictive Biomarkers of Trabectedin Efficacy in Non-L Soft-tissue Sarcoma Patients
This is a biology driven, monocentric study, designed to identify biomarkers of activity of trabectedin in patients with advanced non-L soft-tissue sarcoma.
- Conditions
- Soft Tissue Sarcoma Adult, Undifferentiated Pleomorphic Sarcoma, Epithelioid Sarcoma, Solitary Fibrous Tumors
- Trial name
- PIPER (NCT04008238)
- Testing
- Trabectedin
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Institut Bergonié
Malignant Hydrothorax, NSCLC
A Prospective Study to Evaluate the Consistency of Next-Generation Sequencing(NGS)-Panels by Using Malignant Hydrothorax Form NSCLC
A prospective study to evaluate consistency of different NGS-panel. Cell free DNA is purified from each malignant hydrothorax from NSCLC .Different NGS-panels are applied to perform in vitro diagnosis to detect Single Nucleotide…
- Trial name
- NCT03546452
- Testing
- in vitro NGS-panel
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Chest Hospital
Recurrent Endometrial Cancer
Pembrolizumab in Ultramutated and Hypermutated Endometrial Cancer
Primary Objectives: To assess the antitumor activity (proportion of objective response by RECIST 1.1 criteria) of pembrolizumab with objective tumor response in patients with persistent, recurrent or metastatic endometrial cancer…
- Trial name
- NCT02899793
- Testing
- Pembrolizumab
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Yale University
HIV Infections, Neonatal Infection
Immune Response to BCG Vaccination in Neonates Born to HIV and LTBI Infected and Non-infected Mothers
Maternal infections affect the basal immune status of neonates. One of the possible mechanism is the fetomaternal microchimerism, in which some cells and active substances are exchanged bi-directionally between maternal and fetal…
- Conditions
- HIV Infections, Neonatal Infection, LTBI - Latent Tuberculosis Infection, Immune Tolerance
- Trial name
- IMMUNEO (NCT03383211)
- Testing
- RNAseq
- Where
- 2 sites in Moldova
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- George Washington University